Neuroanatomical substrate of visuospatial and visuoperceptual impairment in Parkinson's disease
Identifieur interne : 002A53 ( Main/Merge ); précédent : 002A52; suivant : 002A54Neuroanatomical substrate of visuospatial and visuoperceptual impairment in Parkinson's disease
Auteurs : Joana B. Pereira [Espagne] ; Carme Junqué [Espagne] ; María-Jo E Martí [Espagne] ; Blanca Ramirez-Ruiz [Espagne] ; Nuria Bargall [Espagne] ; Eduardo Tolosa [Espagne]Source :
- Movement Disorders [ 0885-3185 ] ; 2009-06-15.
English descriptors
- KwdEn :
- Aged, Brain Mapping, Female, Humans, Magnetic Resonance Imaging (methods), Male, Memory (physiology), Mental Status Schedule, Neuropsychological Tests, Parkinson Disease (complications), Parkinson Disease (pathology), Parkinson's disease, Pattern Recognition, Visual (physiology), Perceptual Disorders (etiology), Perceptual Disorders (pathology), Photic Stimulation (methods), Regression Analysis, Retrospective Studies, Space Perception (physiology), Visual Acuity (physiology), visuospatial/visuoperceptual impairment, voxel‐based morphometry.
- MESH :
- complications : Parkinson Disease.
- etiology : Perceptual Disorders.
- methods : Magnetic Resonance Imaging, Photic Stimulation.
- pathology : Parkinson Disease, Perceptual Disorders.
- physiology : Memory, Pattern Recognition, Visual, Space Perception, Visual Acuity.
- Aged, Brain Mapping, Female, Humans, Male, Mental Status Schedule, Neuropsychological Tests, Regression Analysis, Retrospective Studies.
Abstract
To determine magnetic resonance imaging patterns of gray matter (GM) atrophy underlying visuospatial and visuoperceptual impairment in Parkinson's disease (PD), we applied voxel‐based morphometry to 36 nondemented PD patients and correlated their whole brain GM density with performance on three visuospatial and visuoperceptual tests. In addition, group comparisons between patients and 20 healthy controls were also performed. Correlations between visuospatial performance and GM density were found in the superior parietal lobules and the superior occipital gyrus of PD patients. Poor performance on visuoperceptual tests was also found to be significantly associated with GM decreases in the fusiform, the parahippocampus, and the middle occipital gyrus. Finally, group comparisons between controls and patients showed widespread GM cortical reductions in PD, involving posterior temporal and parietal regions. Taken together, these findings suggest that visuospatial and visuoperceptual dysfunctions reflect structural GM changes in temporo‐parietal cortical regions of PD patients. © 2009 Movement Disorder Society
Url:
DOI: 10.1002/mds.22560
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type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Tolosa, Eduardo" sort="Tolosa, Eduardo" uniqKey="Tolosa E" first="Eduardo" last="Tolosa">Eduardo Tolosa</name><affiliation wicri:level="3"><country xml:lang="fr">Espagne</country><wicri:regionArea>Institute of Biomedical Research August Pi i Sunyer (IDIBAPS), Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation><affiliation><wicri:noCountry code="subField">Hospital Clínic de Barcelona</wicri:noCountry></affiliation><affiliation wicri:level="3"><country xml:lang="fr">Espagne</country><wicri:regionArea>Centro de Investigación Biomédica en Red sobre Enfermedades, Neurodegenerativas (CIBERNED), Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2009-06-15">2009-06-15</date><biblScope unit="vol">24</biblScope><biblScope unit="issue">8</biblScope><biblScope unit="page" from="1193">1193</biblScope><biblScope unit="page" to="1199">1199</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">C520D3C48BB388DE02D721E40C68FBD55F372953</idno><idno type="DOI">10.1002/mds.22560</idno><idno type="ArticleID">MDS22560</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Brain Mapping</term><term>Female</term><term>Humans</term><term>Magnetic Resonance Imaging (methods)</term><term>Male</term><term>Memory (physiology)</term><term>Mental Status Schedule</term><term>Neuropsychological Tests</term><term>Parkinson Disease (complications)</term><term>Parkinson Disease (pathology)</term><term>Parkinson's disease</term><term>Pattern Recognition, Visual (physiology)</term><term>Perceptual Disorders (etiology)</term><term>Perceptual Disorders (pathology)</term><term>Photic Stimulation (methods)</term><term>Regression Analysis</term><term>Retrospective Studies</term><term>Space Perception (physiology)</term><term>Visual Acuity (physiology)</term><term>visuospatial/visuoperceptual impairment</term><term>voxel‐based morphometry</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Perceptual Disorders</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Magnetic Resonance Imaging</term><term>Photic Stimulation</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Parkinson Disease</term><term>Perceptual Disorders</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Memory</term><term>Pattern Recognition, Visual</term><term>Space Perception</term><term>Visual Acuity</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Brain Mapping</term><term>Female</term><term>Humans</term><term>Male</term><term>Mental Status Schedule</term><term>Neuropsychological Tests</term><term>Regression Analysis</term><term>Retrospective Studies</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">To determine magnetic resonance imaging patterns of gray matter (GM) atrophy underlying visuospatial and visuoperceptual impairment in Parkinson's disease (PD), we applied voxel‐based morphometry to 36 nondemented PD patients and correlated their whole brain GM density with performance on three visuospatial and visuoperceptual tests. In addition, group comparisons between patients and 20 healthy controls were also performed. Correlations between visuospatial performance and GM density were found in the superior parietal lobules and the superior occipital gyrus of PD patients. Poor performance on visuoperceptual tests was also found to be significantly associated with GM decreases in the fusiform, the parahippocampus, and the middle occipital gyrus. Finally, group comparisons between controls and patients showed widespread GM cortical reductions in PD, involving posterior temporal and parietal regions. Taken together, these findings suggest that visuospatial and visuoperceptual dysfunctions reflect structural GM changes in temporo‐parietal cortical regions of PD patients. © 2009 Movement Disorder Society</div></front></TEI><double doi="10.1002/mds.22560"><ISTEX><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Neuroanatomical substrate of visuospatial and visuoperceptual impairment in Parkinson's disease</title><author><name sortKey="Pereira, Joana B" sort="Pereira, Joana B" uniqKey="Pereira J" first="Joana B." last="Pereira">Joana B. Pereira</name></author><author><name sortKey="Junque, Carme" sort="Junque, Carme" uniqKey="Junque C" first="Carme" last="Junqué">Carme Junqué</name></author><author><name sortKey="Marti, Maria O E" sort="Marti, Maria O E" uniqKey="Marti M" first="María-Jo E" last="Martí">María-Jo E Martí</name></author><author><name sortKey="Ramirez Uiz, Blanca" sort="Ramirez Uiz, Blanca" uniqKey="Ramirez Uiz B" first="Blanca" last="Ramirez-Ruiz">Blanca Ramirez-Ruiz</name></author><author><name sortKey="Bargall, Nuria" sort="Bargall, Nuria" uniqKey="Bargall N" first="Nuria" last="Bargall">Nuria Bargall</name></author><author><name sortKey="Tolosa, Eduardo" sort="Tolosa, Eduardo" uniqKey="Tolosa E" first="Eduardo" last="Tolosa">Eduardo Tolosa</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:C520D3C48BB388DE02D721E40C68FBD55F372953</idno><date when="2009" year="2009">2009</date><idno type="doi">10.1002/mds.22560</idno><idno type="url">https://api.istex.fr/document/C520D3C48BB388DE02D721E40C68FBD55F372953/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">001C12</idno><idno type="wicri:Area/Istex/Curation">001C12</idno><idno type="wicri:Area/Istex/Checkpoint">000D94</idno><idno type="wicri:doubleKey">0885-3185:2009:Pereira J:neuroanatomical:substrate:of</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Neuroanatomical substrate of visuospatial and visuoperceptual impairment in Parkinson's disease</title><author><name sortKey="Pereira, Joana B" sort="Pereira, Joana B" uniqKey="Pereira J" first="Joana B." last="Pereira">Joana B. Pereira</name><affiliation wicri:level="3"><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Psychiatry and Clinical Psychobiology, University of Barcelona, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation><affiliation wicri:level="3"><country xml:lang="fr">Espagne</country><wicri:regionArea>Institute of Biomedical Research August Pi i Sunyer (IDIBAPS), Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation><affiliation wicri:level="3"><country xml:lang="fr">Espagne</country><wicri:regionArea>Centro de Investigación Biomédica en Red sobre Enfermedades, Neurodegenerativas (CIBERNED), Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Junque, Carme" sort="Junque, Carme" uniqKey="Junque C" first="Carme" last="Junqué">Carme Junqué</name><affiliation wicri:level="3"><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Psychiatry and Clinical Psychobiology, University of Barcelona, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation><affiliation wicri:level="3"><country xml:lang="fr">Espagne</country><wicri:regionArea>Institute of Biomedical Research August Pi i Sunyer (IDIBAPS), Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation><affiliation wicri:level="3"><country xml:lang="fr">Espagne</country><wicri:regionArea>Centro de Investigación Biomédica en Red sobre Enfermedades, Neurodegenerativas (CIBERNED), Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Marti, Maria O E" sort="Marti, Maria O E" uniqKey="Marti M" first="María-Jo E" last="Martí">María-Jo E Martí</name><affiliation wicri:level="3"><country xml:lang="fr">Espagne</country><wicri:regionArea>Institute of Biomedical Research August Pi i Sunyer (IDIBAPS), Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation><affiliation><wicri:noCountry code="subField">Hospital Clínic de Barcelona</wicri:noCountry></affiliation><affiliation wicri:level="3"><country xml:lang="fr">Espagne</country><wicri:regionArea>Centro de Investigación Biomédica en Red sobre Enfermedades, Neurodegenerativas (CIBERNED), Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Ramirez Uiz, Blanca" sort="Ramirez Uiz, Blanca" uniqKey="Ramirez Uiz B" first="Blanca" last="Ramirez-Ruiz">Blanca Ramirez-Ruiz</name><affiliation wicri:level="3"><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Psychiatry and Clinical Psychobiology, University of Barcelona, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation><affiliation wicri:level="3"><country xml:lang="fr">Espagne</country><wicri:regionArea>Institute of Biomedical Research August Pi i Sunyer (IDIBAPS), Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation><affiliation wicri:level="3"><country xml:lang="fr">Espagne</country><wicri:regionArea>Centro de Investigación Biomédica en Red sobre Enfermedades, Neurodegenerativas (CIBERNED), Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Bargall, Nuria" sort="Bargall, Nuria" uniqKey="Bargall N" first="Nuria" last="Bargall">Nuria Bargall</name><affiliation wicri:level="3"><country xml:lang="fr">Espagne</country><wicri:regionArea>Institute of Biomedical Research August Pi i Sunyer (IDIBAPS), Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation><affiliation wicri:level="3"><country xml:lang="fr">Espagne</country><wicri:regionArea>Centre de Diagnòstic per la Imatge Hospital Clinic de Barcelona (CDIC), Barcelona</wicri:regionArea><placeName><settlement 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type="region">Catalogne</region></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2009-06-15">2009-06-15</date><biblScope unit="vol">24</biblScope><biblScope unit="issue">8</biblScope><biblScope unit="page" from="1193">1193</biblScope><biblScope unit="page" to="1199">1199</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">C520D3C48BB388DE02D721E40C68FBD55F372953</idno><idno type="DOI">10.1002/mds.22560</idno><idno type="ArticleID">MDS22560</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Parkinson's disease</term><term>visuospatial/visuoperceptual impairment</term><term>voxel‐based morphometry</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">To determine magnetic resonance imaging patterns of gray matter (GM) atrophy underlying visuospatial and visuoperceptual impairment in Parkinson's disease (PD), we applied voxel‐based morphometry to 36 nondemented PD patients and correlated their whole brain GM density with performance on three visuospatial and visuoperceptual tests. In addition, group comparisons between patients and 20 healthy controls were also performed. Correlations between visuospatial performance and GM density were found in the superior parietal lobules and the superior occipital gyrus of PD patients. Poor performance on visuoperceptual tests was also found to be significantly associated with GM decreases in the fusiform, the parahippocampus, and the middle occipital gyrus. Finally, group comparisons between controls and patients showed widespread GM cortical reductions in PD, involving posterior temporal and parietal regions. Taken together, these findings suggest that visuospatial and visuoperceptual dysfunctions reflect structural GM changes in temporo‐parietal cortical regions of PD patients. © 2009 Movement Disorder Society</div></front></TEI></ISTEX><PubMed><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Neuroanatomical substrate of visuospatial and visuoperceptual impairment in Parkinson's disease.</title><author><name sortKey="Pereira, Joana B" sort="Pereira, Joana B" uniqKey="Pereira J" first="Joana B" last="Pereira">Joana B. Pereira</name><affiliation wicri:level="3"><nlm:affiliation>Department of Psychiatry and Clinical Psychobiology, University of Barcelona, Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Psychiatry and Clinical Psychobiology, University of Barcelona, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Junque, Carme" sort="Junque, Carme" uniqKey="Junque C" first="Carme" last="Junqué">Carme Junqué</name></author><author><name sortKey="Marti, Maria Jo E" sort="Marti, Maria Jo E" uniqKey="Marti M" first="María-Jo E" last="Martí">María-Jo E Martí</name></author><author><name sortKey="Ramirez Ruiz, Blanca" sort="Ramirez Ruiz, Blanca" uniqKey="Ramirez Ruiz B" first="Blanca" last="Ramirez-Ruiz">Blanca Ramirez-Ruiz</name></author><author><name sortKey="Bargall, Nuria" sort="Bargall, Nuria" uniqKey="Bargall N" first="Nuria" last="Bargall">Nuria Bargall</name></author><author><name sortKey="Tolosa, Eduardo" sort="Tolosa, Eduardo" uniqKey="Tolosa E" first="Eduardo" last="Tolosa">Eduardo Tolosa</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2009">2009</date><idno type="doi">10.1002/mds.22560</idno><idno type="RBID">pubmed:19412935</idno><idno type="pmid">19412935</idno><idno type="wicri:Area/PubMed/Corpus">001D44</idno><idno type="wicri:Area/PubMed/Curation">001D44</idno><idno type="wicri:Area/PubMed/Checkpoint">001C99</idno><idno type="wicri:Area/Ncbi/Merge">002633</idno><idno type="wicri:Area/Ncbi/Curation">002633</idno><idno type="wicri:Area/Ncbi/Checkpoint">002633</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Neuroanatomical substrate of visuospatial and visuoperceptual impairment in Parkinson's disease.</title><author><name sortKey="Pereira, Joana B" sort="Pereira, Joana B" uniqKey="Pereira J" first="Joana B" last="Pereira">Joana B. Pereira</name><affiliation wicri:level="3"><nlm:affiliation>Department of Psychiatry and Clinical Psychobiology, University of Barcelona, Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Psychiatry and Clinical Psychobiology, University of Barcelona, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Junque, Carme" sort="Junque, Carme" uniqKey="Junque C" first="Carme" last="Junqué">Carme Junqué</name></author><author><name sortKey="Marti, Maria Jo E" sort="Marti, Maria Jo E" uniqKey="Marti M" first="María-Jo E" last="Martí">María-Jo E Martí</name></author><author><name sortKey="Ramirez Ruiz, Blanca" sort="Ramirez Ruiz, Blanca" uniqKey="Ramirez Ruiz B" first="Blanca" last="Ramirez-Ruiz">Blanca Ramirez-Ruiz</name></author><author><name sortKey="Bargall, Nuria" sort="Bargall, Nuria" uniqKey="Bargall N" first="Nuria" last="Bargall">Nuria Bargall</name></author><author><name sortKey="Tolosa, Eduardo" sort="Tolosa, Eduardo" uniqKey="Tolosa E" first="Eduardo" last="Tolosa">Eduardo Tolosa</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="eISSN">1531-8257</idno><imprint><date when="2009" type="published">2009</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Brain Mapping</term><term>Female</term><term>Humans</term><term>Magnetic Resonance Imaging (methods)</term><term>Male</term><term>Memory (physiology)</term><term>Mental Status Schedule</term><term>Neuropsychological Tests</term><term>Parkinson Disease (complications)</term><term>Parkinson Disease (pathology)</term><term>Pattern Recognition, Visual (physiology)</term><term>Perceptual Disorders (etiology)</term><term>Perceptual Disorders (pathology)</term><term>Photic Stimulation (methods)</term><term>Regression Analysis</term><term>Retrospective Studies</term><term>Space Perception (physiology)</term><term>Visual Acuity (physiology)</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Perceptual Disorders</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Magnetic Resonance Imaging</term><term>Photic Stimulation</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Parkinson Disease</term><term>Perceptual Disorders</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Memory</term><term>Pattern Recognition, Visual</term><term>Space Perception</term><term>Visual Acuity</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Brain Mapping</term><term>Female</term><term>Humans</term><term>Male</term><term>Mental Status Schedule</term><term>Neuropsychological Tests</term><term>Regression Analysis</term><term>Retrospective Studies</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">To determine magnetic resonance imaging patterns of gray matter (GM) atrophy underlying visuospatial and visuoperceptual impairment in Parkinson's disease (PD), we applied voxel-based morphometry to 36 nondemented PD patients and correlated their whole brain GM density with performance on three visuospatial and visuoperceptual tests. In addition, group comparisons between patients and 20 healthy controls were also performed. Correlations between visuospatial performance and GM density were found in the superior parietal lobules and the superior occipital gyrus of PD patients. Poor performance on visuoperceptual tests was also found to be significantly associated with GM decreases in the fusiform, the parahippocampus, and the middle occipital gyrus. Finally, group comparisons between controls and patients showed widespread GM cortical reductions in PD, involving posterior temporal and parietal regions. Taken together, these findings suggest that visuospatial and visuoperceptual dysfunctions reflect structural GM changes in temporo-parietal cortical regions of PD patients.</div></front></TEI></PubMed></double></record>Pour manipuler ce document sous Unix (Dilib)
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