MovDisordV3, Main, Merge, bibRecord, 003754

Paroxysmal Dyskinesias in Mice

Identifieur interne : 003754 ( Main/Merge ); précédent : 003753; suivant : 003755

Paroxysmal Dyskinesias in Mice

Auteurs : Thomas L. Shirley [États-Unis] ; Lekha M. Rao [États-Unis] ; Ellen J. Hess [États-Unis] ; H. A. Jinnah [États-Unis]

Source :

Movement disorders [ 0885-3185 ] ; 2008.

RBID : Pascal:08-0133670

Descripteurs français

Pascal (Inist)
- Dyskinésie, Dystonie, Pathologie du système nerveux, Animal, Souris.

English descriptors

KwdEn :
- Animal, Dyskinesia, Dystonia, Mouse, Nervous system diseases.

Abstract

Animal models of human disease are important tools for revealing the underlying mechanisms of pathophysiology and developing therapeutic strategies. Several unique mouse calcium channel mutants have been identified with nonepileptic, episodic dyskinetic movements that are phenotypically similar to human paroxysmal dyskinesias. In this report, video demonstrations of these motor attacks are provided for two previously described mouse mutants, tottering and lethargic, as well as a new one, rocker. Semiquantitative comparisons using two different rating scales reveal differences in attack morphology, severity, and duration among the strains. These mice provide three independent models of paroxysmal dyskinesia and support for prior proposals that channelopathies may underlie the human disorders.

Links toward previous steps (curation, corpus...)

to stream PascalFrancis, to step Corpus: 001382
to stream PascalFrancis, to step Curation: 001937
to stream PascalFrancis, to step Checkpoint: 001146

Links to Exploration step

Pascal:08-0133670

Le document en format XML

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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Paroxysmal Dyskinesias in Mice</title>
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<author><name sortKey="Hess, Ellen J" sort="Hess, Ellen J" uniqKey="Hess E" first="Ellen J." last="Hess">Ellen J. Hess</name>
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<series><title level="j" type="main">Movement disorders</title>
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<front><div type="abstract" xml:lang="en">Animal models of human disease are important tools for revealing the underlying mechanisms of pathophysiology and developing therapeutic strategies. Several unique mouse calcium channel mutants have been identified with nonepileptic, episodic dyskinetic movements that are phenotypically similar to human paroxysmal dyskinesias. In this report, video demonstrations of these motor attacks are provided for two previously described mouse mutants, tottering and lethargic, as well as a new one, rocker. Semiquantitative comparisons using two different rating scales reveal differences in attack morphology, severity, and duration among the strains. These mice provide three independent models of paroxysmal dyskinesia and support for prior proposals that channelopathies may underlie the human disorders.</div>
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<tree><country name="États-Unis"><region name="Maryland"><name sortKey="Shirley, Thomas L" sort="Shirley, Thomas L" uniqKey="Shirley T" first="Thomas L." last="Shirley">Thomas L. Shirley</name>
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<name sortKey="Hess, Ellen J" sort="Hess, Ellen J" uniqKey="Hess E" first="Ellen J." last="Hess">Ellen J. Hess</name>
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	Movement Disorders (revue)
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.

Movement Disorders (revue)

Paroxysmal Dyskinesias in Mice

Paroxysmal Dyskinesias in Mice

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri