Hypokinesia in Huntington's disease co‐occurs with cognitive and global dysfunctioning
Identifieur interne : 002082 ( Main/Merge ); précédent : 002081; suivant : 002083Hypokinesia in Huntington's disease co‐occurs with cognitive and global dysfunctioning
Auteurs : Nanda Reedeker [Pays-Bas] ; Rose C. Van Der Mast [Pays-Bas] ; Erik J. Giltay [Pays-Bas] ; Erik Van Duijn [Pays-Bas] ; Raymond A. C. Roos [Pays-Bas]Source :
- Movement Disorders [ 0885-3185 ] ; 2010-08-15.
English descriptors
- KwdEn :
- Adult, Cognition Disorders (etiology), Cross-Sectional Studies, Executive Function (physiology), Female, Humans, Huntington Disease (complications), Huntington's disease, Hypokinesia (etiology), Linear Models, Male, Mental Status Schedule, Middle Aged, Neurologic Examination (methods), Neuropsychological Tests, Statistics as Topic, apathy, cognition, global functioning, hypokinesia.
- MESH :
- complications : Huntington Disease.
- etiology : Cognition Disorders, Hypokinesia.
- methods : Neurologic Examination.
- physiology : Executive Function.
- Adult, Cross-Sectional Studies, Female, Humans, Linear Models, Male, Mental Status Schedule, Middle Aged, Neuropsychological Tests, Statistics as Topic.
Abstract
Besides chorea, hypokinesia is an important motor disturbance in Huntington's disease (HD) but its clinical, neuropsychiatric, and cognitive functioning correlates are largely unknown. This cross‐sectional study investigates correlates of hypokinesia in HD and its effect on global functioning. Among 150 HD gene carriers, 96 patients were clinically motor manifest. Hypokinesia was assessed using the motor section of the Unified Huntington's Disease Rating Scale and global functioning was measured using the Total Functioning Capacity (TFC) scale. Neuropsychiatric measures included the Apathy Scale and the Composite International Diagnostic Interview for diagnosis of depression. The Mini Mental State Examination (MMSE) and a composite executive cognitive measure were used to assess global and executive cognitive functioning, respectively. Compared with 45 patients with no or mild hypokinesia, 51 patients with moderate to severe hypokinesia showed a significant difference in most clinical and neuropsychiatric variables and had worse cognitive functioning scores. However, using forward logistic regression analysis, poor executive cognitive functioning was the only independent correlate of hypokinesia (OR 7.33; 95% CI: 2.82–19.0; P < 0.001). Hypokinesia score was inversely associated with the TFC score (P < 0.001), also after adjusting for chorea, use of antipsychotics, apathy, and global and executive cognitive functioning. In conclusion, the presence of moderate to severe hypokinesia in HD patients co‐occurs with executive cognitive dysfunction and adversely affects global functioning. © 2010 Movement Disorder Society
Url:
DOI: 10.1002/mds.23136
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Giltay</name><affiliation wicri:level="1"><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Psychiatry, Leiden University Medical Center</wicri:regionArea><wicri:noRegion>Leiden University Medical Center</wicri:noRegion></affiliation></author><author><name sortKey="Van Duijn, Erik" sort="Van Duijn, Erik" uniqKey="Van Duijn E" first="Erik" last="Van Duijn">Erik Van Duijn</name><affiliation wicri:level="1"><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Psychiatry, Leiden University Medical Center</wicri:regionArea><wicri:noRegion>Leiden University Medical Center</wicri:noRegion></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Center for Mental Health Care Delfland, Delft</wicri:regionArea><wicri:noRegion>Delft</wicri:noRegion></affiliation></author><author><name sortKey="Roos, Raymond A C" sort="Roos, Raymond A C" uniqKey="Roos R" first="Raymond A. C." last="Roos">Raymond A. C. Roos</name><affiliation wicri:level="1"><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Neurology, Leiden University Medical Center</wicri:regionArea><wicri:noRegion>Leiden University Medical Center</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2010-08-15">2010-08-15</date><biblScope unit="vol">25</biblScope><biblScope unit="issue">11</biblScope><biblScope unit="page" from="1612">1612</biblScope><biblScope unit="page" to="1618">1618</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">AB66D653B93EDE4E8E89F0D9B92DBA97A2670370</idno><idno type="DOI">10.1002/mds.23136</idno><idno type="ArticleID">MDS23136</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Cognition Disorders (etiology)</term><term>Cross-Sectional Studies</term><term>Executive Function (physiology)</term><term>Female</term><term>Humans</term><term>Huntington Disease (complications)</term><term>Huntington's disease</term><term>Hypokinesia (etiology)</term><term>Linear Models</term><term>Male</term><term>Mental Status Schedule</term><term>Middle Aged</term><term>Neurologic Examination (methods)</term><term>Neuropsychological Tests</term><term>Statistics as Topic</term><term>apathy</term><term>cognition</term><term>global functioning</term><term>hypokinesia</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Huntington Disease</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Cognition Disorders</term><term>Hypokinesia</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Neurologic Examination</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Executive Function</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Cross-Sectional Studies</term><term>Female</term><term>Humans</term><term>Linear Models</term><term>Male</term><term>Mental Status Schedule</term><term>Middle Aged</term><term>Neuropsychological Tests</term><term>Statistics as Topic</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Besides chorea, hypokinesia is an important motor disturbance in Huntington's disease (HD) but its clinical, neuropsychiatric, and cognitive functioning correlates are largely unknown. This cross‐sectional study investigates correlates of hypokinesia in HD and its effect on global functioning. Among 150 HD gene carriers, 96 patients were clinically motor manifest. Hypokinesia was assessed using the motor section of the Unified Huntington's Disease Rating Scale and global functioning was measured using the Total Functioning Capacity (TFC) scale. Neuropsychiatric measures included the Apathy Scale and the Composite International Diagnostic Interview for diagnosis of depression. The Mini Mental State Examination (MMSE) and a composite executive cognitive measure were used to assess global and executive cognitive functioning, respectively. Compared with 45 patients with no or mild hypokinesia, 51 patients with moderate to severe hypokinesia showed a significant difference in most clinical and neuropsychiatric variables and had worse cognitive functioning scores. However, using forward logistic regression analysis, poor executive cognitive functioning was the only independent correlate of hypokinesia (OR 7.33; 95% CI: 2.82–19.0; P < 0.001). Hypokinesia score was inversely associated with the TFC score (P < 0.001), also after adjusting for chorea, use of antipsychotics, apathy, and global and executive cognitive functioning. In conclusion, the presence of moderate to severe hypokinesia in HD patients co‐occurs with executive cognitive dysfunction and adversely affects global functioning. © 2010 Movement Disorder Society</div></front></TEI><double doi="10.1002/mds.23136"><ISTEX><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Hypokinesia in Huntington's disease co‐occurs with cognitive and global dysfunctioning</title><author><name sortKey="Reedeker, Nanda" sort="Reedeker, Nanda" uniqKey="Reedeker N" first="Nanda" last="Reedeker">Nanda Reedeker</name></author><author><name sortKey="Van Der Mast, Rose C" sort="Van Der Mast, Rose C" uniqKey="Van Der Mast R" first="Rose C." last="Van Der Mast">Rose C. Van Der Mast</name></author><author><name sortKey="Giltay, Erik J" sort="Giltay, Erik J" uniqKey="Giltay E" first="Erik J." last="Giltay">Erik J. Giltay</name></author><author><name sortKey="Van Duijn, Erik" sort="Van Duijn, Erik" uniqKey="Van Duijn E" first="Erik" last="Van Duijn">Erik Van Duijn</name></author><author><name sortKey="Roos, Raymond A C" sort="Roos, Raymond A C" uniqKey="Roos R" first="Raymond A. C." last="Roos">Raymond A. C. Roos</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:AB66D653B93EDE4E8E89F0D9B92DBA97A2670370</idno><date when="2010" year="2010">2010</date><idno type="doi">10.1002/mds.23136</idno><idno type="url">https://api.istex.fr/document/AB66D653B93EDE4E8E89F0D9B92DBA97A2670370/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">001230</idno><idno type="wicri:Area/Istex/Curation">001230</idno><idno type="wicri:Area/Istex/Checkpoint">000925</idno><idno type="wicri:doubleKey">0885-3185:2010:Reedeker N:hypokinesia:in:huntington</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Hypokinesia in Huntington's disease co‐occurs with cognitive and global dysfunctioning</title><author><name sortKey="Reedeker, Nanda" sort="Reedeker, Nanda" uniqKey="Reedeker N" first="Nanda" last="Reedeker">Nanda Reedeker</name><affiliation wicri:level="1"><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Psychiatry, Leiden University Medical Center</wicri:regionArea><wicri:noRegion>Leiden University Medical Center</wicri:noRegion></affiliation></author><author><name sortKey="Van Der Mast, Rose C" sort="Van Der Mast, Rose C" uniqKey="Van Der Mast R" first="Rose C." last="Van Der Mast">Rose C. Van Der Mast</name><affiliation wicri:level="1"><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Psychiatry, Leiden University Medical Center</wicri:regionArea><wicri:noRegion>Leiden University Medical Center</wicri:noRegion></affiliation></author><author><name sortKey="Giltay, Erik J" sort="Giltay, Erik J" uniqKey="Giltay E" first="Erik J." last="Giltay">Erik J. Giltay</name><affiliation wicri:level="1"><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Psychiatry, Leiden University Medical Center</wicri:regionArea><wicri:noRegion>Leiden University Medical Center</wicri:noRegion></affiliation></author><author><name sortKey="Van Duijn, Erik" sort="Van Duijn, Erik" uniqKey="Van Duijn E" first="Erik" last="Van Duijn">Erik Van Duijn</name><affiliation wicri:level="1"><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Psychiatry, Leiden University Medical Center</wicri:regionArea><wicri:noRegion>Leiden University Medical Center</wicri:noRegion></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Center for Mental Health Care Delfland, Delft</wicri:regionArea><wicri:noRegion>Delft</wicri:noRegion></affiliation></author><author><name sortKey="Roos, Raymond A C" sort="Roos, Raymond A C" uniqKey="Roos R" first="Raymond A. C." last="Roos">Raymond A. C. Roos</name><affiliation wicri:level="1"><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Neurology, Leiden University Medical Center</wicri:regionArea><wicri:noRegion>Leiden University Medical Center</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2010-08-15">2010-08-15</date><biblScope unit="vol">25</biblScope><biblScope unit="issue">11</biblScope><biblScope unit="page" from="1612">1612</biblScope><biblScope unit="page" to="1618">1618</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">AB66D653B93EDE4E8E89F0D9B92DBA97A2670370</idno><idno type="DOI">10.1002/mds.23136</idno><idno type="ArticleID">MDS23136</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Huntington's disease</term><term>apathy</term><term>cognition</term><term>global functioning</term><term>hypokinesia</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Besides chorea, hypokinesia is an important motor disturbance in Huntington's disease (HD) but its clinical, neuropsychiatric, and cognitive functioning correlates are largely unknown. This cross‐sectional study investigates correlates of hypokinesia in HD and its effect on global functioning. Among 150 HD gene carriers, 96 patients were clinically motor manifest. Hypokinesia was assessed using the motor section of the Unified Huntington's Disease Rating Scale and global functioning was measured using the Total Functioning Capacity (TFC) scale. Neuropsychiatric measures included the Apathy Scale and the Composite International Diagnostic Interview for diagnosis of depression. The Mini Mental State Examination (MMSE) and a composite executive cognitive measure were used to assess global and executive cognitive functioning, respectively. Compared with 45 patients with no or mild hypokinesia, 51 patients with moderate to severe hypokinesia showed a significant difference in most clinical and neuropsychiatric variables and had worse cognitive functioning scores. However, using forward logistic regression analysis, poor executive cognitive functioning was the only independent correlate of hypokinesia (OR 7.33; 95% CI: 2.82–19.0; P < 0.001). Hypokinesia score was inversely associated with the TFC score (P < 0.001), also after adjusting for chorea, use of antipsychotics, apathy, and global and executive cognitive functioning. In conclusion, the presence of moderate to severe hypokinesia in HD patients co‐occurs with executive cognitive dysfunction and adversely affects global functioning. © 2010 Movement Disorder Society</div></front></TEI></ISTEX><PubMed><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Hypokinesia in Huntington's disease co-occurs with cognitive and global dysfunctioning.</title><author><name sortKey="Reedeker, Nanda" sort="Reedeker, Nanda" uniqKey="Reedeker N" first="Nanda" last="Reedeker">Nanda Reedeker</name><affiliation wicri:level="3"><nlm:affiliation>Department of Psychiatry, Leiden University Medical Center, Leiden, The Netherlands. w.reedeker@lumc.nl</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Psychiatry, Leiden University Medical Center, Leiden</wicri:regionArea><placeName><settlement type="city">Leyde</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Van Der Mast, Rose C" sort="Van Der Mast, Rose C" uniqKey="Van Der Mast R" first="Rose C" last="Van Der Mast">Rose C. Van Der Mast</name></author><author><name sortKey="Giltay, Erik J" sort="Giltay, Erik J" uniqKey="Giltay E" first="Erik J" last="Giltay">Erik J. Giltay</name></author><author><name sortKey="Van Duijn, Erik" sort="Van Duijn, Erik" uniqKey="Van Duijn E" first="Erik" last="Van Duijn">Erik Van Duijn</name></author><author><name sortKey="Roos, Raymond A C" sort="Roos, Raymond A C" uniqKey="Roos R" first="Raymond A C" last="Roos">Raymond A C. Roos</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2010">2010</date><idno type="doi">10.1002/mds.23136</idno><idno type="RBID">pubmed:20629165</idno><idno type="pmid">20629165</idno><idno type="wicri:Area/PubMed/Corpus">001714</idno><idno type="wicri:Area/PubMed/Curation">001714</idno><idno type="wicri:Area/PubMed/Checkpoint">001842</idno><idno type="wicri:Area/Ncbi/Merge">002D03</idno><idno type="wicri:Area/Ncbi/Curation">002D03</idno><idno type="wicri:Area/Ncbi/Checkpoint">002D03</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Hypokinesia in Huntington's disease co-occurs with cognitive and global dysfunctioning.</title><author><name sortKey="Reedeker, Nanda" sort="Reedeker, Nanda" uniqKey="Reedeker N" first="Nanda" last="Reedeker">Nanda Reedeker</name><affiliation wicri:level="3"><nlm:affiliation>Department of Psychiatry, Leiden University Medical Center, Leiden, The Netherlands. w.reedeker@lumc.nl</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Psychiatry, Leiden University Medical Center, Leiden</wicri:regionArea><placeName><settlement type="city">Leyde</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Van Der Mast, Rose C" sort="Van Der Mast, Rose C" uniqKey="Van Der Mast R" first="Rose C" last="Van Der Mast">Rose C. Van Der Mast</name></author><author><name sortKey="Giltay, Erik J" sort="Giltay, Erik J" uniqKey="Giltay E" first="Erik J" last="Giltay">Erik J. Giltay</name></author><author><name sortKey="Van Duijn, Erik" sort="Van Duijn, Erik" uniqKey="Van Duijn E" first="Erik" last="Van Duijn">Erik Van Duijn</name></author><author><name sortKey="Roos, Raymond A C" sort="Roos, Raymond A C" uniqKey="Roos R" first="Raymond A C" last="Roos">Raymond A C. Roos</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="eISSN">1531-8257</idno><imprint><date when="2010" type="published">2010</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Cognition Disorders (etiology)</term><term>Cross-Sectional Studies</term><term>Executive Function (physiology)</term><term>Female</term><term>Humans</term><term>Huntington Disease (complications)</term><term>Hypokinesia (etiology)</term><term>Linear Models</term><term>Male</term><term>Mental Status Schedule</term><term>Middle Aged</term><term>Neurologic Examination (methods)</term><term>Neuropsychological Tests</term><term>Statistics as Topic</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Huntington Disease</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Cognition Disorders</term><term>Hypokinesia</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Neurologic Examination</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Executive Function</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Cross-Sectional Studies</term><term>Female</term><term>Humans</term><term>Linear Models</term><term>Male</term><term>Mental Status Schedule</term><term>Middle Aged</term><term>Neuropsychological Tests</term><term>Statistics as Topic</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Besides chorea, hypokinesia is an important motor disturbance in Huntington's disease (HD) but its clinical, neuropsychiatric, and cognitive functioning correlates are largely unknown. This cross-sectional study investigates correlates of hypokinesia in HD and its effect on global functioning. Among 150 HD gene carriers, 96 patients were clinically motor manifest. Hypokinesia was assessed using the motor section of the Unified Huntington's Disease Rating Scale and global functioning was measured using the Total Functioning Capacity (TFC) scale. Neuropsychiatric measures included the Apathy Scale and the Composite International Diagnostic Interview for diagnosis of depression. The Mini Mental State Examination (MMSE) and a composite executive cognitive measure were used to assess global and executive cognitive functioning, respectively. Compared with 45 patients with no or mild hypokinesia, 51 patients with moderate to severe hypokinesia showed a significant difference in most clinical and neuropsychiatric variables and had worse cognitive functioning scores. However, using forward logistic regression analysis, poor executive cognitive functioning was the only independent correlate of hypokinesia (OR 7.33; 95% CI: 2.82-19.0; P < 0.001). Hypokinesia score was inversely associated with the TFC score (P < 0.001), also after adjusting for chorea, use of antipsychotics, apathy, and global and executive cognitive functioning. In conclusion, the presence of moderate to severe hypokinesia in HD patients co-occurs with executive cognitive dysfunction and adversely affects global functioning.</div></front></TEI></PubMed></double></record>Pour manipuler ce document sous Unix (Dilib)
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