Low LDL cholesterol and increased risk of Parkinson's disease: Prospective results from Honolulu‐Asia Aging Study
Identifieur interne : 003356 ( Main/Merge ); précédent : 003355; suivant : 003357Low LDL cholesterol and increased risk of Parkinson's disease: Prospective results from Honolulu‐Asia Aging Study
Auteurs : Xuemei Huang [États-Unis] ; Robert D. Abbott [États-Unis, Japon] ; Helen Petrovitch [États-Unis] ; Richard B. Mailman [États-Unis] ; G. Webster Ross [États-Unis]Source :
- Movement Disorders [ 0885-3185 ] ; 2008-05-15.
English descriptors
- KwdEn :
- Aged, Aging (physiology), Apolipoprotein E2 (blood), Cholesterol, LDL (blood), Humans, LDL cholesterol, Male, Middle Aged, Parkinson Disease (blood), Parkinson Disease (epidemiology), Parkinson's disease, Prevalence, Prospective Studies, Questionnaires, Risk Factors, Smoking (epidemiology), apolipoprotein E, statin, prospective study.
- MESH :
- chemical , blood : Apolipoprotein E2, Cholesterol, LDL.
- blood : Parkinson Disease.
- epidemiology : Parkinson Disease, Smoking.
- physiology : Aging.
- Aged, Humans, Male, Middle Aged, Prevalence, Prospective Studies, Questionnaires, Risk Factors.
Abstract
Low‐density lipoprotein cholesterol (LDL‐C) levels are suggested to be associated inversely with Parkinson's disease (PD). To test the hypothesis that LDL‐C levels may increase PD risk, we studied a prospective cohort of 3,233 men (Honolulu‐Asia Aging Study) for whom the LDL‐C from fasting lipid profiles was obtained during 1991 to 1993. The cohort was followed longitudinally until 2001 for incident Parkinson's cases. During follow‐up, 41 men developed PD (18.4/10,000 person‐years). Although the incidence of PD increased with decreasing LDL‐C in a dose‐dependent manner, the association was only significant for men aged 71 to 75 years. In the latter group, risk of PD declined from 38.5/10,000 person‐years in men with LDL‐C levels <80 mg/dl to less than 9/10,000 person‐years for concentrations that were ≥140 mg/dl. After adjustment for age, smoking, coffee intake, and other factors, the relative odds of PD for men at the 80th versus the 20th percentile of LDL‐C (135 vs. 85 mg/dl) was 0.4 (95% confidence interval: 0.2, 0.9). This prospective study supports the hypothesis that low LDL‐C is associated with an increased risk of PD. Although confirmation is required, the underlying mechanisms may be useful in understanding key aspects of PD. © 2008 Movement Disorder Society
Url:
DOI: 10.1002/mds.22013
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<front><div type="abstract" xml:lang="en">Low‐density lipoprotein cholesterol (LDL‐C) levels are suggested to be associated inversely with Parkinson's disease (PD). To test the hypothesis that LDL‐C levels may increase PD risk, we studied a prospective cohort of 3,233 men (Honolulu‐Asia Aging Study) for whom the LDL‐C from fasting lipid profiles was obtained during 1991 to 1993. The cohort was followed longitudinally until 2001 for incident Parkinson's cases. During follow‐up, 41 men developed PD (18.4/10,000 person‐years). Although the incidence of PD increased with decreasing LDL‐C in a dose‐dependent manner, the association was only significant for men aged 71 to 75 years. In the latter group, risk of PD declined from 38.5/10,000 person‐years in men with LDL‐C levels <80 mg/dl to less than 9/10,000 person‐years for concentrations that were ≥140 mg/dl. After adjustment for age, smoking, coffee intake, and other factors, the relative odds of PD for men at the 80th versus the 20th percentile of LDL‐C (135 vs. 85 mg/dl) was 0.4 (95% confidence interval: 0.2, 0.9). This prospective study supports the hypothesis that low LDL‐C is associated with an increased risk of PD. Although confirmation is required, the underlying mechanisms may be useful in understanding key aspects of PD. © 2008 Movement Disorder Society</div>
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<front><div type="abstract" xml:lang="en">Low‐density lipoprotein cholesterol (LDL‐C) levels are suggested to be associated inversely with Parkinson's disease (PD). To test the hypothesis that LDL‐C levels may increase PD risk, we studied a prospective cohort of 3,233 men (Honolulu‐Asia Aging Study) for whom the LDL‐C from fasting lipid profiles was obtained during 1991 to 1993. The cohort was followed longitudinally until 2001 for incident Parkinson's cases. During follow‐up, 41 men developed PD (18.4/10,000 person‐years). Although the incidence of PD increased with decreasing LDL‐C in a dose‐dependent manner, the association was only significant for men aged 71 to 75 years. In the latter group, risk of PD declined from 38.5/10,000 person‐years in men with LDL‐C levels <80 mg/dl to less than 9/10,000 person‐years for concentrations that were ≥140 mg/dl. After adjustment for age, smoking, coffee intake, and other factors, the relative odds of PD for men at the 80th versus the 20th percentile of LDL‐C (135 vs. 85 mg/dl) was 0.4 (95% confidence interval: 0.2, 0.9). This prospective study supports the hypothesis that low LDL‐C is associated with an increased risk of PD. Although confirmation is required, the underlying mechanisms may be useful in understanding key aspects of PD. © 2008 Movement Disorder Society</div>
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<author><name sortKey="Abbott, Robert D" sort="Abbott, Robert D" uniqKey="Abbott R" first="Robert D" last="Abbott">Robert D. Abbott</name>
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<author><name sortKey="Petrovitch, Helen" sort="Petrovitch, Helen" uniqKey="Petrovitch H" first="Helen" last="Petrovitch">Helen Petrovitch</name>
</author>
<author><name sortKey="Mailman, Richard B" sort="Mailman, Richard B" uniqKey="Mailman R" first="Richard B" last="Mailman">Richard B. Mailman</name>
</author>
<author><name sortKey="Ross, G Webster" sort="Ross, G Webster" uniqKey="Ross G" first="G Webster" last="Ross">G Webster Ross</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="2008">2008</date>
<idno type="doi">10.1002/mds.22013</idno>
<idno type="RBID">pubmed:18381649</idno>
<idno type="pmid">18381649</idno>
<idno type="wicri:Area/PubMed/Corpus">002277</idno>
<idno type="wicri:Area/PubMed/Curation">002277</idno>
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<idno type="wicri:Area/Ncbi/Checkpoint">002084</idno>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">Low LDL cholesterol and increased risk of Parkinson's disease: prospective results from Honolulu-Asia Aging Study.</title>
<author><name sortKey="Huang, Xuemei" sort="Huang, Xuemei" uniqKey="Huang X" first="Xuemei" last="Huang">Xuemei Huang</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, University of North Carolina School of Medicine, Chapel Hill, North Carolina 27599-7025, USA. xuemei@med.unc.edu</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, University of North Carolina School of Medicine, Chapel Hill, North Carolina 27599-7025</wicri:regionArea>
<wicri:noRegion>North Carolina 27599-7025</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Abbott, Robert D" sort="Abbott, Robert D" uniqKey="Abbott R" first="Robert D" last="Abbott">Robert D. Abbott</name>
</author>
<author><name sortKey="Petrovitch, Helen" sort="Petrovitch, Helen" uniqKey="Petrovitch H" first="Helen" last="Petrovitch">Helen Petrovitch</name>
</author>
<author><name sortKey="Mailman, Richard B" sort="Mailman, Richard B" uniqKey="Mailman R" first="Richard B" last="Mailman">Richard B. Mailman</name>
</author>
<author><name sortKey="Ross, G Webster" sort="Ross, G Webster" uniqKey="Ross G" first="G Webster" last="Ross">G Webster Ross</name>
</author>
</analytic>
<series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title>
<idno type="eISSN">1531-8257</idno>
<imprint><date when="2008" type="published">2008</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term>
<term>Aging (physiology)</term>
<term>Apolipoprotein E2 (blood)</term>
<term>Cholesterol, LDL (blood)</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Parkinson Disease (blood)</term>
<term>Parkinson Disease (epidemiology)</term>
<term>Prevalence</term>
<term>Prospective Studies</term>
<term>Questionnaires</term>
<term>Risk Factors</term>
<term>Smoking (epidemiology)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Apolipoprotein E2</term>
<term>Cholesterol, LDL</term>
</keywords>
<keywords scheme="MESH" qualifier="blood" xml:lang="en"><term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Parkinson Disease</term>
<term>Smoking</term>
</keywords>
<keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Aging</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Aged</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Prevalence</term>
<term>Prospective Studies</term>
<term>Questionnaires</term>
<term>Risk Factors</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Low-density lipoprotein cholesterol (LDL-C) levels are suggested to be associated inversely with Parkinson's disease (PD). To test the hypothesis that LDL-C levels may increase PD risk, we studied a prospective cohort of 3,233 men (Honolulu-Asia Aging Study) for whom the LDL-C from fasting lipid profiles was obtained during 1991 to 1993. The cohort was followed longitudinally until 2001 for incident Parkinson's cases. During follow-up, 41 men developed PD (18.4/10,000 person-years). Although the incidence of PD increased with decreasing LDL-C in a dose-dependent manner, the association was only significant for men aged 71 to 75 years. In the latter group, risk of PD declined from 38.5/10,000 person-years in men with LDL-C levels <80 mg/dl to less than 9/10,000 person-years for concentrations that were > or =140 mg/dl. After adjustment for age, smoking, coffee intake, and other factors, the relative odds of PD for men at the 80th versus the 20th percentile of LDL-C (135 vs. 85 mg/dl) was 0.4 (95% confidence interval: 0.2, 0.9). This prospective study supports the hypothesis that low LDL-C is associated with an increased risk of PD. Although confirmation is required, the underlying mechanisms may be useful in understanding key aspects of PD.</div>
</front>
</TEI>
</PubMed>
</double>
</record>
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