Subthalamic‐thalamic DBS in a case with spinocerebellar ataxia type 2 and severe tremor—A unusual clinical benefit
Identifieur interne : 003A74 ( Main/Merge ); précédent : 003A73; suivant : 003A75Subthalamic‐thalamic DBS in a case with spinocerebellar ataxia type 2 and severe tremor—A unusual clinical benefit
Auteurs : Hans-Joachim Freund [Allemagne] ; Utako B. Barnikol [Allemagne] ; Dagmar Nolte [Allemagne] ; Harald Treuer [Allemagne] ; Georg Auburger [Allemagne] ; Peter A. Tass [Allemagne] ; Madjid Samii [Allemagne] ; Volker Sturm [Allemagne]Source :
- Movement Disorders [ 0885-3185 ] ; 2007-04-15.
English descriptors
- KwdEn :
- Activities of Daily Living (classification), Adult, Deep Brain Stimulation, Electrodes, Implanted, Female, Follow-Up Studies, Humans, Neurologic Examination, Spinocerebellar Ataxias (diagnosis), Spinocerebellar Ataxias (physiopathology), Spinocerebellar Ataxias (therapy), Subthalamic Nucleus (physiopathology), Torticollis (diagnosis), Torticollis (physiopathology), Torticollis (therapy), Treatment Outcome, Tremor (diagnosis), Tremor (physiopathology), Tremor (therapy), Ventral Thalamic Nuclei (physiopathology), cerebellar tremor, deep brain stimulation, long‐lasting benefit, subthalamic target.
- MESH :
- classification : Activities of Daily Living.
- diagnosis : Spinocerebellar Ataxias, Torticollis, Tremor.
- physiopathology : Spinocerebellar Ataxias, Subthalamic Nucleus, Torticollis, Tremor, Ventral Thalamic Nuclei.
- therapy : Spinocerebellar Ataxias, Torticollis, Tremor.
- Adult, Deep Brain Stimulation, Electrodes, Implanted, Female, Follow-Up Studies, Humans, Neurologic Examination, Treatment Outcome.
Abstract
This is a single case report of a patient with spinocerebellar ataxia type 2 (SCA2) and severe tremor. Whereas disease progression with prevailing ataxia and dysmetria was slow over the first symptomatic 6 years, 6 months prior to operation were characterized by the development of a severe, debilitating postural tremor rendering the patient unable to independently sit, stand, speak, or swallow. Deep brain stimulation (DBS) at a subthalamic–thalamic electrode position almost completely arrested her tremor. The patient regained the functional state prior to her rapid disease progression allowing a restricted range of daily activities. Her condition has remained approximately stable over the two postoperative years to date. In addition to the efficacy of DBS on cerebellar tremor, the results illustrate a remarkable improvement of the patient's general condition and independence.
Url:
DOI: 10.1002/mds.21338
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Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2007-04-15">2007-04-15</date><biblScope unit="vol">22</biblScope><biblScope unit="issue">5</biblScope><biblScope unit="page" from="732">732</biblScope><biblScope unit="page" to="735">735</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">B79BA13EC8F75FDB2547F5F9F6AED56023BA7AD7</idno><idno type="DOI">10.1002/mds.21338</idno><idno type="ArticleID">MDS21338</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Activities of Daily Living (classification)</term><term>Adult</term><term>Deep Brain Stimulation</term><term>Electrodes, Implanted</term><term>Female</term><term>Follow-Up Studies</term><term>Humans</term><term>Neurologic Examination</term><term>Spinocerebellar Ataxias (diagnosis)</term><term>Spinocerebellar Ataxias (physiopathology)</term><term>Spinocerebellar Ataxias (therapy)</term><term>Subthalamic Nucleus (physiopathology)</term><term>Torticollis (diagnosis)</term><term>Torticollis (physiopathology)</term><term>Torticollis (therapy)</term><term>Treatment Outcome</term><term>Tremor (diagnosis)</term><term>Tremor (physiopathology)</term><term>Tremor (therapy)</term><term>Ventral Thalamic Nuclei (physiopathology)</term><term>cerebellar tremor</term><term>deep brain stimulation</term><term>long‐lasting benefit</term><term>subthalamic target</term></keywords><keywords scheme="MESH" qualifier="classification" xml:lang="en"><term>Activities of Daily Living</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Spinocerebellar Ataxias</term><term>Torticollis</term><term>Tremor</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Spinocerebellar Ataxias</term><term>Subthalamic Nucleus</term><term>Torticollis</term><term>Tremor</term><term>Ventral Thalamic Nuclei</term></keywords><keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Spinocerebellar Ataxias</term><term>Torticollis</term><term>Tremor</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Deep Brain Stimulation</term><term>Electrodes, Implanted</term><term>Female</term><term>Follow-Up Studies</term><term>Humans</term><term>Neurologic Examination</term><term>Treatment Outcome</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">This is a single case report of a patient with spinocerebellar ataxia type 2 (SCA2) and severe tremor. Whereas disease progression with prevailing ataxia and dysmetria was slow over the first symptomatic 6 years, 6 months prior to operation were characterized by the development of a severe, debilitating postural tremor rendering the patient unable to independently sit, stand, speak, or swallow. Deep brain stimulation (DBS) at a subthalamic–thalamic electrode position almost completely arrested her tremor. The patient regained the functional state prior to her rapid disease progression allowing a restricted range of daily activities. Her condition has remained approximately stable over the two postoperative years to date. In addition to the efficacy of DBS on cerebellar tremor, the results illustrate a remarkable improvement of the patient's general condition and independence.</div></front></TEI><double doi="10.1002/mds.21338"><ISTEX><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Subthalamic‐thalamic DBS in a case with spinocerebellar ataxia type 2 and severe tremor—A unusual clinical benefit</title><author><name sortKey="Freund, Hans Oachim" sort="Freund, Hans Oachim" uniqKey="Freund H" first="Hans-Joachim" last="Freund">Hans-Joachim Freund</name></author><author><name sortKey="Barnikol, Utako B" sort="Barnikol, Utako B" uniqKey="Barnikol U" first="Utako B." last="Barnikol">Utako B. Barnikol</name></author><author><name sortKey="Nolte, Dagmar" sort="Nolte, Dagmar" uniqKey="Nolte D" first="Dagmar" last="Nolte">Dagmar Nolte</name></author><author><name sortKey="Treuer, Harald" sort="Treuer, Harald" uniqKey="Treuer H" first="Harald" last="Treuer">Harald Treuer</name></author><author><name sortKey="Auburger, Georg" sort="Auburger, Georg" uniqKey="Auburger G" first="Georg" last="Auburger">Georg Auburger</name></author><author><name sortKey="Tass, Peter A" sort="Tass, Peter A" uniqKey="Tass P" first="Peter A." last="Tass">Peter A. Tass</name></author><author><name sortKey="Samii, Madjid" sort="Samii, Madjid" uniqKey="Samii M" first="Madjid" last="Samii">Madjid Samii</name></author><author><name sortKey="Sturm, Volker" sort="Sturm, Volker" uniqKey="Sturm V" first="Volker" last="Sturm">Volker Sturm</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:B79BA13EC8F75FDB2547F5F9F6AED56023BA7AD7</idno><date when="2007" year="2007">2007</date><idno type="doi">10.1002/mds.21338</idno><idno type="url">https://api.istex.fr/document/B79BA13EC8F75FDB2547F5F9F6AED56023BA7AD7/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">003380</idno><idno type="wicri:Area/Istex/Curation">003380</idno><idno type="wicri:Area/Istex/Checkpoint">001660</idno><idno type="wicri:doubleKey">0885-3185:2007:Freund H:subthalamic:thalamic:dbs</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Subthalamic‐thalamic DBS in a case with spinocerebellar ataxia type 2 and severe tremor—A unusual clinical benefit</title><author><name sortKey="Freund, Hans Oachim" sort="Freund, Hans Oachim" uniqKey="Freund H" first="Hans-Joachim" last="Freund">Hans-Joachim Freund</name><affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Neuroscience and Biophysics 3, Research Center Jülich, Jülich</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Juliers</settlement></placeName></affiliation><affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Virtual Institute of Neuromodulation, Research Center Jülich, Jülich</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Juliers</settlement></placeName></affiliation><affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country><wicri:regionArea>International Neuroscience Institute, Hannover</wicri:regionArea><placeName><region type="land" nuts="2">Basse-Saxe</region><settlement type="city">Hanovre</settlement></placeName></affiliation></author><author><name sortKey="Barnikol, Utako B" sort="Barnikol, Utako B" uniqKey="Barnikol U" first="Utako B." last="Barnikol">Utako B. Barnikol</name><affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Virtual Institute of Neuromodulation, Research Center Jülich, Jülich</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Juliers</settlement></placeName></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Stereotactic and Functional Neurosurgery, University of Cologne, Cologne</wicri:regionArea><wicri:noRegion>Cologne</wicri:noRegion><wicri:noRegion>Cologne</wicri:noRegion></affiliation></author><author><name sortKey="Nolte, Dagmar" sort="Nolte, Dagmar" uniqKey="Nolte D" first="Dagmar" last="Nolte">Dagmar Nolte</name><affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Human Genetics, University of Giessen, Giessen</wicri:regionArea><wicri:noRegion>Giessen</wicri:noRegion><wicri:noRegion>Giessen</wicri:noRegion></affiliation></author><author><name sortKey="Treuer, Harald" sort="Treuer, Harald" uniqKey="Treuer H" first="Harald" last="Treuer">Harald Treuer</name><affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Stereotactic and Functional Neurosurgery, University of Cologne, Cologne</wicri:regionArea><wicri:noRegion>Cologne</wicri:noRegion><wicri:noRegion>Cologne</wicri:noRegion></affiliation></author><author><name sortKey="Auburger, Georg" sort="Auburger, Georg" uniqKey="Auburger G" first="Georg" last="Auburger">Georg Auburger</name><affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Section of Molecular Neurogenetics, Department of Neurology, Johann Wolfgang Goethe University, Frankfurt/Main</wicri:regionArea><wicri:noRegion>Frankfurt/Main</wicri:noRegion><wicri:noRegion>Frankfurt/Main</wicri:noRegion></affiliation></author><author><name sortKey="Tass, Peter A" sort="Tass, Peter A" uniqKey="Tass P" first="Peter A." last="Tass">Peter A. Tass</name><affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Neuroscience and Biophysics 3, Research Center Jülich, Jülich</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Juliers</settlement></placeName></affiliation><affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Virtual Institute of Neuromodulation, Research Center Jülich, Jülich</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Juliers</settlement></placeName></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Stereotactic and Functional Neurosurgery, University of Cologne, Cologne</wicri:regionArea><wicri:noRegion>Cologne</wicri:noRegion><wicri:noRegion>Cologne</wicri:noRegion></affiliation><affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Brain Imaging Center West, Research Center Jülich, Jülich</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Juliers</settlement></placeName></affiliation></author><author><name sortKey="Samii, Madjid" sort="Samii, Madjid" uniqKey="Samii M" first="Madjid" last="Samii">Madjid Samii</name><affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country><wicri:regionArea>International Neuroscience Institute, Hannover</wicri:regionArea><placeName><region type="land" nuts="2">Basse-Saxe</region><settlement type="city">Hanovre</settlement></placeName></affiliation></author><author><name sortKey="Sturm, Volker" sort="Sturm, Volker" uniqKey="Sturm V" first="Volker" last="Sturm">Volker Sturm</name><affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Virtual Institute of Neuromodulation, Research Center Jülich, Jülich</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Juliers</settlement></placeName></affiliation><affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country><wicri:regionArea>International Neuroscience Institute, Hannover</wicri:regionArea><placeName><region type="land" nuts="2">Basse-Saxe</region><settlement type="city">Hanovre</settlement></placeName></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Stereotactic and Functional Neurosurgery, University of Cologne, Cologne</wicri:regionArea><wicri:noRegion>Cologne</wicri:noRegion><wicri:noRegion>Cologne</wicri:noRegion></affiliation><affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Leibniz Institute for Neurobiology, Center for Learning and Memory Research, Magdeburg</wicri:regionArea><placeName><region type="land" nuts="2">Saxe-Anhalt</region><settlement type="city">Magdebourg</settlement></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2007-04-15">2007-04-15</date><biblScope unit="vol">22</biblScope><biblScope unit="issue">5</biblScope><biblScope unit="page" from="732">732</biblScope><biblScope unit="page" to="735">735</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">B79BA13EC8F75FDB2547F5F9F6AED56023BA7AD7</idno><idno type="DOI">10.1002/mds.21338</idno><idno type="ArticleID">MDS21338</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>cerebellar tremor</term><term>deep brain stimulation</term><term>long‐lasting benefit</term><term>subthalamic target</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">This is a single case report of a patient with spinocerebellar ataxia type 2 (SCA2) and severe tremor. Whereas disease progression with prevailing ataxia and dysmetria was slow over the first symptomatic 6 years, 6 months prior to operation were characterized by the development of a severe, debilitating postural tremor rendering the patient unable to independently sit, stand, speak, or swallow. Deep brain stimulation (DBS) at a subthalamic–thalamic electrode position almost completely arrested her tremor. The patient regained the functional state prior to her rapid disease progression allowing a restricted range of daily activities. Her condition has remained approximately stable over the two postoperative years to date. In addition to the efficacy of DBS on cerebellar tremor, the results illustrate a remarkable improvement of the patient's general condition and independence.</div></front></TEI></ISTEX><PubMed><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Subthalamic-thalamic DBS in a case with spinocerebellar ataxia type 2 and severe tremor-A unusual clinical benefit.</title><author><name sortKey="Freund, Hans Joachim" sort="Freund, Hans Joachim" uniqKey="Freund H" first="Hans-Joachim" last="Freund">Hans-Joachim Freund</name><affiliation wicri:level="3"><nlm:affiliation>Institute of Neuroscience and Biophysics 3, Research Center Jülich, Jülich, Germany. h.j.freund@fz-juelich.de</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Neuroscience and Biophysics 3, Research Center Jülich, Jülich</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Juliers</settlement></placeName></affiliation></author><author><name sortKey="Barnikol, Utako B" sort="Barnikol, Utako B" uniqKey="Barnikol U" first="Utako B" last="Barnikol">Utako B. Barnikol</name></author><author><name sortKey="Nolte, Dagmar" sort="Nolte, Dagmar" uniqKey="Nolte D" first="Dagmar" last="Nolte">Dagmar Nolte</name></author><author><name sortKey="Treuer, Harald" sort="Treuer, Harald" uniqKey="Treuer H" first="Harald" last="Treuer">Harald Treuer</name></author><author><name sortKey="Auburger, Georg" sort="Auburger, Georg" uniqKey="Auburger G" first="Georg" last="Auburger">Georg Auburger</name></author><author><name sortKey="Tass, Peter A" sort="Tass, Peter A" uniqKey="Tass P" first="Peter A" last="Tass">Peter A. Tass</name></author><author><name sortKey="Samii, Madjid" sort="Samii, Madjid" uniqKey="Samii M" first="Madjid" last="Samii">Madjid Samii</name></author><author><name sortKey="Sturm, Volker" sort="Sturm, Volker" uniqKey="Sturm V" first="Volker" last="Sturm">Volker Sturm</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2007">2007</date><idno type="doi">10.1002/mds.21338</idno><idno type="RBID">pubmed:17265523</idno><idno type="pmid">17265523</idno><idno type="wicri:Area/PubMed/Corpus">002869</idno><idno type="wicri:Area/PubMed/Curation">002869</idno><idno type="wicri:Area/PubMed/Checkpoint">002533</idno><idno type="wicri:Area/Ncbi/Merge">001A70</idno><idno type="wicri:Area/Ncbi/Curation">001A70</idno><idno type="wicri:Area/Ncbi/Checkpoint">001A70</idno><idno type="wicri:doubleKey">0885-3185:2007:Freund H:subthalamic:thalamic:dbs</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Subthalamic-thalamic DBS in a case with spinocerebellar ataxia type 2 and severe tremor-A unusual clinical benefit.</title><author><name sortKey="Freund, Hans Joachim" sort="Freund, Hans Joachim" uniqKey="Freund H" first="Hans-Joachim" last="Freund">Hans-Joachim Freund</name><affiliation wicri:level="3"><nlm:affiliation>Institute of Neuroscience and Biophysics 3, Research Center Jülich, Jülich, Germany. h.j.freund@fz-juelich.de</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Neuroscience and Biophysics 3, Research Center Jülich, Jülich</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Juliers</settlement></placeName></affiliation></author><author><name sortKey="Barnikol, Utako B" sort="Barnikol, Utako B" uniqKey="Barnikol U" first="Utako B" last="Barnikol">Utako B. Barnikol</name></author><author><name sortKey="Nolte, Dagmar" sort="Nolte, Dagmar" uniqKey="Nolte D" first="Dagmar" last="Nolte">Dagmar Nolte</name></author><author><name sortKey="Treuer, Harald" sort="Treuer, Harald" uniqKey="Treuer H" first="Harald" last="Treuer">Harald Treuer</name></author><author><name sortKey="Auburger, Georg" sort="Auburger, Georg" uniqKey="Auburger G" first="Georg" last="Auburger">Georg Auburger</name></author><author><name sortKey="Tass, Peter A" sort="Tass, Peter A" uniqKey="Tass P" first="Peter A" last="Tass">Peter A. Tass</name></author><author><name sortKey="Samii, Madjid" sort="Samii, Madjid" uniqKey="Samii M" first="Madjid" last="Samii">Madjid Samii</name></author><author><name sortKey="Sturm, Volker" sort="Sturm, Volker" uniqKey="Sturm V" first="Volker" last="Sturm">Volker Sturm</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="ISSN">0885-3185</idno><imprint><date when="2007" type="published">2007</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Activities of Daily Living (classification)</term><term>Adult</term><term>Deep Brain Stimulation</term><term>Electrodes, Implanted</term><term>Female</term><term>Follow-Up Studies</term><term>Humans</term><term>Neurologic Examination</term><term>Spinocerebellar Ataxias (diagnosis)</term><term>Spinocerebellar Ataxias (physiopathology)</term><term>Spinocerebellar Ataxias (therapy)</term><term>Subthalamic Nucleus (physiopathology)</term><term>Torticollis (diagnosis)</term><term>Torticollis (physiopathology)</term><term>Torticollis (therapy)</term><term>Treatment Outcome</term><term>Tremor (diagnosis)</term><term>Tremor (physiopathology)</term><term>Tremor (therapy)</term><term>Ventral Thalamic Nuclei (physiopathology)</term></keywords><keywords scheme="MESH" qualifier="classification" xml:lang="en"><term>Activities of Daily Living</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Spinocerebellar Ataxias</term><term>Torticollis</term><term>Tremor</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Spinocerebellar Ataxias</term><term>Subthalamic Nucleus</term><term>Torticollis</term><term>Tremor</term><term>Ventral Thalamic Nuclei</term></keywords><keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Spinocerebellar Ataxias</term><term>Torticollis</term><term>Tremor</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Deep Brain Stimulation</term><term>Electrodes, Implanted</term><term>Female</term><term>Follow-Up Studies</term><term>Humans</term><term>Neurologic Examination</term><term>Treatment Outcome</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">This is a single case report of a patient with spinocerebellar ataxia type 2 (SCA2) and severe tremor. Whereas disease progression with prevailing ataxia and dysmetria was slow over the first symptomatic 6 years, 6 months prior to operation were characterized by the development of a severe, debilitating postural tremor rendering the patient unable to independently sit, stand, speak, or swallow. Deep brain stimulation (DBS) at a subthalamic-thalamic electrode position almost completely arrested her tremor. The patient regained the functional state prior to her rapid disease progression allowing a restricted range of daily activities. Her condition has remained approximately stable over the two postoperative years to date. In addition to the efficacy of DBS on cerebellar tremor, the results illustrate a remarkable improvement of the patient's general condition and independence.</div></front></TEI></PubMed></double></record>Pour manipuler ce document sous Unix (Dilib)
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