Cross‐sectional and longitudinal studies of three‐dimensional stereotactic surface projection SPECT analysis in Parkinson's disease
Identifieur interne : 002C32 ( Main/Merge ); précédent : 002C31; suivant : 002C33Cross‐sectional and longitudinal studies of three‐dimensional stereotactic surface projection SPECT analysis in Parkinson's disease
Auteurs : Yasushi Osaki [Japon] ; Yukari Morita [Japon] ; Mitsutaka Fukumoto [Japon] ; Naoki Akagi [Japon] ; Shoji Yoshida [Japon] ; Yoshinori Doi [Japon]Source :
- Movement Disorders [ 0885-3185 ] ; 2009-07-30.
English descriptors
- KwdEn :
- Aged, Aged, 80 and over, Brain Mapping, Cross-Sectional Studies, Female, Geriatric Assessment, Humans, Imaging, Three-Dimensional (methods), Longitudinal Studies, Male, Middle Aged, Parkinson Disease (radionuclide imaging), Parkinson's disease, Parkinson's disease with dementia, SPECT, Stereotaxic Techniques, Tomography, Emission-Computed, Single-Photon (methods).
- MESH :
- methods : Imaging, Three-Dimensional, Tomography, Emission-Computed, Single-Photon.
- radionuclide imaging : Parkinson Disease.
- Aged, Aged, 80 and over, Brain Mapping, Cross-Sectional Studies, Female, Geriatric Assessment, Humans, Longitudinal Studies, Male, Middle Aged, Stereotaxic Techniques.
Abstract
Although dementia is increasingly recognized as a common feature in Parkinson's disease (PD), its pathological substrate remains unknown. We conducted cross‐sectional and longitudinal brain perfusion SPECT analyses to explore changes during the course of developing dementia in PD. Fifty‐five patients originally diagnosed with PD were imaged in the cross‐sectional study. Twenty‐one of these, nine without dementia and 12 with dementia (PDD), were included in the longitudinal study to observe perfusion changes during the course of their disease. Data were analyzed using three‐dimensional stereotactic surface projection SPECT analysis. The UK Parkinson's Disease Society Brain Bank criteria were used to diagnose PD and the revised criteria for the clinical diagnosis of dementia with Lewy bodies for PDD. The cross‐sectional study showed that patients with PDD had significantly reduced perfusion in the right posterior cingulate, the right precuneus and the left posterior cingulate area. In the longitudinal study, significantly reduced perfusion was observed in the left anterior frontal gyrus in PD without dementia, and in the right inferior parietal lobule in those that developed PDD. We suggest that a relationship exists between developing dementia in PDD and reduced perfusion in the posterior parietal area. © 2009 Movement Disorder Society
Url:
DOI: 10.1002/mds.22623
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<front><div type="abstract" xml:lang="en">Although dementia is increasingly recognized as a common feature in Parkinson's disease (PD), its pathological substrate remains unknown. We conducted cross‐sectional and longitudinal brain perfusion SPECT analyses to explore changes during the course of developing dementia in PD. Fifty‐five patients originally diagnosed with PD were imaged in the cross‐sectional study. Twenty‐one of these, nine without dementia and 12 with dementia (PDD), were included in the longitudinal study to observe perfusion changes during the course of their disease. Data were analyzed using three‐dimensional stereotactic surface projection SPECT analysis. The UK Parkinson's Disease Society Brain Bank criteria were used to diagnose PD and the revised criteria for the clinical diagnosis of dementia with Lewy bodies for PDD. The cross‐sectional study showed that patients with PDD had significantly reduced perfusion in the right posterior cingulate, the right precuneus and the left posterior cingulate area. In the longitudinal study, significantly reduced perfusion was observed in the left anterior frontal gyrus in PD without dementia, and in the right inferior parietal lobule in those that developed PDD. We suggest that a relationship exists between developing dementia in PDD and reduced perfusion in the posterior parietal area. © 2009 Movement Disorder Society</div>
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<front><div type="abstract" xml:lang="en">Although dementia is increasingly recognized as a common feature in Parkinson's disease (PD), its pathological substrate remains unknown. We conducted cross‐sectional and longitudinal brain perfusion SPECT analyses to explore changes during the course of developing dementia in PD. Fifty‐five patients originally diagnosed with PD were imaged in the cross‐sectional study. Twenty‐one of these, nine without dementia and 12 with dementia (PDD), were included in the longitudinal study to observe perfusion changes during the course of their disease. Data were analyzed using three‐dimensional stereotactic surface projection SPECT analysis. The UK Parkinson's Disease Society Brain Bank criteria were used to diagnose PD and the revised criteria for the clinical diagnosis of dementia with Lewy bodies for PDD. The cross‐sectional study showed that patients with PDD had significantly reduced perfusion in the right posterior cingulate, the right precuneus and the left posterior cingulate area. In the longitudinal study, significantly reduced perfusion was observed in the left anterior frontal gyrus in PD without dementia, and in the right inferior parietal lobule in those that developed PDD. We suggest that a relationship exists between developing dementia in PDD and reduced perfusion in the posterior parietal area. © 2009 Movement Disorder Society</div>
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<front><div type="abstract" xml:lang="en">Although dementia is increasingly recognized as a common feature in Parkinson's disease (PD), its pathological substrate remains unknown. We conducted cross-sectional and longitudinal brain perfusion SPECT analyses to explore changes during the course of developing dementia in PD. Fifty-five patients originally diagnosed with PD were imaged in the cross-sectional study. Twenty-one of these, nine without dementia and 12 with dementia (PDD), were included in the longitudinal study to observe perfusion changes during the course of their disease. Data were analyzed using three-dimensional stereotactic surface projection SPECT analysis. The UK Parkinson's Disease Society Brain Bank criteria were used to diagnose PD and the revised criteria for the clinical diagnosis of dementia with Lewy bodies for PDD. The cross-sectional study showed that patients with PDD had significantly reduced perfusion in the right posterior cingulate, the right precuneus and the left posterior cingulate area. In the longitudinal study, significantly reduced perfusion was observed in the left anterior frontal gyrus in PD without dementia, and in the right inferior parietal lobule in those that developed PDD. We suggest that a relationship exists between developing dementia in PDD and reduced perfusion in the posterior parietal area.</div>
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