Botulinum neurotoxin type A injections reduce spasticity in mild to moderate hereditary spastic paraplegia— Report of 19 cases
Identifieur interne : 003551 ( Main/Merge ); précédent : 003550; suivant : 003552Botulinum neurotoxin type A injections reduce spasticity in mild to moderate hereditary spastic paraplegia— Report of 19 cases
Auteurs : Martin J. Hecht [Allemagne] ; Henning Stolze [Allemagne] ; Matthias Auf Dem Brinke [Allemagne] ; Ralf Giess [Allemagne] ; Thoams Treig [Allemagne] ; Martin Winterholler [Allemagne] ; Jörg Wissel [Allemagne]Source :
- Movement Disorders [ 0885-3185 ] ; 2008-01-30.
English descriptors
- KwdEn :
- Adolescent, Adult, Aged, Botulinum Toxins, Type A (therapeutic use), Child, Female, HSP, Humans, Male, Middle Aged, Muscle Spasticity (drug therapy), Muscle Spasticity (etiology), Neuromuscular Agents (therapeutic use), Spastic Paraplegia, Hereditary (complications), Spastic Paraplegia, Hereditary (drug therapy), botulinum toxin A, hereditary spastic paraplegia, spasticity, therapy.
- MESH :
- chemical , therapeutic use : Botulinum Toxins, Type A, Neuromuscular Agents.
- complications : Spastic Paraplegia, Hereditary.
- drug therapy : Muscle Spasticity, Spastic Paraplegia, Hereditary.
- etiology : Muscle Spasticity.
- Adolescent, Adult, Aged, Child, Female, Humans, Male, Middle Aged.
Abstract
Hereditary spastic paraplegia (HSP) is characterized by lower extremity spasticity. Symptomatic therapy generally includes physical therapy and oral antispastic agents, in selected cases intrathecal baclofen. Because of the positive results in other treatments of spasticity, the use of botulinum neurotoxin type A (BoNT‐A) might also be considered for patients with HSP. We report the effect of BoNT‐A injections in 19 unselected patients with HSP treated by the members of the German Spasticity Education Group. In 17 patients, the modified Ashworth scale had improved by one point. In one patient, it improved by three points. Most of the patients reported reduction of spasticity. BoNT‐A injections were continued in 11 of 19 patients (57.9%). All of the patients with continued injections had a good or very good global subjective improvement. Patients with less pronounced spasticity and patients with accompanying physical therapy tended to exhibit a better effect. Only four patients reported adverse effects which were increased weakness in three patients and pain in one patient. BoNT‐A injections appear to reduce spasticity effectively and safely, especially in patients with mild to moderate spasticity. The preliminary results of our case series should encourage larger studies of BoNT‐A injections in HSP. © 2007 Movement Disorder Society
Url:
DOI: 10.1002/mds.21809
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Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2008-01-30">2008-01-30</date><biblScope unit="vol">23</biblScope><biblScope unit="issue">2</biblScope><biblScope unit="page" from="228">228</biblScope><biblScope unit="page" to="233">233</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">F81B4DBBD9C958C89334DDEEF27F05A7B3CA503F</idno><idno type="DOI">10.1002/mds.21809</idno><idno type="ArticleID">MDS21809</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Aged</term><term>Botulinum Toxins, Type A (therapeutic use)</term><term>Child</term><term>Female</term><term>HSP</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Muscle Spasticity (drug therapy)</term><term>Muscle Spasticity (etiology)</term><term>Neuromuscular Agents (therapeutic use)</term><term>Spastic Paraplegia, Hereditary (complications)</term><term>Spastic Paraplegia, Hereditary (drug therapy)</term><term>botulinum toxin A</term><term>hereditary spastic paraplegia</term><term>spasticity</term><term>therapy</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Botulinum Toxins, Type A</term><term>Neuromuscular Agents</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Spastic Paraplegia, Hereditary</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Muscle Spasticity</term><term>Spastic Paraplegia, Hereditary</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Muscle Spasticity</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Aged</term><term>Child</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Hereditary spastic paraplegia (HSP) is characterized by lower extremity spasticity. Symptomatic therapy generally includes physical therapy and oral antispastic agents, in selected cases intrathecal baclofen. Because of the positive results in other treatments of spasticity, the use of botulinum neurotoxin type A (BoNT‐A) might also be considered for patients with HSP. We report the effect of BoNT‐A injections in 19 unselected patients with HSP treated by the members of the German Spasticity Education Group. In 17 patients, the modified Ashworth scale had improved by one point. In one patient, it improved by three points. Most of the patients reported reduction of spasticity. BoNT‐A injections were continued in 11 of 19 patients (57.9%). All of the patients with continued injections had a good or very good global subjective improvement. Patients with less pronounced spasticity and patients with accompanying physical therapy tended to exhibit a better effect. Only four patients reported adverse effects which were increased weakness in three patients and pain in one patient. BoNT‐A injections appear to reduce spasticity effectively and safely, especially in patients with mild to moderate spasticity. The preliminary results of our case series should encourage larger studies of BoNT‐A injections in HSP. © 2007 Movement Disorder Society</div></front></TEI><double doi="10.1002/mds.21809"><ISTEX><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Botulinum neurotoxin type A injections reduce spasticity in mild to moderate hereditary spastic paraplegia— Report of 19 cases</title><author><name sortKey="Hecht, Martin J" sort="Hecht, Martin J" uniqKey="Hecht M" first="Martin J." last="Hecht">Martin J. Hecht</name></author><author><name sortKey="Stolze, Henning" sort="Stolze, Henning" uniqKey="Stolze H" first="Henning" last="Stolze">Henning Stolze</name></author><author><name sortKey="Auf Dem Brinke, Matthias" sort="Auf Dem Brinke, Matthias" uniqKey="Auf Dem Brinke M" first="Matthias" last="Auf Dem Brinke">Matthias Auf Dem Brinke</name></author><author><name sortKey="Giess, Ralf" sort="Giess, Ralf" uniqKey="Giess R" first="Ralf" last="Giess">Ralf Giess</name></author><author><name sortKey="Treig, Thoams" sort="Treig, Thoams" uniqKey="Treig T" first="Thoams" last="Treig">Thoams Treig</name></author><author><name sortKey="Winterholler, Martin" sort="Winterholler, Martin" uniqKey="Winterholler M" first="Martin" last="Winterholler">Martin Winterholler</name></author><author><name sortKey="Wissel, Jorg" sort="Wissel, Jorg" uniqKey="Wissel J" first="Jörg" last="Wissel">Jörg Wissel</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:F81B4DBBD9C958C89334DDEEF27F05A7B3CA503F</idno><date when="2008" year="2008">2008</date><idno type="doi">10.1002/mds.21809</idno><idno type="url">https://api.istex.fr/document/F81B4DBBD9C958C89334DDEEF27F05A7B3CA503F/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">001A91</idno><idno type="wicri:Area/Istex/Curation">001A91</idno><idno type="wicri:Area/Istex/Checkpoint">001529</idno><idno type="wicri:doubleKey">0885-3185:2008:Hecht M:botulinum:neurotoxin:type</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Botulinum neurotoxin type A injections reduce spasticity in mild to moderate hereditary spastic paraplegia— Report of 19 cases</title><author><name sortKey="Hecht, Martin J" sort="Hecht, Martin J" uniqKey="Hecht M" first="Martin J." last="Hecht">Martin J. Hecht</name><affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, University of Erlangen‐Nuremberg, Erlangen</wicri:regionArea><placeName><settlement type="city">Erlangen</settlement><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Moyenne-Franconie</region></placeName></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, BKH Kaufbeuren</wicri:regionArea><wicri:noRegion>BKH Kaufbeuren</wicri:noRegion><wicri:noRegion>BKH Kaufbeuren</wicri:noRegion></affiliation></author><author><name sortKey="Stolze, Henning" sort="Stolze, Henning" uniqKey="Stolze H" first="Henning" last="Stolze">Henning Stolze</name><affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, University of Kiel, Kiel</wicri:regionArea><placeName><region type="land" nuts="2">Schleswig-Holstein</region><settlement type="city">Kiel</settlement></placeName></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, Diako Hospital, Flensburg</wicri:regionArea><wicri:noRegion>Flensburg</wicri:noRegion><wicri:noRegion>Flensburg</wicri:noRegion></affiliation></author><author><name sortKey="Auf Dem Brinke, Matthias" sort="Auf Dem Brinke, Matthias" uniqKey="Auf Dem Brinke M" first="Matthias" last="Auf Dem Brinke">Matthias Auf Dem Brinke</name><affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurological Rehabilitation, Bad Wildungen</wicri:regionArea><wicri:noRegion>Bad Wildungen</wicri:noRegion><wicri:noRegion>Bad Wildungen</wicri:noRegion></affiliation></author><author><name sortKey="Giess, Ralf" sort="Giess, Ralf" uniqKey="Giess R" first="Ralf" last="Giess">Ralf Giess</name><affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, Henriettenstiftung, Hannover</wicri:regionArea><placeName><region type="land" nuts="2">Basse-Saxe</region><settlement type="city">Hanovre</settlement></placeName></affiliation></author><author><name sortKey="Treig, Thoams" sort="Treig, Thoams" uniqKey="Treig T" first="Thoams" last="Treig">Thoams Treig</name><affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Neurological Rehabilitation Centre, Ernst‐Moritz‐Arndt University, Greifswald</wicri:regionArea><wicri:noRegion>Greifswald</wicri:noRegion><wicri:noRegion>Greifswald</wicri:noRegion></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Neurological Rehabilitation Centre, Schwarzwaldkliniken, Bad Krozingen</wicri:regionArea><wicri:noRegion>Bad Krozingen</wicri:noRegion><wicri:noRegion>Bad Krozingen</wicri:noRegion></affiliation></author><author><name sortKey="Winterholler, Martin" sort="Winterholler, Martin" uniqKey="Winterholler M" first="Martin" last="Winterholler">Martin Winterholler</name><affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, Rummelsberger Kliniken, Schwarzenbruck</wicri:regionArea><wicri:noRegion>Schwarzenbruck</wicri:noRegion><wicri:noRegion>Schwarzenbruck</wicri:noRegion></affiliation></author><author><name sortKey="Wissel, Jorg" sort="Wissel, Jorg" uniqKey="Wissel J" first="Jörg" last="Wissel">Jörg Wissel</name><affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurological Rehabilitation, Beelitz Heilstätten, Beelitz</wicri:regionArea><wicri:noRegion>Beelitz</wicri:noRegion><wicri:noRegion>Beelitz</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2008-01-30">2008-01-30</date><biblScope unit="vol">23</biblScope><biblScope unit="issue">2</biblScope><biblScope unit="page" from="228">228</biblScope><biblScope unit="page" to="233">233</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">F81B4DBBD9C958C89334DDEEF27F05A7B3CA503F</idno><idno type="DOI">10.1002/mds.21809</idno><idno type="ArticleID">MDS21809</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>HSP</term><term>botulinum toxin A</term><term>hereditary spastic paraplegia</term><term>spasticity</term><term>therapy</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Hereditary spastic paraplegia (HSP) is characterized by lower extremity spasticity. Symptomatic therapy generally includes physical therapy and oral antispastic agents, in selected cases intrathecal baclofen. Because of the positive results in other treatments of spasticity, the use of botulinum neurotoxin type A (BoNT‐A) might also be considered for patients with HSP. We report the effect of BoNT‐A injections in 19 unselected patients with HSP treated by the members of the German Spasticity Education Group. In 17 patients, the modified Ashworth scale had improved by one point. In one patient, it improved by three points. Most of the patients reported reduction of spasticity. BoNT‐A injections were continued in 11 of 19 patients (57.9%). All of the patients with continued injections had a good or very good global subjective improvement. Patients with less pronounced spasticity and patients with accompanying physical therapy tended to exhibit a better effect. Only four patients reported adverse effects which were increased weakness in three patients and pain in one patient. BoNT‐A injections appear to reduce spasticity effectively and safely, especially in patients with mild to moderate spasticity. The preliminary results of our case series should encourage larger studies of BoNT‐A injections in HSP. © 2007 Movement Disorder Society</div></front></TEI></ISTEX><PubMed><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Botulinum neurotoxin type A injections reduce spasticity in mild to moderate hereditary spastic paraplegia--report of 19 cases.</title><author><name sortKey="Hecht, Martin J" sort="Hecht, Martin J" uniqKey="Hecht M" first="Martin J" last="Hecht">Martin J. Hecht</name><affiliation wicri:level="3"><nlm:affiliation>Department of Neurology, University of Erlangen-Nuremberg, Erlangen, Germany. martin.hecht@bkh-kaufbeuren.de</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, University of Erlangen-Nuremberg, Erlangen</wicri:regionArea><placeName><settlement type="city">Erlangen</settlement><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Moyenne-Franconie</region></placeName></affiliation></author><author><name sortKey="Stolze, Henning" sort="Stolze, Henning" uniqKey="Stolze H" first="Henning" last="Stolze">Henning Stolze</name></author><author><name sortKey="Auf Dem Brinke, Matthias" sort="Auf Dem Brinke, Matthias" uniqKey="Auf Dem Brinke M" first="Matthias" last="Auf Dem Brinke">Matthias Auf Dem Brinke</name></author><author><name sortKey="Giess, Ralf" sort="Giess, Ralf" uniqKey="Giess R" first="Ralf" last="Giess">Ralf Giess</name></author><author><name sortKey="Treig, Thoams" sort="Treig, Thoams" uniqKey="Treig T" first="Thoams" last="Treig">Thoams Treig</name></author><author><name sortKey="Winterholler, Martin" sort="Winterholler, Martin" uniqKey="Winterholler M" first="Martin" last="Winterholler">Martin Winterholler</name></author><author><name sortKey="Wissel, Jorg" sort="Wissel, Jorg" uniqKey="Wissel J" first="Jörg" last="Wissel">Jörg Wissel</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2008">2008</date><idno type="doi">10.1002/mds.21809</idno><idno type="RBID">pubmed:17999430</idno><idno type="pmid">17999430</idno><idno type="wicri:Area/PubMed/Corpus">002441</idno><idno type="wicri:Area/PubMed/Curation">002441</idno><idno type="wicri:Area/PubMed/Checkpoint">002407</idno><idno type="wicri:Area/Ncbi/Merge">001F18</idno><idno type="wicri:Area/Ncbi/Curation">001F18</idno><idno type="wicri:Area/Ncbi/Checkpoint">001F18</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Botulinum neurotoxin type A injections reduce spasticity in mild to moderate hereditary spastic paraplegia--report of 19 cases.</title><author><name sortKey="Hecht, Martin J" sort="Hecht, Martin J" uniqKey="Hecht M" first="Martin J" last="Hecht">Martin J. Hecht</name><affiliation wicri:level="3"><nlm:affiliation>Department of Neurology, University of Erlangen-Nuremberg, Erlangen, Germany. martin.hecht@bkh-kaufbeuren.de</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, University of Erlangen-Nuremberg, Erlangen</wicri:regionArea><placeName><settlement type="city">Erlangen</settlement><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Moyenne-Franconie</region></placeName></affiliation></author><author><name sortKey="Stolze, Henning" sort="Stolze, Henning" uniqKey="Stolze H" first="Henning" last="Stolze">Henning Stolze</name></author><author><name sortKey="Auf Dem Brinke, Matthias" sort="Auf Dem Brinke, Matthias" uniqKey="Auf Dem Brinke M" first="Matthias" last="Auf Dem Brinke">Matthias Auf Dem Brinke</name></author><author><name sortKey="Giess, Ralf" sort="Giess, Ralf" uniqKey="Giess R" first="Ralf" last="Giess">Ralf Giess</name></author><author><name sortKey="Treig, Thoams" sort="Treig, Thoams" uniqKey="Treig T" first="Thoams" last="Treig">Thoams Treig</name></author><author><name sortKey="Winterholler, Martin" sort="Winterholler, Martin" uniqKey="Winterholler M" first="Martin" last="Winterholler">Martin Winterholler</name></author><author><name sortKey="Wissel, Jorg" sort="Wissel, Jorg" uniqKey="Wissel J" first="Jörg" last="Wissel">Jörg Wissel</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="eISSN">1531-8257</idno><imprint><date when="2008" type="published">2008</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Aged</term><term>Botulinum Toxins, Type A (therapeutic use)</term><term>Child</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Muscle Spasticity (drug therapy)</term><term>Muscle Spasticity (etiology)</term><term>Neuromuscular Agents (therapeutic use)</term><term>Spastic Paraplegia, Hereditary (complications)</term><term>Spastic Paraplegia, Hereditary (drug therapy)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Botulinum Toxins, Type A</term><term>Neuromuscular Agents</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Spastic Paraplegia, Hereditary</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Muscle Spasticity</term><term>Spastic Paraplegia, Hereditary</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Muscle Spasticity</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Aged</term><term>Child</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Hereditary spastic paraplegia (HSP) is characterized by lower extremity spasticity. Symptomatic therapy generally includes physical therapy and oral antispastic agents, in selected cases intrathecal baclofen. Because of the positive results in other treatments of spasticity, the use of botulinum neurotoxin type A (BoNT-A) might also be considered for patients with HSP. We report the effect of BoNT-A injections in 19 unselected patients with HSP treated by the members of the German Spasticity Education Group. In 17 patients, the modified Ashworth scale had improved by one point. In one patient, it improved by three points. Most of the patients reported reduction of spasticity. BoNT-A injections were continued in 11 of 19 patients (57.9%). All of the patients with continued injections had a good or very good global subjective improvement. Patients with less pronounced spasticity and patients with accompanying physical therapy tended to exhibit a better effect. Only four patients reported adverse effects which were increased weakness in three patients and pain in one patient. BoNT-A injections appear to reduce spasticity effectively and safely, especially in patients with mild to moderate spasticity. The preliminary results of our case series should encourage larger studies of BoNT-A injections in HSP.</div></front></TEI></PubMed></double></record>Pour manipuler ce document sous Unix (Dilib)
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