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Motor Laterality Asymmetry and Nonmotor Symptoms in Parkinson's Disease

Identifieur interne : 002546 ( Main/Merge ); précédent : 002545; suivant : 002547

Motor Laterality Asymmetry and Nonmotor Symptoms in Parkinson's Disease

Auteurs : Esther Cubo [Espagne] ; Pablo Martinez Martin [Espagne] ; Jesus A. Martin-Gonzalez [Espagne] ; Carmen Rodriguez-Blazquez [Espagne] ; Jaime Kulisevsky [Espagne]

Source :

Movement disorders [ 0885-3185 ] ; 2010.

RBID : Pascal:10-0096511

Descripteurs français

Pascal (Inist)
- Trouble moteur, Maladie de Parkinson, Pathologie du système nerveux, Latéralité, Asymétrie.

English descriptors

KwdEn :
- Asymmetry, Laterality, Motor system disorder, Nervous system diseases, Parkinson disease.

Abstract

Background: In patients with Parkinson's disease (PD), asymmetric motor signs provide an interesting model to evaluate whether asymmetric nigrostriatal degeneration can affect neuropsychological function and other nonmotor symptoms (NMS). This study was designed to evaluate the predominant laterality of motor symptoms and its relationship with cognition and other NMS in idiopathic PD. Methods: Nationwide, longitudinal, and multicenter study (ELEP Registry) using outpatients with PD. Left PD (LPD) and right PD (RPD) was defined based on the motor signs on the SCOPA-motor scale. To include the clinical spectrum of asymmetric PD patients, we considered two groups of patients with mild-moderate and extreme asymmetry. Predominant LPD or RPD with mild-moderate versus extreme asymmetry were compared using the following scales: cognition, psychosis (Parkinson Psychosis Rating Scale), anxiety/depression, sleep (and autonomic dysfunction at baseline and I year later. Nonparametric tests were used for comparison. Results: One hundred forty-nine PD patients (74 RPD and 75 LPD) with mild-moderate asymmetry and 90 (47 RPD and 43 LPD) with extreme asymmetry and a mean age of 64.5 (10.4) years were included. Extreme RPD had higher Parkinson Psychosis Rating Scale scores over time (P = 0.005) compared with LPD, but no significant differences were observed between LPD and RPD in terms of other NMS. Conclusions: These findings suggest that damage to left-hemisphere plays a disproportionately greater role in PD-related psychosis over time. In contrast, motor laterality does not consistently affect other NMS, suggesting that NMS are related to a more widespread brain disorder.

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Pascal:10-0096511

Le document en format XML

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<author><name sortKey="Rodriguez Blazquez, Carmen" sort="Rodriguez Blazquez, Carmen" uniqKey="Rodriguez Blazquez C" first="Carmen" last="Rodriguez-Blazquez">Carmen Rodriguez-Blazquez</name>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Motor Laterality Asymmetry and Nonmotor Symptoms in Parkinson's Disease</title>
<author><name sortKey="Cubo, Esther" sort="Cubo, Esther" uniqKey="Cubo E" first="Esther" last="Cubo">Esther Cubo</name>
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<author><name sortKey="Martinez Martin, Pablo" sort="Martinez Martin, Pablo" uniqKey="Martinez Martin P" first="Pablo" last="Martinez Martin">Pablo Martinez Martin</name>
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<author><name sortKey="Martin Gonzalez, Jesus A" sort="Martin Gonzalez, Jesus A" uniqKey="Martin Gonzalez J" first="Jesus A." last="Martin-Gonzalez">Jesus A. Martin-Gonzalez</name>
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<author><name sortKey="Rodriguez Blazquez, Carmen" sort="Rodriguez Blazquez, Carmen" uniqKey="Rodriguez Blazquez C" first="Carmen" last="Rodriguez-Blazquez">Carmen Rodriguez-Blazquez</name>
<affiliation wicri:level="3"><inist:fA14 i1="02"><s1>National Center for Epidemiology and CIBERNED, Carlos III Institute of Health</s1>
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<sZ>4 aut.</sZ>
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<keywords scheme="Pascal" xml:lang="fr"><term>Trouble moteur</term>
<term>Maladie de Parkinson</term>
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<term>Latéralité</term>
<term>Asymétrie</term>
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<front><div type="abstract" xml:lang="en">Background: In patients with Parkinson's disease (PD), asymmetric motor signs provide an interesting model to evaluate whether asymmetric nigrostriatal degeneration can affect neuropsychological function and other nonmotor symptoms (NMS). This study was designed to evaluate the predominant laterality of motor symptoms and its relationship with cognition and other NMS in idiopathic PD. Methods: Nationwide, longitudinal, and multicenter study (ELEP Registry) using outpatients with PD. Left PD (LPD) and right PD (RPD) was defined based on the motor signs on the SCOPA-motor scale. To include the clinical spectrum of asymmetric PD patients, we considered two groups of patients with mild-moderate and extreme asymmetry. Predominant LPD or RPD with mild-moderate versus extreme asymmetry were compared using the following scales: cognition, psychosis (Parkinson Psychosis Rating Scale), anxiety/depression, sleep (and autonomic dysfunction at baseline and I year later. Nonparametric tests were used for comparison. Results: One hundred forty-nine PD patients (74 RPD and 75 LPD) with mild-moderate asymmetry and 90 (47 RPD and 43 LPD) with extreme asymmetry and a mean age of 64.5 (10.4) years were included. Extreme RPD had higher Parkinson Psychosis Rating Scale scores over time (P = 0.005) compared with LPD, but no significant differences were observed between LPD and RPD in terms of other NMS. Conclusions: These findings suggest that damage to left-hemisphere plays a disproportionately greater role in PD-related psychosis over time. In contrast, motor laterality does not consistently affect other NMS, suggesting that NMS are related to a more widespread brain disorder.</div>
</front>
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<tree><country name="Espagne"><noRegion><name sortKey="Cubo, Esther" sort="Cubo, Esther" uniqKey="Cubo E" first="Esther" last="Cubo">Esther Cubo</name>
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<name sortKey="Kulisevsky, Jaime" sort="Kulisevsky, Jaime" uniqKey="Kulisevsky J" first="Jaime" last="Kulisevsky">Jaime Kulisevsky</name>
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<name sortKey="Martinez Martin, Pablo" sort="Martinez Martin, Pablo" uniqKey="Martinez Martin P" first="Pablo" last="Martinez Martin">Pablo Martinez Martin</name>
<name sortKey="Rodriguez Blazquez, Carmen" sort="Rodriguez Blazquez, Carmen" uniqKey="Rodriguez Blazquez C" first="Carmen" last="Rodriguez-Blazquez">Carmen Rodriguez-Blazquez</name>
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	Movement Disorders (revue)
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Movement Disorders (revue)

Motor Laterality Asymmetry and Nonmotor Symptoms in Parkinson's Disease

Motor Laterality Asymmetry and Nonmotor Symptoms in Parkinson's Disease

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri