Clinical and Dual-Tasking Aspects In Frequent and Infrequent Fallers with Progressive Supranuclear Palsy
Identifieur interne : 002738 ( Main/Merge ); précédent : 002737; suivant : 002739Clinical and Dual-Tasking Aspects In Frequent and Infrequent Fallers with Progressive Supranuclear Palsy
Auteurs : Ulrich Lindemann [Allemagne] ; Simone Nicolai [Allemagne] ; Denis Beische [Allemagne] ; Clemens Becker [Allemagne] ; Karin Srulijes [Allemagne] ; Elisabeth Dietzel [Allemagne] ; Sarah Bauer [Allemagne] ; Daniela Berg [Allemagne] ; Walter Maetzler [Allemagne]Source :
- Movement disorders [ 0885-3185 ] ; 2010.
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- Pascal (Inist)
English descriptors
Abstract
Progressive supranuclear palsy (PSP) is a rare neurodegenerative disease with no sufficient therapeutic options to date. Falls are the most devastating feature. The causes of these falls are not well understood. To test the impact of PSP-associated motor and cognitive features on falls, 26 PSP patients were prospectively recruited and divided into frequent fallers (> one fall/month, 18 patients) and infrequent fallers (< one fall/month, 8 patients). Further parameters were assessed by clinical investigation and biomechanical gait and balance analysis with and without dual-task paradigms. Physical activity was measured through an ambulatory device. Frequent fallers scored higher on the total PSP rating scale and the subscales "history," "mental," "bulbar," "supranuclear ocular motor," and "gait/midline exam" but not on disease duration, the subscale "limb exam," the UPDRS motor score and the sway analysis. Frequent fallers also showed an increased probability of an altered walking pattern with shortened step lengths and increased cadence under a dual-task situation. It is concluded that the occurrence of falls in PSP seems strongly associated with the deterioration of bulbar function, but not relevantly with typical parkinsonian features like rigidity and bradykinesia. The decreased ability to deal with distraction of attention under a dual-task situation points to a relevant impact of cortical and subcortical dysfunction on the frequency of falls.
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">Clinical and Dual-Tasking Aspects In Frequent and Infrequent Fallers with Progressive Supranuclear Palsy</title><author><name sortKey="Lindemann, Ulrich" sort="Lindemann, Ulrich" uniqKey="Lindemann U" first="Ulrich" last="Lindemann">Ulrich Lindemann</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Clinical Gerontology, Robert-Bosch-Hospital</s1><s2>Stuttgart</s2><s3>DEU</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Stuttgart</region><settlement type="city">Stuttgart</settlement></placeName></affiliation></author><author><name sortKey="Nicolai, Simone" sort="Nicolai, Simone" uniqKey="Nicolai S" first="Simone" last="Nicolai">Simone Nicolai</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Clinical Gerontology, Robert-Bosch-Hospital</s1><s2>Stuttgart</s2><s3>DEU</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Stuttgart</region><settlement type="city">Stuttgart</settlement></placeName></affiliation></author><author><name sortKey="Beische, Denis" sort="Beische, Denis" uniqKey="Beische D" first="Denis" last="Beische">Denis Beische</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Clinical Gerontology, Robert-Bosch-Hospital</s1><s2>Stuttgart</s2><s3>DEU</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Stuttgart</region><settlement 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uniqKey="Bauer S" first="Sarah" last="Bauer">Sarah Bauer</name><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Department of Neurodegenerative Diseases, Hertie Institute for Clinical Brain Research</s1><s2>Tuebingen</s2><s3>DEU</s3><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Tübingen</region><settlement type="city">Tübingen</settlement></placeName></affiliation></author><author><name sortKey="Berg, Daniela" sort="Berg, Daniela" uniqKey="Berg D" first="Daniela" last="Berg">Daniela Berg</name><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Department of Neurodegenerative Diseases, Hertie Institute for Clinical Brain Research</s1><s2>Tuebingen</s2><s3>DEU</s3><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region 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aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Tübingen</region><settlement type="city">Tübingen</settlement></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">10-0315068</idno><date when="2010">2010</date><idno type="stanalyst">PASCAL 10-0315068 INIST</idno><idno type="RBID">Pascal:10-0315068</idno><idno type="wicri:Area/PascalFrancis/Corpus">000A57</idno><idno type="wicri:Area/PascalFrancis/Curation">002262</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">000B51</idno><idno type="wicri:doubleKey">0885-3185:2010:Lindemann U:clinical:and:dual</idno><idno type="wicri:Area/Main/Merge">002738</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Clinical and Dual-Tasking Aspects In Frequent and Infrequent Fallers with Progressive Supranuclear Palsy</title><author><name sortKey="Lindemann, Ulrich" sort="Lindemann, Ulrich" uniqKey="Lindemann U" first="Ulrich" last="Lindemann">Ulrich Lindemann</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Clinical Gerontology, Robert-Bosch-Hospital</s1><s2>Stuttgart</s2><s3>DEU</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Stuttgart</region><settlement type="city">Stuttgart</settlement></placeName></affiliation></author><author><name sortKey="Nicolai, Simone" sort="Nicolai, Simone" uniqKey="Nicolai S" first="Simone" last="Nicolai">Simone Nicolai</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Clinical Gerontology, Robert-Bosch-Hospital</s1><s2>Stuttgart</s2><s3>DEU</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Stuttgart</region><settlement type="city">Stuttgart</settlement></placeName></affiliation></author><author><name sortKey="Beische, Denis" sort="Beische, Denis" uniqKey="Beische D" first="Denis" last="Beische">Denis Beische</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Clinical Gerontology, Robert-Bosch-Hospital</s1><s2>Stuttgart</s2><s3>DEU</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Stuttgart</region><settlement type="city">Stuttgart</settlement></placeName></affiliation></author><author><name sortKey="Becker, Clemens" sort="Becker, Clemens" uniqKey="Becker C" first="Clemens" last="Becker">Clemens Becker</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Clinical Gerontology, Robert-Bosch-Hospital</s1><s2>Stuttgart</s2><s3>DEU</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Stuttgart</region><settlement type="city">Stuttgart</settlement></placeName></affiliation></author><author><name sortKey="Srulijes, Karin" sort="Srulijes, Karin" uniqKey="Srulijes K" first="Karin" last="Srulijes">Karin Srulijes</name><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Department of Neurodegenerative Diseases, Hertie Institute for Clinical Brain Research</s1><s2>Tuebingen</s2><s3>DEU</s3><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Tübingen</region><settlement type="city">Tübingen</settlement></placeName></affiliation></author><author><name sortKey="Dietzel, Elisabeth" sort="Dietzel, Elisabeth" uniqKey="Dietzel E" first="Elisabeth" last="Dietzel">Elisabeth Dietzel</name><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Department of Neurodegenerative Diseases, Hertie Institute for Clinical Brain Research</s1><s2>Tuebingen</s2><s3>DEU</s3><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Tübingen</region><settlement type="city">Tübingen</settlement></placeName></affiliation></author><author><name sortKey="Bauer, Sarah" sort="Bauer, Sarah" uniqKey="Bauer S" first="Sarah" last="Bauer">Sarah Bauer</name><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Department of Neurodegenerative Diseases, Hertie Institute for Clinical Brain Research</s1><s2>Tuebingen</s2><s3>DEU</s3><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Tübingen</region><settlement type="city">Tübingen</settlement></placeName></affiliation></author><author><name sortKey="Berg, Daniela" sort="Berg, Daniela" uniqKey="Berg D" first="Daniela" last="Berg">Daniela Berg</name><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Department of Neurodegenerative Diseases, Hertie Institute for Clinical Brain Research</s1><s2>Tuebingen</s2><s3>DEU</s3><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Tübingen</region><settlement type="city">Tübingen</settlement></placeName></affiliation></author><author><name sortKey="Maetzler, Walter" sort="Maetzler, Walter" uniqKey="Maetzler W" first="Walter" last="Maetzler">Walter Maetzler</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Clinical Gerontology, Robert-Bosch-Hospital</s1><s2>Stuttgart</s2><s3>DEU</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Stuttgart</region><settlement type="city">Stuttgart</settlement></placeName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Department of Neurodegenerative Diseases, Hertie Institute for Clinical Brain Research</s1><s2>Tuebingen</s2><s3>DEU</s3><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Tübingen</region><settlement type="city">Tübingen</settlement></placeName></affiliation></author></analytic><series><title level="j" type="main">Movement disorders</title><title level="j" type="abbreviated">Mov. disord.</title><idno type="ISSN">0885-3185</idno><imprint><date when="2010">2010</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Movement disorders</title><title level="j" type="abbreviated">Mov. disord.</title><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Nervous system diseases</term><term>Supranuclear ophthalmoplegia</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Pathologie du système nerveux</term><term>Ophtalmoplégie supranucléaire</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Progressive supranuclear palsy (PSP) is a rare neurodegenerative disease with no sufficient therapeutic options to date. Falls are the most devastating feature. The causes of these falls are not well understood. To test the impact of PSP-associated motor and cognitive features on falls, 26 PSP patients were prospectively recruited and divided into frequent fallers (> one fall/month, 18 patients) and infrequent fallers (< one fall/month, 8 patients). Further parameters were assessed by clinical investigation and biomechanical gait and balance analysis with and without dual-task paradigms. Physical activity was measured through an ambulatory device. Frequent fallers scored higher on the total PSP rating scale and the subscales "history," "mental," "bulbar," "supranuclear ocular motor," and "gait/midline exam" but not on disease duration, the subscale "limb exam," the UPDRS motor score and the sway analysis. Frequent fallers also showed an increased probability of an altered walking pattern with shortened step lengths and increased cadence under a dual-task situation. It is concluded that the occurrence of falls in PSP seems strongly associated with the deterioration of bulbar function, but not relevantly with typical parkinsonian features like rigidity and bradykinesia. The decreased ability to deal with distraction of attention under a dual-task situation points to a relevant impact of cortical and subcortical dysfunction on the frequency of falls.</div></front></TEI><affiliations><list><country><li>Allemagne</li></country><region><li>Bade-Wurtemberg</li><li>District de Stuttgart</li><li>District de Tübingen</li></region><settlement><li>Stuttgart</li><li>Tübingen</li></settlement></list><tree><country name="Allemagne"><region name="Bade-Wurtemberg"><name sortKey="Lindemann, Ulrich" sort="Lindemann, Ulrich" uniqKey="Lindemann U" first="Ulrich" last="Lindemann">Ulrich Lindemann</name></region><name sortKey="Bauer, Sarah" sort="Bauer, Sarah" uniqKey="Bauer S" first="Sarah" last="Bauer">Sarah Bauer</name><name sortKey="Becker, Clemens" sort="Becker, Clemens" uniqKey="Becker C" first="Clemens" last="Becker">Clemens Becker</name><name sortKey="Beische, Denis" sort="Beische, Denis" uniqKey="Beische D" first="Denis" last="Beische">Denis Beische</name><name sortKey="Berg, Daniela" sort="Berg, Daniela" uniqKey="Berg D" first="Daniela" last="Berg">Daniela Berg</name><name sortKey="Dietzel, Elisabeth" sort="Dietzel, Elisabeth" uniqKey="Dietzel E" first="Elisabeth" last="Dietzel">Elisabeth Dietzel</name><name sortKey="Maetzler, Walter" sort="Maetzler, Walter" uniqKey="Maetzler W" first="Walter" last="Maetzler">Walter Maetzler</name><name sortKey="Maetzler, Walter" sort="Maetzler, Walter" uniqKey="Maetzler W" first="Walter" last="Maetzler">Walter Maetzler</name><name sortKey="Nicolai, Simone" sort="Nicolai, Simone" uniqKey="Nicolai S" first="Simone" last="Nicolai">Simone Nicolai</name><name sortKey="Srulijes, Karin" sort="Srulijes, Karin" uniqKey="Srulijes K" first="Karin" last="Srulijes">Karin Srulijes</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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