MovDisordV3, Main, Merge, bibRecord, 003984

Altered Dorsal Premotor-Motor Interhemispheric Pathway Activity in Focal Arm Dystonia

Identifieur interne : 003984 ( Main/Merge ); précédent : 003983; suivant : 003985

Altered Dorsal Premotor-Motor Interhemispheric Pathway Activity in Focal Arm Dystonia

Auteurs : Giacomo Koch [Royaume-Uni, Italie] ; Susanne Schneider [Royaume-Uni] ; Tobias B Umer [Allemagne] ; Michele Franca [Royaume-Uni] ; Alexander Münchau [Allemagne] ; Binith Cheeran [Royaume-Uni] ; Miguel Fernandez Del Olmo [Royaume-Uni, Espagne] ; Carla Cordivari [Royaume-Uni] ; Elisabeth Rounis [Royaume-Uni] ; Carlo Caltagirone [Italie] ; Kailash Bhatia [Royaume-Uni] ; John C. Rothwell [Royaume-Uni]

Source :

Movement disorders [ 0885-3185 ] ; 2008.

RBID : Pascal:08-0247711

Descripteurs français

Pascal (Inist)
- Dystonie, Pathologie du système nerveux, Voie motrice, Stimulation couplée, Stimulation magnétique transcrânienne, Cortex prémoteur.

English descriptors

KwdEn :
- Dystonia, Motor pathway, Nervous system diseases, Paired stimulation, Premotor cortex, Transcranial magnetic stimulation.

Abstract

Given the possible role of dorsal premotor cortex (PMd) in the pathophysiology of dystonia, we used transcranial magnetic stimulation (TMS) methods to study PMd and PMd-primary motor cortex (Ml) interactions in patients with focal arm dystonia. Here, we tested the connectivity between left PMd and right Ml as well as the intracortical excitability of PMd in 11 right-handed patients with focal arm/hand dystonia and nine age-matched healthy controls. The results showed that excitability of the inhibitory connection between PMd and M1 was reduced in patients, but there was no significant difference to healthy subjects in the excitability of the facilitatory connection. A triple stimulation technique in which pairs of TMS pulses are given over PMd and their interaction measured in terms of the effect on the baseline PMd-Ml connection failed to reveal the usual pattern of interaction between the pairs of PMd stimuli. Indeed, the results in patients were similar to those seen in a group of young healthy subjects after the excitability of PMd had been changed by pretreatment with high-frequency rTMS. We suggest that reduced transcallosal inhibition from the PMd may be involved in the altered pattern of abnormal muscle contractions of agonists and antagonists (overflow).

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Le document en format XML

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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Altered Dorsal Premotor-Motor Interhemispheric Pathway Activity in Focal Arm Dystonia</title>
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<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
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</affiliation>
</author>
<author><name sortKey="Rounis, Elisabeth" sort="Rounis, Elisabeth" uniqKey="Rounis E" first="Elisabeth" last="Rounis">Elisabeth Rounis</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, University College London, Queen Square</s1>
<s2>London</s2>
<s3>GBR</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
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<country>Royaume-Uni</country>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Caltagirone, Carlo" sort="Caltagirone, Carlo" uniqKey="Caltagirone C" first="Carlo" last="Caltagirone">Carlo Caltagirone</name>
<affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Laboratorio di Neurologia Clinica e Comportamentale, Fondazione Santa Lucia IRCCS, Via Ardeatina, 306</s1>
<s2>Rome</s2>
<s3>ITA</s3>
<sZ>1 aut.</sZ>
<sZ>10 aut.</sZ>
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<country>Italie</country>
<placeName><settlement type="city">Rome</settlement>
<region nuts="2">Latium</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Clinica Neurologica, Dipartimento di Neuroscienze, Università di Roma Tor Vergata, Via Montpellier 1</s1>
<s2>Rome</s2>
<s3>ITA</s3>
<sZ>1 aut.</sZ>
<sZ>10 aut.</sZ>
</inist:fA14>
<country>Italie</country>
<placeName><settlement type="city">Rome</settlement>
<region nuts="2">Latium</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Bhatia, Kailash" sort="Bhatia, Kailash" uniqKey="Bhatia K" first="Kailash" last="Bhatia">Kailash Bhatia</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, University College London, Queen Square</s1>
<s2>London</s2>
<s3>GBR</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>4 aut.</sZ>
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<country>Royaume-Uni</country>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Rothwell, John C" sort="Rothwell, John C" uniqKey="Rothwell J" first="John C." last="Rothwell">John C. Rothwell</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, University College London, Queen Square</s1>
<s2>London</s2>
<s3>GBR</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>6 aut.</sZ>
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<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>12 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j" type="main">Movement disorders</title>
<title level="j" type="abbreviated">Mov. disord.</title>
<idno type="ISSN">0885-3185</idno>
<imprint><date when="2008">2008</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><title level="j" type="main">Movement disorders</title>
<title level="j" type="abbreviated">Mov. disord.</title>
<idno type="ISSN">0885-3185</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Dystonia</term>
<term>Motor pathway</term>
<term>Nervous system diseases</term>
<term>Paired stimulation</term>
<term>Premotor cortex</term>
<term>Transcranial magnetic stimulation</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Dystonie</term>
<term>Pathologie du   système nerveux</term>
<term>Voie motrice</term>
<term>Stimulation couplée</term>
<term>Stimulation magnétique transcrânienne</term>
<term>Cortex prémoteur</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Given the possible role of dorsal premotor cortex (PMd) in the pathophysiology of dystonia, we used transcranial magnetic stimulation (TMS) methods to study PMd and PMd-primary motor cortex (Ml) interactions in patients with focal arm dystonia. Here, we tested the connectivity between left PMd and right Ml as well as the intracortical excitability of PMd in 11 right-handed patients with focal arm/hand dystonia and nine age-matched healthy controls. The results showed that excitability of the inhibitory connection between PMd and M1 was reduced in patients, but there was no significant difference to healthy subjects in the excitability of the facilitatory connection. A triple stimulation technique in which pairs of TMS pulses are given over PMd and their interaction measured in terms of the effect on the baseline PMd-Ml connection failed to reveal the usual pattern of interaction between the pairs of PMd stimuli. Indeed, the results in patients were similar to those seen in a group of young healthy subjects after the excitability of PMd had been changed by pretreatment with high-frequency rTMS. We suggest that reduced transcallosal inhibition from the PMd may be involved in the altered pattern of abnormal muscle contractions of agonists and antagonists (overflow).</div>
</front>
</TEI>
<affiliations><list><country><li>Allemagne</li>
<li>Espagne</li>
<li>Italie</li>
<li>Royaume-Uni</li>
</country>
<region><li>Angleterre</li>
<li>Grand Londres</li>
<li>Hambourg</li>
<li>Latium</li>
</region>
<settlement><li>Hambourg</li>
<li>Londres</li>
<li>Rome</li>
</settlement>
</list>
<tree><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Koch, Giacomo" sort="Koch, Giacomo" uniqKey="Koch G" first="Giacomo" last="Koch">Giacomo Koch</name>
</region>
<name sortKey="Bhatia, Kailash" sort="Bhatia, Kailash" uniqKey="Bhatia K" first="Kailash" last="Bhatia">Kailash Bhatia</name>
<name sortKey="Cheeran, Binith" sort="Cheeran, Binith" uniqKey="Cheeran B" first="Binith" last="Cheeran">Binith Cheeran</name>
<name sortKey="Cordivari, Carla" sort="Cordivari, Carla" uniqKey="Cordivari C" first="Carla" last="Cordivari">Carla Cordivari</name>
<name sortKey="Fernandez Del Olmo, Miguel" sort="Fernandez Del Olmo, Miguel" uniqKey="Fernandez Del Olmo M" first="Miguel" last="Fernandez Del Olmo">Miguel Fernandez Del Olmo</name>
<name sortKey="Franca, Michele" sort="Franca, Michele" uniqKey="Franca M" first="Michele" last="Franca">Michele Franca</name>
<name sortKey="Rothwell, John C" sort="Rothwell, John C" uniqKey="Rothwell J" first="John C." last="Rothwell">John C. Rothwell</name>
<name sortKey="Rounis, Elisabeth" sort="Rounis, Elisabeth" uniqKey="Rounis E" first="Elisabeth" last="Rounis">Elisabeth Rounis</name>
<name sortKey="Schneider, Susanne" sort="Schneider, Susanne" uniqKey="Schneider S" first="Susanne" last="Schneider">Susanne Schneider</name>
</country>
<country name="Italie"><region name="Latium"><name sortKey="Koch, Giacomo" sort="Koch, Giacomo" uniqKey="Koch G" first="Giacomo" last="Koch">Giacomo Koch</name>
</region>
<name sortKey="Caltagirone, Carlo" sort="Caltagirone, Carlo" uniqKey="Caltagirone C" first="Carlo" last="Caltagirone">Carlo Caltagirone</name>
<name sortKey="Caltagirone, Carlo" sort="Caltagirone, Carlo" uniqKey="Caltagirone C" first="Carlo" last="Caltagirone">Carlo Caltagirone</name>
<name sortKey="Koch, Giacomo" sort="Koch, Giacomo" uniqKey="Koch G" first="Giacomo" last="Koch">Giacomo Koch</name>
</country>
<country name="Allemagne"><region name="Hambourg"><name sortKey="B Umer, Tobias" sort="B Umer, Tobias" uniqKey="B Umer T" first="Tobias" last="B Umer">Tobias B Umer</name>
</region>
<name sortKey="Munchau, Alexander" sort="Munchau, Alexander" uniqKey="Munchau A" first="Alexander" last="Münchau">Alexander Münchau</name>
</country>
<country name="Espagne"><noRegion><name sortKey="Fernandez Del Olmo, Miguel" sort="Fernandez Del Olmo, Miguel" uniqKey="Fernandez Del Olmo M" first="Miguel" last="Fernandez Del Olmo">Miguel Fernandez Del Olmo</name>
</noRegion>
</country>
</tree>
</affiliations>
</record>

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	Movement Disorders (revue)
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Movement Disorders (revue)

Altered Dorsal Premotor-Motor Interhemispheric Pathway Activity in Focal Arm Dystonia

Altered Dorsal Premotor-Motor Interhemispheric Pathway Activity in Focal Arm Dystonia

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