Synchronized Brain Network Associated with Essential Tremor as Revealed by Magnetoencephalography
Identifieur interne : 002D93 ( Main/Merge ); précédent : 002D92; suivant : 002D94Synchronized Brain Network Associated with Essential Tremor as Revealed by Magnetoencephalography
Auteurs : Alfons Schnitzler [Allemagne] ; Christian Münks [Allemagne] ; Markus Butz [Allemagne] ; Lars Timmermann [Allemagne] ; Joachim Gross [Royaume-Uni]Source :
- Movement disorders [ 0885-3185 ] ; 2009.
Descripteurs français
- Pascal (Inist)
English descriptors
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Abstract
Despite the fact that essential tremor (ET) is the most prevalent movement disorder, the underlying pathological mechanisms are not fully understood. There is accumulating evidence that this specific type of tremor is mainly of central origin, in particular involving inferior olive, cerebellum, thalamus, and primary motor cortex. We studied 8 patients with ET recording simultaneously neural activity with a whole-scalp neuromagnetometer and tremor activity with surface electromyography (EMG). Subjects performed an isometric contraction of the left forearm. Tremor frequency of 5 to 7 Hz and its first harmonic were clearly evident in power spectra of EMG recordings. We used the localization technique dynamic imaging of coherent sources (DICS) to identify cerebral areas coherent to the EMG signal at tremor frequency and its first harmonic. All subjects showed coherence to the contralateral primary motor cortex. In a further step, DICS was used to identify areas of significant cerebro-cerebral coherence. The analysis revealed a network of areas consisting of contralateral primary motor cortex, premotor cortex, thalamus, brainstem, and ipsilateral cerebellum. These results are consistent with the view that in ET, a network of cerebral areas including brainstem shows oscillatory interactions, which lead to a rhythmic modulation of muscle activity becoming apparent as tremor.
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Magnetoencephalography</title><author><name sortKey="Schnitzler, Alfons" sort="Schnitzler, Alfons" uniqKey="Schnitzler A" first="Alfons" last="Schnitzler">Alfons Schnitzler</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Clinical Neuroscience and Medical Psychology, Heinrich-Heine University</s1><s2>Düsseldorf</s2><s3>DEU</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>Düsseldorf</wicri:noRegion><wicri:noRegion>Heinrich-Heine University</wicri:noRegion><wicri:noRegion>Düsseldorf</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Neurology, Heinrich-Heine University</s1><s2>Düsseldorf</s2><s3>DEU</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>Düsseldorf</wicri:noRegion><wicri:noRegion>Heinrich-Heine University</wicri:noRegion><wicri:noRegion>Düsseldorf</wicri:noRegion></affiliation></author><author><name sortKey="Munks, Christian" sort="Munks, Christian" uniqKey="Munks C" first="Christian" last="Münks">Christian Münks</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Clinical Neuroscience and Medical Psychology, Heinrich-Heine University</s1><s2>Düsseldorf</s2><s3>DEU</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>Düsseldorf</wicri:noRegion><wicri:noRegion>Heinrich-Heine University</wicri:noRegion><wicri:noRegion>Düsseldorf</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Neurology, Heinrich-Heine University</s1><s2>Düsseldorf</s2><s3>DEU</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>Düsseldorf</wicri:noRegion><wicri:noRegion>Heinrich-Heine University</wicri:noRegion><wicri:noRegion>Düsseldorf</wicri:noRegion></affiliation></author><author><name sortKey="Butz, Markus" sort="Butz, Markus" uniqKey="Butz M" first="Markus" last="Butz">Markus Butz</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Clinical Neuroscience and Medical Psychology, Heinrich-Heine University</s1><s2>Düsseldorf</s2><s3>DEU</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>Düsseldorf</wicri:noRegion><wicri:noRegion>Heinrich-Heine University</wicri:noRegion><wicri:noRegion>Düsseldorf</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Neurology, Heinrich-Heine University</s1><s2>Düsseldorf</s2><s3>DEU</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>Düsseldorf</wicri:noRegion><wicri:noRegion>Heinrich-Heine University</wicri:noRegion><wicri:noRegion>Düsseldorf</wicri:noRegion></affiliation></author><author><name sortKey="Timmermann, Lars" sort="Timmermann, Lars" uniqKey="Timmermann L" first="Lars" last="Timmermann">Lars Timmermann</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Department of Neurology, University Hospital Cologne</s1><s2>Cologne</s2><s3>DEU</s3><sZ>4 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>Cologne</wicri:noRegion><wicri:noRegion>University Hospital Cologne</wicri:noRegion><wicri:noRegion>Cologne</wicri:noRegion></affiliation></author><author><name sortKey="Gross, Joachim" sort="Gross, Joachim" uniqKey="Gross J" first="Joachim" last="Gross">Joachim Gross</name><affiliation wicri:level="4"><inist:fA14 i1="04"><s1>Department of Psychology, Centre for Cognitive Neuroimaging (CCNi), University of Glasgow</s1><s2>Glasgow, Scotland</s2><s3>GBR</s3><sZ>5 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Glasgow</settlement><region type="country">Écosse</region></placeName><orgName type="university">Université de Glasgow</orgName></affiliation></author></analytic><series><title level="j" type="main">Movement disorders</title><title level="j" type="abbreviated">Mov. disord.</title><idno type="ISSN">0885-3185</idno><imprint><date when="2009">2009</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Movement disorders</title><title level="j" type="abbreviated">Mov. disord.</title><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Coherence</term><term>Coupling</term><term>Encephalon</term><term>Magnetoencephalography</term><term>Nervous system diseases</term><term>Oscillation</term><term>Synchronization</term><term>Tremor</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Tremblement</term><term>Pathologie du système nerveux</term><term>Encéphale</term><term>Magnétoencéphalographie</term><term>Oscillation</term><term>Couplage</term><term>Cohérence</term><term>Synchronisation</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Despite the fact that essential tremor (ET) is the most prevalent movement disorder, the underlying pathological mechanisms are not fully understood. There is accumulating evidence that this specific type of tremor is mainly of central origin, in particular involving inferior olive, cerebellum, thalamus, and primary motor cortex. We studied 8 patients with ET recording simultaneously neural activity with a whole-scalp neuromagnetometer and tremor activity with surface electromyography (EMG). Subjects performed an isometric contraction of the left forearm. Tremor frequency of 5 to 7 Hz and its first harmonic were clearly evident in power spectra of EMG recordings. We used the localization technique dynamic imaging of coherent sources (DICS) to identify cerebral areas coherent to the EMG signal at tremor frequency and its first harmonic. All subjects showed coherence to the contralateral primary motor cortex. In a further step, DICS was used to identify areas of significant cerebro-cerebral coherence. The analysis revealed a network of areas consisting of contralateral primary motor cortex, premotor cortex, thalamus, brainstem, and ipsilateral cerebellum. These results are consistent with the view that in ET, a network of cerebral areas including brainstem shows oscillatory interactions, which lead to a rhythmic modulation of muscle activity becoming apparent as tremor.</div></front></TEI><affiliations><list><country><li>Allemagne</li><li>Royaume-Uni</li></country><region><li>Écosse</li></region><settlement><li>Glasgow</li></settlement><orgName><li>Université de Glasgow</li></orgName></list><tree><country name="Allemagne"><noRegion><name sortKey="Schnitzler, Alfons" sort="Schnitzler, Alfons" uniqKey="Schnitzler A" first="Alfons" last="Schnitzler">Alfons Schnitzler</name></noRegion><name sortKey="Butz, Markus" sort="Butz, Markus" uniqKey="Butz M" first="Markus" last="Butz">Markus Butz</name><name sortKey="Butz, Markus" sort="Butz, Markus" uniqKey="Butz M" first="Markus" last="Butz">Markus Butz</name><name sortKey="Munks, Christian" sort="Munks, Christian" uniqKey="Munks C" first="Christian" last="Münks">Christian Münks</name><name sortKey="Munks, Christian" sort="Munks, Christian" uniqKey="Munks C" first="Christian" last="Münks">Christian Münks</name><name sortKey="Schnitzler, Alfons" sort="Schnitzler, Alfons" uniqKey="Schnitzler A" first="Alfons" last="Schnitzler">Alfons Schnitzler</name><name sortKey="Timmermann, Lars" sort="Timmermann, Lars" uniqKey="Timmermann L" first="Lars" last="Timmermann">Lars Timmermann</name></country><country name="Royaume-Uni"><region name="Écosse"><name sortKey="Gross, Joachim" sort="Gross, Joachim" uniqKey="Gross J" first="Joachim" last="Gross">Joachim Gross</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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