Magnetic resonance spectroscopic evidence for presupplementary motor area neuronal dysfunction in Parkinson's disease
Identifieur interne : 003C79 ( Main/Merge ); précédent : 003C78; suivant : 003C80Magnetic resonance spectroscopic evidence for presupplementary motor area neuronal dysfunction in Parkinson's disease
Auteurs : Richard M. Camicioli [Canada] ; Christopher C. Hanstock [Canada] ; Thomas P. Bouchard [Canada] ; Myrlene Gee [Canada] ; Nancy J. Fisher [Canada] ; W. R. Wayne Martin [Canada]Source :
- Movement Disorders [ 0885-3185 ] ; 2007-02-15.
English descriptors
- KwdEn :
- Aged, Aged, 80 and over, Analysis of Variance, Female, Hoehn and Yahr Rating, Humans, Magnetic Resonance Imaging, Magnetic Resonance Spectroscopy, Male, Motor Cortex (pathology), Parkinson Disease (pathology), Parkinson Disease (physiopathology), Parkinson's disease, Unified Parkinson's Disease Rating Scale, magnetic resonance spectroscopy, motor signs.
- MESH :
- pathology : Motor Cortex, Parkinson Disease.
- physiopathology : Parkinson Disease.
- Aged, Aged, 80 and over, Analysis of Variance, Female, Humans, Magnetic Resonance Imaging, Magnetic Resonance Spectroscopy, Male.
Abstract
The anterior cingulate (AC) gyrus and the presupplementary motor area (pre‐SMA) show pathological changes in Parkinson's disease (PD). We examined if PD patients show magnetic resonance spectroscopy (MRS) changes in NAA/Cr in the AC, pre‐SMA, or posterior cingulate (PC). Forty‐four (27 male, 17 female) healthy nondemented PD patients and 38 controls (18 male, 20 female) 65 years of age and older were examined using the Unified Parkinson's Disease Rating Scale (UPDRS), Mini‐Mental State Examination, Frontal Assessment Battery, and Geriatric Depression Scale. MRS was performed at 1.5 T. Voxels (8 cc; PRESS; TE = 80; TR = 1,600 ms) were placed mid‐sagittally. Gray matter and white matter volumes were measured within voxels using SPM2. Spectra were analyzed using LC model to yield NAA/Cr and Cho/Cr. Demographic and cognitive measures did not differ between groups. Motor UPDRS was 17.7 ± 8.8 for PD. Pre‐SMA NAA/Cr was lower in PD (PD: 1.39 ± 0.17; control: 1.47 ± 0.16; P = 0.045) and correlated negatively with age (r = 0.39; P = 0.01), but not with UPDRS, disease duration, or dopamine equivalents. AC and PC NAA/Cr and Cho/Cr in any region did not differ (P > 0.05). In conclusion, pre‐SMA NAA/Cr was selectively decreased in PD, consistent with neuronal dysfunction. This should be further examined as a biomarker of disease in PD. © 2006 Movement Disorder Society
Url:
DOI: 10.1002/mds.21288
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: 001B61
- to stream Istex, to step Curation: 001B61
- to stream Istex, to step Checkpoint: 001865
- to stream PubMed, to step Corpus: 002919
- to stream PubMed, to step Curation: 002919
- to stream PubMed, to step Checkpoint: 002729
- to stream Ncbi, to step Merge: 001A20
- to stream Ncbi, to step Curation: 001A20
- to stream Ncbi, to step Checkpoint: 001A20
Links to Exploration step
ISTEX:A0C2A1BAA3D06B7A30213F50E081DC25E4BEBBFALe document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Magnetic resonance spectroscopic evidence for presupplementary motor area neuronal dysfunction in Parkinson's disease</title>
<author><name sortKey="Camicioli, Richard M" sort="Camicioli, Richard M" uniqKey="Camicioli R" first="Richard M." last="Camicioli">Richard M. Camicioli</name>
</author>
<author><name sortKey="Hanstock, Christopher C" sort="Hanstock, Christopher C" uniqKey="Hanstock C" first="Christopher C." last="Hanstock">Christopher C. Hanstock</name>
</author>
<author><name sortKey="Bouchard, Thomas P" sort="Bouchard, Thomas P" uniqKey="Bouchard T" first="Thomas P." last="Bouchard">Thomas P. Bouchard</name>
</author>
<author><name sortKey="Gee, Myrlene" sort="Gee, Myrlene" uniqKey="Gee M" first="Myrlene" last="Gee">Myrlene Gee</name>
</author>
<author><name sortKey="Fisher, Nancy J" sort="Fisher, Nancy J" uniqKey="Fisher N" first="Nancy J." last="Fisher">Nancy J. Fisher</name>
</author>
<author><name sortKey="Martin, W R Wayne" sort="Martin, W R Wayne" uniqKey="Martin W" first="W. R. Wayne" last="Martin">W. R. Wayne Martin</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">ISTEX</idno>
<idno type="RBID">ISTEX:A0C2A1BAA3D06B7A30213F50E081DC25E4BEBBFA</idno>
<date when="2007" year="2007">2007</date>
<idno type="doi">10.1002/mds.21288</idno>
<idno type="url">https://api.istex.fr/document/A0C2A1BAA3D06B7A30213F50E081DC25E4BEBBFA/fulltext/pdf</idno>
<idno type="wicri:Area/Istex/Corpus">001B61</idno>
<idno type="wicri:Area/Istex/Curation">001B61</idno>
<idno type="wicri:Area/Istex/Checkpoint">001865</idno>
<idno type="wicri:doubleKey">0885-3185:2007:Camicioli R:magnetic:resonance:spectroscopic</idno>
<idno type="wicri:source">PubMed</idno>
<idno type="RBID">pubmed:17216652</idno>
<idno type="wicri:Area/PubMed/Corpus">002919</idno>
<idno type="wicri:Area/PubMed/Curation">002919</idno>
<idno type="wicri:Area/PubMed/Checkpoint">002729</idno>
<idno type="wicri:Area/Ncbi/Merge">001A20</idno>
<idno type="wicri:Area/Ncbi/Curation">001A20</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">001A20</idno>
<idno type="wicri:doubleKey">0885-3185:2007:Camicioli R:magnetic:resonance:spectroscopic</idno>
<idno type="wicri:Area/Main/Merge">003C79</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Magnetic resonance spectroscopic evidence for presupplementary motor area neuronal dysfunction in Parkinson's disease</title>
<author><name sortKey="Camicioli, Richard M" sort="Camicioli, Richard M" uniqKey="Camicioli R" first="Richard M." last="Camicioli">Richard M. Camicioli</name>
<affiliation wicri:level="1"><country xml:lang="fr">Canada</country>
<wicri:regionArea>Department of Medicine (Neurology), University of Alberta, Edmonton, Alberta</wicri:regionArea>
<wicri:noRegion>Alberta</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Hanstock, Christopher C" sort="Hanstock, Christopher C" uniqKey="Hanstock C" first="Christopher C." last="Hanstock">Christopher C. Hanstock</name>
<affiliation wicri:level="1"><country xml:lang="fr">Canada</country>
<wicri:regionArea>Department of Biomedical Engineering, University of Alberta, Edmonton, Alberta</wicri:regionArea>
<wicri:noRegion>Alberta</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Bouchard, Thomas P" sort="Bouchard, Thomas P" uniqKey="Bouchard T" first="Thomas P." last="Bouchard">Thomas P. Bouchard</name>
<affiliation wicri:level="1"><country xml:lang="fr">Canada</country>
<wicri:regionArea>Department of Medicine (Neurology), University of Alberta, Edmonton, Alberta</wicri:regionArea>
<wicri:noRegion>Alberta</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Gee, Myrlene" sort="Gee, Myrlene" uniqKey="Gee M" first="Myrlene" last="Gee">Myrlene Gee</name>
<affiliation wicri:level="1"><country xml:lang="fr">Canada</country>
<wicri:regionArea>Department of Biomedical Engineering, University of Alberta, Edmonton, Alberta</wicri:regionArea>
<wicri:noRegion>Alberta</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Fisher, Nancy J" sort="Fisher, Nancy J" uniqKey="Fisher N" first="Nancy J." last="Fisher">Nancy J. Fisher</name>
<affiliation wicri:level="1"><country xml:lang="fr">Canada</country>
<wicri:regionArea>Division of Neurosciences, University of Alberta, Edmonton, Alberta</wicri:regionArea>
<wicri:noRegion>Alberta</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Martin, W R Wayne" sort="Martin, W R Wayne" uniqKey="Martin W" first="W. R. Wayne" last="Martin">W. R. Wayne Martin</name>
<affiliation wicri:level="1"><country xml:lang="fr">Canada</country>
<wicri:regionArea>Department of Medicine (Neurology), University of Alberta, Edmonton, Alberta</wicri:regionArea>
<wicri:noRegion>Alberta</wicri:noRegion>
</affiliation>
</author>
</analytic>
<monogr></monogr>
<series><title level="j">Movement Disorders</title>
<title level="j" type="sub">Official Journal of the Movement Disorder Society</title>
<title level="j" type="abbrev">Mov. Disord.</title>
<idno type="ISSN">0885-3185</idno>
<idno type="eISSN">1531-8257</idno>
<imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher>
<pubPlace>Hoboken</pubPlace>
<date type="published" when="2007-02-15">2007-02-15</date>
<biblScope unit="vol">22</biblScope>
<biblScope unit="issue">3</biblScope>
<biblScope unit="page" from="382">382</biblScope>
<biblScope unit="page" to="386">386</biblScope>
</imprint>
<idno type="ISSN">0885-3185</idno>
</series>
<idno type="istex">A0C2A1BAA3D06B7A30213F50E081DC25E4BEBBFA</idno>
<idno type="DOI">10.1002/mds.21288</idno>
<idno type="ArticleID">MDS21288</idno>
</biblStruct>
</sourceDesc>
<seriesStmt><idno type="ISSN">0885-3185</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term>
<term>Aged, 80 and over</term>
<term>Analysis of Variance</term>
<term>Female</term>
<term>Hoehn and Yahr Rating</term>
<term>Humans</term>
<term>Magnetic Resonance Imaging</term>
<term>Magnetic Resonance Spectroscopy</term>
<term>Male</term>
<term>Motor Cortex (pathology)</term>
<term>Parkinson Disease (pathology)</term>
<term>Parkinson Disease (physiopathology)</term>
<term>Parkinson's disease</term>
<term>Unified Parkinson's Disease Rating Scale</term>
<term>magnetic resonance spectroscopy</term>
<term>motor signs</term>
</keywords>
<keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Motor Cortex</term>
<term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Aged</term>
<term>Aged, 80 and over</term>
<term>Analysis of Variance</term>
<term>Female</term>
<term>Humans</term>
<term>Magnetic Resonance Imaging</term>
<term>Magnetic Resonance Spectroscopy</term>
<term>Male</term>
</keywords>
</textClass>
<langUsage><language ident="en">en</language>
</langUsage>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">The anterior cingulate (AC) gyrus and the presupplementary motor area (pre‐SMA) show pathological changes in Parkinson's disease (PD). We examined if PD patients show magnetic resonance spectroscopy (MRS) changes in NAA/Cr in the AC, pre‐SMA, or posterior cingulate (PC). Forty‐four (27 male, 17 female) healthy nondemented PD patients and 38 controls (18 male, 20 female) 65 years of age and older were examined using the Unified Parkinson's Disease Rating Scale (UPDRS), Mini‐Mental State Examination, Frontal Assessment Battery, and Geriatric Depression Scale. MRS was performed at 1.5 T. Voxels (8 cc; PRESS; TE = 80; TR = 1,600 ms) were placed mid‐sagittally. Gray matter and white matter volumes were measured within voxels using SPM2. Spectra were analyzed using LC model to yield NAA/Cr and Cho/Cr. Demographic and cognitive measures did not differ between groups. Motor UPDRS was 17.7 ± 8.8 for PD. Pre‐SMA NAA/Cr was lower in PD (PD: 1.39 ± 0.17; control: 1.47 ± 0.16; P = 0.045) and correlated negatively with age (r = 0.39; P = 0.01), but not with UPDRS, disease duration, or dopamine equivalents. AC and PC NAA/Cr and Cho/Cr in any region did not differ (P > 0.05). In conclusion, pre‐SMA NAA/Cr was selectively decreased in PD, consistent with neuronal dysfunction. This should be further examined as a biomarker of disease in PD. © 2006 Movement Disorder Society</div>
</front>
</TEI>
<double doi="10.1002/mds.21288"><ISTEX><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Magnetic resonance spectroscopic evidence for presupplementary motor area neuronal dysfunction in Parkinson's disease</title>
<author><name sortKey="Camicioli, Richard M" sort="Camicioli, Richard M" uniqKey="Camicioli R" first="Richard M." last="Camicioli">Richard M. Camicioli</name>
</author>
<author><name sortKey="Hanstock, Christopher C" sort="Hanstock, Christopher C" uniqKey="Hanstock C" first="Christopher C." last="Hanstock">Christopher C. Hanstock</name>
</author>
<author><name sortKey="Bouchard, Thomas P" sort="Bouchard, Thomas P" uniqKey="Bouchard T" first="Thomas P." last="Bouchard">Thomas P. Bouchard</name>
</author>
<author><name sortKey="Gee, Myrlene" sort="Gee, Myrlene" uniqKey="Gee M" first="Myrlene" last="Gee">Myrlene Gee</name>
</author>
<author><name sortKey="Fisher, Nancy J" sort="Fisher, Nancy J" uniqKey="Fisher N" first="Nancy J." last="Fisher">Nancy J. Fisher</name>
</author>
<author><name sortKey="Martin, W R Wayne" sort="Martin, W R Wayne" uniqKey="Martin W" first="W. R. Wayne" last="Martin">W. R. Wayne Martin</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">ISTEX</idno>
<idno type="RBID">ISTEX:A0C2A1BAA3D06B7A30213F50E081DC25E4BEBBFA</idno>
<date when="2007" year="2007">2007</date>
<idno type="doi">10.1002/mds.21288</idno>
<idno type="url">https://api.istex.fr/document/A0C2A1BAA3D06B7A30213F50E081DC25E4BEBBFA/fulltext/pdf</idno>
<idno type="wicri:Area/Istex/Corpus">001B61</idno>
<idno type="wicri:Area/Istex/Curation">001B61</idno>
<idno type="wicri:Area/Istex/Checkpoint">001865</idno>
<idno type="wicri:doubleKey">0885-3185:2007:Camicioli R:magnetic:resonance:spectroscopic</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Magnetic resonance spectroscopic evidence for presupplementary motor area neuronal dysfunction in Parkinson's disease</title>
<author><name sortKey="Camicioli, Richard M" sort="Camicioli, Richard M" uniqKey="Camicioli R" first="Richard M." last="Camicioli">Richard M. Camicioli</name>
<affiliation wicri:level="1"><country xml:lang="fr">Canada</country>
<wicri:regionArea>Department of Medicine (Neurology), University of Alberta, Edmonton, Alberta</wicri:regionArea>
<wicri:noRegion>Alberta</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Hanstock, Christopher C" sort="Hanstock, Christopher C" uniqKey="Hanstock C" first="Christopher C." last="Hanstock">Christopher C. Hanstock</name>
<affiliation wicri:level="1"><country xml:lang="fr">Canada</country>
<wicri:regionArea>Department of Biomedical Engineering, University of Alberta, Edmonton, Alberta</wicri:regionArea>
<wicri:noRegion>Alberta</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Bouchard, Thomas P" sort="Bouchard, Thomas P" uniqKey="Bouchard T" first="Thomas P." last="Bouchard">Thomas P. Bouchard</name>
<affiliation wicri:level="1"><country xml:lang="fr">Canada</country>
<wicri:regionArea>Department of Medicine (Neurology), University of Alberta, Edmonton, Alberta</wicri:regionArea>
<wicri:noRegion>Alberta</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Gee, Myrlene" sort="Gee, Myrlene" uniqKey="Gee M" first="Myrlene" last="Gee">Myrlene Gee</name>
<affiliation wicri:level="1"><country xml:lang="fr">Canada</country>
<wicri:regionArea>Department of Biomedical Engineering, University of Alberta, Edmonton, Alberta</wicri:regionArea>
<wicri:noRegion>Alberta</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Fisher, Nancy J" sort="Fisher, Nancy J" uniqKey="Fisher N" first="Nancy J." last="Fisher">Nancy J. Fisher</name>
<affiliation wicri:level="1"><country xml:lang="fr">Canada</country>
<wicri:regionArea>Division of Neurosciences, University of Alberta, Edmonton, Alberta</wicri:regionArea>
<wicri:noRegion>Alberta</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Martin, W R Wayne" sort="Martin, W R Wayne" uniqKey="Martin W" first="W. R. Wayne" last="Martin">W. R. Wayne Martin</name>
<affiliation wicri:level="1"><country xml:lang="fr">Canada</country>
<wicri:regionArea>Department of Medicine (Neurology), University of Alberta, Edmonton, Alberta</wicri:regionArea>
<wicri:noRegion>Alberta</wicri:noRegion>
</affiliation>
</author>
</analytic>
<monogr></monogr>
<series><title level="j">Movement Disorders</title>
<title level="j" type="sub">Official Journal of the Movement Disorder Society</title>
<title level="j" type="abbrev">Mov. Disord.</title>
<idno type="ISSN">0885-3185</idno>
<idno type="eISSN">1531-8257</idno>
<imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher>
<pubPlace>Hoboken</pubPlace>
<date type="published" when="2007-02-15">2007-02-15</date>
<biblScope unit="vol">22</biblScope>
<biblScope unit="issue">3</biblScope>
<biblScope unit="page" from="382">382</biblScope>
<biblScope unit="page" to="386">386</biblScope>
</imprint>
<idno type="ISSN">0885-3185</idno>
</series>
<idno type="istex">A0C2A1BAA3D06B7A30213F50E081DC25E4BEBBFA</idno>
<idno type="DOI">10.1002/mds.21288</idno>
<idno type="ArticleID">MDS21288</idno>
</biblStruct>
</sourceDesc>
<seriesStmt><idno type="ISSN">0885-3185</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Hoehn and Yahr Rating</term>
<term>Parkinson's disease</term>
<term>Unified Parkinson's Disease Rating Scale</term>
<term>magnetic resonance spectroscopy</term>
<term>motor signs</term>
</keywords>
</textClass>
<langUsage><language ident="en">en</language>
</langUsage>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">The anterior cingulate (AC) gyrus and the presupplementary motor area (pre‐SMA) show pathological changes in Parkinson's disease (PD). We examined if PD patients show magnetic resonance spectroscopy (MRS) changes in NAA/Cr in the AC, pre‐SMA, or posterior cingulate (PC). Forty‐four (27 male, 17 female) healthy nondemented PD patients and 38 controls (18 male, 20 female) 65 years of age and older were examined using the Unified Parkinson's Disease Rating Scale (UPDRS), Mini‐Mental State Examination, Frontal Assessment Battery, and Geriatric Depression Scale. MRS was performed at 1.5 T. Voxels (8 cc; PRESS; TE = 80; TR = 1,600 ms) were placed mid‐sagittally. Gray matter and white matter volumes were measured within voxels using SPM2. Spectra were analyzed using LC model to yield NAA/Cr and Cho/Cr. Demographic and cognitive measures did not differ between groups. Motor UPDRS was 17.7 ± 8.8 for PD. Pre‐SMA NAA/Cr was lower in PD (PD: 1.39 ± 0.17; control: 1.47 ± 0.16; P = 0.045) and correlated negatively with age (r = 0.39; P = 0.01), but not with UPDRS, disease duration, or dopamine equivalents. AC and PC NAA/Cr and Cho/Cr in any region did not differ (P > 0.05). In conclusion, pre‐SMA NAA/Cr was selectively decreased in PD, consistent with neuronal dysfunction. This should be further examined as a biomarker of disease in PD. © 2006 Movement Disorder Society</div>
</front>
</TEI>
</ISTEX>
<PubMed><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Magnetic resonance spectroscopic evidence for presupplementary motor area neuronal dysfunction in Parkinson's disease.</title>
<author><name sortKey="Camicioli, Richard M" sort="Camicioli, Richard M" uniqKey="Camicioli R" first="Richard M" last="Camicioli">Richard M. Camicioli</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Medicine (Neurology), University of Alberta, Edmonton, Alberta, Canada. rcamicio@ualberta.ca</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Department of Medicine (Neurology), University of Alberta, Edmonton, Alberta</wicri:regionArea>
<wicri:noRegion>Alberta</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Hanstock, Christopher C" sort="Hanstock, Christopher C" uniqKey="Hanstock C" first="Christopher C" last="Hanstock">Christopher C. Hanstock</name>
</author>
<author><name sortKey="Bouchard, Thomas P" sort="Bouchard, Thomas P" uniqKey="Bouchard T" first="Thomas P" last="Bouchard">Thomas P. Bouchard</name>
</author>
<author><name sortKey="Gee, Myrlene" sort="Gee, Myrlene" uniqKey="Gee M" first="Myrlene" last="Gee">Myrlene Gee</name>
</author>
<author><name sortKey="Fisher, Nancy J" sort="Fisher, Nancy J" uniqKey="Fisher N" first="Nancy J" last="Fisher">Nancy J. Fisher</name>
</author>
<author><name sortKey="Martin, W R Wayne" sort="Martin, W R Wayne" uniqKey="Martin W" first="W R Wayne" last="Martin">W R Wayne Martin</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="2007">2007</date>
<idno type="doi">10.1002/mds.21288</idno>
<idno type="RBID">pubmed:17216652</idno>
<idno type="pmid">17216652</idno>
<idno type="wicri:Area/PubMed/Corpus">002919</idno>
<idno type="wicri:Area/PubMed/Curation">002919</idno>
<idno type="wicri:Area/PubMed/Checkpoint">002729</idno>
<idno type="wicri:Area/Ncbi/Merge">001A20</idno>
<idno type="wicri:Area/Ncbi/Curation">001A20</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">001A20</idno>
<idno type="wicri:doubleKey">0885-3185:2007:Camicioli R:magnetic:resonance:spectroscopic</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">Magnetic resonance spectroscopic evidence for presupplementary motor area neuronal dysfunction in Parkinson's disease.</title>
<author><name sortKey="Camicioli, Richard M" sort="Camicioli, Richard M" uniqKey="Camicioli R" first="Richard M" last="Camicioli">Richard M. Camicioli</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Medicine (Neurology), University of Alberta, Edmonton, Alberta, Canada. rcamicio@ualberta.ca</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Department of Medicine (Neurology), University of Alberta, Edmonton, Alberta</wicri:regionArea>
<wicri:noRegion>Alberta</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Hanstock, Christopher C" sort="Hanstock, Christopher C" uniqKey="Hanstock C" first="Christopher C" last="Hanstock">Christopher C. Hanstock</name>
</author>
<author><name sortKey="Bouchard, Thomas P" sort="Bouchard, Thomas P" uniqKey="Bouchard T" first="Thomas P" last="Bouchard">Thomas P. Bouchard</name>
</author>
<author><name sortKey="Gee, Myrlene" sort="Gee, Myrlene" uniqKey="Gee M" first="Myrlene" last="Gee">Myrlene Gee</name>
</author>
<author><name sortKey="Fisher, Nancy J" sort="Fisher, Nancy J" uniqKey="Fisher N" first="Nancy J" last="Fisher">Nancy J. Fisher</name>
</author>
<author><name sortKey="Martin, W R Wayne" sort="Martin, W R Wayne" uniqKey="Martin W" first="W R Wayne" last="Martin">W R Wayne Martin</name>
</author>
</analytic>
<series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title>
<idno type="ISSN">0885-3185</idno>
<imprint><date when="2007" type="published">2007</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term>
<term>Aged, 80 and over</term>
<term>Analysis of Variance</term>
<term>Female</term>
<term>Humans</term>
<term>Magnetic Resonance Imaging</term>
<term>Magnetic Resonance Spectroscopy</term>
<term>Male</term>
<term>Motor Cortex (pathology)</term>
<term>Parkinson Disease (pathology)</term>
<term>Parkinson Disease (physiopathology)</term>
</keywords>
<keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Motor Cortex</term>
<term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Aged</term>
<term>Aged, 80 and over</term>
<term>Analysis of Variance</term>
<term>Female</term>
<term>Humans</term>
<term>Magnetic Resonance Imaging</term>
<term>Magnetic Resonance Spectroscopy</term>
<term>Male</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">The anterior cingulate (AC) gyrus and the presupplementary motor area (pre-SMA) show pathological changes in Parkinson's disease (PD). We examined if PD patients show magnetic resonance spectroscopy (MRS) changes in NAA/Cr in the AC, pre-SMA, or posterior cingulate (PC). Forty-four (27 male, 17 female) healthy nondemented PD patients and 38 controls (18 male, 20 female) 65 years of age and older were examined using the Unified Parkinson's Disease Rating Scale (UPDRS), Mini-Mental State Examination, Frontal Assessment Battery, and Geriatric Depression Scale. MRS was performed at 1.5 T. Voxels (8 cc; PRESS; TE = 80; TR = 1,600 ms) were placed mid-sagittally. Gray matter and white matter volumes were measured within voxels using SPM2. Spectra were analyzed using LC model to yield NAA/Cr and Cho/Cr. Demographic and cognitive measures did not differ between groups. Motor UPDRS was 17.7 +/- 8.8 for PD. Pre-SMA NAA/Cr was lower in PD (PD: 1.39 +/- 0.17; control: 1.47 +/- 0.16; P = 0.045) and correlated negatively with age (r = 0.39; P = 0.01), but not with UPDRS, disease duration, or dopamine equivalents. AC and PC NAA/Cr and Cho/Cr in any region did not differ (P > 0.05). In conclusion, pre-SMA NAA/Cr was selectively decreased in PD, consistent with neuronal dysfunction. This should be further examined as a biomarker of disease in PD.</div>
</front>
</TEI>
</PubMed>
</double>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Santé/explor/MovDisordV3/Data/Main/Merge
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 003C79 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Merge/biblio.hfd -nk 003C79 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Santé |area= MovDisordV3 |flux= Main |étape= Merge |type= RBID |clé= ISTEX:A0C2A1BAA3D06B7A30213F50E081DC25E4BEBBFA |texte= Magnetic resonance spectroscopic evidence for presupplementary motor area neuronal dysfunction in Parkinson's disease }}
This area was generated with Dilib version V0.6.23. |