Anatomical Differences Between CBS-Corticobasal Degeneration and CBS-Alzheimer's Disease
Identifieur interne : 002789 ( Main/Merge ); précédent : 002788; suivant : 002790Anatomical Differences Between CBS-Corticobasal Degeneration and CBS-Alzheimer's Disease
Auteurs : Keith A. Josephs [États-Unis] ; Jennifer L. Whitwell [États-Unis] ; Bradley F. Boeve [États-Unis] ; David S. Knopman [États-Unis] ; Ronald C. Petersen [États-Unis] ; William T. Hu [États-Unis] ; Joseph E. Parisi [États-Unis] ; Dennis W. Dickson [États-Unis] ; Clifford R. Jr Jack [États-Unis]Source :
- Movement disorders [ 0885-3185 ] ; 2010.
Descripteurs français
- Pascal (Inist)
English descriptors
Abstract
We compare patterns of gray matter loss on MRI in subjects presenting as corticobasal syndrome (CBS) with Alzheimer disease pathology (CBS-AD) to those presenting as CBS with corticobasal degeneration pathology (CBS-CBD). Voxel-based morphometry was used to compare patterns of gray matter loss in pathologically confirmed CBS-AD subjects (n = 5) and CBS-CBD subjects (n = 6) to a group of healthy controls (n = 20), and to each other. Atlas based parcellation using the automated anatomic labeling atlas was also utilized in a region-of-interest analysis to account for laterality. The CBS-AD subjects were younger at the time of scan when compared with CBS-CBD subjects (median: 60 years vs. 69; P = 0.04). After adjusting for age at time of MRI scan, the CBS-AD subjects showed loss in posterior frontal, temporal, and superior and inferior parietal lobes, while CBS-CBD showed more focal loss predominantly in the posterior frontal lobes when compared with controls. In both CBS-AD and CBS-CBD groups, there was basal ganglia volume loss, yet relative sparing of hippocampi. On direct comparisons between the two subject groups, CBS-AD showed greater loss in both temporal and inferior parietal cortices than CBS-CBD. No regions showed greater loss in the CBS-CBD group compared to the CBS-AD group. These findings persisted when laterality was taken into account. In subjects presenting with CBS, prominent temporoparietal, especially posterior temporal and inferior parietal, atrophy may be a clue to the presence of underlying AD pathology.
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Anatomical Differences Between CBS-Corticobasal Degeneration and CBS-Alzheimer's Disease</title>
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<affiliation wicri:level="2"><inist:fA14 i1="03"><s1>Department of Neurology, Emory University</s1>
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<author><name sortKey="Parisi, Joseph E" sort="Parisi, Joseph E" uniqKey="Parisi J" first="Joseph E." last="Parisi">Joseph E. Parisi</name>
<affiliation wicri:level="2"><inist:fA14 i1="04"><s1>Department of Laboratory Medicine and Pathology, Mayo Clinic</s1>
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<s2>Jacksonville, Florida</s2>
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</placeName>
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<author><name sortKey="Jack, Clifford R Jr" sort="Jack, Clifford R Jr" uniqKey="Jack C" first="Clifford R. Jr" last="Jack">Clifford R. Jr Jack</name>
<affiliation wicri:level="2"><inist:fA14 i1="02"><s1>Department of Radiology, Mayo Clinic</s1>
<s2>Rochester, Minnesota</s2>
<s3>USA</s3>
<sZ>2 aut.</sZ>
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</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Minnesota</region>
</placeName>
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<series><title level="j" type="main">Movement disorders</title>
<title level="j" type="abbreviated">Mov. disord.</title>
<idno type="ISSN">0885-3185</idno>
<imprint><date when="2010">2010</date>
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<seriesStmt><title level="j" type="main">Movement disorders</title>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Alzheimer disease</term>
<term>Degeneration</term>
<term>Morphometry</term>
<term>Nervous system diseases</term>
<term>Voxel</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Dégénérescence</term>
<term>Démence d'Alzheimer</term>
<term>Pathologie du système nerveux</term>
<term>Voxel</term>
<term>Morphométrie</term>
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<front><div type="abstract" xml:lang="en">We compare patterns of gray matter loss on MRI in subjects presenting as corticobasal syndrome (CBS) with Alzheimer disease pathology (CBS-AD) to those presenting as CBS with corticobasal degeneration pathology (CBS-CBD). Voxel-based morphometry was used to compare patterns of gray matter loss in pathologically confirmed CBS-AD subjects (n = 5) and CBS-CBD subjects (n = 6) to a group of healthy controls (n = 20), and to each other. Atlas based parcellation using the automated anatomic labeling atlas was also utilized in a region-of-interest analysis to account for laterality. The CBS-AD subjects were younger at the time of scan when compared with CBS-CBD subjects (median: 60 years vs. 69; P = 0.04). After adjusting for age at time of MRI scan, the CBS-AD subjects showed loss in posterior frontal, temporal, and superior and inferior parietal lobes, while CBS-CBD showed more focal loss predominantly in the posterior frontal lobes when compared with controls. In both CBS-AD and CBS-CBD groups, there was basal ganglia volume loss, yet relative sparing of hippocampi. On direct comparisons between the two subject groups, CBS-AD showed greater loss in both temporal and inferior parietal cortices than CBS-CBD. No regions showed greater loss in the CBS-CBD group compared to the CBS-AD group. These findings persisted when laterality was taken into account. In subjects presenting with CBS, prominent temporoparietal, especially posterior temporal and inferior parietal, atrophy may be a clue to the presence of underlying AD pathology.</div>
</front>
</TEI>
<affiliations><list><country><li>États-Unis</li>
</country>
<region><li>Floride</li>
<li>Géorgie (États-Unis)</li>
<li>Minnesota</li>
</region>
</list>
<tree><country name="États-Unis"><region name="Minnesota"><name sortKey="Josephs, Keith A" sort="Josephs, Keith A" uniqKey="Josephs K" first="Keith A." last="Josephs">Keith A. Josephs</name>
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<name sortKey="Boeve, Bradley F" sort="Boeve, Bradley F" uniqKey="Boeve B" first="Bradley F." last="Boeve">Bradley F. Boeve</name>
<name sortKey="Dickson, Dennis W" sort="Dickson, Dennis W" uniqKey="Dickson D" first="Dennis W." last="Dickson">Dennis W. Dickson</name>
<name sortKey="Hu, William T" sort="Hu, William T" uniqKey="Hu W" first="William T." last="Hu">William T. Hu</name>
<name sortKey="Jack, Clifford R Jr" sort="Jack, Clifford R Jr" uniqKey="Jack C" first="Clifford R. Jr" last="Jack">Clifford R. Jr Jack</name>
<name sortKey="Knopman, David S" sort="Knopman, David S" uniqKey="Knopman D" first="David S." last="Knopman">David S. Knopman</name>
<name sortKey="Parisi, Joseph E" sort="Parisi, Joseph E" uniqKey="Parisi J" first="Joseph E." last="Parisi">Joseph E. Parisi</name>
<name sortKey="Petersen, Ronald C" sort="Petersen, Ronald C" uniqKey="Petersen R" first="Ronald C." last="Petersen">Ronald C. Petersen</name>
<name sortKey="Whitwell, Jennifer L" sort="Whitwell, Jennifer L" uniqKey="Whitwell J" first="Jennifer L." last="Whitwell">Jennifer L. Whitwell</name>
</country>
</tree>
</affiliations>
</record>
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