Assessment of restless legs syndrome—Methodological approaches for use in practice and clinical trials
Identifieur interne : 003F32 ( Main/Merge ); précédent : 003F31; suivant : 003F33Assessment of restless legs syndrome—Methodological approaches for use in practice and clinical trials
Auteurs : Ralf Kohnen [Allemagne] ; Richard P. Allen [États-Unis] ; Heike Benes [Allemagne] ; Diego Garcia-Borreguero [Espagne] ; Wayne A. Hening [États-Unis] ; Karin Stiasny-Kolster [Allemagne] ; Marco Zucconi [Italie]Source :
- Movement Disorders [ 0885-3185 ] ; 2007.
English descriptors
- KwdEn :
- Activities of Daily Living, Clinical Trials as Topic, Endpoint Determination, Humans, Quality of Life, Restless Legs Syndrome (complications), Restless Legs Syndrome (diagnosis), Restless Legs Syndrome (therapy), Severity of Illness Index, quality of life, questionnaire, rating scale, restless legs syndrome, severity.
- MESH :
- complications : Restless Legs Syndrome.
- diagnosis : Restless Legs Syndrome.
- therapy : Restless Legs Syndrome.
- Activities of Daily Living, Clinical Trials as Topic, Endpoint Determination, Humans, Quality of Life, Severity of Illness Index.
Abstract
The Restless Legs Syndrome (RLS) is a sensorimotor disorder that has only recently been extensively investigated by validated methods. Following the first presentation of diagnostic criteria by the International RLS Study Group in 1995, several methods were specifically developed for clinical trials in RLS or adapted from other areas of medicine and health sciences. We present a critical overview on validated methods to assess (1) severity of RLS symptoms [International RLS Rating Scale (IRLS), John Hopkins RLS Severity Scale (JHRLSSS), the RLS‐6 scales, and the investigtor‐based Clincial Global Impressions (CGI)]; (2) quality of life [RLS Quality of Life Instrument (RLS‐QLI), Hopkins RLS Quality of Life Questionnaire (RLSQoL), and the RLS Quality of Life Questionnaire (QoL‐RLS)]; (3) sleep disturbances and sudden onset of sleep; (4) sleep laboratory methods (polysomnography, limb activity monitoring by actigraphy) to evaluate sleep and periodic leg movements (including the “suggested immobilization test”); and (5) severity of augmentation (Augmentation Severity Rating Scale, ASRS). It is concluded that several validated methods are available to investigate the main features of RLS in practice and in clinical trials; however, further developments are needed to address new questions like the consequences of RLS on life functioning in areas such as ability to travel, days missed at work or impaired work performance. © 2007 Movement Disorder Society
Url:
DOI: 10.1002/mds.21588
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<front><div type="abstract" xml:lang="en">The Restless Legs Syndrome (RLS) is a sensorimotor disorder that has only recently been extensively investigated by validated methods. Following the first presentation of diagnostic criteria by the International RLS Study Group in 1995, several methods were specifically developed for clinical trials in RLS or adapted from other areas of medicine and health sciences. We present a critical overview on validated methods to assess (1) severity of RLS symptoms [International RLS Rating Scale (IRLS), John Hopkins RLS Severity Scale (JHRLSSS), the RLS‐6 scales, and the investigtor‐based Clincial Global Impressions (CGI)]; (2) quality of life [RLS Quality of Life Instrument (RLS‐QLI), Hopkins RLS Quality of Life Questionnaire (RLSQoL), and the RLS Quality of Life Questionnaire (QoL‐RLS)]; (3) sleep disturbances and sudden onset of sleep; (4) sleep laboratory methods (polysomnography, limb activity monitoring by actigraphy) to evaluate sleep and periodic leg movements (including the “suggested immobilization test”); and (5) severity of augmentation (Augmentation Severity Rating Scale, ASRS). It is concluded that several validated methods are available to investigate the main features of RLS in practice and in clinical trials; however, further developments are needed to address new questions like the consequences of RLS on life functioning in areas such as ability to travel, days missed at work or impaired work performance. © 2007 Movement Disorder Society</div>
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<front><div type="abstract" xml:lang="en">The Restless Legs Syndrome (RLS) is a sensorimotor disorder that has only recently been extensively investigated by validated methods. Following the first presentation of diagnostic criteria by the International RLS Study Group in 1995, several methods were specifically developed for clinical trials in RLS or adapted from other areas of medicine and health sciences. We present a critical overview on validated methods to assess (1) severity of RLS symptoms [International RLS Rating Scale (IRLS), John Hopkins RLS Severity Scale (JHRLSSS), the RLS‐6 scales, and the investigtor‐based Clincial Global Impressions (CGI)]; (2) quality of life [RLS Quality of Life Instrument (RLS‐QLI), Hopkins RLS Quality of Life Questionnaire (RLSQoL), and the RLS Quality of Life Questionnaire (QoL‐RLS)]; (3) sleep disturbances and sudden onset of sleep; (4) sleep laboratory methods (polysomnography, limb activity monitoring by actigraphy) to evaluate sleep and periodic leg movements (including the “suggested immobilization test”); and (5) severity of augmentation (Augmentation Severity Rating Scale, ASRS). It is concluded that several validated methods are available to investigate the main features of RLS in practice and in clinical trials; however, further developments are needed to address new questions like the consequences of RLS on life functioning in areas such as ability to travel, days missed at work or impaired work performance. © 2007 Movement Disorder Society</div>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">Assessment of restless legs syndrome--methodological approaches for use in practice and clinical trials.</title>
<author><name sortKey="Kohnen, Ralf" sort="Kohnen, Ralf" uniqKey="Kohnen R" first="Ralf" last="Kohnen">Ralf Kohnen</name>
<affiliation wicri:level="1"><nlm:affiliation>IMEREM Institute for Medical Research Management, Biometrics Ltd., University of Erlangen-Nuremberg, Nuremberg, Germany. kohnen@imerem.de</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>IMEREM Institute for Medical Research Management, Biometrics Ltd., University of Erlangen-Nuremberg, Nuremberg</wicri:regionArea>
<wicri:noRegion>Nuremberg</wicri:noRegion>
<wicri:noRegion>Nuremberg</wicri:noRegion>
<wicri:noRegion>Nuremberg</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Allen, Richard P" sort="Allen, Richard P" uniqKey="Allen R" first="Richard P" last="Allen">Richard P. Allen</name>
</author>
<author><name sortKey="Benes, Heike" sort="Benes, Heike" uniqKey="Benes H" first="Heike" last="Benes">Heike Benes</name>
</author>
<author><name sortKey="Garcia Borreguero, Diego" sort="Garcia Borreguero, Diego" uniqKey="Garcia Borreguero D" first="Diego" last="Garcia-Borreguero">Diego Garcia-Borreguero</name>
</author>
<author><name sortKey="Hening, Wayne A" sort="Hening, Wayne A" uniqKey="Hening W" first="Wayne A" last="Hening">Wayne A. Hening</name>
</author>
<author><name sortKey="Stiasny Kolster, Karin" sort="Stiasny Kolster, Karin" uniqKey="Stiasny Kolster K" first="Karin" last="Stiasny-Kolster">Karin Stiasny-Kolster</name>
</author>
<author><name sortKey="Zucconi, Marco" sort="Zucconi, Marco" uniqKey="Zucconi M" first="Marco" last="Zucconi">Marco Zucconi</name>
</author>
</analytic>
<series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title>
<idno type="ISSN">0885-3185</idno>
<imprint><date when="2007" type="published">2007</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Activities of Daily Living</term>
<term>Clinical Trials as Topic</term>
<term>Endpoint Determination</term>
<term>Humans</term>
<term>Quality of Life</term>
<term>Restless Legs Syndrome (complications)</term>
<term>Restless Legs Syndrome (diagnosis)</term>
<term>Restless Legs Syndrome (therapy)</term>
<term>Severity of Illness Index</term>
</keywords>
<keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Restless Legs Syndrome</term>
</keywords>
<keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Restless Legs Syndrome</term>
</keywords>
<keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Restless Legs Syndrome</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Activities of Daily Living</term>
<term>Clinical Trials as Topic</term>
<term>Endpoint Determination</term>
<term>Humans</term>
<term>Quality of Life</term>
<term>Severity of Illness Index</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">The Restless Legs Syndrome (RLS) is a sensorimotor disorder that has only recently been extensively investigated by validated methods. Following the first presentation of diagnostic criteria by the International RLS Study Group in 1995, several methods were specifically developed for clinical trials in RLS or adapted from other areas of medicine and health sciences. We present a critical overview on validated methods to assess (1) severity of RLS symptoms [International RLS Rating Scale (IRLS), John Hopkins RLS Severity Scale (JHRLSSS), the RLS-6 scales, and the investigator-based Clincial Global Impressions (CGI)]; (2) quality of life [RLS Quality of Life Instrument (RLS-QLI), Hopkins RLS Quality of Life Questionnaire (RLSQoL), and the RLS Quality of Life Questionnaire (QoL-RLS)]; (3) sleep disturbances and sudden onset of sleep; (4) sleep laboratory methods (polysomnography, limb activity monitoring by actigraphy) to evaluate sleep and periodic leg movements (including the "suggested immobilization test"); and (5) severity of augmentation (Augmentation Severity Rating Scale, ASRS). It is concluded that several validated methods are available to investigate the main features of RLS in practice and in clinical trials; however, further developments are needed to address new questions like the consequences of RLS on life functioning in areas such as ability to travel, days missed at work or impaired work performance.</div>
</front>
</TEI>
</PubMed>
</double>
</record>
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