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Potassium Channel Blocker 4-Aminopyridine is Effective in Interictal Cerebellar Symptoms in Episodic Ataxia Type 2 : A Video Case Report

Identifieur interne : 003740 ( Main/Merge ); précédent : 003739; suivant : 003741

Potassium Channel Blocker 4-Aminopyridine is Effective in Interictal Cerebellar Symptoms in Episodic Ataxia Type 2 : A Video Case Report

Auteurs : Matthias Löhle [Allemagne] ; Wiebke Schrempf [Allemagne] ; Martin Wolz [Allemagne] ; Heinz Reichmann [Allemagne] ; Alexander Storch [Allemagne]

Source :

Movement disorders [ 0885-3185 ] ; 2008.

RBID : Pascal:08-0396197

Descripteurs français

Pascal (Inist)
- Pathologie du système nerveux, Antagoniste canal potassium, Ataxie cérébelleuse, Etude cas.

English descriptors

KwdEn :
- Case study, Cerebellar ataxia, Nervous system diseases, Potassium channel antagonist.

Abstract

Episodic ataxia type 2 (EA2) is an autosomal- dominant hereditary disorder clinically characterized by recurrent attacks of vertigo, imbalance and ataxia. Studies have shown that 4-aminopyridine (4-AP) is capable to prevent these attacks. However, there are no reports whether 4-AP is able to attenuate interictal cerebellar ataxia. Using the scale for assessment and rating of ataxia (SARA), we examined the efficacy of 4-AP on interictal ataxia in a 63-year-old female patient who suffered from EA2 since the age of 57. EA2 was diagnosed based on clinical criteria and not genetically proven. When treatment with 4-AP was paused the patient was suffering from marked gait and stance ataxia. After re-initiation of treatment with 5 mg 4-AP t.i.d., there was pronounced improvement in gait and stance ataxia. Within 24 hours SARA score lowered from 8.5 to 4.5 points. We conclude that 4-AP may be beneficial for interictal cerebellar ataxia in late onset EA2.

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Pascal:08-0396197

Le document en format XML

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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Potassium Channel Blocker 4-Aminopyridine is Effective in Interictal Cerebellar Symptoms in Episodic Ataxia Type 2 : A Video Case Report</title>
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<front><div type="abstract" xml:lang="en">Episodic ataxia type 2 (EA2) is an autosomal- dominant hereditary disorder clinically characterized by recurrent attacks of vertigo, imbalance and ataxia. Studies have shown that 4-aminopyridine (4-AP) is capable to prevent these attacks. However, there are no reports whether 4-AP is able to attenuate interictal cerebellar ataxia. Using the scale for assessment and rating of ataxia (SARA), we examined the efficacy of 4-AP on interictal ataxia in a 63-year-old female patient who suffered from EA2 since the age of 57. EA2 was diagnosed based on clinical criteria and not genetically proven. When treatment with 4-AP was paused the patient was suffering from marked gait and stance ataxia. After re-initiation of treatment with 5 mg 4-AP t.i.d., there was pronounced improvement in gait and stance ataxia. Within 24 hours SARA score lowered from 8.5 to 4.5 points. We conclude that 4-AP may be beneficial for interictal cerebellar ataxia in late onset EA2.</div>
</front>
</TEI>
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	Movement Disorders (revue)
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Movement Disorders (revue)

Potassium Channel Blocker 4-Aminopyridine is Effective in Interictal Cerebellar Symptoms in Episodic Ataxia Type 2 : A Video Case Report

Potassium Channel Blocker 4-Aminopyridine is Effective in Interictal Cerebellar Symptoms in Episodic Ataxia Type 2 : A Video Case Report

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri