MovDisordV3, Main, Merge, bibRecord, 003828

Intact Presupplementary Motor Area Function in Early, Untreated Parkinson's Disease

Identifieur interne : 003828 ( Main/Merge ); précédent : 003827; suivant : 003829

Intact Presupplementary Motor Area Function in Early, Untreated Parkinson's Disease

Auteurs : W. R. Wayne Martin [Canada] ; Marguerite Wieler [Canada] ; Myrlene Gee [Canada] ; Christopher C. Hanstock [Canada] ; Richard M. Camicioli [Canada]

Source :

Movement disorders [ 0885-3185 ] ; 2008.

RBID : Pascal:08-0487387

Descripteurs français

Pascal (Inist)
- Maladie de Parkinson, Pathologie du système nerveux, Aire motrice supplémentaire, Spectrométrie RMN.

English descriptors

KwdEn :
- NMR spectrometry, Nervous system diseases, Parkinson disease, Supplementary motor area.

Abstract

Although motor symptoms of Parkinson's disease (PD) are initially responsive to dopamine replacement therapy, nonresponsive features develop over time, suggesting that impaired dopaminergic function alone may not be wholly responsible for all the motor features of the disease. Previous studies suggest impaired function in the presupplementary motor area (pre-SMA) in PD. Our objective was to determine whether pre-SMA abnormalities are present in untreated patients with early disease. We measured N-acetyl aspartate (NAA)/creatine (Cr) and choline (Cho)/Cr ratios in pre-SMA in 26 untreated patients with early PD (disease duration 3.0 ± 2.0 yr) and 15 control subjects with single voxel magnetic resonance spectroscopy. Neither NAA/Cr nor Cho/Cr ratios differed significantly between groups. These observations suggest that, although pre-SMA function is impaired in moderately advanced PD, it is relatively spared in early disease. We suggest that pre-SMA dysfunction is in part responsible for the dopamine nonresponsive features associated with disease progression.

Links toward previous steps (curation, corpus...)

to stream PascalFrancis, to step Corpus: 001110
to stream PascalFrancis, to step Curation: 001C09
to stream PascalFrancis, to step Checkpoint: 001220

Links to Exploration step

Pascal:08-0487387

Le document en format XML

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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Intact Presupplementary Motor Area Function in Early, Untreated Parkinson's Disease</title>
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<front><div type="abstract" xml:lang="en">Although motor symptoms of Parkinson's disease (PD) are initially responsive to dopamine replacement therapy, nonresponsive features develop over time, suggesting that impaired dopaminergic function alone may not be wholly responsible for all the motor features of the disease. Previous studies suggest impaired function in the presupplementary motor area (pre-SMA) in PD. Our objective was to determine whether pre-SMA abnormalities are present in untreated patients with early disease. We measured N-acetyl aspartate (NAA)/creatine (Cr) and choline (Cho)/Cr ratios in pre-SMA in 26 untreated patients with early PD (disease duration 3.0 ± 2.0 yr) and 15 control subjects with single voxel magnetic resonance spectroscopy. Neither NAA/Cr nor Cho/Cr ratios differed significantly between groups. These observations suggest that, although pre-SMA function is impaired in moderately advanced PD, it is relatively spared in early disease. We suggest that pre-SMA dysfunction is in part responsible for the dopamine nonresponsive features associated with disease progression.</div>
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	Movement Disorders (revue)
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Movement Disorders (revue)

Intact Presupplementary Motor Area Function in Early, Untreated Parkinson's Disease

Intact Presupplementary Motor Area Function in Early, Untreated Parkinson's Disease

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri