MovDisordV3, Main, Merge, bibRecord, 002F09

Micro Lesion Effect of the Globus Pallidus Internus and Outcome with Deep Brain Stimulation in Patients with Parkinson Disease and Dystonia

Identifieur interne : 002F09 ( Main/Merge ); précédent : 002F08; suivant : 002F10

Micro Lesion Effect of the Globus Pallidus Internus and Outcome with Deep Brain Stimulation in Patients with Parkinson Disease and Dystonia

Auteurs : Maria G. Cersosimo [Argentine] ; Gabriela B. Raina [Argentine] ; Eduardo E. Benarroch [États-Unis] ; Fabian Piedimonte [Argentine] ; Gabriela Gonzalez Aleman [Argentine] ; Federico E. Micheli [Argentine]

Source :

Movement disorders [ 0885-3185 ] ; 2009.

RBID : Pascal:09-0358923

Descripteurs français

Pascal (Inist)
- Maladie de Parkinson, Dystonie, Pathologie du système nerveux, Pronostic, Homme, Stimulation cérébrale profonde.
Wicri :
- topic : Homme.

English descriptors

KwdEn :
- Deep brain stimulation, Dystonia, Human, Nervous system diseases, Parkinson disease, Prognosis.

Abstract

To determine whether the immediate response to electrode implantation (micro lesion effect, MLE) in the internal segment of the globus pallidus (GPi) predicts symptom improvement with deep brain stimulation (DBS) at 6 months in patients with Parkinson's disease (PD) or generalized dystonia. Electrode implantation in the subthalamic nucleus (STN) prior to electrical stimulation has been reported to predict a beneficial effect of DBS in patients with PD, but whether this is also the case for the GPi in either PD or dystonia patients has not been established. We studied 20 patients (11 with PD and 9 with dystonia) who underwent electrode implantation in the GPi. Effects were assessed using standardized scales after 24 hours, weekly for 3 weeks prior to starting DBS, and after 6 months of DBS. 10 of 11 PD and 8 of 9 dystonia cases who benefited from electrode implantation also showed improvement in all motor and disability scores after 6 months of DBS of the GPi. One dystonia patient who did not show MLE benefited from DBS. The presence of MLE after electrode implantation in the GPi may help predict motor benefit from DBS in PD and generalized dystonia patients.

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Pascal:09-0358923

Le document en format XML

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<author><name sortKey="Benarroch, Eduardo E" sort="Benarroch, Eduardo E" uniqKey="Benarroch E" first="Eduardo E." last="Benarroch">Eduardo E. Benarroch</name>
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<author><name sortKey="Piedimonte, Fabian" sort="Piedimonte, Fabian" uniqKey="Piedimonte F" first="Fabian" last="Piedimonte">Fabian Piedimonte</name>
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<author><name sortKey="Gonzalez Aleman, Gabriela" sort="Gonzalez Aleman, Gabriela" uniqKey="Gonzalez Aleman G" first="Gabriela" last="Gonzalez Aleman">Gabriela Gonzalez Aleman</name>
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<author><name sortKey="Micheli, Federico E" sort="Micheli, Federico E" uniqKey="Micheli F" first="Federico E." last="Micheli">Federico E. Micheli</name>
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<series><title level="j" type="main">Movement disorders</title>
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<keywords scheme="Pascal" xml:lang="fr"><term>Maladie de Parkinson</term>
<term>Dystonie</term>
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<front><div type="abstract" xml:lang="en">To determine whether the immediate response to electrode implantation (micro lesion effect, MLE) in the internal segment of the globus pallidus (GPi) predicts symptom improvement with deep brain stimulation (DBS) at 6 months in patients with Parkinson's disease (PD) or generalized dystonia. Electrode implantation in the subthalamic nucleus (STN) prior to electrical stimulation has been reported to predict a beneficial effect of DBS in patients with PD, but whether this is also the case for the GPi in either PD or dystonia patients has not been established. We studied 20 patients (11 with PD and 9 with dystonia) who underwent electrode implantation in the GPi. Effects were assessed using standardized scales after 24 hours, weekly for 3 weeks prior to starting DBS, and after 6 months of DBS. 10 of 11 PD and 8 of 9 dystonia cases who benefited from electrode implantation also showed improvement in all motor and disability scores after 6 months of DBS of the GPi. One dystonia patient who did not show MLE benefited from DBS. The presence of MLE after electrode implantation in the GPi may help predict motor benefit from DBS in PD and generalized dystonia patients.</div>
</front>
</TEI>
<affiliations><list><country><li>Argentine</li>
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<tree><country name="Argentine"><noRegion><name sortKey="Cersosimo, Maria G" sort="Cersosimo, Maria G" uniqKey="Cersosimo M" first="Maria G." last="Cersosimo">Maria G. Cersosimo</name>
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<name sortKey="Gonzalez Aleman, Gabriela" sort="Gonzalez Aleman, Gabriela" uniqKey="Gonzalez Aleman G" first="Gabriela" last="Gonzalez Aleman">Gabriela Gonzalez Aleman</name>
<name sortKey="Micheli, Federico E" sort="Micheli, Federico E" uniqKey="Micheli F" first="Federico E." last="Micheli">Federico E. Micheli</name>
<name sortKey="Piedimonte, Fabian" sort="Piedimonte, Fabian" uniqKey="Piedimonte F" first="Fabian" last="Piedimonte">Fabian Piedimonte</name>
<name sortKey="Raina, Gabriela B" sort="Raina, Gabriela B" uniqKey="Raina G" first="Gabriela B." last="Raina">Gabriela B. Raina</name>
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<country name="États-Unis"><region name="Minnesota"><name sortKey="Benarroch, Eduardo E" sort="Benarroch, Eduardo E" uniqKey="Benarroch E" first="Eduardo E." last="Benarroch">Eduardo E. Benarroch</name>
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	Movement Disorders (revue)
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Movement Disorders (revue)

Micro Lesion Effect of the Globus Pallidus Internus and Outcome with Deep Brain Stimulation in Patients with Parkinson Disease and Dystonia

Micro Lesion Effect of the Globus Pallidus Internus and Outcome with Deep Brain Stimulation in Patients with Parkinson Disease and Dystonia

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri