Set-Shifting and Behavioral Dysfunction in Primary Focal Dystonia
Identifieur interne : 003704 ( Main/Merge ); précédent : 003703; suivant : 003705Set-Shifting and Behavioral Dysfunction in Primary Focal Dystonia
Auteurs : Paulo Bugalho [Portugal] ; Bernardo Correa [Portugal] ; Joao Guimaraes [Portugal] ; Miguel Xavier [Portugal]Source :
- Movement disorders [ 0885-3185 ] ; 2008.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
Abstract
: The occurrence of cognitive and behavioral symptoms in patients with primary dystonia remains a matter of debate. We compared 45 patients with primary dystonia with 27 control subjects for performance on neuropsychological tasks with a load on executive-Wisconsin Card Sorting Test (WCST) and Stroop test, and visuospatial-Benton's visual retention test (BVRT) and Block assembly test from Wechsler Adult Intelligence Scale BAT-functions, as well as for intensity of obsessive-compulsive symptoms (Yale Brown Obsessive Compulsive Scale, Y-BOCS). Correlation analysis was performed between neuropsychological performance, dystonia characteristics (duration, age of onset) and severity (Unified Dystonia Rating Scale, UDRS), and Y-BOCS. Patients made more perseverative errors on the WCST (P = 0.042) and had a higher mean Y-BOCS (P = 0.003) score than controls. Timed tests (BVRT, BAT, Stroop test) correlated with UDRS. Y-BOCS, WCST, and UDRS scores were not significantly correlated with one another.These results suggest that patients with primary dystonia may have set-shifting deficits and a higher intensity of obsessive compulsive symptoms when compared to healthy subjects. This may reflect a pattern of complex neurophysiological dysfunction involving dorsolateral, orbitofrontal, and motor frontostriatal circuits.
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Pascal:08-0133661Le document en format XML
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<front><div type="abstract" xml:lang="en">: The occurrence of cognitive and behavioral symptoms in patients with primary dystonia remains a matter of debate. We compared 45 patients with primary dystonia with 27 control subjects for performance on neuropsychological tasks with a load on executive-Wisconsin Card Sorting Test (WCST) and Stroop test, and visuospatial-Benton's visual retention test (BVRT) and Block assembly test from Wechsler Adult Intelligence Scale BAT-functions, as well as for intensity of obsessive-compulsive symptoms (Yale Brown Obsessive Compulsive Scale, Y-BOCS). Correlation analysis was performed between neuropsychological performance, dystonia characteristics (duration, age of onset) and severity (Unified Dystonia Rating Scale, UDRS), and Y-BOCS. Patients made more perseverative errors on the WCST (P = 0.042) and had a higher mean Y-BOCS (P = 0.003) score than controls. Timed tests (BVRT, BAT, Stroop test) correlated with UDRS. Y-BOCS, WCST, and UDRS scores were not significantly correlated with one another.These results suggest that patients with primary dystonia may have set-shifting deficits and a higher intensity of obsessive compulsive symptoms when compared to healthy subjects. This may reflect a pattern of complex neurophysiological dysfunction involving dorsolateral, orbitofrontal, and motor frontostriatal circuits.</div>
</front>
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<tree><country name="Portugal"><noRegion><name sortKey="Bugalho, Paulo" sort="Bugalho, Paulo" uniqKey="Bugalho P" first="Paulo" last="Bugalho">Paulo Bugalho</name>
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<name sortKey="Correa, Bernardo" sort="Correa, Bernardo" uniqKey="Correa B" first="Bernardo" last="Correa">Bernardo Correa</name>
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<name sortKey="Guimaraes, Joao" sort="Guimaraes, Joao" uniqKey="Guimaraes J" first="Joao" last="Guimaraes">Joao Guimaraes</name>
<name sortKey="Guimaraes, Joao" sort="Guimaraes, Joao" uniqKey="Guimaraes J" first="Joao" last="Guimaraes">Joao Guimaraes</name>
<name sortKey="Xavier, Miguel" sort="Xavier, Miguel" uniqKey="Xavier M" first="Miguel" last="Xavier">Miguel Xavier</name>
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