Risk factors for executive dysfunction after subthalamic nucleus stimulation in Parkinson's disease
Identifieur interne : 001E62 ( Main/Merge ); précédent : 001E61; suivant : 001E63Risk factors for executive dysfunction after subthalamic nucleus stimulation in Parkinson's disease
Auteurs : Christine Daniels [Allemagne] ; Paul Krack [Allemagne] ; Jens Volkmann [Allemagne] ; Markus O. Pinsker [Allemagne] ; Martin Krause [Allemagne] ; Volker Tronnier [Allemagne] ; Manja Kloss [Allemagne] ; Alfons Schnitzler [Allemagne] ; Lars Wojtecki [Allemagne] ; Kai Bötzel [Allemagne] ; Adrian Danek [Allemagne] ; Rüdiger Hilker [Allemagne] ; Volker Sturm [Allemagne] ; Andreas Kupsch [Allemagne] ; Elfriede Karner [Autriche] ; Günther Deuschl [Allemagne] ; Karsten Witt [Allemagne]Source :
- Movement Disorders [ 0885-3185 ] ; 2010-08-15.
English descriptors
- KwdEn :
- Aged, Cognition Disorders (etiology), Deep Brain Stimulation (adverse effects), Executive Function (physiology), Female, Follow-Up Studies, Humans, Male, Middle Aged, Neuropsychological Tests, Parkinson Disease (physiopathology), Parkinson Disease (therapy), Parkinson's disease, Risk Factors, Statistics as Topic, Subthalamic Nucleus (physiology), deep brain stimulation, executive functions, subthalamic nucleus, verbal fluency.
- MESH :
- adverse effects : Deep Brain Stimulation.
- etiology : Cognition Disorders.
- physiology : Executive Function, Subthalamic Nucleus.
- physiopathology : Parkinson Disease.
- therapy : Parkinson Disease.
- Aged, Female, Follow-Up Studies, Humans, Male, Middle Aged, Neuropsychological Tests, Risk Factors, Statistics as Topic.
Abstract
A slight decline in cognitive functions and especially in executive functioning after deep brain stimulation (DBS) of the nucleus subthalamicus (STN) in patients with Parkinson's disease (PD) has been described. This study evaluated baseline parameters that contribute to a deterioration of cognitive functioning after DBS. We analyzed data from the neuropsychological protocol in a randomized controlled study comparing DBS with best medical treatment (BMT). Change scores were calculated for the cognitive domains “global cognitive functioning,” “memory,” “working memory,” “attention,” and “executive function.” These domain‐specific change scores were correlated with previously defined preoperative parameters. Compared with the BMT group (63 patients), the STN‐DBS group (60 patients) showed a significant decline only in the domain executive function 6 months after DBS, which was significantly correlated with age, levodopa‐equivalence dosage (LED) and axial subscore of the UPDRS in the off‐medication state at baseline. Multiple regression analysis showed that these three factors explained, however, only about 23% of the variance. Patients with higher age, higher baseline LED, and/or higher axial subscore of the UPDRS at baseline have an increased risk for worsening of executive function after STN‐DBS. High scores of these factors might reflect an advanced stage of disease progression. As these baseline factors explained the variance of the change score executive function only to a minor proportion, other factors including the surgical procedure, the exact placement of the electrode or postsurgical management might be more relevant for a decline in executive functioning after STN‐DBS. © 2010 Movement Disorder Society
Url:
- https://api.istex.fr/document/93BD43D9A68C911E46F438EAA53F9605C4BC45CC/fulltext/pdf
- http://www.hal.inserm.fr/inserm-00666166
DOI: 10.1002/mds.23078
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Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName></affiliation></author><author><name sortKey="Danek, Adrian" sort="Danek, Adrian" uniqKey="Danek A" first="Adrian" last="Danek">Adrian Danek</name><affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, Ludwig‐Maximilians‐University, Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName></affiliation></author><author><name sortKey="Hilker, Rudiger" sort="Hilker, Rudiger" uniqKey="Hilker R" first="Rüdiger" last="Hilker">Rüdiger Hilker</name><affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, Cologne University, Cologne</wicri:regionArea><wicri:noRegion>Cologne</wicri:noRegion><wicri:noRegion>Cologne</wicri:noRegion></affiliation></author><author><name sortKey="Sturm, Volker" sort="Sturm, Volker" uniqKey="Sturm V" first="Volker" last="Sturm">Volker Sturm</name><affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurosurgery, Cologne University, Cologne</wicri:regionArea><wicri:noRegion>Cologne</wicri:noRegion><wicri:noRegion>Cologne</wicri:noRegion></affiliation></author><author><name sortKey="Kupsch, Andreas" sort="Kupsch, Andreas" uniqKey="Kupsch A" first="Andreas" last="Kupsch">Andreas Kupsch</name><affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, Charité Hospital, Humboldt University, Berlin</wicri:regionArea><placeName><region type="land" nuts="3">Berlin</region><settlement type="city">Berlin</settlement></placeName></affiliation></author><author><name sortKey="Karner, Elfriede" sort="Karner, Elfriede" uniqKey="Karner E" first="Elfriede" last="Karner">Elfriede Karner</name><affiliation wicri:level="1"><country xml:lang="fr">Autriche</country><wicri:regionArea>Department of Neurology, Innsbruck Medical University, Innsbruck</wicri:regionArea><wicri:noRegion>Innsbruck</wicri:noRegion></affiliation></author><author><name sortKey="Deuschl, Gunther" sort="Deuschl, Gunther" uniqKey="Deuschl G" first="Günther" last="Deuschl">Günther Deuschl</name><affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, Christian‐Albrechts‐University, Kiel</wicri:regionArea><placeName><region type="land" nuts="2">Schleswig-Holstein</region><settlement type="city">Kiel</settlement></placeName></affiliation></author><author><name sortKey="Witt, Karsten" sort="Witt, Karsten" uniqKey="Witt K" first="Karsten" last="Witt">Karsten Witt</name><affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, Christian‐Albrechts‐University, Kiel</wicri:regionArea><placeName><region type="land" nuts="2">Schleswig-Holstein</region><settlement type="city">Kiel</settlement></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2010-08-15">2010-08-15</date><biblScope unit="vol">25</biblScope><biblScope unit="issue">11</biblScope><biblScope unit="page" from="1583">1583</biblScope><biblScope unit="page" to="1589">1589</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">93BD43D9A68C911E46F438EAA53F9605C4BC45CC</idno><idno type="DOI">10.1002/mds.23078</idno><idno type="ArticleID">MDS23078</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Cognition Disorders (etiology)</term><term>Deep Brain Stimulation (adverse effects)</term><term>Executive Function (physiology)</term><term>Female</term><term>Follow-Up Studies</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Neuropsychological Tests</term><term>Parkinson Disease (physiopathology)</term><term>Parkinson Disease (therapy)</term><term>Parkinson's disease</term><term>Risk Factors</term><term>Statistics as Topic</term><term>Subthalamic Nucleus (physiology)</term><term>deep brain stimulation</term><term>executive functions</term><term>subthalamic nucleus</term><term>verbal fluency</term></keywords><keywords scheme="MESH" qualifier="adverse effects" xml:lang="en"><term>Deep Brain Stimulation</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Cognition Disorders</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Executive Function</term><term>Subthalamic Nucleus</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Female</term><term>Follow-Up Studies</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Neuropsychological Tests</term><term>Risk Factors</term><term>Statistics as Topic</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">A slight decline in cognitive functions and especially in executive functioning after deep brain stimulation (DBS) of the nucleus subthalamicus (STN) in patients with Parkinson's disease (PD) has been described. This study evaluated baseline parameters that contribute to a deterioration of cognitive functioning after DBS. We analyzed data from the neuropsychological protocol in a randomized controlled study comparing DBS with best medical treatment (BMT). Change scores were calculated for the cognitive domains “global cognitive functioning,” “memory,” “working memory,” “attention,” and “executive function.” These domain‐specific change scores were correlated with previously defined preoperative parameters. Compared with the BMT group (63 patients), the STN‐DBS group (60 patients) showed a significant decline only in the domain executive function 6 months after DBS, which was significantly correlated with age, levodopa‐equivalence dosage (LED) and axial subscore of the UPDRS in the off‐medication state at baseline. Multiple regression analysis showed that these three factors explained, however, only about 23% of the variance. Patients with higher age, higher baseline LED, and/or higher axial subscore of the UPDRS at baseline have an increased risk for worsening of executive function after STN‐DBS. High scores of these factors might reflect an advanced stage of disease progression. As these baseline factors explained the variance of the change score executive function only to a minor proportion, other factors including the surgical procedure, the exact placement of the electrode or postsurgical management might be more relevant for a decline in executive functioning after STN‐DBS. © 2010 Movement Disorder Society</div></front></TEI><double doi="10.1002/mds.23078"><HAL><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Risk factors for executive dysfunction after subthalamic nucleus stimulation in Parkinson's disease.</title><author><name sortKey="Daniels, Christine" sort="Daniels, Christine" uniqKey="Daniels C" first="Christine" last="Daniels">Christine Daniels</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-182743" status="INCOMING"><orgName>Department of Neurology</orgName><desc><address><country key="DE"></country></address></desc><listRelation><relation active="#struct-302868" type="direct"></relation></listRelation><tutelles><tutelle active="#struct-302868" type="direct"><org type="institution" xml:id="struct-302868" status="VALID"><orgName>Christian-Albrechts-Universität [Kiel]</orgName><orgName type="acronym">CAU</orgName><desc><address><addrLine>Christian-Albrechts-Platz 4 -24118 Kiel</addrLine><country key="DE"></country></address><ref type="url">http://www.uni-kiel.de</ref></desc></org></tutelle></tutelles></hal:affiliation><country>Allemagne</country></affiliation></author><author><name sortKey="Krack, Paul" sort="Krack, Paul" uniqKey="Krack P" first="Paul" last="Krack">Paul Krack</name><affiliation wicri:level="1"><hal:affiliation type="researchteam" xml:id="struct-399397" status="INCOMING"><orgName>ANTE-INSERM U836, équipe 10, Dynamique des réseaux neuronaux du mouvement</orgName><desc><address><country key="DE"></country></address></desc><listRelation><relation active="#struct-182743" type="direct"></relation><relation active="#struct-302868" type="indirect"></relation></listRelation><tutelles><tutelle active="#struct-182743" type="direct"><org type="laboratory" xml:id="struct-182743" status="INCOMING"><orgName>Department of Neurology</orgName><desc><address><country key="DE"></country></address></desc><listRelation><relation active="#struct-302868" type="direct"></relation></listRelation></org></tutelle><tutelle active="#struct-302868" type="indirect"><org type="institution" xml:id="struct-302868" status="VALID"><orgName>Christian-Albrechts-Universität [Kiel]</orgName><orgName type="acronym">CAU</orgName><desc><address><addrLine>Christian-Albrechts-Platz 4 -24118 Kiel</addrLine><country key="DE"></country></address><ref type="url">http://www.uni-kiel.de</ref></desc></org></tutelle></tutelles></hal:affiliation><country>Allemagne</country></affiliation></author><author><name sortKey="Volkmann, Jens" sort="Volkmann, Jens" uniqKey="Volkmann J" first="Jens" last="Volkmann">Jens Volkmann</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-182743" status="INCOMING"><orgName>Department of Neurology</orgName><desc><address><country key="DE"></country></address></desc><listRelation><relation active="#struct-302868" type="direct"></relation></listRelation><tutelles><tutelle active="#struct-302868" type="direct"><org type="institution" xml:id="struct-302868" status="VALID"><orgName>Christian-Albrechts-Universität [Kiel]</orgName><orgName type="acronym">CAU</orgName><desc><address><addrLine>Christian-Albrechts-Platz 4 -24118 Kiel</addrLine><country key="DE"></country></address><ref type="url">http://www.uni-kiel.de</ref></desc></org></tutelle></tutelles></hal:affiliation><country>Allemagne</country></affiliation></author><author><name sortKey="Pinsker, Markus O" sort="Pinsker, Markus O" uniqKey="Pinsker M" first="Markus O" last="Pinsker">Markus O. Pinsker</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-182744" status="INCOMING"><orgName>Department of Neurosurgery</orgName><desc><address><country key="DE"></country></address></desc><listRelation><relation active="#struct-302868" type="direct"></relation></listRelation><tutelles><tutelle active="#struct-302868" type="direct"><org type="institution" xml:id="struct-302868" status="VALID"><orgName>Christian-Albrechts-Universität [Kiel]</orgName><orgName type="acronym">CAU</orgName><desc><address><addrLine>Christian-Albrechts-Platz 4 -24118 Kiel</addrLine><country key="DE"></country></address><ref type="url">http://www.uni-kiel.de</ref></desc></org></tutelle></tutelles></hal:affiliation><country>Allemagne</country></affiliation></author><author><name sortKey="Krause, Martin" sort="Krause, Martin" uniqKey="Krause M" first="Martin" last="Krause">Martin Krause</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-182745" status="INCOMING"><orgName>Department of Neurology</orgName><desc><address><country key="DE"></country></address></desc><listRelation><relation active="#struct-318879" type="direct"></relation></listRelation><tutelles><tutelle active="#struct-318879" type="direct"><org type="institution" xml:id="struct-318879" status="INCOMING"><orgName>Heidelberg University</orgName><desc><address><country key="FR"></country></address></desc></org></tutelle></tutelles></hal:affiliation><country>Allemagne</country></affiliation></author><author><name sortKey="Tronnier, Volker" sort="Tronnier, Volker" uniqKey="Tronnier V" first="Volker" last="Tronnier">Volker Tronnier</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-182746" status="INCOMING"><orgName>Department of Neurosurgery</orgName><desc><address><country key="DE"></country></address></desc><listRelation><relation active="#struct-345711" type="direct"></relation></listRelation><tutelles><tutelle active="#struct-345711" type="direct"><org type="institution" xml:id="struct-345711" status="INCOMING"><orgName>Heidelberg University, Heidelberg</orgName><desc><address><country key="FR"></country></address></desc></org></tutelle></tutelles></hal:affiliation><country>Allemagne</country></affiliation></author><author><name sortKey="Kloss, Manja" sort="Kloss, Manja" uniqKey="Kloss M" first="Manja" last="Kloss">Manja Kloss</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-182745" status="INCOMING"><orgName>Department of Neurology</orgName><desc><address><country key="DE"></country></address></desc><listRelation><relation active="#struct-318879" type="direct"></relation></listRelation><tutelles><tutelle active="#struct-318879" type="direct"><org type="institution" xml:id="struct-318879" status="INCOMING"><orgName>Heidelberg University</orgName><desc><address><country key="FR"></country></address></desc></org></tutelle></tutelles></hal:affiliation><country>Allemagne</country></affiliation></author><author><name sortKey="Schnitzler, Alfons" sort="Schnitzler, Alfons" uniqKey="Schnitzler A" first="Alfons" last="Schnitzler">Alfons Schnitzler</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-182747" status="INCOMING"><orgName>Department of Neurology</orgName><desc><address><country key="DE"></country></address></desc><listRelation><relation active="#struct-345712" type="direct"></relation></listRelation><tutelles><tutelle active="#struct-345712" type="direct"><org type="institution" xml:id="struct-345712" status="INCOMING"><orgName>Heinrich Heine University, Dusseldorf</orgName><desc><address><country key="FR"></country></address></desc></org></tutelle></tutelles></hal:affiliation><country>Allemagne</country></affiliation></author><author><name sortKey="Wojtecki, Lars" sort="Wojtecki, Lars" uniqKey="Wojtecki L" first="Lars" last="Wojtecki">Lars Wojtecki</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-182747" status="INCOMING"><orgName>Department of Neurology</orgName><desc><address><country key="DE"></country></address></desc><listRelation><relation active="#struct-345712" type="direct"></relation></listRelation><tutelles><tutelle active="#struct-345712" type="direct"><org type="institution" xml:id="struct-345712" status="INCOMING"><orgName>Heinrich Heine University, Dusseldorf</orgName><desc><address><country key="FR"></country></address></desc></org></tutelle></tutelles></hal:affiliation><country>Allemagne</country></affiliation></author><author><name sortKey="Botzel, Kai" sort="Botzel, Kai" uniqKey="Botzel K" first="Kai" last="Bötzel">Kai Bötzel</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-182748" status="INCOMING"><orgName>Neurology department</orgName><desc><address><addrLine>Munich</addrLine><country key="DE"></country></address></desc><listRelation><relation active="#struct-352547" type="direct"></relation></listRelation><tutelles><tutelle active="#struct-352547" type="direct"><org type="institution" xml:id="struct-352547" status="INCOMING"><orgName>Ludwig-Maximilians-Universität Munich</orgName><desc><address><country key="FR"></country></address></desc></org></tutelle></tutelles></hal:affiliation><country>Allemagne</country></affiliation></author><author><name sortKey="Danek, Adrian" sort="Danek, Adrian" uniqKey="Danek A" first="Adrian" last="Danek">Adrian Danek</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-182748" status="INCOMING"><orgName>Neurology department</orgName><desc><address><addrLine>Munich</addrLine><country key="DE"></country></address></desc><listRelation><relation active="#struct-352547" type="direct"></relation></listRelation><tutelles><tutelle active="#struct-352547" type="direct"><org type="institution" xml:id="struct-352547" status="INCOMING"><orgName>Ludwig-Maximilians-Universität Munich</orgName><desc><address><country key="FR"></country></address></desc></org></tutelle></tutelles></hal:affiliation><country>Allemagne</country></affiliation></author><author><name sortKey="Hilker, Rudiger" sort="Hilker, Rudiger" uniqKey="Hilker R" first="Rüdiger" last="Hilker">Rüdiger Hilker</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-182749" status="INCOMING"><orgName>Department of Neurology</orgName><desc><address><country key="DE"></country></address></desc><listRelation><relation active="#struct-321596" type="direct"></relation></listRelation><tutelles><tutelle active="#struct-321596" type="direct"><org type="institution" xml:id="struct-321596" status="INCOMING"><orgName>Cologne University</orgName><desc><address><country key="FR"></country></address></desc></org></tutelle></tutelles></hal:affiliation><country>Allemagne</country></affiliation></author><author><name sortKey="Sturm, Volker" sort="Sturm, Volker" uniqKey="Sturm V" first="Volker" last="Sturm">Volker Sturm</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-182750" status="INCOMING"><orgName>Department of Neurosurgery</orgName><desc><address><country key="DE"></country></address></desc><listRelation><relation active="#struct-321596" type="direct"></relation></listRelation><tutelles><tutelle active="#struct-321596" type="direct"><org type="institution" xml:id="struct-321596" status="INCOMING"><orgName>Cologne University</orgName><desc><address><country key="FR"></country></address></desc></org></tutelle></tutelles></hal:affiliation><country>Allemagne</country></affiliation></author><author><name sortKey="Kupsch, Andreas" sort="Kupsch, Andreas" uniqKey="Kupsch A" first="Andreas" last="Kupsch">Andreas Kupsch</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-182751" status="INCOMING"><orgName>Department of Neurology</orgName><desc><address><addrLine>Charity Hospital - Berlin</addrLine><country key="DE"></country></address></desc><listRelation><relation active="#struct-139189" type="direct"></relation></listRelation><tutelles><tutelle active="#struct-139189" type="direct"><org type="institution" xml:id="struct-139189" status="VALID"><orgName>Humboldt Universität zu Berlin [Berlin]</orgName><desc><address><addrLine>Unter den Linden 610099 Berlin</addrLine><country key="DE"></country></address><ref type="url">https://www.hu-berlin.de/en/</ref></desc></org></tutelle></tutelles></hal:affiliation><country>Allemagne</country></affiliation></author><author><name sortKey="Karner, Elfriede" sort="Karner, Elfriede" uniqKey="Karner E" first="Elfriede" last="Karner">Elfriede Karner</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-182752" status="INCOMING"><orgName>Department of Neurology</orgName><desc><address><addrLine>Innsbruck</addrLine><country key="AT"></country></address></desc><listRelation><relation active="#struct-314191" type="direct"></relation></listRelation><tutelles><tutelle active="#struct-314191" type="direct"><org type="institution" xml:id="struct-314191" status="INCOMING"><orgName>Innsbruck Medical University</orgName><desc><address><country key="FR"></country></address></desc></org></tutelle></tutelles></hal:affiliation><country>Autriche</country></affiliation></author><author><name sortKey="Deuschl, Gunther" sort="Deuschl, Gunther" uniqKey="Deuschl G" first="Günther" last="Deuschl">Günther Deuschl</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-182743" status="INCOMING"><orgName>Department of Neurology</orgName><desc><address><country key="DE"></country></address></desc><listRelation><relation active="#struct-302868" type="direct"></relation></listRelation><tutelles><tutelle active="#struct-302868" type="direct"><org type="institution" xml:id="struct-302868" status="VALID"><orgName>Christian-Albrechts-Universität [Kiel]</orgName><orgName type="acronym">CAU</orgName><desc><address><addrLine>Christian-Albrechts-Platz 4 -24118 Kiel</addrLine><country key="DE"></country></address><ref type="url">http://www.uni-kiel.de</ref></desc></org></tutelle></tutelles></hal:affiliation><country>Allemagne</country></affiliation></author><author><name sortKey="Witt, Karsten" sort="Witt, Karsten" uniqKey="Witt K" first="Karsten" last="Witt">Karsten Witt</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-182743" status="INCOMING"><orgName>Department of Neurology</orgName><desc><address><country key="DE"></country></address></desc><listRelation><relation active="#struct-302868" type="direct"></relation></listRelation><tutelles><tutelle active="#struct-302868" type="direct"><org type="institution" xml:id="struct-302868" status="VALID"><orgName>Christian-Albrechts-Universität [Kiel]</orgName><orgName type="acronym">CAU</orgName><desc><address><addrLine>Christian-Albrechts-Platz 4 -24118 Kiel</addrLine><country key="DE"></country></address><ref type="url">http://www.uni-kiel.de</ref></desc></org></tutelle></tutelles></hal:affiliation><country>Allemagne</country></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">HAL</idno><idno type="RBID">Hal:inserm-00666166</idno><idno type="halId">inserm-00666166</idno><idno type="halUri">http://www.hal.inserm.fr/inserm-00666166</idno><idno type="url">http://www.hal.inserm.fr/inserm-00666166</idno><idno type="doi">10.1002/mds.23078</idno><date when="2010-08-15">2010-08-15</date><idno type="wicri:Area/Hal/Corpus">000053</idno><idno type="wicri:Area/Hal/Curation">000053</idno><idno type="wicri:Area/Hal/Checkpoint">000023</idno><idno type="wicri:doubleKey">0885-3185:2010:Daniels C:risk:factors:for</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Risk factors for executive dysfunction after subthalamic nucleus stimulation in Parkinson's disease.</title><author><name sortKey="Daniels, Christine" sort="Daniels, Christine" uniqKey="Daniels C" first="Christine" last="Daniels">Christine Daniels</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-182743" status="INCOMING"><orgName>Department of Neurology</orgName><desc><address><country key="DE"></country></address></desc><listRelation><relation active="#struct-302868" type="direct"></relation></listRelation><tutelles><tutelle active="#struct-302868" type="direct"><org type="institution" xml:id="struct-302868" status="VALID"><orgName>Christian-Albrechts-Universität [Kiel]</orgName><orgName type="acronym">CAU</orgName><desc><address><addrLine>Christian-Albrechts-Platz 4 -24118 Kiel</addrLine><country key="DE"></country></address><ref type="url">http://www.uni-kiel.de</ref></desc></org></tutelle></tutelles></hal:affiliation><country>Allemagne</country></affiliation></author><author><name sortKey="Krack, Paul" sort="Krack, Paul" uniqKey="Krack P" first="Paul" last="Krack">Paul Krack</name><affiliation wicri:level="1"><hal:affiliation type="researchteam" xml:id="struct-399397" status="INCOMING"><orgName>ANTE-INSERM U836, équipe 10, Dynamique des réseaux neuronaux du mouvement</orgName><desc><address><country key="DE"></country></address></desc><listRelation><relation active="#struct-182743" type="direct"></relation><relation active="#struct-302868" type="indirect"></relation></listRelation><tutelles><tutelle active="#struct-182743" type="direct"><org type="laboratory" xml:id="struct-182743" status="INCOMING"><orgName>Department of Neurology</orgName><desc><address><country key="DE"></country></address></desc><listRelation><relation active="#struct-302868" type="direct"></relation></listRelation></org></tutelle><tutelle active="#struct-302868" type="indirect"><org type="institution" xml:id="struct-302868" status="VALID"><orgName>Christian-Albrechts-Universität [Kiel]</orgName><orgName type="acronym">CAU</orgName><desc><address><addrLine>Christian-Albrechts-Platz 4 -24118 Kiel</addrLine><country key="DE"></country></address><ref type="url">http://www.uni-kiel.de</ref></desc></org></tutelle></tutelles></hal:affiliation><country>Allemagne</country></affiliation></author><author><name sortKey="Volkmann, Jens" sort="Volkmann, Jens" uniqKey="Volkmann J" first="Jens" last="Volkmann">Jens Volkmann</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-182743" status="INCOMING"><orgName>Department of Neurology</orgName><desc><address><country key="DE"></country></address></desc><listRelation><relation active="#struct-302868" type="direct"></relation></listRelation><tutelles><tutelle active="#struct-302868" type="direct"><org type="institution" xml:id="struct-302868" status="VALID"><orgName>Christian-Albrechts-Universität [Kiel]</orgName><orgName type="acronym">CAU</orgName><desc><address><addrLine>Christian-Albrechts-Platz 4 -24118 Kiel</addrLine><country key="DE"></country></address><ref type="url">http://www.uni-kiel.de</ref></desc></org></tutelle></tutelles></hal:affiliation><country>Allemagne</country></affiliation></author><author><name sortKey="Pinsker, Markus O" sort="Pinsker, Markus O" uniqKey="Pinsker M" first="Markus O" last="Pinsker">Markus O. Pinsker</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-182744" status="INCOMING"><orgName>Department of Neurosurgery</orgName><desc><address><country key="DE"></country></address></desc><listRelation><relation active="#struct-302868" type="direct"></relation></listRelation><tutelles><tutelle active="#struct-302868" type="direct"><org type="institution" xml:id="struct-302868" status="VALID"><orgName>Christian-Albrechts-Universität [Kiel]</orgName><orgName type="acronym">CAU</orgName><desc><address><addrLine>Christian-Albrechts-Platz 4 -24118 Kiel</addrLine><country key="DE"></country></address><ref type="url">http://www.uni-kiel.de</ref></desc></org></tutelle></tutelles></hal:affiliation><country>Allemagne</country></affiliation></author><author><name sortKey="Krause, Martin" sort="Krause, Martin" uniqKey="Krause M" first="Martin" last="Krause">Martin Krause</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-182745" status="INCOMING"><orgName>Department of Neurology</orgName><desc><address><country key="DE"></country></address></desc><listRelation><relation active="#struct-318879" type="direct"></relation></listRelation><tutelles><tutelle active="#struct-318879" type="direct"><org type="institution" xml:id="struct-318879" status="INCOMING"><orgName>Heidelberg University</orgName><desc><address><country key="FR"></country></address></desc></org></tutelle></tutelles></hal:affiliation><country>Allemagne</country></affiliation></author><author><name sortKey="Tronnier, Volker" sort="Tronnier, Volker" uniqKey="Tronnier V" first="Volker" last="Tronnier">Volker Tronnier</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-182746" status="INCOMING"><orgName>Department of Neurosurgery</orgName><desc><address><country key="DE"></country></address></desc><listRelation><relation active="#struct-345711" type="direct"></relation></listRelation><tutelles><tutelle active="#struct-345711" type="direct"><org type="institution" xml:id="struct-345711" status="INCOMING"><orgName>Heidelberg University, Heidelberg</orgName><desc><address><country key="FR"></country></address></desc></org></tutelle></tutelles></hal:affiliation><country>Allemagne</country></affiliation></author><author><name sortKey="Kloss, Manja" sort="Kloss, Manja" uniqKey="Kloss M" first="Manja" last="Kloss">Manja Kloss</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-182745" status="INCOMING"><orgName>Department of Neurology</orgName><desc><address><country key="DE"></country></address></desc><listRelation><relation active="#struct-318879" type="direct"></relation></listRelation><tutelles><tutelle active="#struct-318879" type="direct"><org type="institution" xml:id="struct-318879" status="INCOMING"><orgName>Heidelberg University</orgName><desc><address><country key="FR"></country></address></desc></org></tutelle></tutelles></hal:affiliation><country>Allemagne</country></affiliation></author><author><name sortKey="Schnitzler, Alfons" sort="Schnitzler, Alfons" uniqKey="Schnitzler A" first="Alfons" last="Schnitzler">Alfons Schnitzler</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-182747" status="INCOMING"><orgName>Department of Neurology</orgName><desc><address><country key="DE"></country></address></desc><listRelation><relation active="#struct-345712" type="direct"></relation></listRelation><tutelles><tutelle active="#struct-345712" type="direct"><org type="institution" xml:id="struct-345712" status="INCOMING"><orgName>Heinrich Heine University, Dusseldorf</orgName><desc><address><country key="FR"></country></address></desc></org></tutelle></tutelles></hal:affiliation><country>Allemagne</country></affiliation></author><author><name sortKey="Wojtecki, Lars" sort="Wojtecki, Lars" uniqKey="Wojtecki L" first="Lars" last="Wojtecki">Lars Wojtecki</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-182747" status="INCOMING"><orgName>Department of Neurology</orgName><desc><address><country key="DE"></country></address></desc><listRelation><relation active="#struct-345712" type="direct"></relation></listRelation><tutelles><tutelle active="#struct-345712" type="direct"><org type="institution" xml:id="struct-345712" status="INCOMING"><orgName>Heinrich Heine University, Dusseldorf</orgName><desc><address><country key="FR"></country></address></desc></org></tutelle></tutelles></hal:affiliation><country>Allemagne</country></affiliation></author><author><name sortKey="Botzel, Kai" sort="Botzel, Kai" uniqKey="Botzel K" first="Kai" last="Bötzel">Kai Bötzel</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-182748" status="INCOMING"><orgName>Neurology department</orgName><desc><address><addrLine>Munich</addrLine><country key="DE"></country></address></desc><listRelation><relation active="#struct-352547" type="direct"></relation></listRelation><tutelles><tutelle active="#struct-352547" type="direct"><org type="institution" xml:id="struct-352547" status="INCOMING"><orgName>Ludwig-Maximilians-Universität Munich</orgName><desc><address><country key="FR"></country></address></desc></org></tutelle></tutelles></hal:affiliation><country>Allemagne</country></affiliation></author><author><name sortKey="Danek, Adrian" sort="Danek, Adrian" uniqKey="Danek A" first="Adrian" last="Danek">Adrian Danek</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-182748" status="INCOMING"><orgName>Neurology department</orgName><desc><address><addrLine>Munich</addrLine><country key="DE"></country></address></desc><listRelation><relation active="#struct-352547" type="direct"></relation></listRelation><tutelles><tutelle active="#struct-352547" type="direct"><org type="institution" xml:id="struct-352547" status="INCOMING"><orgName>Ludwig-Maximilians-Universität Munich</orgName><desc><address><country key="FR"></country></address></desc></org></tutelle></tutelles></hal:affiliation><country>Allemagne</country></affiliation></author><author><name sortKey="Hilker, Rudiger" sort="Hilker, Rudiger" uniqKey="Hilker R" first="Rüdiger" last="Hilker">Rüdiger Hilker</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-182749" status="INCOMING"><orgName>Department of Neurology</orgName><desc><address><country key="DE"></country></address></desc><listRelation><relation active="#struct-321596" type="direct"></relation></listRelation><tutelles><tutelle active="#struct-321596" type="direct"><org type="institution" xml:id="struct-321596" status="INCOMING"><orgName>Cologne University</orgName><desc><address><country key="FR"></country></address></desc></org></tutelle></tutelles></hal:affiliation><country>Allemagne</country></affiliation></author><author><name sortKey="Sturm, Volker" sort="Sturm, Volker" uniqKey="Sturm V" first="Volker" last="Sturm">Volker Sturm</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-182750" status="INCOMING"><orgName>Department of Neurosurgery</orgName><desc><address><country key="DE"></country></address></desc><listRelation><relation active="#struct-321596" type="direct"></relation></listRelation><tutelles><tutelle active="#struct-321596" type="direct"><org type="institution" xml:id="struct-321596" status="INCOMING"><orgName>Cologne University</orgName><desc><address><country key="FR"></country></address></desc></org></tutelle></tutelles></hal:affiliation><country>Allemagne</country></affiliation></author><author><name sortKey="Kupsch, Andreas" sort="Kupsch, Andreas" uniqKey="Kupsch A" first="Andreas" last="Kupsch">Andreas Kupsch</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-182751" status="INCOMING"><orgName>Department of Neurology</orgName><desc><address><addrLine>Charity Hospital - Berlin</addrLine><country key="DE"></country></address></desc><listRelation><relation active="#struct-139189" type="direct"></relation></listRelation><tutelles><tutelle active="#struct-139189" type="direct"><org type="institution" xml:id="struct-139189" status="VALID"><orgName>Humboldt Universität zu Berlin [Berlin]</orgName><desc><address><addrLine>Unter den Linden 610099 Berlin</addrLine><country key="DE"></country></address><ref type="url">https://www.hu-berlin.de/en/</ref></desc></org></tutelle></tutelles></hal:affiliation><country>Allemagne</country></affiliation></author><author><name sortKey="Karner, Elfriede" sort="Karner, Elfriede" uniqKey="Karner E" first="Elfriede" last="Karner">Elfriede Karner</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-182752" status="INCOMING"><orgName>Department of Neurology</orgName><desc><address><addrLine>Innsbruck</addrLine><country key="AT"></country></address></desc><listRelation><relation active="#struct-314191" type="direct"></relation></listRelation><tutelles><tutelle active="#struct-314191" type="direct"><org type="institution" xml:id="struct-314191" status="INCOMING"><orgName>Innsbruck Medical University</orgName><desc><address><country key="FR"></country></address></desc></org></tutelle></tutelles></hal:affiliation><country>Autriche</country></affiliation></author><author><name sortKey="Deuschl, Gunther" sort="Deuschl, Gunther" uniqKey="Deuschl G" first="Günther" last="Deuschl">Günther Deuschl</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-182743" status="INCOMING"><orgName>Department of Neurology</orgName><desc><address><country key="DE"></country></address></desc><listRelation><relation active="#struct-302868" type="direct"></relation></listRelation><tutelles><tutelle active="#struct-302868" type="direct"><org type="institution" xml:id="struct-302868" status="VALID"><orgName>Christian-Albrechts-Universität [Kiel]</orgName><orgName type="acronym">CAU</orgName><desc><address><addrLine>Christian-Albrechts-Platz 4 -24118 Kiel</addrLine><country key="DE"></country></address><ref type="url">http://www.uni-kiel.de</ref></desc></org></tutelle></tutelles></hal:affiliation><country>Allemagne</country></affiliation></author><author><name sortKey="Witt, Karsten" sort="Witt, Karsten" uniqKey="Witt K" first="Karsten" last="Witt">Karsten Witt</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-182743" status="INCOMING"><orgName>Department of Neurology</orgName><desc><address><country key="DE"></country></address></desc><listRelation><relation active="#struct-302868" type="direct"></relation></listRelation><tutelles><tutelle active="#struct-302868" type="direct"><org type="institution" xml:id="struct-302868" status="VALID"><orgName>Christian-Albrechts-Universität [Kiel]</orgName><orgName type="acronym">CAU</orgName><desc><address><addrLine>Christian-Albrechts-Platz 4 -24118 Kiel</addrLine><country key="DE"></country></address><ref type="url">http://www.uni-kiel.de</ref></desc></org></tutelle></tutelles></hal:affiliation><country>Allemagne</country></affiliation></author></analytic><idno type="DOI">10.1002/mds.23078</idno><series><title level="j">Movement Disorders</title><idno type="ISSN">0885-3185</idno><imprint><date type="datePub">2010-08-15</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">A slight decline in cognitive functions and especially in executive functioning after deep brain stimulation (DBS) of the nucleus subthalamicus (STN) in patients with Parkinson's disease (PD) has been described. This study evaluated baseline parameters that contribute to a deterioration of cognitive functioning after DBS. We analyzed data from the neuropsychological protocol in a randomized controlled study comparing DBS with best medical treatment (BMT). Change scores were calculated for the cognitive domains "global cognitive functioning," "memory," "working memory," "attention," and "executive function." These domain-specific change scores were correlated with previously defined preoperative parameters. Compared with the BMT group (63 patients), the STN-DBS group (60 patients) showed a significant decline only in the domain executive function 6 months after DBS, which was significantly correlated with age, levodopa-equivalence dosage (LED) and axial subscore of the UPDRS in the off-medication state at baseline. Multiple regression analysis showed that these three factors explained, however, only about 23% of the variance. Patients with higher age, higher baseline LED, and/or higher axial subscore of the UPDRS at baseline have an increased risk for worsening of executive function after STN-DBS. High scores of these factors might reflect an advanced stage of disease progression. As these baseline factors explained the variance of the change score executive function only to a minor proportion, other factors including the surgical procedure, the exact placement of the electrode or postsurgical management might be more relevant for a decline in executive functioning after STN-DBS.</div></front></TEI></HAL><ISTEX><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Risk factors for executive dysfunction after subthalamic nucleus stimulation in Parkinson's disease</title><author><name sortKey="Daniels, Christine" sort="Daniels, Christine" uniqKey="Daniels C" first="Christine" last="Daniels">Christine Daniels</name></author><author><name sortKey="Krack, Paul" sort="Krack, Paul" uniqKey="Krack P" first="Paul" last="Krack">Paul Krack</name></author><author><name sortKey="Volkmann, Jens" sort="Volkmann, Jens" uniqKey="Volkmann J" first="Jens" last="Volkmann">Jens Volkmann</name></author><author><name sortKey="Pinsker, Markus O" sort="Pinsker, Markus O" uniqKey="Pinsker M" first="Markus O." last="Pinsker">Markus O. Pinsker</name></author><author><name sortKey="Krause, Martin" sort="Krause, Martin" uniqKey="Krause M" first="Martin" last="Krause">Martin Krause</name></author><author><name sortKey="Tronnier, Volker" sort="Tronnier, Volker" uniqKey="Tronnier V" first="Volker" last="Tronnier">Volker Tronnier</name></author><author><name sortKey="Kloss, Manja" sort="Kloss, Manja" uniqKey="Kloss M" first="Manja" last="Kloss">Manja Kloss</name></author><author><name sortKey="Schnitzler, Alfons" sort="Schnitzler, Alfons" uniqKey="Schnitzler A" first="Alfons" last="Schnitzler">Alfons Schnitzler</name></author><author><name sortKey="Wojtecki, Lars" sort="Wojtecki, Lars" uniqKey="Wojtecki L" first="Lars" last="Wojtecki">Lars Wojtecki</name></author><author><name sortKey="Botzel, Kai" sort="Botzel, Kai" uniqKey="Botzel K" first="Kai" last="Bötzel">Kai Bötzel</name></author><author><name sortKey="Danek, Adrian" sort="Danek, Adrian" uniqKey="Danek A" first="Adrian" last="Danek">Adrian Danek</name></author><author><name sortKey="Hilker, Rudiger" sort="Hilker, Rudiger" uniqKey="Hilker R" first="Rüdiger" last="Hilker">Rüdiger Hilker</name></author><author><name sortKey="Sturm, Volker" sort="Sturm, Volker" uniqKey="Sturm V" first="Volker" last="Sturm">Volker Sturm</name></author><author><name sortKey="Kupsch, Andreas" sort="Kupsch, Andreas" uniqKey="Kupsch A" first="Andreas" last="Kupsch">Andreas Kupsch</name></author><author><name sortKey="Karner, Elfriede" sort="Karner, Elfriede" uniqKey="Karner E" first="Elfriede" last="Karner">Elfriede Karner</name></author><author><name sortKey="Deuschl, Gunther" sort="Deuschl, Gunther" uniqKey="Deuschl G" first="Günther" last="Deuschl">Günther Deuschl</name></author><author><name sortKey="Witt, Karsten" sort="Witt, Karsten" uniqKey="Witt K" first="Karsten" last="Witt">Karsten Witt</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:93BD43D9A68C911E46F438EAA53F9605C4BC45CC</idno><date when="2010" year="2010">2010</date><idno type="doi">10.1002/mds.23078</idno><idno type="url">https://api.istex.fr/document/93BD43D9A68C911E46F438EAA53F9605C4BC45CC/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">000943</idno><idno type="wicri:Area/Istex/Curation">000943</idno><idno type="wicri:Area/Istex/Checkpoint">000705</idno><idno type="wicri:doubleKey">0885-3185:2010:Daniels C:risk:factors:for</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Risk factors for executive dysfunction after subthalamic nucleus stimulation in Parkinson's disease</title><author><name sortKey="Daniels, Christine" sort="Daniels, Christine" uniqKey="Daniels C" first="Christine" last="Daniels">Christine Daniels</name><affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, Christian‐Albrechts‐University, Kiel</wicri:regionArea><placeName><region type="land" nuts="2">Schleswig-Holstein</region><settlement type="city">Kiel</settlement></placeName></affiliation></author><author><name sortKey="Krack, Paul" sort="Krack, Paul" uniqKey="Krack P" first="Paul" last="Krack">Paul Krack</name><affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, Christian‐Albrechts‐University, Kiel</wicri:regionArea><placeName><region type="land" nuts="2">Schleswig-Holstein</region><settlement type="city">Kiel</settlement></placeName></affiliation></author><author><name sortKey="Volkmann, Jens" sort="Volkmann, Jens" uniqKey="Volkmann J" first="Jens" last="Volkmann">Jens Volkmann</name><affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, Christian‐Albrechts‐University, Kiel</wicri:regionArea><placeName><region type="land" nuts="2">Schleswig-Holstein</region><settlement type="city">Kiel</settlement></placeName></affiliation></author><author><name sortKey="Pinsker, Markus O" sort="Pinsker, Markus O" uniqKey="Pinsker M" first="Markus O." last="Pinsker">Markus O. Pinsker</name><affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurosurgery, Christian‐Albrechts‐University, Kiel</wicri:regionArea><placeName><region type="land" nuts="2">Schleswig-Holstein</region><settlement type="city">Kiel</settlement></placeName></affiliation></author><author><name sortKey="Krause, Martin" sort="Krause, Martin" uniqKey="Krause M" first="Martin" last="Krause">Martin Krause</name><affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, Heidelberg University, Heidelberg</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Heidelberg</settlement></placeName></affiliation></author><author><name sortKey="Tronnier, Volker" sort="Tronnier, Volker" uniqKey="Tronnier V" first="Volker" last="Tronnier">Volker Tronnier</name><affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurosurgery, Heidelberg University, Heidelberg</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Heidelberg</settlement></placeName></affiliation></author><author><name sortKey="Kloss, Manja" sort="Kloss, Manja" uniqKey="Kloss M" first="Manja" last="Kloss">Manja Kloss</name><affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, Heidelberg University, Heidelberg</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Heidelberg</settlement></placeName></affiliation></author><author><name sortKey="Schnitzler, Alfons" sort="Schnitzler, Alfons" uniqKey="Schnitzler A" first="Alfons" last="Schnitzler">Alfons Schnitzler</name><affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, Heinrich Heine University, Dusseldorf</wicri:regionArea><wicri:noRegion>Dusseldorf</wicri:noRegion><wicri:noRegion>Dusseldorf</wicri:noRegion></affiliation></author><author><name sortKey="Wojtecki, Lars" sort="Wojtecki, Lars" uniqKey="Wojtecki L" first="Lars" last="Wojtecki">Lars Wojtecki</name><affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, Heinrich Heine University, Dusseldorf</wicri:regionArea><wicri:noRegion>Dusseldorf</wicri:noRegion><wicri:noRegion>Dusseldorf</wicri:noRegion></affiliation></author><author><name sortKey="Botzel, Kai" sort="Botzel, Kai" uniqKey="Botzel K" first="Kai" last="Bötzel">Kai Bötzel</name><affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, Ludwig‐Maximilians‐University, Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName></affiliation></author><author><name sortKey="Danek, Adrian" sort="Danek, Adrian" uniqKey="Danek A" first="Adrian" last="Danek">Adrian Danek</name><affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, Ludwig‐Maximilians‐University, Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName></affiliation></author><author><name sortKey="Hilker, Rudiger" sort="Hilker, Rudiger" uniqKey="Hilker R" first="Rüdiger" last="Hilker">Rüdiger Hilker</name><affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, Cologne University, Cologne</wicri:regionArea><wicri:noRegion>Cologne</wicri:noRegion><wicri:noRegion>Cologne</wicri:noRegion></affiliation></author><author><name sortKey="Sturm, Volker" sort="Sturm, Volker" uniqKey="Sturm V" first="Volker" last="Sturm">Volker Sturm</name><affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurosurgery, Cologne University, Cologne</wicri:regionArea><wicri:noRegion>Cologne</wicri:noRegion><wicri:noRegion>Cologne</wicri:noRegion></affiliation></author><author><name sortKey="Kupsch, Andreas" sort="Kupsch, Andreas" uniqKey="Kupsch A" first="Andreas" last="Kupsch">Andreas Kupsch</name><affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, Charité Hospital, Humboldt University, Berlin</wicri:regionArea><placeName><region type="land" nuts="3">Berlin</region><settlement type="city">Berlin</settlement></placeName></affiliation></author><author><name sortKey="Karner, Elfriede" sort="Karner, Elfriede" uniqKey="Karner E" first="Elfriede" last="Karner">Elfriede Karner</name><affiliation wicri:level="1"><country xml:lang="fr">Autriche</country><wicri:regionArea>Department of Neurology, Innsbruck Medical University, Innsbruck</wicri:regionArea><wicri:noRegion>Innsbruck</wicri:noRegion></affiliation></author><author><name sortKey="Deuschl, Gunther" sort="Deuschl, Gunther" uniqKey="Deuschl G" first="Günther" last="Deuschl">Günther Deuschl</name><affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, Christian‐Albrechts‐University, Kiel</wicri:regionArea><placeName><region type="land" nuts="2">Schleswig-Holstein</region><settlement type="city">Kiel</settlement></placeName></affiliation></author><author><name sortKey="Witt, Karsten" sort="Witt, Karsten" uniqKey="Witt K" first="Karsten" last="Witt">Karsten Witt</name><affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, Christian‐Albrechts‐University, Kiel</wicri:regionArea><placeName><region type="land" nuts="2">Schleswig-Holstein</region><settlement type="city">Kiel</settlement></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2010-08-15">2010-08-15</date><biblScope unit="vol">25</biblScope><biblScope unit="issue">11</biblScope><biblScope unit="page" from="1583">1583</biblScope><biblScope unit="page" to="1589">1589</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">93BD43D9A68C911E46F438EAA53F9605C4BC45CC</idno><idno type="DOI">10.1002/mds.23078</idno><idno type="ArticleID">MDS23078</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Parkinson's disease</term><term>deep brain stimulation</term><term>executive functions</term><term>subthalamic nucleus</term><term>verbal fluency</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">A slight decline in cognitive functions and especially in executive functioning after deep brain stimulation (DBS) of the nucleus subthalamicus (STN) in patients with Parkinson's disease (PD) has been described. This study evaluated baseline parameters that contribute to a deterioration of cognitive functioning after DBS. We analyzed data from the neuropsychological protocol in a randomized controlled study comparing DBS with best medical treatment (BMT). Change scores were calculated for the cognitive domains “global cognitive functioning,” “memory,” “working memory,” “attention,” and “executive function.” These domain‐specific change scores were correlated with previously defined preoperative parameters. Compared with the BMT group (63 patients), the STN‐DBS group (60 patients) showed a significant decline only in the domain executive function 6 months after DBS, which was significantly correlated with age, levodopa‐equivalence dosage (LED) and axial subscore of the UPDRS in the off‐medication state at baseline. Multiple regression analysis showed that these three factors explained, however, only about 23% of the variance. Patients with higher age, higher baseline LED, and/or higher axial subscore of the UPDRS at baseline have an increased risk for worsening of executive function after STN‐DBS. High scores of these factors might reflect an advanced stage of disease progression. As these baseline factors explained the variance of the change score executive function only to a minor proportion, other factors including the surgical procedure, the exact placement of the electrode or postsurgical management might be more relevant for a decline in executive functioning after STN‐DBS. © 2010 Movement Disorder Society</div></front></TEI></ISTEX><PubMed><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Risk factors for executive dysfunction after subthalamic nucleus stimulation in Parkinson's disease.</title><author><name sortKey="Daniels, Christine" sort="Daniels, Christine" uniqKey="Daniels C" first="Christine" last="Daniels">Christine Daniels</name><affiliation wicri:level="3"><nlm:affiliation>Department of Neurology, Christian-Albrechts-University, Kiel, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, Christian-Albrechts-University, Kiel</wicri:regionArea><placeName><region type="land" nuts="2">Schleswig-Holstein</region><settlement type="city">Kiel</settlement></placeName></affiliation></author><author><name sortKey="Krack, Paul" sort="Krack, Paul" uniqKey="Krack P" first="Paul" last="Krack">Paul Krack</name></author><author><name sortKey="Volkmann, Jens" sort="Volkmann, Jens" uniqKey="Volkmann J" first="Jens" last="Volkmann">Jens Volkmann</name></author><author><name sortKey="Pinsker, Markus O" sort="Pinsker, Markus O" uniqKey="Pinsker M" first="Markus O" last="Pinsker">Markus O. Pinsker</name></author><author><name sortKey="Krause, Martin" sort="Krause, Martin" uniqKey="Krause M" first="Martin" last="Krause">Martin Krause</name></author><author><name sortKey="Tronnier, Volker" sort="Tronnier, Volker" uniqKey="Tronnier V" first="Volker" last="Tronnier">Volker Tronnier</name></author><author><name sortKey="Kloss, Manja" sort="Kloss, Manja" uniqKey="Kloss M" first="Manja" last="Kloss">Manja Kloss</name></author><author><name sortKey="Schnitzler, Alfons" sort="Schnitzler, Alfons" uniqKey="Schnitzler A" first="Alfons" last="Schnitzler">Alfons Schnitzler</name></author><author><name sortKey="Wojtecki, Lars" sort="Wojtecki, Lars" uniqKey="Wojtecki L" first="Lars" last="Wojtecki">Lars Wojtecki</name></author><author><name sortKey="Botzel, Kai" sort="Botzel, Kai" uniqKey="Botzel K" first="Kai" last="Bötzel">Kai Bötzel</name></author><author><name sortKey="Danek, Adrian" sort="Danek, Adrian" uniqKey="Danek A" first="Adrian" last="Danek">Adrian Danek</name></author><author><name sortKey="Hilker, Rudiger" sort="Hilker, Rudiger" uniqKey="Hilker R" first="Rüdiger" last="Hilker">Rüdiger Hilker</name></author><author><name sortKey="Sturm, Volker" sort="Sturm, Volker" uniqKey="Sturm V" first="Volker" last="Sturm">Volker Sturm</name></author><author><name sortKey="Kupsch, Andreas" sort="Kupsch, Andreas" uniqKey="Kupsch A" first="Andreas" last="Kupsch">Andreas Kupsch</name></author><author><name sortKey="Karner, Elfriede" sort="Karner, Elfriede" uniqKey="Karner E" first="Elfriede" last="Karner">Elfriede Karner</name></author><author><name sortKey="Deuschl, Gunther" sort="Deuschl, Gunther" uniqKey="Deuschl G" first="Günther" last="Deuschl">Günther Deuschl</name></author><author><name sortKey="Witt, Karsten" sort="Witt, Karsten" uniqKey="Witt K" first="Karsten" last="Witt">Karsten Witt</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2010">2010</date><idno type="doi">10.1002/mds.23078</idno><idno type="RBID">pubmed:20589868</idno><idno type="pmid">20589868</idno><idno type="wicri:Area/PubMed/Corpus">001788</idno><idno type="wicri:Area/PubMed/Curation">001788</idno><idno type="wicri:Area/PubMed/Checkpoint">001632</idno><idno type="wicri:Area/Ncbi/Merge">002C29</idno><idno type="wicri:Area/Ncbi/Curation">002C29</idno><idno type="wicri:Area/Ncbi/Checkpoint">002C29</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Risk factors for executive dysfunction after subthalamic nucleus stimulation in Parkinson's disease.</title><author><name sortKey="Daniels, Christine" sort="Daniels, Christine" uniqKey="Daniels C" first="Christine" last="Daniels">Christine Daniels</name><affiliation wicri:level="3"><nlm:affiliation>Department of Neurology, Christian-Albrechts-University, Kiel, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, Christian-Albrechts-University, Kiel</wicri:regionArea><placeName><region type="land" nuts="2">Schleswig-Holstein</region><settlement type="city">Kiel</settlement></placeName></affiliation></author><author><name sortKey="Krack, Paul" sort="Krack, Paul" uniqKey="Krack P" first="Paul" last="Krack">Paul Krack</name></author><author><name sortKey="Volkmann, Jens" sort="Volkmann, Jens" uniqKey="Volkmann J" first="Jens" last="Volkmann">Jens Volkmann</name></author><author><name sortKey="Pinsker, Markus O" sort="Pinsker, Markus O" uniqKey="Pinsker M" first="Markus O" last="Pinsker">Markus O. Pinsker</name></author><author><name sortKey="Krause, Martin" sort="Krause, Martin" uniqKey="Krause M" first="Martin" last="Krause">Martin Krause</name></author><author><name sortKey="Tronnier, Volker" sort="Tronnier, Volker" uniqKey="Tronnier V" first="Volker" last="Tronnier">Volker Tronnier</name></author><author><name sortKey="Kloss, Manja" sort="Kloss, Manja" uniqKey="Kloss M" first="Manja" last="Kloss">Manja Kloss</name></author><author><name sortKey="Schnitzler, Alfons" sort="Schnitzler, Alfons" uniqKey="Schnitzler A" first="Alfons" last="Schnitzler">Alfons Schnitzler</name></author><author><name sortKey="Wojtecki, Lars" sort="Wojtecki, Lars" uniqKey="Wojtecki L" first="Lars" last="Wojtecki">Lars Wojtecki</name></author><author><name sortKey="Botzel, Kai" sort="Botzel, Kai" uniqKey="Botzel K" first="Kai" last="Bötzel">Kai Bötzel</name></author><author><name sortKey="Danek, Adrian" sort="Danek, Adrian" uniqKey="Danek A" first="Adrian" last="Danek">Adrian Danek</name></author><author><name sortKey="Hilker, Rudiger" sort="Hilker, Rudiger" uniqKey="Hilker R" first="Rüdiger" last="Hilker">Rüdiger Hilker</name></author><author><name sortKey="Sturm, Volker" sort="Sturm, Volker" uniqKey="Sturm V" first="Volker" last="Sturm">Volker Sturm</name></author><author><name sortKey="Kupsch, Andreas" sort="Kupsch, Andreas" uniqKey="Kupsch A" first="Andreas" last="Kupsch">Andreas Kupsch</name></author><author><name sortKey="Karner, Elfriede" sort="Karner, Elfriede" uniqKey="Karner E" first="Elfriede" last="Karner">Elfriede Karner</name></author><author><name sortKey="Deuschl, Gunther" sort="Deuschl, Gunther" uniqKey="Deuschl G" first="Günther" last="Deuschl">Günther Deuschl</name></author><author><name sortKey="Witt, Karsten" sort="Witt, Karsten" uniqKey="Witt K" first="Karsten" last="Witt">Karsten Witt</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="eISSN">1531-8257</idno><imprint><date when="2010" type="published">2010</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Cognition Disorders (etiology)</term><term>Deep Brain Stimulation (adverse effects)</term><term>Executive Function (physiology)</term><term>Female</term><term>Follow-Up Studies</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Neuropsychological Tests</term><term>Parkinson Disease (physiopathology)</term><term>Parkinson Disease (therapy)</term><term>Risk Factors</term><term>Statistics as Topic</term><term>Subthalamic Nucleus (physiology)</term></keywords><keywords scheme="MESH" qualifier="adverse effects" xml:lang="en"><term>Deep Brain Stimulation</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Cognition Disorders</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Executive Function</term><term>Subthalamic Nucleus</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Female</term><term>Follow-Up Studies</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Neuropsychological Tests</term><term>Risk Factors</term><term>Statistics as Topic</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">A slight decline in cognitive functions and especially in executive functioning after deep brain stimulation (DBS) of the nucleus subthalamicus (STN) in patients with Parkinson's disease (PD) has been described. This study evaluated baseline parameters that contribute to a deterioration of cognitive functioning after DBS. We analyzed data from the neuropsychological protocol in a randomized controlled study comparing DBS with best medical treatment (BMT). Change scores were calculated for the cognitive domains "global cognitive functioning," "memory," "working memory," "attention," and "executive function." These domain-specific change scores were correlated with previously defined preoperative parameters. Compared with the BMT group (63 patients), the STN-DBS group (60 patients) showed a significant decline only in the domain executive function 6 months after DBS, which was significantly correlated with age, levodopa-equivalence dosage (LED) and axial subscore of the UPDRS in the off-medication state at baseline. Multiple regression analysis showed that these three factors explained, however, only about 23% of the variance. Patients with higher age, higher baseline LED, and/or higher axial subscore of the UPDRS at baseline have an increased risk for worsening of executive function after STN-DBS. High scores of these factors might reflect an advanced stage of disease progression. As these baseline factors explained the variance of the change score executive function only to a minor proportion, other factors including the surgical procedure, the exact placement of the electrode or postsurgical management might be more relevant for a decline in executive functioning after STN-DBS.</div></front></TEI></PubMed></double></record>Pour manipuler ce document sous Unix (Dilib)
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