Comparing Bromocriptine Effects with Levodopa Effects on Bladder Function in Parkinson's Disease
Identifieur interne : 003034 ( Main/Merge ); précédent : 003033; suivant : 003035Comparing Bromocriptine Effects with Levodopa Effects on Bladder Function in Parkinson's Disease
Auteurs : Tomoyuki Uchiyama [Japon] ; Ryuji Sakakibara [Japon] ; Tatsuya Yamamoto [Japon] ; Takashi Ito [Japon] ; Chiharu Yamaguchi [Japon] ; Yusuke Awa [Japon] ; Masashi Yano [Japon] ; Mitsuru Yanagisawa [Japon] ; Makoto Kobayashi [Japon] ; Yoshinori Higuchi [Japon] ; Tomohiko Ichikawa [Japon] ; Tomonori Yamanishi [Japon] ; Takamichi Hattori [Japon] ; Satoshi Kuwabara [Japon]Source :
- Movement disorders [ 0885-3185 ] ; 2009.
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- Pascal (Inist)
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Abstract
To evaluate the effects of bromocriptine on bladder function in Parkinson's disease (PD) patients and compare these effects with those of (L-dopa). We recruited 8 patients with PD. Urodynamic study (UDS) was performed before and 1 hour after administering 100 mg L-dopa/decarboxylase inhibitor (DCI) and 2.5 hours after administering 7.5 mg bromocriptine. After the bromocriptine administration, urinary urgency aggravated. UDS revealed a decreased bladder volume at which detrusor overactivity (DO) was initiated, a decreased bladder volume at first sensation of bladder filling (FSV) (P < 0.05), an increased maximum Watts Factor value (WFmax) (detrusor contractility), a decreased Abrams-Griffiths (AG) number (urethral obstruction), and a decreased postvoid residual (PVR) (P < 0.01). Similarly, after the KL-dopa administration, urinary urgency aggravated. UDS revealed an aggravated DO (P < 0.05), a decreased FSV and bladder capacity (P < 0.01, 0.05), an increased WFmax (P < 0.05), an increased AG number, and a decreased PVR (P < 0.01). A single dose of bromocriptine proved to exacerbate urinary urgency and DO in the storage phase, and improve bladder emptying through increased detrusor contractility and decreased bladder outlet obstruction, within hours. With the exception of bladder outlet obstruction, these effects of bromocriptine are similar to the effects of L-dopa, albeit slightly less pronounced.
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">Comparing Bromocriptine Effects with Levodopa Effects on Bladder Function in Parkinson's Disease</title><author><name sortKey="Uchiyama, Tomoyuki" sort="Uchiyama, Tomoyuki" uniqKey="Uchiyama T" first="Tomoyuki" last="Uchiyama">Tomoyuki Uchiyama</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurology, Graduate School of Medicine, Chiba University</s1><s2>Chuo-ku, Chiba</s2><s3>JPN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>9 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ></inist:fA14><country>Japon</country><wicri:noRegion>Chuo-ku, Chiba</wicri:noRegion></affiliation></author><author><name sortKey="Sakakibara, Ryuji" sort="Sakakibara, Ryuji" uniqKey="Sakakibara R" first="Ryuji" last="Sakakibara">Ryuji Sakakibara</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurology, Graduate School of Medicine, Chiba University</s1><s2>Chuo-ku, Chiba</s2><s3>JPN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>9 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ></inist:fA14><country>Japon</country><wicri:noRegion>Chuo-ku, Chiba</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Neurology Division, Department of Internal Medicine, Sakura Medical Center, Toho University</s1><s2>Sakura</s2><s3>JPN</s3><sZ>2 aut.</sZ></inist:fA14><country>Japon</country><wicri:noRegion>Sakura</wicri:noRegion></affiliation></author><author><name sortKey="Yamamoto, Tatsuya" sort="Yamamoto, Tatsuya" uniqKey="Yamamoto T" first="Tatsuya" last="Yamamoto">Tatsuya Yamamoto</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurology, Graduate School of Medicine, Chiba University</s1><s2>Chuo-ku, Chiba</s2><s3>JPN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>9 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ></inist:fA14><country>Japon</country><wicri:noRegion>Chuo-ku, Chiba</wicri:noRegion></affiliation></author><author><name sortKey="Ito, Takashi" sort="Ito, Takashi" uniqKey="Ito T" first="Takashi" last="Ito">Takashi Ito</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurology, Graduate School of Medicine, Chiba University</s1><s2>Chuo-ku, Chiba</s2><s3>JPN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>9 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ></inist:fA14><country>Japon</country><wicri:noRegion>Chuo-ku, Chiba</wicri:noRegion></affiliation></author><author><name sortKey="Yamaguchi, Chiharu" sort="Yamaguchi, Chiharu" uniqKey="Yamaguchi C" first="Chiharu" last="Yamaguchi">Chiharu Yamaguchi</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Central Laboratory Unit, Chiba University Hospital</s1><s2>Chiba</s2><s3>JPN</s3><sZ>5 aut.</sZ></inist:fA14><country>Japon</country><wicri:noRegion>Chiba</wicri:noRegion></affiliation></author><author><name sortKey="Awa, Yusuke" sort="Awa, Yusuke" uniqKey="Awa Y" first="Yusuke" last="Awa">Yusuke Awa</name><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Department of Urology, Graduate School of Medicine, Chiba University</s1><s2>Chuo-ku, Chiba</s2><s3>JPN</s3><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>Japon</country><wicri:noRegion>Chuo-ku, Chiba</wicri:noRegion></affiliation></author><author><name sortKey="Yano, Masashi" sort="Yano, Masashi" uniqKey="Yano M" first="Masashi" last="Yano">Masashi Yano</name><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Department of Urology, Graduate School of Medicine, Chiba University</s1><s2>Chuo-ku, Chiba</s2><s3>JPN</s3><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>Japon</country><wicri:noRegion>Chuo-ku, Chiba</wicri:noRegion></affiliation></author><author><name sortKey="Yanagisawa, Mitsuru" sort="Yanagisawa, Mitsuru" uniqKey="Yanagisawa M" first="Mitsuru" last="Yanagisawa">Mitsuru Yanagisawa</name><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Department of Urology, Graduate School of Medicine, Chiba University</s1><s2>Chuo-ku, Chiba</s2><s3>JPN</s3><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>Japon</country><wicri:noRegion>Chuo-ku, Chiba</wicri:noRegion></affiliation></author><author><name sortKey="Kobayashi, Makoto" sort="Kobayashi, Makoto" uniqKey="Kobayashi M" first="Makoto" last="Kobayashi">Makoto Kobayashi</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurology, Graduate School of Medicine, Chiba University</s1><s2>Chuo-ku, Chiba</s2><s3>JPN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>9 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ></inist:fA14><country>Japon</country><wicri:noRegion>Chuo-ku, Chiba</wicri:noRegion></affiliation></author><author><name sortKey="Higuchi, Yoshinori" sort="Higuchi, Yoshinori" uniqKey="Higuchi Y" first="Yoshinori" last="Higuchi">Yoshinori Higuchi</name><affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Department of Neurosurgery, Graduate School of Medicine, Chiba University</s1><s2>Chuo-ku, Chiba</s2><s3>JPN</s3><sZ>10 aut.</sZ></inist:fA14><country>Japon</country><wicri:noRegion>Chuo-ku, Chiba</wicri:noRegion></affiliation></author><author><name sortKey="Ichikawa, Tomohiko" sort="Ichikawa, Tomohiko" uniqKey="Ichikawa T" first="Tomohiko" last="Ichikawa">Tomohiko Ichikawa</name><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Department of Urology, Graduate School of Medicine, Chiba University</s1><s2>Chuo-ku, Chiba</s2><s3>JPN</s3><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>Japon</country><wicri:noRegion>Chuo-ku, Chiba</wicri:noRegion></affiliation></author><author><name sortKey="Yamanishi, Tomonori" sort="Yamanishi, Tomonori" uniqKey="Yamanishi T" first="Tomonori" last="Yamanishi">Tomonori Yamanishi</name><affiliation wicri:level="1"><inist:fA14 i1="06"><s1>Department of Urology, Koshigaya Hospital, Dokkyo Medical College</s1><s2>Tochigi</s2><s3>JPN</s3><sZ>12 aut.</sZ></inist:fA14><country>Japon</country><wicri:noRegion>Tochigi</wicri:noRegion></affiliation></author><author><name sortKey="Hattori, Takamichi" sort="Hattori, Takamichi" uniqKey="Hattori T" first="Takamichi" last="Hattori">Takamichi Hattori</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurology, Graduate School of Medicine, Chiba University</s1><s2>Chuo-ku, Chiba</s2><s3>JPN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>9 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ></inist:fA14><country>Japon</country><wicri:noRegion>Chuo-ku, Chiba</wicri:noRegion></affiliation></author><author><name sortKey="Kuwabara, Satoshi" sort="Kuwabara, Satoshi" uniqKey="Kuwabara S" first="Satoshi" last="Kuwabara">Satoshi Kuwabara</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurology, Graduate School of Medicine, Chiba University</s1><s2>Chuo-ku, Chiba</s2><s3>JPN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>9 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ></inist:fA14><country>Japon</country><wicri:noRegion>Chuo-ku, Chiba</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">10-0071238</idno><date when="2009">2009</date><idno type="stanalyst">PASCAL 10-0071238 INIST</idno><idno type="RBID">Pascal:10-0071238</idno><idno type="wicri:Area/PascalFrancis/Corpus">000C74</idno><idno type="wicri:Area/PascalFrancis/Curation">002045</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">000F37</idno><idno type="wicri:doubleKey">0885-3185:2009:Uchiyama T:comparing:bromocriptine:effects</idno><idno type="wicri:Area/Main/Merge">003034</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Comparing Bromocriptine Effects with Levodopa Effects on Bladder Function in Parkinson's Disease</title><author><name sortKey="Uchiyama, Tomoyuki" sort="Uchiyama, Tomoyuki" uniqKey="Uchiyama T" first="Tomoyuki" last="Uchiyama">Tomoyuki Uchiyama</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurology, Graduate School of Medicine, Chiba University</s1><s2>Chuo-ku, Chiba</s2><s3>JPN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>9 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ></inist:fA14><country>Japon</country><wicri:noRegion>Chuo-ku, Chiba</wicri:noRegion></affiliation></author><author><name sortKey="Sakakibara, Ryuji" sort="Sakakibara, Ryuji" uniqKey="Sakakibara R" first="Ryuji" last="Sakakibara">Ryuji Sakakibara</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurology, Graduate School of Medicine, Chiba University</s1><s2>Chuo-ku, Chiba</s2><s3>JPN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>9 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ></inist:fA14><country>Japon</country><wicri:noRegion>Chuo-ku, Chiba</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Neurology Division, Department of Internal Medicine, Sakura Medical Center, Toho University</s1><s2>Sakura</s2><s3>JPN</s3><sZ>2 aut.</sZ></inist:fA14><country>Japon</country><wicri:noRegion>Sakura</wicri:noRegion></affiliation></author><author><name sortKey="Yamamoto, Tatsuya" sort="Yamamoto, Tatsuya" uniqKey="Yamamoto T" first="Tatsuya" last="Yamamoto">Tatsuya Yamamoto</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurology, Graduate School of Medicine, Chiba University</s1><s2>Chuo-ku, Chiba</s2><s3>JPN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>9 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ></inist:fA14><country>Japon</country><wicri:noRegion>Chuo-ku, Chiba</wicri:noRegion></affiliation></author><author><name sortKey="Ito, Takashi" sort="Ito, Takashi" uniqKey="Ito T" first="Takashi" last="Ito">Takashi Ito</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurology, Graduate School of Medicine, Chiba University</s1><s2>Chuo-ku, Chiba</s2><s3>JPN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>9 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ></inist:fA14><country>Japon</country><wicri:noRegion>Chuo-ku, Chiba</wicri:noRegion></affiliation></author><author><name sortKey="Yamaguchi, Chiharu" sort="Yamaguchi, Chiharu" uniqKey="Yamaguchi C" first="Chiharu" last="Yamaguchi">Chiharu Yamaguchi</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Central Laboratory Unit, Chiba University Hospital</s1><s2>Chiba</s2><s3>JPN</s3><sZ>5 aut.</sZ></inist:fA14><country>Japon</country><wicri:noRegion>Chiba</wicri:noRegion></affiliation></author><author><name sortKey="Awa, Yusuke" sort="Awa, Yusuke" uniqKey="Awa Y" first="Yusuke" last="Awa">Yusuke Awa</name><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Department of Urology, Graduate School of Medicine, Chiba University</s1><s2>Chuo-ku, Chiba</s2><s3>JPN</s3><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>Japon</country><wicri:noRegion>Chuo-ku, Chiba</wicri:noRegion></affiliation></author><author><name sortKey="Yano, Masashi" sort="Yano, Masashi" uniqKey="Yano M" first="Masashi" last="Yano">Masashi Yano</name><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Department of Urology, Graduate School of Medicine, Chiba University</s1><s2>Chuo-ku, Chiba</s2><s3>JPN</s3><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>Japon</country><wicri:noRegion>Chuo-ku, Chiba</wicri:noRegion></affiliation></author><author><name sortKey="Yanagisawa, Mitsuru" sort="Yanagisawa, Mitsuru" uniqKey="Yanagisawa M" first="Mitsuru" last="Yanagisawa">Mitsuru Yanagisawa</name><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Department of Urology, Graduate School of Medicine, Chiba University</s1><s2>Chuo-ku, Chiba</s2><s3>JPN</s3><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>Japon</country><wicri:noRegion>Chuo-ku, Chiba</wicri:noRegion></affiliation></author><author><name sortKey="Kobayashi, Makoto" sort="Kobayashi, Makoto" uniqKey="Kobayashi M" first="Makoto" last="Kobayashi">Makoto Kobayashi</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurology, Graduate School of Medicine, Chiba University</s1><s2>Chuo-ku, Chiba</s2><s3>JPN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>9 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ></inist:fA14><country>Japon</country><wicri:noRegion>Chuo-ku, Chiba</wicri:noRegion></affiliation></author><author><name sortKey="Higuchi, Yoshinori" sort="Higuchi, Yoshinori" uniqKey="Higuchi Y" first="Yoshinori" last="Higuchi">Yoshinori Higuchi</name><affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Department of Neurosurgery, Graduate School of Medicine, Chiba University</s1><s2>Chuo-ku, Chiba</s2><s3>JPN</s3><sZ>10 aut.</sZ></inist:fA14><country>Japon</country><wicri:noRegion>Chuo-ku, Chiba</wicri:noRegion></affiliation></author><author><name sortKey="Ichikawa, Tomohiko" sort="Ichikawa, Tomohiko" uniqKey="Ichikawa T" first="Tomohiko" last="Ichikawa">Tomohiko Ichikawa</name><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Department of Urology, Graduate School of Medicine, Chiba University</s1><s2>Chuo-ku, Chiba</s2><s3>JPN</s3><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>Japon</country><wicri:noRegion>Chuo-ku, Chiba</wicri:noRegion></affiliation></author><author><name sortKey="Yamanishi, Tomonori" sort="Yamanishi, Tomonori" uniqKey="Yamanishi T" first="Tomonori" last="Yamanishi">Tomonori Yamanishi</name><affiliation wicri:level="1"><inist:fA14 i1="06"><s1>Department of Urology, Koshigaya Hospital, Dokkyo Medical College</s1><s2>Tochigi</s2><s3>JPN</s3><sZ>12 aut.</sZ></inist:fA14><country>Japon</country><wicri:noRegion>Tochigi</wicri:noRegion></affiliation></author><author><name sortKey="Hattori, Takamichi" sort="Hattori, Takamichi" uniqKey="Hattori T" first="Takamichi" last="Hattori">Takamichi Hattori</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurology, Graduate School of Medicine, Chiba University</s1><s2>Chuo-ku, Chiba</s2><s3>JPN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>9 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ></inist:fA14><country>Japon</country><wicri:noRegion>Chuo-ku, Chiba</wicri:noRegion></affiliation></author><author><name sortKey="Kuwabara, Satoshi" sort="Kuwabara, Satoshi" uniqKey="Kuwabara S" first="Satoshi" last="Kuwabara">Satoshi Kuwabara</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurology, Graduate School of Medicine, Chiba University</s1><s2>Chuo-ku, Chiba</s2><s3>JPN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>9 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ></inist:fA14><country>Japon</country><wicri:noRegion>Chuo-ku, Chiba</wicri:noRegion></affiliation></author></analytic><series><title level="j" type="main">Movement disorders</title><title level="j" type="abbreviated">Mov. disord.</title><idno type="ISSN">0885-3185</idno><imprint><date when="2009">2009</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Movement disorders</title><title level="j" type="abbreviated">Mov. disord.</title><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Bladder disease</term><term>Bladder function</term><term>Bromocriptine</term><term>Dysfunction</term><term>Levodopa</term><term>Nervous system diseases</term><term>Parkinson disease</term><term>Parkinsonism</term><term>Urinary bladder</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Pathologie de la vessie</term><term>Maladie de Parkinson</term><term>Parkinsonisme</term><term>Pathologie du système nerveux</term><term>Bromocriptine</term><term>Lévodopa</term><term>Fonction vésicale</term><term>Vessie urinaire</term><term>Trouble fonctionnel</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">To evaluate the effects of bromocriptine on bladder function in Parkinson's disease (PD) patients and compare these effects with those of (L-dopa). We recruited 8 patients with PD. Urodynamic study (UDS) was performed before and 1 hour after administering 100 mg L-dopa/decarboxylase inhibitor (DCI) and 2.5 hours after administering 7.5 mg bromocriptine. After the bromocriptine administration, urinary urgency aggravated. UDS revealed a decreased bladder volume at which detrusor overactivity (DO) was initiated, a decreased bladder volume at first sensation of bladder filling (FSV) (P < 0.05), an increased maximum Watts Factor value (WFmax) (detrusor contractility), a decreased Abrams-Griffiths (AG) number (urethral obstruction), and a decreased postvoid residual (PVR) (P < 0.01). Similarly, after the KL-dopa administration, urinary urgency aggravated. UDS revealed an aggravated DO (P < 0.05), a decreased FSV and bladder capacity (P < 0.01, 0.05), an increased WFmax (P < 0.05), an increased AG number, and a decreased PVR (P < 0.01). A single dose of bromocriptine proved to exacerbate urinary urgency and DO in the storage phase, and improve bladder emptying through increased detrusor contractility and decreased bladder outlet obstruction, within hours. With the exception of bladder outlet obstruction, these effects of bromocriptine are similar to the effects of L-dopa, albeit slightly less pronounced.</div></front></TEI><affiliations><list><country><li>Japon</li></country></list><tree><country name="Japon"><noRegion><name sortKey="Uchiyama, Tomoyuki" sort="Uchiyama, Tomoyuki" uniqKey="Uchiyama T" first="Tomoyuki" last="Uchiyama">Tomoyuki Uchiyama</name></noRegion><name sortKey="Awa, Yusuke" sort="Awa, Yusuke" uniqKey="Awa Y" first="Yusuke" last="Awa">Yusuke Awa</name><name sortKey="Hattori, Takamichi" sort="Hattori, Takamichi" uniqKey="Hattori T" first="Takamichi" last="Hattori">Takamichi Hattori</name><name sortKey="Higuchi, Yoshinori" sort="Higuchi, Yoshinori" uniqKey="Higuchi Y" first="Yoshinori" last="Higuchi">Yoshinori Higuchi</name><name sortKey="Ichikawa, Tomohiko" sort="Ichikawa, Tomohiko" uniqKey="Ichikawa T" first="Tomohiko" last="Ichikawa">Tomohiko Ichikawa</name><name sortKey="Ito, Takashi" sort="Ito, Takashi" uniqKey="Ito T" first="Takashi" last="Ito">Takashi Ito</name><name sortKey="Kobayashi, Makoto" sort="Kobayashi, Makoto" uniqKey="Kobayashi M" first="Makoto" last="Kobayashi">Makoto Kobayashi</name><name sortKey="Kuwabara, Satoshi" sort="Kuwabara, Satoshi" uniqKey="Kuwabara S" first="Satoshi" last="Kuwabara">Satoshi Kuwabara</name><name sortKey="Sakakibara, Ryuji" sort="Sakakibara, Ryuji" uniqKey="Sakakibara R" first="Ryuji" last="Sakakibara">Ryuji Sakakibara</name><name sortKey="Sakakibara, Ryuji" sort="Sakakibara, Ryuji" uniqKey="Sakakibara R" first="Ryuji" last="Sakakibara">Ryuji Sakakibara</name><name sortKey="Yamaguchi, Chiharu" sort="Yamaguchi, Chiharu" uniqKey="Yamaguchi C" first="Chiharu" last="Yamaguchi">Chiharu Yamaguchi</name><name sortKey="Yamamoto, Tatsuya" sort="Yamamoto, Tatsuya" uniqKey="Yamamoto T" first="Tatsuya" last="Yamamoto">Tatsuya Yamamoto</name><name sortKey="Yamanishi, Tomonori" sort="Yamanishi, Tomonori" uniqKey="Yamanishi T" first="Tomonori" last="Yamanishi">Tomonori Yamanishi</name><name sortKey="Yanagisawa, Mitsuru" sort="Yanagisawa, Mitsuru" uniqKey="Yanagisawa M" first="Mitsuru" last="Yanagisawa">Mitsuru Yanagisawa</name><name sortKey="Yano, Masashi" sort="Yano, Masashi" uniqKey="Yano M" first="Masashi" last="Yano">Masashi Yano</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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