MovDisordV3, Main, Merge, bibRecord, 002B14

Increased oxidative stress in patients with amyotrophic lateral sclerosis/Parkinsonism‐dementia complex in the Kii peninsula, Japan

Identifieur interne : 002B14 ( Main/Merge ); précédent : 002B13; suivant : 002B15

Increased oxidative stress in patients with amyotrophic lateral sclerosis/Parkinsonism‐dementia complex in the Kii peninsula, Japan

Auteurs : Satoru Morimoto [Japon] ; Shigeki Kuzuhara [Japon] ; Yasumasa Kokubo [Japon]

Source :

Movement Disorders [ 0885-3185 ] ; 2009-01-15.

RBID : ISTEX:D23DFA2E0ADB2DF87F59AEE2B5B907522D8315AD

Descripteurs français

Wicri :
- geographic : Japon.
- topic : Guam.

English descriptors

KwdEn :
- ALS, Aged, Aged, 80 and over, Amyotrophic Lateral Sclerosis (epidemiology), Amyotrophic Lateral Sclerosis (metabolism), Amyotrophic Lateral Sclerosis (urine), Creatinine (therapeutic use), Endemic Diseases, Female, Guam, Guanosine (analogs & derivatives), Guanosine (urine), Humans, Japan (epidemiology), Kii, Male, Oxidative Stress, Parkinsonian Disorders (epidemiology), Parkinsonian Disorders (metabolism), Parkinsonian Disorders (urine), Parkinsonism‐dementia complex, Severity of Illness Index, Tauopathies (epidemiology), Tauopathies (metabolism), Tauopathies (urine), oxidative stress.
MESH :
- chemical , analogs & derivatives : Guanosine.
- chemical , therapeutic use : Creatinine.
- geographic , epidemiology : Japan.
- epidemiology : Amyotrophic Lateral Sclerosis, Parkinsonian Disorders, Tauopathies.
- metabolism : Amyotrophic Lateral Sclerosis, Parkinsonian Disorders, Tauopathies.
- urine : Amyotrophic Lateral Sclerosis, Guanosine, Parkinsonian Disorders, Tauopathies.
- Aged, Aged, 80 and over, Endemic Diseases, Female, Humans, Male, Oxidative Stress, Severity of Illness Index.

Abstract

Amyotrophic lateral sclerosis and Parkinsonism‐dementia complex of the Kii peninsula (Kii ALS/PDC) is an endemic and a tauopathy, which shows clinical symptoms of amyotrophy, parkinsonism, and dementia. The objective of this study was to report the role of oxidative stress on Kii ALS/PDC using biochemical analysis. Urinary 8‐hydroxydeoxyguanosine (8‐OHdG)/creatinine ratio was analyzed in 11 patients with Kii ALS/PDC and 8 normal controls. The mean level of urinary 8‐OHdG/creatinine ratio of the patients with Kii ALS/PDC was significantly higher than that of control subjects. Oxidative stress may be implicated in pathogenesis of Kii ALS/PDC. © 2008 Movement Disorder Society

Url:

https://api.istex.fr/document/D23DFA2E0ADB2DF87F59AEE2B5B907522D8315AD/fulltext/pdf

DOI: 10.1002/mds.22362

Links to Exploration step

ISTEX:D23DFA2E0ADB2DF87F59AEE2B5B907522D8315AD

Le document en format XML

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<author><name sortKey="Morimoto, Satoru" sort="Morimoto, Satoru" uniqKey="Morimoto S" first="Satoru" last="Morimoto">Satoru Morimoto</name>
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<author><name sortKey="Kuzuhara, Shigeki" sort="Kuzuhara, Shigeki" uniqKey="Kuzuhara S" first="Shigeki" last="Kuzuhara">Shigeki Kuzuhara</name>
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<author><name sortKey="Kokubo, Yasumasa" sort="Kokubo, Yasumasa" uniqKey="Kokubo Y" first="Yasumasa" last="Kokubo">Yasumasa Kokubo</name>
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<series><title level="j">Movement Disorders</title>
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<term>Aged</term>
<term>Aged, 80 and over</term>
<term>Amyotrophic Lateral Sclerosis (epidemiology)</term>
<term>Amyotrophic Lateral Sclerosis (metabolism)</term>
<term>Amyotrophic Lateral Sclerosis (urine)</term>
<term>Creatinine (therapeutic use)</term>
<term>Endemic Diseases</term>
<term>Female</term>
<term>Guam</term>
<term>Guanosine (analogs & derivatives)</term>
<term>Guanosine (urine)</term>
<term>Humans</term>
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<term>Kii</term>
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<term>Oxidative Stress</term>
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<term>Parkinsonism‐dementia complex</term>
<term>Severity of Illness Index</term>
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<term>Tauopathies (metabolism)</term>
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<keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Amyotrophic Lateral Sclerosis</term>
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<front><div type="abstract" xml:lang="en">Amyotrophic lateral sclerosis and Parkinsonism‐dementia complex of the Kii peninsula (Kii ALS/PDC) is an endemic and a tauopathy, which shows clinical symptoms of amyotrophy, parkinsonism, and dementia. The objective of this study was to report the role of oxidative stress on Kii ALS/PDC using biochemical analysis. Urinary 8‐hydroxydeoxyguanosine (8‐OHdG)/creatinine ratio was analyzed in 11 patients with Kii ALS/PDC and 8 normal controls. The mean level of urinary 8‐OHdG/creatinine ratio of the patients with Kii ALS/PDC was significantly higher than that of control subjects. Oxidative stress may be implicated in pathogenesis of Kii ALS/PDC. © 2008 Movement Disorder Society</div>
</front>
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<front><div type="abstract" xml:lang="en">Amyotrophic lateral sclerosis and Parkinsonism‐dementia complex of the Kii peninsula (Kii ALS/PDC) is an endemic and a tauopathy, which shows clinical symptoms of amyotrophy, parkinsonism, and dementia. The objective of this study was to report the role of oxidative stress on Kii ALS/PDC using biochemical analysis. Urinary 8‐hydroxydeoxyguanosine (8‐OHdG)/creatinine ratio was analyzed in 11 patients with Kii ALS/PDC and 8 normal controls. The mean level of urinary 8‐OHdG/creatinine ratio of the patients with Kii ALS/PDC was significantly higher than that of control subjects. Oxidative stress may be implicated in pathogenesis of Kii ALS/PDC. © 2008 Movement Disorder Society</div>
</front>
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<PubMed><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Increased oxidative stress in patients with amyotrophic lateral sclerosis/Parkinsonism-dementia complex in the Kii peninsula, Japan.</title>
<author><name sortKey="Morimoto, Satoru" sort="Morimoto, Satoru" uniqKey="Morimoto S" first="Satoru" last="Morimoto">Satoru Morimoto</name>
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<author><name sortKey="Kokubo, Yasumasa" sort="Kokubo, Yasumasa" uniqKey="Kokubo Y" first="Yasumasa" last="Kokubo">Yasumasa Kokubo</name>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term>
<term>Aged, 80 and over</term>
<term>Amyotrophic Lateral Sclerosis (epidemiology)</term>
<term>Amyotrophic Lateral Sclerosis (metabolism)</term>
<term>Amyotrophic Lateral Sclerosis (urine)</term>
<term>Creatinine (therapeutic use)</term>
<term>Endemic Diseases</term>
<term>Female</term>
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<term>Parkinsonian Disorders (urine)</term>
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<front><div type="abstract" xml:lang="en">Amyotrophic lateral sclerosis and Parkinsonism-dementia complex of the Kii peninsula (Kii ALS/PDC) is an endemic and a tauopathy, which shows clinical symptoms of amyotrophy, parkinsonism, and dementia. The objective of this study was to report the role of oxidative stress on Kii ALS/PDC using biochemical analysis. Urinary 8-hydroxydeoxyguanosine (8-OHdG)/creatinine ratio was analyzed in 11 patients with Kii ALS/PDC and 8 normal controls. The mean level of urinary 8-OHdG/creatinine ratio of the patients with Kii ALS/PDC was significantly higher than that of control subjects. Oxidative stress may be implicated in pathogenesis of Kii ALS/PDC.</div>
</front>
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Movement Disorders (revue)

Increased oxidative stress in patients with amyotrophic lateral sclerosis/Parkinsonism‐dementia complex in the Kii peninsula, Japan

Increased oxidative stress in patients with amyotrophic lateral sclerosis/Parkinsonism‐dementia complex in the Kii peninsula, Japan

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Descripteurs français

English descriptors

Abstract

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Pour manipuler ce document sous Unix (Dilib)

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	Movement Disorders (revue)
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