Functional Brain Imaging in Pure Akinesia with Gait Freezing : [18F] FDG PET and [18F] FP-CIT PET Analyses
Identifieur interne : 002F69 ( Main/Merge ); précédent : 002F68; suivant : 002F70Functional Brain Imaging in Pure Akinesia with Gait Freezing : [18F] FDG PET and [18F] FP-CIT PET Analyses
Auteurs : Hee K. Park [Corée du Sud] ; Jae S. Kim [Corée du Sud] ; Ki C. Im [Corée du Sud] ; Seung J. Oh [Corée du Sud] ; Mi J. Kim [Corée du Sud] ; Jae-Hong Lee [Corée du Sud] ; Sun J. Chung [Corée du Sud] ; Myoung C. Lee [Corée du Sud]Source :
- Movement disorders [ 0885-3185 ] ; 2009.
Descripteurs français
- Pascal (Inist)
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- topic : Congélation.
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Abstract
Pure akinesia with gait freezing (PAGF) has characteristic features, including freezing of gait and prominent speech disturbance without rigidity or tremor. The purpose of this study was to investigate changes in brain glucose metabolism and presynaptic dopaminergic function in PAGF. By using [18F] fluorodeoxyglucose (FDG) PET, 11 patients with PAGF were compared with 14 patients with probable progressive supranuclear palsy (PSP), 13 patients with Parkinson's disease (PD), and 11 normal controls. [18F] N-(3-fluoropropyl)-2p-carbon ethoxy-3β-(4-iodophenyl) nortropane (FP-CIT) PET was performed in 11 patients with PAGF and with 10 normal controls. The PAGF patients showed decreased glucose metabolism in the midbrain when compared with normal controls. PSP patients showed a similar topographic distribution of glucose hypometabolism with additional areas, including the frontal cortex, when compared with normal controls. The FP-CIT PET findings in patients with PAGF revealed severely decreased uptake bilaterally in the basal ganglia. These findings suggest that both PAGF and PSP may be part of the same pathophysiologic spectrum of disease. However, the reason why PAGF manifests clinically in a different manner needs to be further elucidated.
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Asan Medical Center, University of Ulsan College of Medicine</s1><s2>Seoul</s2><s3>KOR</s3><sZ>1 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>Corée du Sud</country><placeName><settlement type="city">Séoul</settlement></placeName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Department of Neurology, College of Medicine, Hanyang University</s1><s2>Seoul</s2><s3>KOR</s3><sZ>1 aut.</sZ></inist:fA14><country>Corée du Sud</country><placeName><settlement type="city">Séoul</settlement></placeName></affiliation></author><author><name sortKey="Kim, Jae S" sort="Kim, Jae S" uniqKey="Kim J" first="Jae S." last="Kim">Jae S. Kim</name><affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Department of Nuclear Medicine, Asan Medical Center, University of Ulsan College of Medicine</s1><s2>Seoul</s2><s3>KOR</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ></inist:fA14><country>Corée du Sud</country><placeName><settlement type="city">Séoul</settlement></placeName></affiliation></author><author><name sortKey="Im, Ki C" sort="Im, Ki C" uniqKey="Im K" first="Ki C." last="Im">Ki C. Im</name><affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Department of Nuclear Medicine, Asan Medical Center, University of Ulsan College of Medicine</s1><s2>Seoul</s2><s3>KOR</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ></inist:fA14><country>Corée du Sud</country><placeName><settlement type="city">Séoul</settlement></placeName></affiliation></author><author><name sortKey="Oh, Seung J" sort="Oh, Seung J" uniqKey="Oh S" first="Seung J." last="Oh">Seung J. Oh</name><affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Department of Nuclear Medicine, Asan Medical Center, University of Ulsan College of Medicine</s1><s2>Seoul</s2><s3>KOR</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ></inist:fA14><country>Corée du Sud</country><placeName><settlement type="city">Séoul</settlement></placeName></affiliation></author><author><name sortKey="Kim, Mi J" sort="Kim, Mi J" uniqKey="Kim M" first="Mi J." last="Kim">Mi J. Kim</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Neurology, Center for Parkinsonism and Other Movement Disorders. Asan Medical Center, University of Ulsan College of Medicine</s1><s2>Seoul</s2><s3>KOR</s3><sZ>1 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>Corée du Sud</country><placeName><settlement type="city">Séoul</settlement></placeName></affiliation></author><author><name sortKey="Lee, Jae Hong" sort="Lee, Jae Hong" uniqKey="Lee J" first="Jae-Hong" last="Lee">Jae-Hong Lee</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Neurology, Center for Parkinsonism and Other Movement Disorders. Asan Medical Center, University of Ulsan College of Medicine</s1><s2>Seoul</s2><s3>KOR</s3><sZ>1 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>Corée du Sud</country><placeName><settlement type="city">Séoul</settlement></placeName></affiliation></author><author><name sortKey="Chung, Sun J" sort="Chung, Sun J" uniqKey="Chung S" first="Sun J." last="Chung">Sun J. Chung</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Neurology, Center for Parkinsonism and Other Movement Disorders. Asan Medical Center, University of Ulsan College of Medicine</s1><s2>Seoul</s2><s3>KOR</s3><sZ>1 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>Corée du Sud</country><placeName><settlement type="city">Séoul</settlement></placeName></affiliation></author><author><name sortKey="Lee, Myoung C" sort="Lee, Myoung C" uniqKey="Lee M" first="Myoung C." last="Lee">Myoung C. Lee</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Neurology, Center for Parkinsonism and Other Movement Disorders. Asan Medical Center, University of Ulsan College of Medicine</s1><s2>Seoul</s2><s3>KOR</s3><sZ>1 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>Corée du Sud</country><placeName><settlement type="city">Séoul</settlement></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">09-0104583</idno><date when="2009">2009</date><idno type="stanalyst">PASCAL 09-0104583 INIST</idno><idno type="RBID">Pascal:09-0104583</idno><idno type="wicri:Area/PascalFrancis/Corpus">000F81</idno><idno type="wicri:Area/PascalFrancis/Curation">001D38</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">000E72</idno><idno type="wicri:doubleKey">0885-3185:2009:Park H:functional:brain:imaging</idno><idno type="wicri:Area/Main/Merge">002F69</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Functional Brain Imaging in Pure Akinesia with Gait Freezing : [<sup>18</sup>F] FDG PET and [<sup>18</sup>F] FP-CIT PET Analyses</title><author><name sortKey="Park, Hee K" sort="Park, Hee K" uniqKey="Park H" first="Hee K." last="Park">Hee K. Park</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Neurology, Center for Parkinsonism and Other Movement Disorders. Asan Medical Center, University of Ulsan College of Medicine</s1><s2>Seoul</s2><s3>KOR</s3><sZ>1 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>Corée du Sud</country><placeName><settlement type="city">Séoul</settlement></placeName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Department of Neurology, College of Medicine, Hanyang University</s1><s2>Seoul</s2><s3>KOR</s3><sZ>1 aut.</sZ></inist:fA14><country>Corée du Sud</country><placeName><settlement type="city">Séoul</settlement></placeName></affiliation></author><author><name sortKey="Kim, Jae S" sort="Kim, Jae S" uniqKey="Kim J" first="Jae S." last="Kim">Jae S. Kim</name><affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Department of Nuclear Medicine, Asan Medical Center, University of Ulsan College of Medicine</s1><s2>Seoul</s2><s3>KOR</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ></inist:fA14><country>Corée du Sud</country><placeName><settlement type="city">Séoul</settlement></placeName></affiliation></author><author><name sortKey="Im, Ki C" sort="Im, Ki C" uniqKey="Im K" first="Ki C." last="Im">Ki C. Im</name><affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Department of Nuclear Medicine, Asan Medical Center, University of Ulsan College of Medicine</s1><s2>Seoul</s2><s3>KOR</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ></inist:fA14><country>Corée du Sud</country><placeName><settlement type="city">Séoul</settlement></placeName></affiliation></author><author><name sortKey="Oh, Seung J" sort="Oh, Seung J" uniqKey="Oh S" first="Seung J." last="Oh">Seung J. Oh</name><affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Department of Nuclear Medicine, Asan Medical Center, University of Ulsan College of Medicine</s1><s2>Seoul</s2><s3>KOR</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ></inist:fA14><country>Corée du Sud</country><placeName><settlement type="city">Séoul</settlement></placeName></affiliation></author><author><name sortKey="Kim, Mi J" sort="Kim, Mi J" uniqKey="Kim M" first="Mi J." last="Kim">Mi J. Kim</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Neurology, Center for Parkinsonism and Other Movement Disorders. Asan Medical Center, University of Ulsan College of Medicine</s1><s2>Seoul</s2><s3>KOR</s3><sZ>1 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>Corée du Sud</country><placeName><settlement type="city">Séoul</settlement></placeName></affiliation></author><author><name sortKey="Lee, Jae Hong" sort="Lee, Jae Hong" uniqKey="Lee J" first="Jae-Hong" last="Lee">Jae-Hong Lee</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Neurology, Center for Parkinsonism and Other Movement Disorders. Asan Medical Center, University of Ulsan College of Medicine</s1><s2>Seoul</s2><s3>KOR</s3><sZ>1 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>Corée du Sud</country><placeName><settlement type="city">Séoul</settlement></placeName></affiliation></author><author><name sortKey="Chung, Sun J" sort="Chung, Sun J" uniqKey="Chung S" first="Sun J." last="Chung">Sun J. Chung</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Neurology, Center for Parkinsonism and Other Movement Disorders. Asan Medical Center, University of Ulsan College of Medicine</s1><s2>Seoul</s2><s3>KOR</s3><sZ>1 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>Corée du Sud</country><placeName><settlement type="city">Séoul</settlement></placeName></affiliation></author><author><name sortKey="Lee, Myoung C" sort="Lee, Myoung C" uniqKey="Lee M" first="Myoung C." last="Lee">Myoung C. Lee</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Neurology, Center for Parkinsonism and Other Movement Disorders. Asan Medical Center, University of Ulsan College of Medicine</s1><s2>Seoul</s2><s3>KOR</s3><sZ>1 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>Corée du Sud</country><placeName><settlement type="city">Séoul</settlement></placeName></affiliation></author></analytic><series><title level="j" type="main">Movement disorders</title><title level="j" type="abbreviated">Mov. disord.</title><idno type="ISSN">0885-3185</idno><imprint><date when="2009">2009</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Movement disorders</title><title level="j" type="abbreviated">Mov. disord.</title><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Akinesia</term><term>Emission tomography</term><term>Encephalon</term><term>Freezing</term><term>Functional imaging</term><term>Nervous system diseases</term><term>Positron emission tomography</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Akinésie</term><term>Pathologie du système nerveux</term><term>Imagerie fonctionnelle</term><term>Encéphale</term><term>Congélation</term><term>Tomoscintigraphie</term><term>Tomographie par émission de positons</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Congélation</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Pure akinesia with gait freezing (PAGF) has characteristic features, including freezing of gait and prominent speech disturbance without rigidity or tremor. The purpose of this study was to investigate changes in brain glucose metabolism and presynaptic dopaminergic function in PAGF. By using [<sup>18</sup>F] fluorodeoxyglucose (FDG) PET, 11 patients with PAGF were compared with 14 patients with probable progressive supranuclear palsy (PSP), 13 patients with Parkinson's disease (PD), and 11 normal controls. [<sup>18</sup>F] N-(3-fluoropropyl)-2p-carbon ethoxy-3β-(4-iodophenyl) nortropane (FP-CIT) PET was performed in 11 patients with PAGF and with 10 normal controls. The PAGF patients showed decreased glucose metabolism in the midbrain when compared with normal controls. PSP patients showed a similar topographic distribution of glucose hypometabolism with additional areas, including the frontal cortex, when compared with normal controls. The FP-CIT PET findings in patients with PAGF revealed severely decreased uptake bilaterally in the basal ganglia. These findings suggest that both PAGF and PSP may be part of the same pathophysiologic spectrum of disease. However, the reason why PAGF manifests clinically in a different manner needs to be further elucidated.</div></front></TEI><affiliations><list><country><li>Corée du Sud</li></country><settlement><li>Séoul</li></settlement></list><tree><country name="Corée du Sud"><noRegion><name sortKey="Park, Hee K" sort="Park, Hee K" uniqKey="Park H" first="Hee K." last="Park">Hee K. Park</name></noRegion><name sortKey="Chung, Sun J" sort="Chung, Sun J" uniqKey="Chung S" first="Sun J." last="Chung">Sun J. Chung</name><name sortKey="Im, Ki C" sort="Im, Ki C" uniqKey="Im K" first="Ki C." last="Im">Ki C. Im</name><name sortKey="Kim, Jae S" sort="Kim, Jae S" uniqKey="Kim J" first="Jae S." last="Kim">Jae S. Kim</name><name sortKey="Kim, Mi J" sort="Kim, Mi J" uniqKey="Kim M" first="Mi J." last="Kim">Mi J. Kim</name><name sortKey="Lee, Jae Hong" sort="Lee, Jae Hong" uniqKey="Lee J" first="Jae-Hong" last="Lee">Jae-Hong Lee</name><name sortKey="Lee, Myoung C" sort="Lee, Myoung C" uniqKey="Lee M" first="Myoung C." last="Lee">Myoung C. Lee</name><name sortKey="Oh, Seung J" sort="Oh, Seung J" uniqKey="Oh S" first="Seung J." last="Oh">Seung J. Oh</name><name sortKey="Park, Hee K" sort="Park, Hee K" uniqKey="Park H" first="Hee K." last="Park">Hee K. Park</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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