MovDisordV3, Main, Merge, bibRecord, 001D14

Accuracy of Magnetic Resonance Parkinsonism Index for Differentiation of Progressive Supranuclear Palsy from Probable or Possible Parkinson Disease

Identifieur interne : 001D14 ( Main/Merge ); précédent : 001D13; suivant : 001D15

Accuracy of Magnetic Resonance Parkinsonism Index for Differentiation of Progressive Supranuclear Palsy from Probable or Possible Parkinson Disease

Auteurs : Maurizio Morelli [Italie] ; Gennarina Arabia [Italie] ; Maria Salsone [Italie] ; Fabiana Novellino [Italie] ; Laura Giofre [Italie] ; Rosina Paletta [Italie] ; Demetrio Messina [Italie] ; Giuseppe Nicoletti [Italie] ; Francesca Condino [Italie] ; Olivier Gallo [Italie] ; Pierluigi Lanza [Italie] ; Aldo Quattrone [Italie]

Source :

Movement disorders [ 0885-3185 ] ; 2011.

RBID : Pascal:11-0211291

Descripteurs français

Pascal (Inist)
- Parkinsonisme, Maladie de Parkinson, Pathologie du système nerveux, Précision, Ophtalmoplégie supranucléaire, Mésencéphale.

English descriptors

KwdEn :
- Accuracy, Midbrain, Nervous system diseases, Parkinson disease, Parkinsonism, Supranuclear ophthalmoplegia.

Abstract

Background: Combined measurements on conventional magnetic resonance imaging (MRI), such as midbrain area/pons area or magnetic resonance parkinsonism index (MRPI) (pons area/midbrain area x middle cerebellar peduncle width/superior cerebellar peduncle width), have been proposed as powerful tools in the differential diagnosis between progressive supranuclear palsy (PSP) and Parkinson disease (PD). In this study, we evaluated the accuracy of MRPI, compared with midbrain/pons ratio, in distinguishing PSP from probable and possible PD. Methods: Forty-two PSP patients, 170 probable PD patients, 132 possible PD patients, and 38 control subjects underwent MRI and, for each patient, midbrain/ pons ratio and MRPI were calculated. Results: Midbrain/pons ratio showed low accuracy in distinguishing PSP patients from those with probable PD (92.9% sensitivity; 85.3% specificity; 86.8% diagnostic accuracy) or those with possible PD (88.1 % sensitivity, 88.3% specificity, and 88.2% diagnostic accuracy) and control subjects (97.6% sensitivity, 92.1 % specificity, and 95% diagnostic accuracy). By contrast, MRPI showed higher accuracy to distinguish PSP from probable PD (100% sensitivity, 99.4% specificity, and 99.5% diagnostic accuracy), from possible PD (100% sensitivity, 99.2% specificity, and 99.4% diagnostic accuracy), and from control subjects (sensitivity, specificity, and diagnostic accuracy of 100%). Conclusions: Our study confirms that MRPI is a more accurate measure than midbrain/pons ratio for differentiation of patients with PSP from those with probable and possible PD.

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Pascal:11-0211291

Le document en format XML

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<term>Parkinsonism</term>
<term>Supranuclear ophthalmoplegia</term>
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<keywords scheme="Pascal" xml:lang="fr"><term>Parkinsonisme</term>
<term>Maladie de Parkinson</term>
<term>Pathologie du   système nerveux</term>
<term>Précision</term>
<term>Ophtalmoplégie supranucléaire</term>
<term>Mésencéphale</term>
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<front><div type="abstract" xml:lang="en">Background: Combined measurements on conventional magnetic resonance imaging (MRI), such as midbrain area/pons area or magnetic resonance parkinsonism index (MRPI) (pons area/midbrain area x middle cerebellar peduncle width/superior cerebellar peduncle width), have been proposed as powerful tools in the differential diagnosis between progressive supranuclear palsy (PSP) and Parkinson disease (PD). In this study, we evaluated the accuracy of MRPI, compared with midbrain/pons ratio, in distinguishing PSP from probable and possible PD. Methods: Forty-two PSP patients, 170 probable PD patients, 132 possible PD patients, and 38 control subjects underwent MRI and, for each patient, midbrain/ pons ratio and MRPI were calculated. Results: Midbrain/pons ratio showed low accuracy in distinguishing PSP patients from those with probable PD (92.9% sensitivity; 85.3% specificity; 86.8% diagnostic accuracy) or those with possible PD (88.1 % sensitivity, 88.3% specificity, and 88.2% diagnostic accuracy) and control subjects (97.6% sensitivity, 92.1 % specificity, and 95% diagnostic accuracy). By contrast, MRPI showed higher accuracy to distinguish PSP from probable PD (100% sensitivity, 99.4% specificity, and 99.5% diagnostic accuracy), from possible PD (100% sensitivity, 99.2% specificity, and 99.4% diagnostic accuracy), and from control subjects (sensitivity, specificity, and diagnostic accuracy of 100%). Conclusions: Our study confirms that MRPI is a more accurate measure than midbrain/pons ratio for differentiation of patients with PSP from those with probable and possible PD.</div>
</front>
</TEI>
<affiliations><list><country><li>Italie</li>
</country>
</list>
<tree><country name="Italie"><noRegion><name sortKey="Morelli, Maurizio" sort="Morelli, Maurizio" uniqKey="Morelli M" first="Maurizio" last="Morelli">Maurizio Morelli</name>
</noRegion>
<name sortKey="Arabia, Gennarina" sort="Arabia, Gennarina" uniqKey="Arabia G" first="Gennarina" last="Arabia">Gennarina Arabia</name>
<name sortKey="Condino, Francesca" sort="Condino, Francesca" uniqKey="Condino F" first="Francesca" last="Condino">Francesca Condino</name>
<name sortKey="Gallo, Olivier" sort="Gallo, Olivier" uniqKey="Gallo O" first="Olivier" last="Gallo">Olivier Gallo</name>
<name sortKey="Giofre, Laura" sort="Giofre, Laura" uniqKey="Giofre L" first="Laura" last="Giofre">Laura Giofre</name>
<name sortKey="Lanza, Pierluigi" sort="Lanza, Pierluigi" uniqKey="Lanza P" first="Pierluigi" last="Lanza">Pierluigi Lanza</name>
<name sortKey="Messina, Demetrio" sort="Messina, Demetrio" uniqKey="Messina D" first="Demetrio" last="Messina">Demetrio Messina</name>
<name sortKey="Nicoletti, Giuseppe" sort="Nicoletti, Giuseppe" uniqKey="Nicoletti G" first="Giuseppe" last="Nicoletti">Giuseppe Nicoletti</name>
<name sortKey="Novellino, Fabiana" sort="Novellino, Fabiana" uniqKey="Novellino F" first="Fabiana" last="Novellino">Fabiana Novellino</name>
<name sortKey="Paletta, Rosina" sort="Paletta, Rosina" uniqKey="Paletta R" first="Rosina" last="Paletta">Rosina Paletta</name>
<name sortKey="Quattrone, Aldo" sort="Quattrone, Aldo" uniqKey="Quattrone A" first="Aldo" last="Quattrone">Aldo Quattrone</name>
<name sortKey="Quattrone, Aldo" sort="Quattrone, Aldo" uniqKey="Quattrone A" first="Aldo" last="Quattrone">Aldo Quattrone</name>
<name sortKey="Salsone, Maria" sort="Salsone, Maria" uniqKey="Salsone M" first="Maria" last="Salsone">Maria Salsone</name>
</country>
</tree>
</affiliations>
</record>

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Movement Disorders (revue)

Accuracy of Magnetic Resonance Parkinsonism Index for Differentiation of Progressive Supranuclear Palsy from Probable or Possible Parkinson Disease

Accuracy of Magnetic Resonance Parkinsonism Index for Differentiation of Progressive Supranuclear Palsy from Probable or Possible Parkinson Disease

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