MovDisordV3, Main, Merge, bibRecord, 002791

An Magnetic Resonance Imaging T2*-Weighted Sequence at Short Echo Time to Detect Putaminal Hypointensity in Parkinsonisms

Identifieur interne : 002791 ( Main/Merge ); précédent : 002790; suivant : 002792

An Magnetic Resonance Imaging T2*-Weighted Sequence at Short Echo Time to Detect Putaminal Hypointensity in Parkinsonisms

Auteurs : Gennarina Arabia [Italie] ; Maurizio Morelli [Italie] ; Sandra Paglionico [Italie] ; Fabiana Novellino [Italie] ; Maria Salsone [Italie] ; Laura Giofre [Italie] ; Giusi Torchia [Italie] ; Giuseppe Nicoletti [Italie] ; Demetrio Messina [Italie] ; Francesca Condino [Italie] ; Pierluigi Lanza [Italie] ; Olivier Gallo [Italie] ; Aldo Quattrone [Italie]

Source :

Movement disorders [ 0885-3185 ] ; 2010.

RBID : Pascal:11-0065113

Descripteurs français

Pascal (Inist)
- Parkinsonisme, Maladie de Parkinson, Pathologie du système nerveux, Imagerie RMN, Séquence impulsion, Temps écho.

English descriptors

KwdEn :
- Echo time, Nervous system diseases, Nuclear magnetic resonance imaging, Parkinson disease, Parkinsonism, Pulse sequence.

Abstract

At 1.5 T, T2^*-weighted gradient echo (GE) sequences are more sensitive in revealing mineral deposition in the basal ganglia than standard T2 weighted sequences. T2^*-weighted GE sequences, however, may detect putaminal hypointensities either in patients affected by parkinsonian syndromes or in healthy subjects. The aim of this study was to identify the magnetic resonance imaging (MRI) T2^*-weighted sequence which more specifically detected putaminal hypointensities differentiating atypical parkinsonian syndromes from Parkinson's disease (PD) and control subjects. In a sample of 38 healthy subjects, we performed three T2^*-weighted GE sequences at increasing time echo (TE; TE = 15 millisecond, TE = 25 millisecond, and echoplanar at TE = 40 millisecond ; T2^* sequences study). The sequence not showing any putaminal abnormality in the healthy subjects was then used to assess putaminal signal intensity in 189 patients with PD, 20 patients with multiple system atrophy (MSA), 41 patients with progressive supranuclear palsy (PSP), and in 150 age and sex-matched control subjects. In the T2^* sequences study, the T2^*-weighted TE = 15 (T2^*/15) did not show any putaminal abnormalities in the healthy subjects. This sequence detected putaminal hypointensities in a significantly higher proportion of patients with MSA (35%, P < 0.05) and PSP (24.4%, P < 0.05) than in patients with PD (5.3%), but in none of the controls. The sensitivity of putaminal hypointensity in T2^*/15 sequence was 25.4% for PD, 43.9% for PSP, and 55% for MSA versus controls whereas the specificity was 93.2% for all groups. Despite the suboptimal sensitivity, the high specificity of the T2*/15 sequence performed on routine MRI suggests its usefulness in clinical practice for identifying putaminal hypointensities associated with parkinsonian disorders.

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Pascal:11-0065113

Le document en format XML

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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">An Magnetic Resonance Imaging T2*-Weighted Sequence at Short Echo Time to Detect Putaminal Hypointensity in Parkinsonisms</title>
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<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>13 aut.</sZ>
</inist:fA14>
<country>Italie</country>
<wicri:noRegion>Catanzaro</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Institute of Neurological Sciences, National Research Council, Piano Lago di Mangone</s1>
<s2>Cosenza</s2>
<s3>ITA</s3>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>12 aut.</sZ>
<sZ>13 aut.</sZ>
</inist:fA14>
<country>Italie</country>
<wicri:noRegion>Cosenza</wicri:noRegion>
</affiliation>
</author>
</analytic>
<series><title level="j" type="main">Movement disorders</title>
<title level="j" type="abbreviated">Mov. disord.</title>
<idno type="ISSN">0885-3185</idno>
<imprint><date when="2010">2010</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><title level="j" type="main">Movement disorders</title>
<title level="j" type="abbreviated">Mov. disord.</title>
<idno type="ISSN">0885-3185</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Echo time</term>
<term>Nervous system diseases</term>
<term>Nuclear magnetic resonance imaging</term>
<term>Parkinson disease</term>
<term>Parkinsonism</term>
<term>Pulse sequence</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Parkinsonisme</term>
<term>Maladie de Parkinson</term>
<term>Pathologie du   système nerveux</term>
<term>Imagerie RMN</term>
<term>Séquence impulsion</term>
<term>Temps écho</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">At 1.5 T, T2<sup>*</sup>
-weighted gradient echo (GE) sequences are more sensitive in revealing mineral deposition in the basal ganglia than standard T2 weighted sequences. T2<sup>*</sup>
-weighted GE sequences, however, may detect putaminal hypointensities either in patients affected by parkinsonian syndromes or in healthy subjects. The aim of this study was to identify the magnetic resonance imaging (MRI) T2<sup>*</sup>
-weighted sequence which more specifically detected putaminal hypointensities differentiating atypical parkinsonian syndromes from Parkinson's disease (PD) and control subjects. In a sample of 38 healthy subjects, we performed three T2<sup>*</sup>
-weighted GE sequences at increasing time echo (TE; TE = 15 millisecond, TE = 25 millisecond, and echoplanar at TE = 40 millisecond ; T2<sup>*</sup>
 sequences study). The sequence not showing any putaminal abnormality in the healthy subjects was then used to assess putaminal signal intensity in 189 patients with PD, 20 patients with multiple system atrophy (MSA), 41 patients with progressive supranuclear palsy (PSP), and in 150 age and sex-matched control subjects. In the T2<sup>*</sup>
 sequences study, the T2<sup>*</sup>
-weighted TE = 15 (T2<sup>*</sup>
/15) did not show any putaminal abnormalities in the healthy subjects. This sequence detected putaminal hypointensities in a significantly higher proportion of patients with MSA (35%, P < 0.05) and PSP (24.4%, P < 0.05) than in patients with PD (5.3%), but in none of the controls. The sensitivity of putaminal hypointensity in T2<sup>*</sup>
/15 sequence was 25.4% for PD, 43.9% for PSP, and 55% for MSA versus controls whereas the specificity was 93.2% for all groups. Despite the suboptimal sensitivity, the high specificity of the T2*/15 sequence performed on routine MRI suggests its usefulness in clinical practice for identifying putaminal hypointensities associated with parkinsonian disorders.</div>
</front>
</TEI>
<affiliations><list><country><li>Italie</li>
</country>
</list>
<tree><country name="Italie"><noRegion><name sortKey="Arabia, Gennarina" sort="Arabia, Gennarina" uniqKey="Arabia G" first="Gennarina" last="Arabia">Gennarina Arabia</name>
</noRegion>
<name sortKey="Condino, Francesca" sort="Condino, Francesca" uniqKey="Condino F" first="Francesca" last="Condino">Francesca Condino</name>
<name sortKey="Gallo, Olivier" sort="Gallo, Olivier" uniqKey="Gallo O" first="Olivier" last="Gallo">Olivier Gallo</name>
<name sortKey="Giofre, Laura" sort="Giofre, Laura" uniqKey="Giofre L" first="Laura" last="Giofre">Laura Giofre</name>
<name sortKey="Lanza, Pierluigi" sort="Lanza, Pierluigi" uniqKey="Lanza P" first="Pierluigi" last="Lanza">Pierluigi Lanza</name>
<name sortKey="Messina, Demetrio" sort="Messina, Demetrio" uniqKey="Messina D" first="Demetrio" last="Messina">Demetrio Messina</name>
<name sortKey="Morelli, Maurizio" sort="Morelli, Maurizio" uniqKey="Morelli M" first="Maurizio" last="Morelli">Maurizio Morelli</name>
<name sortKey="Nicoletti, Giuseppe" sort="Nicoletti, Giuseppe" uniqKey="Nicoletti G" first="Giuseppe" last="Nicoletti">Giuseppe Nicoletti</name>
<name sortKey="Novellino, Fabiana" sort="Novellino, Fabiana" uniqKey="Novellino F" first="Fabiana" last="Novellino">Fabiana Novellino</name>
<name sortKey="Paglionico, Sandra" sort="Paglionico, Sandra" uniqKey="Paglionico S" first="Sandra" last="Paglionico">Sandra Paglionico</name>
<name sortKey="Quattrone, Aldo" sort="Quattrone, Aldo" uniqKey="Quattrone A" first="Aldo" last="Quattrone">Aldo Quattrone</name>
<name sortKey="Quattrone, Aldo" sort="Quattrone, Aldo" uniqKey="Quattrone A" first="Aldo" last="Quattrone">Aldo Quattrone</name>
<name sortKey="Salsone, Maria" sort="Salsone, Maria" uniqKey="Salsone M" first="Maria" last="Salsone">Maria Salsone</name>
<name sortKey="Torchia, Giusi" sort="Torchia, Giusi" uniqKey="Torchia G" first="Giusi" last="Torchia">Giusi Torchia</name>
</country>
</tree>
</affiliations>
</record>

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	Movement Disorders (revue)
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Movement Disorders (revue)

An Magnetic Resonance Imaging T2*-Weighted Sequence at Short Echo Time to Detect Putaminal Hypointensity in Parkinsonisms

An Magnetic Resonance Imaging T2*-Weighted Sequence at Short Echo Time to Detect Putaminal Hypointensity in Parkinsonisms

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