MovDisordV3, Main, Merge, bibRecord, 002E15

Respective Potencies of Botox® and Dysport® in a Human Skin Model : A Randomized, Double-blind Study

Identifieur interne : 002E15 ( Main/Merge ); précédent : 002E14; suivant : 002E16

Respective Potencies of Botox® and Dysport® in a Human Skin Model : A Randomized, Double-blind Study

Auteurs : Gottfried Kranz [Autriche] ; Dietrich Haubenberger [Autriche] ; Bemhard Voller [Autriche] ; Martin Posch [Autriche] ; Peter Schnider [Autriche] ; Eduard Auff [Autriche] ; Thomas Sycha [Autriche]

Source :

Movement disorders [ 0885-3185 ] ; 2009.

RBID : Pascal:09-0104588

Descripteurs français

Pascal (Inist)
- Pathologie du système nerveux, Homme, Peau, Modèle, Etude double insu, Bontoxilysin, Sueur.
Wicri :
- topic : Homme.

English descriptors

KwdEn :
- Bontoxilysin, Double blind study, Human, Models, Nervous system diseases, Skin, Sweat.

Abstract

Mouse units used to quantify the activity of botulinum A toxin preparations are not equivalent and issues concerning efficacy and safety remain with regard to their respective potencies and diffusion qualities in human tissue. We compared the effects of Botox® (BOT) and Dysport® (DYS) in different doses and dilutions in a human skin model. Eighteen (8 women, 10 men) healthy volunteers, aged 28.4 years ± 5.7 years were injected intradermally with pure saline, BOT and DYS at 16 points in the abdomen in random order and in a double-blind condition, using two conversion ratios (1:3 and 1:4) and three different dilution schemes. For an objective outcome, the Ninhydrin sweat test was used to compare the anhidrotic areas. Both preparations showed a linear dose and dilution relationship with similar variances of responses for anhidrosis and hypohidrosis, indicating the same reliability of response. The dose equivalence conversion ratios (BOT: DYS) were 1:1.3 for anhidrosis and 1:1.6 for hypohidrosis (1:1.1-1.5 and 1:1.4-1.8 95% confidence intervals). The diffusion characteristics of both products were similar. A dose equivalence factor of more than 1:2 (BOT:DYS) is not supported by these objective and reproducible data.

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Pascal:09-0104588

Le document en format XML

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<author><name sortKey="Posch, Martin" sort="Posch, Martin" uniqKey="Posch M" first="Martin" last="Posch">Martin Posch</name>
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<author><name sortKey="Schnider, Peter" sort="Schnider, Peter" uniqKey="Schnider P" first="Peter" last="Schnider">Peter Schnider</name>
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<author><name sortKey="Auff, Eduard" sort="Auff, Eduard" uniqKey="Auff E" first="Eduard" last="Auff">Eduard Auff</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Neurology, Medical University of Vienna</s1>
<s2>Wien</s2>
<s3>AUT</s3>
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</author>
<author><name sortKey="Sycha, Thomas" sort="Sycha, Thomas" uniqKey="Sycha T" first="Thomas" last="Sycha">Thomas Sycha</name>
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<s2>Wien</s2>
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<placeName><settlement type="city">Vienne (Autriche)</settlement>
<region nuts="2" type="province">Vienne (Autriche)</region>
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<series><title level="j" type="main">Movement disorders</title>
<title level="j" type="abbreviated">Mov. disord.</title>
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<seriesStmt><title level="j" type="main">Movement disorders</title>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Bontoxilysin</term>
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<term>Sweat</term>
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<keywords scheme="Pascal" xml:lang="fr"><term>Pathologie du   système nerveux</term>
<term>Homme</term>
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<front><div type="abstract" xml:lang="en">Mouse units used to quantify the activity of botulinum A toxin preparations are not equivalent and issues concerning efficacy and safety remain with regard to their respective potencies and diffusion qualities in human tissue. We compared the effects of Botox® (BOT) and Dysport® (DYS) in different doses and dilutions in a human skin model. Eighteen (8 women, 10 men) healthy volunteers, aged 28.4 years ± 5.7 years were injected intradermally with pure saline, BOT and DYS at 16 points in the abdomen in random order and in a double-blind condition, using two conversion ratios (1:3 and 1:4) and three different dilution schemes. For an objective outcome, the Ninhydrin sweat test was used to compare the anhidrotic areas. Both preparations showed a linear dose and dilution relationship with similar variances of responses for anhidrosis and hypohidrosis, indicating the same reliability of response. The dose equivalence conversion ratios (BOT: DYS) were 1:1.3 for anhidrosis and 1:1.6 for hypohidrosis (1:1.1-1.5 and 1:1.4-1.8 95% confidence intervals). The diffusion characteristics of both products were similar. A dose equivalence factor of more than 1:2 (BOT:DYS) is not supported by these objective and reproducible data.</div>
</front>
</TEI>
<affiliations><list><country><li>Autriche</li>
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<tree><country name="Autriche"><region name="Vienne (Autriche)"><name sortKey="Kranz, Gottfried" sort="Kranz, Gottfried" uniqKey="Kranz G" first="Gottfried" last="Kranz">Gottfried Kranz</name>
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<name sortKey="Haubenberger, Dietrich" sort="Haubenberger, Dietrich" uniqKey="Haubenberger D" first="Dietrich" last="Haubenberger">Dietrich Haubenberger</name>
<name sortKey="Posch, Martin" sort="Posch, Martin" uniqKey="Posch M" first="Martin" last="Posch">Martin Posch</name>
<name sortKey="Schnider, Peter" sort="Schnider, Peter" uniqKey="Schnider P" first="Peter" last="Schnider">Peter Schnider</name>
<name sortKey="Sycha, Thomas" sort="Sycha, Thomas" uniqKey="Sycha T" first="Thomas" last="Sycha">Thomas Sycha</name>
<name sortKey="Voller, Bemhard" sort="Voller, Bemhard" uniqKey="Voller B" first="Bemhard" last="Voller">Bemhard Voller</name>
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</record>

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	Movement Disorders (revue)
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Movement Disorders (revue)

Respective Potencies of Botox® and Dysport® in a Human Skin Model : A Randomized, Double-blind Study

Respective Potencies of Botox® and Dysport® in a Human Skin Model : A Randomized, Double-blind Study

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri