Pharmacokinetics and pharmacodynamics of levodopa
Identifieur interne : 003274 ( Main/Merge ); précédent : 003273; suivant : 003275Pharmacokinetics and pharmacodynamics of levodopa
Auteurs : John G. Nutt [États-Unis]Source :
- Movement Disorders [ 0885-3185 ] ; 2008.
English descriptors
- KwdEn :
- Antiparkinson Agents (adverse effects), Antiparkinson Agents (pharmacokinetics), Antiparkinson Agents (pharmacology), Antiparkinson Agents (therapeutic use), Humans, Kinetics, Levodopa (adverse effects), Levodopa (pharmacokinetics), Levodopa (pharmacology), Levodopa (therapeutic use), Motor Activity (drug effects), Movement Disorders (etiology), Parkinson Disease (drug therapy), Parkinson Disease (physiopathology), Time Factors, dyskinesia, levodopa, motor fluctuations, short‐duration response.
- MESH :
- chemical , adverse effects : Antiparkinson Agents, Levodopa.
- chemical , pharmacokinetics : Antiparkinson Agents, Levodopa.
- chemical , pharmacology : Antiparkinson Agents, Levodopa.
- chemical , therapeutic use : Antiparkinson Agents, Levodopa.
- drug effects : Motor Activity.
- drug therapy : Parkinson Disease.
- etiology : Movement Disorders.
- physiopathology : Parkinson Disease.
- Humans, Kinetics, Time Factors.
Abstract
The pharmacokinetics and pharmacodynamics of levodopa are dominated by two features: the short plasma half‐life of the drug and the portion of the antiparkinsonian response that parallels the plasma levodopa levels, the so‐called short‐duration response. These features are the basis of motor fluctuations that complicate long‐term therapy with levodopa. Motor fluctuations will predictably improve with measures that prolong the elevations of plasma levodopa or prolong the efficacy of dopamine synthesized from exogenous levodopa. Because dyskinesia is closely linked to the short‐duration response and conceivably part of the short‐duration response, it is less clear that dyskinesia will be improved by therapeutic strategies that reduce motor fluctuations. © 2008 Movement Disorder Society
Url:
DOI: 10.1002/mds.22037
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<front><div type="abstract" xml:lang="en">The pharmacokinetics and pharmacodynamics of levodopa are dominated by two features: the short plasma half-life of the drug and the portion of the antiparkinsonian response that parallels the plasma levodopa levels, the so-called short-duration response. These features are the basis of motor fluctuations that complicate long-term therapy with levodopa. Motor fluctuations will predictably improve with measures that prolong the elevations of plasma levodopa or prolong the efficacy of dopamine synthesized from exogenous levodopa. Because dyskinesia is closely linked to the short-duration response and conceivably part of the short-duration response, it is less clear that dyskinesia will be improved by therapeutic strategies that reduce motor fluctuations.</div>
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