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A Double-Blind, Placebo-Controlled Study to Assess the Mitochondria-Targeted Antioxidant MitoQ as a Disease-Modifying Therapy in Parkinson's Disease

Identifieur interne : 002828 ( Main/Merge ); précédent : 002827; suivant : 002829

A Double-Blind, Placebo-Controlled Study to Assess the Mitochondria-Targeted Antioxidant MitoQ as a Disease-Modifying Therapy in Parkinson's Disease

Auteurs : Barry J. Snow [Nouvelle-Zélande] ; Fiona L. Rolfe [Nouvelle-Zélande] ; Michelle M. Lockhart [Nouvelle-Zélande] ; Christopher M. Frampton [Nouvelle-Zélande] ; John D. O'Sullivan [Australie] ; Victor Fung [Australie] ; Robin A. J. Smith [Nouvelle-Zélande] ; Michael P. Murphy [Royaume-Uni] ; Kenneth M. Taylor [Nouvelle-Zélande]

Source :

Movement disorders [ 0885-3185 ] ; 2010.

RBID : Pascal:10-0413289

Descripteurs français

Pascal (Inist)
- Maladie de Parkinson, Pathologie du système nerveux, Etude double insu, Placebo, Mitochondrie, Antioxydant, Traitement.

English descriptors

KwdEn :
- Antioxidant, Double blind study, Mitochondria, Nervous system diseases, Parkinson disease, Placebo, Treatment.

Abstract

Multiple lines of evidence point to mitochondrial oxidative stress as a potential pathogenic cause for Parkinson's disease (PD). MitoQ is a powerful mitochondrial antioxidant. It is absorbed orally and concentrates within mitochondria where it has been shown to protect against oxidative damage. We enrolled 128 newly diagnosed untreated patients with PD in a double-blind study of two doses of MitoQ compared with placebo to explore the hypothesis that, over 12 months, MitoQ would slow the progression of PD as measured by clinical scores, particularly the Unified Parkinson Disease Rating Scale. We showed no difference between MitoQ and placebo on any measure of PD progression. MitoQ does not slow the progression of PD, and this finding should be taken into account when considering the oxidative stress hypothesis for the pathogenesis of PD.

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Pascal:10-0413289

Le document en format XML

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<author><name sortKey="Murphy, Michael P" sort="Murphy, Michael P" uniqKey="Murphy M" first="Michael P." last="Murphy">Michael P. Murphy</name>
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<author><name sortKey="O Sullivan, John D" sort="O Sullivan, John D" uniqKey="O Sullivan J" first="John D." last="O'Sullivan">John D. O'Sullivan</name>
<affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Division of Medicine, Neurology Research Centre and University of Queensland Clinical School, Royal Brisbane & Women's Hospital</s1>
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<author><name sortKey="Smith, Robin A J" sort="Smith, Robin A J" uniqKey="Smith R" first="Robin A. J." last="Smith">Robin A. J. Smith</name>
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</affiliation>
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<author><name sortKey="Murphy, Michael P" sort="Murphy, Michael P" uniqKey="Murphy M" first="Michael P." last="Murphy">Michael P. Murphy</name>
<affiliation wicri:level="1"><inist:fA14 i1="07"><s1>Medical Research Council Mitochondrial Biology Unit</s1>
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<s3>GBR</s3>
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<wicri:noRegion>Medical Research Council Mitochondrial Biology Unit</wicri:noRegion>
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</author>
<author><name sortKey="Taylor, Kenneth M" sort="Taylor, Kenneth M" uniqKey="Taylor K" first="Kenneth M." last="Taylor">Kenneth M. Taylor</name>
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<series><title level="j" type="main">Movement disorders</title>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Antioxidant</term>
<term>Double blind study</term>
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<term>Nervous system diseases</term>
<term>Parkinson disease</term>
<term>Placebo</term>
<term>Treatment</term>
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<keywords scheme="Pascal" xml:lang="fr"><term>Maladie de Parkinson</term>
<term>Pathologie du   système nerveux</term>
<term>Etude double insu</term>
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<term>Mitochondrie</term>
<term>Antioxydant</term>
<term>Traitement</term>
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<front><div type="abstract" xml:lang="en">Multiple lines of evidence point to mitochondrial oxidative stress as a potential pathogenic cause for Parkinson's disease (PD). MitoQ is a powerful mitochondrial antioxidant. It is absorbed orally and concentrates within mitochondria where it has been shown to protect against oxidative damage. We enrolled 128 newly diagnosed untreated patients with PD in a double-blind study of two doses of MitoQ compared with placebo to explore the hypothesis that, over 12 months, MitoQ would slow the progression of PD as measured by clinical scores, particularly the Unified Parkinson Disease Rating Scale. We showed no difference between MitoQ and placebo on any measure of PD progression. MitoQ does not slow the progression of PD, and this finding should be taken into account when considering the oxidative stress hypothesis for the pathogenesis of PD.</div>
</front>
</TEI>
<affiliations><list><country><li>Australie</li>
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<li>Royaume-Uni</li>
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<tree><country name="Nouvelle-Zélande"><noRegion><name sortKey="Snow, Barry J" sort="Snow, Barry J" uniqKey="Snow B" first="Barry J." last="Snow">Barry J. Snow</name>
</noRegion>
<name sortKey="Frampton, Christopher M" sort="Frampton, Christopher M" uniqKey="Frampton C" first="Christopher M." last="Frampton">Christopher M. Frampton</name>
<name sortKey="Lockhart, Michelle M" sort="Lockhart, Michelle M" uniqKey="Lockhart M" first="Michelle M." last="Lockhart">Michelle M. Lockhart</name>
<name sortKey="Rolfe, Fiona L" sort="Rolfe, Fiona L" uniqKey="Rolfe F" first="Fiona L." last="Rolfe">Fiona L. Rolfe</name>
<name sortKey="Smith, Robin A J" sort="Smith, Robin A J" uniqKey="Smith R" first="Robin A. J." last="Smith">Robin A. J. Smith</name>
<name sortKey="Taylor, Kenneth M" sort="Taylor, Kenneth M" uniqKey="Taylor K" first="Kenneth M." last="Taylor">Kenneth M. Taylor</name>
</country>
<country name="Australie"><noRegion><name sortKey="O Sullivan, John D" sort="O Sullivan, John D" uniqKey="O Sullivan J" first="John D." last="O'Sullivan">John D. O'Sullivan</name>
</noRegion>
<name sortKey="Fung, Victor" sort="Fung, Victor" uniqKey="Fung V" first="Victor" last="Fung">Victor Fung</name>
</country>
<country name="Royaume-Uni"><noRegion><name sortKey="Murphy, Michael P" sort="Murphy, Michael P" uniqKey="Murphy M" first="Michael P." last="Murphy">Michael P. Murphy</name>
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	Movement Disorders (revue)
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Movement Disorders (revue)

A Double-Blind, Placebo-Controlled Study to Assess the Mitochondria-Targeted Antioxidant MitoQ as a Disease-Modifying Therapy in Parkinson's Disease

A Double-Blind, Placebo-Controlled Study to Assess the Mitochondria-Targeted Antioxidant MitoQ as a Disease-Modifying Therapy in Parkinson's Disease

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri