Enlarged Hyperechogenic Substantia Nigra Is Related to Motor Performance and Olfaction in the Elderly
Identifieur interne : 002667 ( Main/Merge ); précédent : 002666; suivant : 002668Enlarged Hyperechogenic Substantia Nigra Is Related to Motor Performance and Olfaction in the Elderly
Auteurs : Daniela Berg [Allemagne] ; Klaus Seppi [Autriche] ; Inga Liepelt [Allemagne] ; Katherine Schweitzer [Allemagne] ; Frank Wollenweber [Allemagne] ; Björn Wolf [Allemagne] ; Ulrich Dillmann [Allemagne] ; Heike Stockner [Autriche] ; Jana Godau [Allemagne] ; Stefan Kiechl [Autriche] ; Alexandra Gaenslen [Allemagne] ; Johann Willeit [Autriche] ; Adriana Di Santo [Allemagne] ; Walter Maetzler [Allemagne] ; Thomas Gasser [Allemagne] ; Werner Poewe [Autriche] ; Stefanie Behnke [Allemagne]Source :
- Movement disorders [ 0885-3185 ] ; 2010.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Personne âgée.
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Abstract
Enlarged substantia nigra hyperechogenicity (SN+) assessed by transcranial sonography (TCS) may be associated with Parkinson's disease (PD) risk markers such as impaired motor performance and hyposmia. The aim of this multicenter cross-sectional study was to define the association between SN+ and these risk markers in a large population older than 50 years without the diagnosis of PD. In three centers (Tuebingen, Homburg, and Innsbruck), 1,839 individuals were examined. The echostatus of the SN was assessed by TCS, motor performance by the Unified Parkinson's Disease Rating Scale (UPDRS) motor score, and olfactory function with Sniffin' Sticks. From the 1,603 subjects included in the analysis, 16.2% were SN+, 23.0% scored above zero in the UPDRS motor section, and 28.0% were hyposmic as defined by less than 75% correctly classified Sniffin' Sticks. SN+ was associated with a UPDRS motor score above zero (OR 1.45, 95% CI 1.08-1.96) and with a lower odor identification capability (OR 1.48, 95% CI 1.12-1.96). The combination of these two features (OR 1.98, 95% CI 1.25-3.15) and UPDRS motor scores >3 lead to higher OR. It is concluded that SN+, impaired motor performance, and hyposmia are frequently observed in the elderly and in isolation are unspecific and of limited use to predict a subject's risk for PD. Whether the association of SN+ with both impaired motor performance and hyposmia as seen in this study predicts an increased risk for the development of PD needs to be evaluated in the follow-up investigations.
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Tuebingen</wicri:noRegion></affiliation></author><author><name sortKey="Dillmann, Ulrich" sort="Dillmann, Ulrich" uniqKey="Dillmann U" first="Ulrich" last="Dillmann">Ulrich Dillmann</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Department of Neurology, University Hospital</s1><s2>Homburg Saar</s2><s3>DEU</s3><sZ>5 aut.</sZ><sZ>7 aut.</sZ><sZ>17 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>Homburg Saar</wicri:noRegion><wicri:noRegion>University Hospital</wicri:noRegion><wicri:noRegion>Homburg Saar</wicri:noRegion></affiliation></author><author><name sortKey="Stockner, Heike" sort="Stockner, Heike" uniqKey="Stockner H" first="Heike" last="Stockner">Heike Stockner</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Neurology, University of Innsbruck</s1><s2>Innsbruck</s2><s3>AUT</s3><sZ>2 aut.</sZ><sZ>8 aut.</sZ><sZ>10 aut.</sZ><sZ>12 aut.</sZ><sZ>16 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Tuebingen</wicri:noRegion></affiliation></author><author><name sortKey="Willeit, Johann" sort="Willeit, Johann" uniqKey="Willeit J" first="Johann" last="Willeit">Johann Willeit</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Neurology, University of Innsbruck</s1><s2>Innsbruck</s2><s3>AUT</s3><sZ>2 aut.</sZ><sZ>8 aut.</sZ><sZ>10 aut.</sZ><sZ>12 aut.</sZ><sZ>16 aut.</sZ></inist:fA14><country>Autriche</country><wicri:noRegion>Innsbruck</wicri:noRegion></affiliation></author><author><name sortKey="Di Santo, Adriana" sort="Di Santo, Adriana" uniqKey="Di Santo A" first="Adriana" last="Di Santo">Adriana Di Santo</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurodegenerative Diseases, Hertie Institute for Clinical Brain Research, University of Tuebingen</s1><s3>DEU</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>6 aut.</sZ><sZ>9 aut.</sZ><sZ>11 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>University of Tuebingen</wicri:noRegion><wicri:noRegion>Department of Neurodegenerative Diseases, Hertie Institute for Clinical Brain Research, University of Tuebingen</wicri:noRegion></affiliation></author><author><name sortKey="Maetzler, Walter" sort="Maetzler, Walter" uniqKey="Maetzler W" first="Walter" last="Maetzler">Walter Maetzler</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurodegenerative Diseases, Hertie Institute for Clinical Brain Research, University of Tuebingen</s1><s3>DEU</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>6 aut.</sZ><sZ>9 aut.</sZ><sZ>11 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>University of Tuebingen</wicri:noRegion><wicri:noRegion>Department of Neurodegenerative Diseases, Hertie Institute for Clinical Brain Research, University of Tuebingen</wicri:noRegion></affiliation></author><author><name sortKey="Gasser, Thomas" sort="Gasser, Thomas" uniqKey="Gasser T" first="Thomas" last="Gasser">Thomas Gasser</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurodegenerative Diseases, Hertie Institute for Clinical Brain Research, University of Tuebingen</s1><s3>DEU</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>6 aut.</sZ><sZ>9 aut.</sZ><sZ>11 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>University of Tuebingen</wicri:noRegion><wicri:noRegion>Department of Neurodegenerative Diseases, Hertie Institute for Clinical Brain Research, University of Tuebingen</wicri:noRegion></affiliation></author><author><name sortKey="Poewe, Werner" sort="Poewe, Werner" uniqKey="Poewe W" first="Werner" last="Poewe">Werner Poewe</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Neurology, University of Innsbruck</s1><s2>Innsbruck</s2><s3>AUT</s3><sZ>2 aut.</sZ><sZ>8 aut.</sZ><sZ>10 aut.</sZ><sZ>12 aut.</sZ><sZ>16 aut.</sZ></inist:fA14><country>Autriche</country><wicri:noRegion>Innsbruck</wicri:noRegion><placeName><settlement type="city">Innsbruck</settlement><region nuts="2" type="region">Tyrol (Land)</region></placeName><orgName type="university">Université de médecine d'Innsbruck</orgName></affiliation></author><author><name sortKey="Behnke, Stefanie" sort="Behnke, Stefanie" uniqKey="Behnke S" first="Stefanie" last="Behnke">Stefanie Behnke</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Department of Neurology, University Hospital</s1><s2>Homburg Saar</s2><s3>DEU</s3><sZ>5 aut.</sZ><sZ>7 aut.</sZ><sZ>17 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>Homburg Saar</wicri:noRegion><wicri:noRegion>University Hospital</wicri:noRegion><wicri:noRegion>Homburg Saar</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">10-0377352</idno><date when="2010">2010</date><idno type="stanalyst">PASCAL 10-0377352 INIST</idno><idno type="RBID">Pascal:10-0377352</idno><idno type="wicri:Area/PascalFrancis/Corpus">000986</idno><idno type="wicri:Area/PascalFrancis/Curation">002333</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">000A80</idno><idno type="wicri:doubleKey">0885-3185:2010:Berg D:enlarged:hyperechogenic:substantia</idno><idno type="wicri:Area/Main/Merge">002667</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Enlarged Hyperechogenic Substantia Nigra Is Related to Motor Performance and Olfaction in the Elderly</title><author><name sortKey="Berg, Daniela" sort="Berg, Daniela" uniqKey="Berg D" first="Daniela" last="Berg">Daniela Berg</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurodegenerative Diseases, Hertie Institute for Clinical Brain Research, University of Tuebingen</s1><s3>DEU</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>6 aut.</sZ><sZ>9 aut.</sZ><sZ>11 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>University of Tuebingen</wicri:noRegion><wicri:noRegion>Department of Neurodegenerative Diseases, Hertie Institute for Clinical Brain Research, University of Tuebingen</wicri:noRegion></affiliation></author><author><name sortKey="Seppi, Klaus" sort="Seppi, Klaus" uniqKey="Seppi K" first="Klaus" last="Seppi">Klaus Seppi</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Neurology, University of Innsbruck</s1><s2>Innsbruck</s2><s3>AUT</s3><sZ>2 aut.</sZ><sZ>8 aut.</sZ><sZ>10 aut.</sZ><sZ>12 aut.</sZ><sZ>16 aut.</sZ></inist:fA14><country>Autriche</country><wicri:noRegion>Innsbruck</wicri:noRegion></affiliation></author><author><name sortKey="Liepelt, Inga" sort="Liepelt, Inga" uniqKey="Liepelt I" first="Inga" last="Liepelt">Inga Liepelt</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurodegenerative Diseases, Hertie Institute for Clinical Brain Research, University of Tuebingen</s1><s3>DEU</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>6 aut.</sZ><sZ>9 aut.</sZ><sZ>11 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>University of Tuebingen</wicri:noRegion><wicri:noRegion>Department of Neurodegenerative Diseases, Hertie Institute for Clinical Brain Research, University of Tuebingen</wicri:noRegion></affiliation></author><author><name sortKey="Schweitzer, Katherine" sort="Schweitzer, Katherine" uniqKey="Schweitzer K" first="Katherine" last="Schweitzer">Katherine Schweitzer</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurodegenerative Diseases, Hertie Institute for Clinical Brain Research, University of Tuebingen</s1><s3>DEU</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>6 aut.</sZ><sZ>9 aut.</sZ><sZ>11 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>University of Tuebingen</wicri:noRegion><wicri:noRegion>Department of Neurodegenerative Diseases, Hertie Institute for Clinical Brain Research, University of Tuebingen</wicri:noRegion></affiliation></author><author><name sortKey="Wollenweber, Frank" sort="Wollenweber, Frank" uniqKey="Wollenweber F" first="Frank" last="Wollenweber">Frank Wollenweber</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Department of Neurology, University Hospital</s1><s2>Homburg Saar</s2><s3>DEU</s3><sZ>5 aut.</sZ><sZ>7 aut.</sZ><sZ>17 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>Homburg Saar</wicri:noRegion><wicri:noRegion>University Hospital</wicri:noRegion><wicri:noRegion>Homburg Saar</wicri:noRegion></affiliation></author><author><name sortKey="Wolf, Bjorn" sort="Wolf, Bjorn" uniqKey="Wolf B" first="Björn" last="Wolf">Björn Wolf</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurodegenerative Diseases, Hertie Institute for Clinical Brain Research, University of Tuebingen</s1><s3>DEU</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>6 aut.</sZ><sZ>9 aut.</sZ><sZ>11 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>University of Tuebingen</wicri:noRegion><wicri:noRegion>Department of Neurodegenerative Diseases, Hertie Institute for Clinical Brain Research, University of Tuebingen</wicri:noRegion></affiliation></author><author><name sortKey="Dillmann, Ulrich" sort="Dillmann, Ulrich" uniqKey="Dillmann U" first="Ulrich" last="Dillmann">Ulrich Dillmann</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Department of Neurology, University Hospital</s1><s2>Homburg Saar</s2><s3>DEU</s3><sZ>5 aut.</sZ><sZ>7 aut.</sZ><sZ>17 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>Homburg Saar</wicri:noRegion><wicri:noRegion>University Hospital</wicri:noRegion><wicri:noRegion>Homburg Saar</wicri:noRegion></affiliation></author><author><name sortKey="Stockner, Heike" sort="Stockner, Heike" uniqKey="Stockner H" first="Heike" last="Stockner">Heike Stockner</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Neurology, University of Innsbruck</s1><s2>Innsbruck</s2><s3>AUT</s3><sZ>2 aut.</sZ><sZ>8 aut.</sZ><sZ>10 aut.</sZ><sZ>12 aut.</sZ><sZ>16 aut.</sZ></inist:fA14><country>Autriche</country><wicri:noRegion>Innsbruck</wicri:noRegion></affiliation></author><author><name sortKey="Godau, Jana" sort="Godau, Jana" uniqKey="Godau J" first="Jana" last="Godau">Jana Godau</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurodegenerative Diseases, Hertie Institute for Clinical Brain Research, University of Tuebingen</s1><s3>DEU</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>6 aut.</sZ><sZ>9 aut.</sZ><sZ>11 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>University of Tuebingen</wicri:noRegion><wicri:noRegion>Department of Neurodegenerative Diseases, Hertie Institute for Clinical Brain Research, University of Tuebingen</wicri:noRegion></affiliation></author><author><name sortKey="Kiechl, Stefan" sort="Kiechl, Stefan" uniqKey="Kiechl S" first="Stefan" last="Kiechl">Stefan Kiechl</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Neurology, University of Innsbruck</s1><s2>Innsbruck</s2><s3>AUT</s3><sZ>2 aut.</sZ><sZ>8 aut.</sZ><sZ>10 aut.</sZ><sZ>12 aut.</sZ><sZ>16 aut.</sZ></inist:fA14><country>Autriche</country><wicri:noRegion>Innsbruck</wicri:noRegion></affiliation></author><author><name sortKey="Gaenslen, Alexandra" sort="Gaenslen, Alexandra" uniqKey="Gaenslen A" first="Alexandra" last="Gaenslen">Alexandra Gaenslen</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurodegenerative Diseases, Hertie Institute for Clinical Brain Research, University of Tuebingen</s1><s3>DEU</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>6 aut.</sZ><sZ>9 aut.</sZ><sZ>11 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>University of Tuebingen</wicri:noRegion><wicri:noRegion>Department of Neurodegenerative Diseases, Hertie Institute for Clinical Brain Research, University of Tuebingen</wicri:noRegion></affiliation></author><author><name sortKey="Willeit, Johann" sort="Willeit, Johann" uniqKey="Willeit J" first="Johann" last="Willeit">Johann Willeit</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Neurology, University of Innsbruck</s1><s2>Innsbruck</s2><s3>AUT</s3><sZ>2 aut.</sZ><sZ>8 aut.</sZ><sZ>10 aut.</sZ><sZ>12 aut.</sZ><sZ>16 aut.</sZ></inist:fA14><country>Autriche</country><wicri:noRegion>Innsbruck</wicri:noRegion></affiliation></author><author><name sortKey="Di Santo, Adriana" sort="Di Santo, Adriana" uniqKey="Di Santo A" first="Adriana" last="Di Santo">Adriana Di Santo</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurodegenerative Diseases, Hertie Institute for Clinical Brain Research, University of Tuebingen</s1><s3>DEU</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>6 aut.</sZ><sZ>9 aut.</sZ><sZ>11 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>University of Tuebingen</wicri:noRegion><wicri:noRegion>Department of Neurodegenerative Diseases, Hertie Institute for Clinical Brain Research, University of Tuebingen</wicri:noRegion></affiliation></author><author><name sortKey="Maetzler, Walter" sort="Maetzler, Walter" uniqKey="Maetzler W" first="Walter" last="Maetzler">Walter Maetzler</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurodegenerative Diseases, Hertie Institute for Clinical Brain Research, University of Tuebingen</s1><s3>DEU</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>6 aut.</sZ><sZ>9 aut.</sZ><sZ>11 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>University of Tuebingen</wicri:noRegion><wicri:noRegion>Department of Neurodegenerative Diseases, Hertie Institute for Clinical Brain Research, University of Tuebingen</wicri:noRegion></affiliation></author><author><name sortKey="Gasser, Thomas" sort="Gasser, Thomas" uniqKey="Gasser T" first="Thomas" last="Gasser">Thomas Gasser</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurodegenerative Diseases, Hertie Institute for Clinical Brain Research, University of Tuebingen</s1><s3>DEU</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>6 aut.</sZ><sZ>9 aut.</sZ><sZ>11 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>University of Tuebingen</wicri:noRegion><wicri:noRegion>Department of Neurodegenerative Diseases, Hertie Institute for Clinical Brain Research, University of Tuebingen</wicri:noRegion></affiliation></author><author><name sortKey="Poewe, Werner" sort="Poewe, Werner" uniqKey="Poewe W" first="Werner" last="Poewe">Werner Poewe</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Neurology, University of Innsbruck</s1><s2>Innsbruck</s2><s3>AUT</s3><sZ>2 aut.</sZ><sZ>8 aut.</sZ><sZ>10 aut.</sZ><sZ>12 aut.</sZ><sZ>16 aut.</sZ></inist:fA14><country>Autriche</country><wicri:noRegion>Innsbruck</wicri:noRegion><placeName><settlement type="city">Innsbruck</settlement><region nuts="2" type="region">Tyrol (Land)</region></placeName><orgName type="university">Université de médecine d'Innsbruck</orgName></affiliation></author><author><name sortKey="Behnke, Stefanie" sort="Behnke, Stefanie" uniqKey="Behnke S" first="Stefanie" last="Behnke">Stefanie Behnke</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Department of Neurology, University Hospital</s1><s2>Homburg Saar</s2><s3>DEU</s3><sZ>5 aut.</sZ><sZ>7 aut.</sZ><sZ>17 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>Homburg Saar</wicri:noRegion><wicri:noRegion>University Hospital</wicri:noRegion><wicri:noRegion>Homburg Saar</wicri:noRegion></affiliation></author></analytic><series><title level="j" type="main">Movement disorders</title><title level="j" type="abbreviated">Mov. disord.</title><idno type="ISSN">0885-3185</idno><imprint><date when="2010">2010</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Movement disorders</title><title level="j" type="abbreviated">Mov. disord.</title><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Cohort study</term><term>Elderly</term><term>Locus niger</term><term>Nervous system diseases</term><term>Olfaction</term><term>Parkinson disease</term><term>Parkinsonism</term><term>Performance</term><term>Ultrasound</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Maladie de Parkinson</term><term>Parkinsonisme</term><term>Pathologie du système nerveux</term><term>Locus niger</term><term>Performance</term><term>Olfaction</term><term>Personne âgée</term><term>Etude cohorte</term><term>Ultrason</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Personne âgée</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Enlarged substantia nigra hyperechogenicity (SN+) assessed by transcranial sonography (TCS) may be associated with Parkinson's disease (PD) risk markers such as impaired motor performance and hyposmia. The aim of this multicenter cross-sectional study was to define the association between SN+ and these risk markers in a large population older than 50 years without the diagnosis of PD. In three centers (Tuebingen, Homburg, and Innsbruck), 1,839 individuals were examined. The echostatus of the SN was assessed by TCS, motor performance by the Unified Parkinson's Disease Rating Scale (UPDRS) motor score, and olfactory function with Sniffin' Sticks. From the 1,603 subjects included in the analysis, 16.2% were SN+, 23.0% scored above zero in the UPDRS motor section, and 28.0% were hyposmic as defined by less than 75% correctly classified Sniffin' Sticks. SN<sub>+</sub> was associated with a UPDRS motor score above zero (OR 1.45, 95% CI 1.08-1.96) and with a lower odor identification capability (OR 1.48, 95% CI 1.12-1.96). The combination of these two features (OR 1.98, 95% CI 1.25-3.15) and UPDRS motor scores >3 lead to higher OR. It is concluded that SN+, impaired motor performance, and hyposmia are frequently observed in the elderly and in isolation are unspecific and of limited use to predict a subject's risk for PD. Whether the association of SN+ with both impaired motor performance and hyposmia as seen in this study predicts an increased risk for the development of PD needs to be evaluated in the follow-up investigations.</div></front></TEI><affiliations><list><country><li>Allemagne</li><li>Autriche</li></country><region><li>Tyrol (Land)</li></region><settlement><li>Innsbruck</li></settlement><orgName><li>Université de médecine d'Innsbruck</li></orgName></list><tree><country name="Allemagne"><noRegion><name sortKey="Berg, Daniela" sort="Berg, Daniela" uniqKey="Berg D" first="Daniela" last="Berg">Daniela Berg</name></noRegion><name sortKey="Behnke, Stefanie" sort="Behnke, Stefanie" uniqKey="Behnke S" first="Stefanie" last="Behnke">Stefanie Behnke</name><name sortKey="Di Santo, Adriana" sort="Di Santo, Adriana" uniqKey="Di Santo A" first="Adriana" last="Di Santo">Adriana Di Santo</name><name sortKey="Dillmann, Ulrich" sort="Dillmann, Ulrich" uniqKey="Dillmann U" first="Ulrich" last="Dillmann">Ulrich Dillmann</name><name sortKey="Gaenslen, Alexandra" sort="Gaenslen, Alexandra" uniqKey="Gaenslen A" first="Alexandra" last="Gaenslen">Alexandra Gaenslen</name><name sortKey="Gasser, Thomas" sort="Gasser, Thomas" uniqKey="Gasser T" first="Thomas" last="Gasser">Thomas Gasser</name><name sortKey="Godau, Jana" sort="Godau, Jana" uniqKey="Godau J" first="Jana" last="Godau">Jana Godau</name><name sortKey="Liepelt, Inga" sort="Liepelt, Inga" uniqKey="Liepelt I" first="Inga" last="Liepelt">Inga Liepelt</name><name sortKey="Maetzler, Walter" sort="Maetzler, Walter" uniqKey="Maetzler W" first="Walter" last="Maetzler">Walter Maetzler</name><name sortKey="Schweitzer, Katherine" sort="Schweitzer, Katherine" uniqKey="Schweitzer K" first="Katherine" last="Schweitzer">Katherine Schweitzer</name><name sortKey="Wolf, Bjorn" sort="Wolf, Bjorn" uniqKey="Wolf B" first="Björn" last="Wolf">Björn Wolf</name><name sortKey="Wollenweber, Frank" sort="Wollenweber, Frank" uniqKey="Wollenweber F" first="Frank" last="Wollenweber">Frank Wollenweber</name></country><country name="Autriche"><noRegion><name sortKey="Seppi, Klaus" sort="Seppi, Klaus" uniqKey="Seppi K" first="Klaus" last="Seppi">Klaus Seppi</name></noRegion><name sortKey="Kiechl, Stefan" sort="Kiechl, Stefan" uniqKey="Kiechl S" first="Stefan" last="Kiechl">Stefan Kiechl</name><name sortKey="Poewe, Werner" sort="Poewe, Werner" uniqKey="Poewe W" first="Werner" last="Poewe">Werner Poewe</name><name sortKey="Stockner, Heike" sort="Stockner, Heike" uniqKey="Stockner H" first="Heike" last="Stockner">Heike Stockner</name><name sortKey="Willeit, Johann" sort="Willeit, Johann" uniqKey="Willeit J" first="Johann" last="Willeit">Johann Willeit</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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