MovDisordV3, Main, Merge, bibRecord, 001C34

Decreased Striatal Dopamine Receptor Binding in Primary Focal Dystonia: A D2 or D3 Defect?

Identifieur interne : 001C34 ( Main/Merge ); précédent : 001C33; suivant : 001C35

Decreased Striatal Dopamine Receptor Binding in Primary Focal Dystonia: A D2 or D3 Defect?

Auteurs : Morvarid Karimi [États-Unis] ; Stephen M. Moerlein [États-Unis] ; Tom O. Videen [États-Unis] ; Robert R. Luedtke [États-Unis] ; Michelle Taylor [États-Unis] ; Robert H. Mach [États-Unis] ; Joel S. Perlmutter [États-Unis]

Source :

Movement disorders [ 0885-3185 ] ; 2011.

RBID : Pascal:11-0143221

Descripteurs français

Pascal (Inist)
- Dystonie, Pathologie du système nerveux, Récepteur dopaminergique, Dopamine, Récepteur dopaminergique D2, Récepteur dopaminergique D3, Tomoscintigraphie, Tomographie par émission de positons.

English descriptors

KwdEn :
- D2 Dopamine receptor, D3 Dopamine receptor, Dopamine, Dopamine receptor, Dystonia, Emission tomography, Nervous system diseases, Positron emission tomography.

Abstract

Dystonia is an involuntary movement disorder characterized by repetitive patterned or sustained muscle contractions causing twisting or abnormal postures. Several lines of evidence suggest that abnormalities of dopaminergic pathways contribute to the pathophysiology of dystonia. In particular, dysfunction of D2-like receptors that mediate function of the indirect pathway in the basal ganglia may play a key role. We have demonstrated with positron emission tomography that patients with primary focal cranial or hand dystonia have reduced putamenal specific binding of [¹⁸F]spiperone, a nonselective D2-like radioligand with nearly equal affinity for serotonergic 5-HT(2A) sites. We then repeated the study with [¹⁸F]N-methyl-benperidol (NMB), a more selective D2-like receptor radioligand with minimal affinity for 5-HT(2A). Surprisingly, there was no decrease in NMB binding in the putamen of subjects with dystonia. Our findings excluded reductions of putamenal uptake greater than 20% with 95% confidence intervals. The analysis of the in vitro selectivity of NMB and spiperone demonstrated that NMB was highly selective for D2 receptors relative to D3 receptors (200-fold difference in affinity), whereas spiperone has similar affinity for all three of the D2-like receptor subtypes. These findings when coupled with other literature suggest that a defect in D3, rather than D2, receptor expression may be associated with primary focal dystonia.

Links toward previous steps (curation, corpus...)

to stream PascalFrancis, to step Corpus: 000737
to stream PascalFrancis, to step Curation: 002581
to stream PascalFrancis, to step Checkpoint: 000644

Links to Exploration step

Pascal:11-0143221

Le document en format XML

<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">Decreased Striatal Dopamine Receptor Binding in Primary Focal Dystonia: A D2 or D3 Defect?</title>
<author><name sortKey="Karimi, Morvarid" sort="Karimi, Morvarid" uniqKey="Karimi M" first="Morvarid" last="Karimi">Morvarid Karimi</name>
<affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Department of Neurology, Washington University School of Medicine</s1>
<s2>Saint Louis, Missouri</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>7 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Missouri (État)</region>
<settlement type="city">Saint-Louis (Missouri)</settlement>
</placeName>
<orgName type="university">École de médecine (Université Washington de Saint-Louis)</orgName>
</affiliation>
</author>
<author><name sortKey="Moerlein, Stephen M" sort="Moerlein, Stephen M" uniqKey="Moerlein S" first="Stephen M." last="Moerlein">Stephen M. Moerlein</name>
<affiliation wicri:level="4"><inist:fA14 i1="02"><s1>Mallinckrodt Institute of Radiology, Washington University School of Medicine</s1>
<s2>Saint Louis, Missouri</s2>
<s3>USA</s3>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Missouri (État)</region>
<settlement type="city">Saint-Louis (Missouri)</settlement>
</placeName>
<orgName type="university">École de médecine (Université Washington de Saint-Louis)</orgName>
</affiliation>
<affiliation wicri:level="4"><inist:fA14 i1="03"><s1>Department of Biochemistry and Molecular Biophysics, Washington University School of Medicine</s1>
<s2>Saint Louis, Missouri</s2>
<s3>USA</s3>
<sZ>2 aut.</sZ>
<sZ>6 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Missouri (État)</region>
<settlement type="city">Saint-Louis (Missouri)</settlement>
</placeName>
<orgName type="university">École de médecine (Université Washington de Saint-Louis)</orgName>
</affiliation>
</author>
<author><name sortKey="Videen, Tom O" sort="Videen, Tom O" uniqKey="Videen T" first="Tom O." last="Videen">Tom O. Videen</name>
<affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Department of Neurology, Washington University School of Medicine</s1>
<s2>Saint Louis, Missouri</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>7 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Missouri (État)</region>
<settlement type="city">Saint-Louis (Missouri)</settlement>
</placeName>
<orgName type="university">École de médecine (Université Washington de Saint-Louis)</orgName>
</affiliation>
<affiliation wicri:level="4"><inist:fA14 i1="02"><s1>Mallinckrodt Institute of Radiology, Washington University School of Medicine</s1>
<s2>Saint Louis, Missouri</s2>
<s3>USA</s3>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Missouri (État)</region>
<settlement type="city">Saint-Louis (Missouri)</settlement>
</placeName>
<orgName type="university">École de médecine (Université Washington de Saint-Louis)</orgName>
</affiliation>
</author>
<author><name sortKey="Luedtke, Robert R" sort="Luedtke, Robert R" uniqKey="Luedtke R" first="Robert R." last="Luedtke">Robert R. Luedtke</name>
<affiliation wicri:level="2"><inist:fA14 i1="04"><s1>Department of Pharmacology and Neuroscience, University of North Texas Health Science Center</s1>
<s2>Fort Worth, Texas</s2>
<s3>USA</s3>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Texas</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Taylor, Michelle" sort="Taylor, Michelle" uniqKey="Taylor M" first="Michelle" last="Taylor">Michelle Taylor</name>
<affiliation wicri:level="2"><inist:fA14 i1="04"><s1>Department of Pharmacology and Neuroscience, University of North Texas Health Science Center</s1>
<s2>Fort Worth, Texas</s2>
<s3>USA</s3>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Texas</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Mach, Robert H" sort="Mach, Robert H" uniqKey="Mach R" first="Robert H." last="Mach">Robert H. Mach</name>
<affiliation wicri:level="4"><inist:fA14 i1="02"><s1>Mallinckrodt Institute of Radiology, Washington University School of Medicine</s1>
<s2>Saint Louis, Missouri</s2>
<s3>USA</s3>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Missouri (État)</region>
<settlement type="city">Saint-Louis (Missouri)</settlement>
</placeName>
<orgName type="university">École de médecine (Université Washington de Saint-Louis)</orgName>
</affiliation>
<affiliation wicri:level="4"><inist:fA14 i1="03"><s1>Department of Biochemistry and Molecular Biophysics, Washington University School of Medicine</s1>
<s2>Saint Louis, Missouri</s2>
<s3>USA</s3>
<sZ>2 aut.</sZ>
<sZ>6 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Missouri (État)</region>
<settlement type="city">Saint-Louis (Missouri)</settlement>
</placeName>
<orgName type="university">École de médecine (Université Washington de Saint-Louis)</orgName>
</affiliation>
<affiliation wicri:level="4"><inist:fA14 i1="05"><s1>Department of Cell Biology and Physiology, Washington University School of Medicine</s1>
<s2>Saint Louis, Missouri</s2>
<s3>USA</s3>
<sZ>6 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Missouri (État)</region>
<settlement type="city">Saint-Louis (Missouri)</settlement>
</placeName>
<orgName type="university">École de médecine (Université Washington de Saint-Louis)</orgName>
</affiliation>
</author>
<author><name sortKey="Perlmutter, Joel S" sort="Perlmutter, Joel S" uniqKey="Perlmutter J" first="Joel S." last="Perlmutter">Joel S. Perlmutter</name>
<affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Department of Neurology, Washington University School of Medicine</s1>
<s2>Saint Louis, Missouri</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>7 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Missouri (État)</region>
<settlement type="city">Saint-Louis (Missouri)</settlement>
</placeName>
<orgName type="university">École de médecine (Université Washington de Saint-Louis)</orgName>
</affiliation>
<affiliation wicri:level="4"><inist:fA14 i1="02"><s1>Mallinckrodt Institute of Radiology, Washington University School of Medicine</s1>
<s2>Saint Louis, Missouri</s2>
<s3>USA</s3>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Missouri (État)</region>
<settlement type="city">Saint-Louis (Missouri)</settlement>
</placeName>
<orgName type="university">École de médecine (Université Washington de Saint-Louis)</orgName>
</affiliation>
<affiliation wicri:level="4"><inist:fA14 i1="06"><s1>Department of Neurobiology, Washington University School of Medicine</s1>
<s2>Saint Louis, Missouri</s2>
<s3>USA</s3>
<sZ>7 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Missouri (État)</region>
<settlement type="city">Saint-Louis (Missouri)</settlement>
</placeName>
<orgName type="university">École de médecine (Université Washington de Saint-Louis)</orgName>
</affiliation>
<affiliation wicri:level="4"><inist:fA14 i1="07"><s1>Department of Occupational Therapy, Washington University School of Medicine</s1>
<s2>Saint Louis, Missouri</s2>
<s3>USA</s3>
<sZ>7 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Missouri (État)</region>
<settlement type="city">Saint-Louis (Missouri)</settlement>
</placeName>
<orgName type="university">École de médecine (Université Washington de Saint-Louis)</orgName>
</affiliation>
<affiliation wicri:level="4"><inist:fA14 i1="08"><s1>Department of Physical Therapy, Washington University School of Medicine</s1>
<s2>Saint Louis, Missouri</s2>
<s3>USA</s3>
<sZ>7 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Missouri (État)</region>
<settlement type="city">Saint-Louis (Missouri)</settlement>
</placeName>
<orgName type="university">École de médecine (Université Washington de Saint-Louis)</orgName>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">INIST</idno>
<idno type="inist">11-0143221</idno>
<date when="2011">2011</date>
<idno type="stanalyst">PASCAL 11-0143221 INIST</idno>
<idno type="RBID">Pascal:11-0143221</idno>
<idno type="wicri:Area/PascalFrancis/Corpus">000737</idno>
<idno type="wicri:Area/PascalFrancis/Curation">002581</idno>
<idno type="wicri:Area/PascalFrancis/Checkpoint">000644</idno>
<idno type="wicri:doubleKey">0885-3185:2011:Karimi M:decreased:striatal:dopamine</idno>
<idno type="wicri:Area/Main/Merge">001C34</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Decreased Striatal Dopamine Receptor Binding in Primary Focal Dystonia: A D2 or D3 Defect?</title>
<author><name sortKey="Karimi, Morvarid" sort="Karimi, Morvarid" uniqKey="Karimi M" first="Morvarid" last="Karimi">Morvarid Karimi</name>
<affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Department of Neurology, Washington University School of Medicine</s1>
<s2>Saint Louis, Missouri</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>7 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Missouri (État)</region>
<settlement type="city">Saint-Louis (Missouri)</settlement>
</placeName>
<orgName type="university">École de médecine (Université Washington de Saint-Louis)</orgName>
</affiliation>
</author>
<author><name sortKey="Moerlein, Stephen M" sort="Moerlein, Stephen M" uniqKey="Moerlein S" first="Stephen M." last="Moerlein">Stephen M. Moerlein</name>
<affiliation wicri:level="4"><inist:fA14 i1="02"><s1>Mallinckrodt Institute of Radiology, Washington University School of Medicine</s1>
<s2>Saint Louis, Missouri</s2>
<s3>USA</s3>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Missouri (État)</region>
<settlement type="city">Saint-Louis (Missouri)</settlement>
</placeName>
<orgName type="university">École de médecine (Université Washington de Saint-Louis)</orgName>
</affiliation>
<affiliation wicri:level="4"><inist:fA14 i1="03"><s1>Department of Biochemistry and Molecular Biophysics, Washington University School of Medicine</s1>
<s2>Saint Louis, Missouri</s2>
<s3>USA</s3>
<sZ>2 aut.</sZ>
<sZ>6 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Missouri (État)</region>
<settlement type="city">Saint-Louis (Missouri)</settlement>
</placeName>
<orgName type="university">École de médecine (Université Washington de Saint-Louis)</orgName>
</affiliation>
</author>
<author><name sortKey="Videen, Tom O" sort="Videen, Tom O" uniqKey="Videen T" first="Tom O." last="Videen">Tom O. Videen</name>
<affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Department of Neurology, Washington University School of Medicine</s1>
<s2>Saint Louis, Missouri</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>7 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Missouri (État)</region>
<settlement type="city">Saint-Louis (Missouri)</settlement>
</placeName>
<orgName type="university">École de médecine (Université Washington de Saint-Louis)</orgName>
</affiliation>
<affiliation wicri:level="4"><inist:fA14 i1="02"><s1>Mallinckrodt Institute of Radiology, Washington University School of Medicine</s1>
<s2>Saint Louis, Missouri</s2>
<s3>USA</s3>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Missouri (État)</region>
<settlement type="city">Saint-Louis (Missouri)</settlement>
</placeName>
<orgName type="university">École de médecine (Université Washington de Saint-Louis)</orgName>
</affiliation>
</author>
<author><name sortKey="Luedtke, Robert R" sort="Luedtke, Robert R" uniqKey="Luedtke R" first="Robert R." last="Luedtke">Robert R. Luedtke</name>
<affiliation wicri:level="2"><inist:fA14 i1="04"><s1>Department of Pharmacology and Neuroscience, University of North Texas Health Science Center</s1>
<s2>Fort Worth, Texas</s2>
<s3>USA</s3>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Texas</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Taylor, Michelle" sort="Taylor, Michelle" uniqKey="Taylor M" first="Michelle" last="Taylor">Michelle Taylor</name>
<affiliation wicri:level="2"><inist:fA14 i1="04"><s1>Department of Pharmacology and Neuroscience, University of North Texas Health Science Center</s1>
<s2>Fort Worth, Texas</s2>
<s3>USA</s3>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Texas</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Mach, Robert H" sort="Mach, Robert H" uniqKey="Mach R" first="Robert H." last="Mach">Robert H. Mach</name>
<affiliation wicri:level="4"><inist:fA14 i1="02"><s1>Mallinckrodt Institute of Radiology, Washington University School of Medicine</s1>
<s2>Saint Louis, Missouri</s2>
<s3>USA</s3>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Missouri (État)</region>
<settlement type="city">Saint-Louis (Missouri)</settlement>
</placeName>
<orgName type="university">École de médecine (Université Washington de Saint-Louis)</orgName>
</affiliation>
<affiliation wicri:level="4"><inist:fA14 i1="03"><s1>Department of Biochemistry and Molecular Biophysics, Washington University School of Medicine</s1>
<s2>Saint Louis, Missouri</s2>
<s3>USA</s3>
<sZ>2 aut.</sZ>
<sZ>6 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Missouri (État)</region>
<settlement type="city">Saint-Louis (Missouri)</settlement>
</placeName>
<orgName type="university">École de médecine (Université Washington de Saint-Louis)</orgName>
</affiliation>
<affiliation wicri:level="4"><inist:fA14 i1="05"><s1>Department of Cell Biology and Physiology, Washington University School of Medicine</s1>
<s2>Saint Louis, Missouri</s2>
<s3>USA</s3>
<sZ>6 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Missouri (État)</region>
<settlement type="city">Saint-Louis (Missouri)</settlement>
</placeName>
<orgName type="university">École de médecine (Université Washington de Saint-Louis)</orgName>
</affiliation>
</author>
<author><name sortKey="Perlmutter, Joel S" sort="Perlmutter, Joel S" uniqKey="Perlmutter J" first="Joel S." last="Perlmutter">Joel S. Perlmutter</name>
<affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Department of Neurology, Washington University School of Medicine</s1>
<s2>Saint Louis, Missouri</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>7 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Missouri (État)</region>
<settlement type="city">Saint-Louis (Missouri)</settlement>
</placeName>
<orgName type="university">École de médecine (Université Washington de Saint-Louis)</orgName>
</affiliation>
<affiliation wicri:level="4"><inist:fA14 i1="02"><s1>Mallinckrodt Institute of Radiology, Washington University School of Medicine</s1>
<s2>Saint Louis, Missouri</s2>
<s3>USA</s3>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Missouri (État)</region>
<settlement type="city">Saint-Louis (Missouri)</settlement>
</placeName>
<orgName type="university">École de médecine (Université Washington de Saint-Louis)</orgName>
</affiliation>
<affiliation wicri:level="4"><inist:fA14 i1="06"><s1>Department of Neurobiology, Washington University School of Medicine</s1>
<s2>Saint Louis, Missouri</s2>
<s3>USA</s3>
<sZ>7 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Missouri (État)</region>
<settlement type="city">Saint-Louis (Missouri)</settlement>
</placeName>
<orgName type="university">École de médecine (Université Washington de Saint-Louis)</orgName>
</affiliation>
<affiliation wicri:level="4"><inist:fA14 i1="07"><s1>Department of Occupational Therapy, Washington University School of Medicine</s1>
<s2>Saint Louis, Missouri</s2>
<s3>USA</s3>
<sZ>7 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Missouri (État)</region>
<settlement type="city">Saint-Louis (Missouri)</settlement>
</placeName>
<orgName type="university">École de médecine (Université Washington de Saint-Louis)</orgName>
</affiliation>
<affiliation wicri:level="4"><inist:fA14 i1="08"><s1>Department of Physical Therapy, Washington University School of Medicine</s1>
<s2>Saint Louis, Missouri</s2>
<s3>USA</s3>
<sZ>7 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Missouri (État)</region>
<settlement type="city">Saint-Louis (Missouri)</settlement>
</placeName>
<orgName type="university">École de médecine (Université Washington de Saint-Louis)</orgName>
</affiliation>
</author>
</analytic>
<series><title level="j" type="main">Movement disorders</title>
<title level="j" type="abbreviated">Mov. disord.</title>
<idno type="ISSN">0885-3185</idno>
<imprint><date when="2011">2011</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><title level="j" type="main">Movement disorders</title>
<title level="j" type="abbreviated">Mov. disord.</title>
<idno type="ISSN">0885-3185</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>D2 Dopamine receptor</term>
<term>D3 Dopamine receptor</term>
<term>Dopamine</term>
<term>Dopamine receptor</term>
<term>Dystonia</term>
<term>Emission tomography</term>
<term>Nervous system diseases</term>
<term>Positron emission tomography</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Dystonie</term>
<term>Pathologie du   système nerveux</term>
<term>Récepteur dopaminergique</term>
<term>Dopamine</term>
<term>Récepteur dopaminergique D2</term>
<term>Récepteur dopaminergique D3</term>
<term>Tomoscintigraphie</term>
<term>Tomographie par émission de positons</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Dystonia is an involuntary movement disorder characterized by repetitive patterned or sustained muscle contractions causing twisting or abnormal postures. Several lines of evidence suggest that abnormalities of dopaminergic pathways contribute to the pathophysiology of dystonia. In particular, dysfunction of D2-like receptors that mediate function of the indirect pathway in the basal ganglia may play a key role. We have demonstrated with positron emission tomography that patients with primary focal cranial or hand dystonia have reduced putamenal specific binding of [<sup>18</sup>
F]spiperone, a nonselective D2-like radioligand with nearly equal affinity for serotonergic 5-HT(2A) sites. We then repeated the study with [<sup>18</sup>
F]N-methyl-benperidol (NMB), a more selective D2-like receptor radioligand with minimal affinity for 5-HT(2A). Surprisingly, there was no decrease in NMB binding in the putamen of subjects with dystonia. Our findings excluded reductions of putamenal uptake greater than 20% with 95% confidence intervals. The analysis of the in vitro selectivity of NMB and spiperone demonstrated that NMB was highly selective for D2 receptors relative to D3 receptors (200-fold difference in affinity), whereas spiperone has similar affinity for all three of the D2-like receptor subtypes. These findings when coupled with other literature suggest that a defect in D3, rather than D2, receptor expression may be associated with primary focal dystonia.</div>
</front>
</TEI>
<affiliations><list><country><li>États-Unis</li>
</country>
<region><li>Missouri (État)</li>
<li>Texas</li>
</region>
<settlement><li>Saint-Louis (Missouri)</li>
</settlement>
<orgName><li>École de médecine (Université Washington de Saint-Louis)</li>
</orgName>
</list>
<tree><country name="États-Unis"><region name="Missouri (État)"><name sortKey="Karimi, Morvarid" sort="Karimi, Morvarid" uniqKey="Karimi M" first="Morvarid" last="Karimi">Morvarid Karimi</name>
</region>
<name sortKey="Luedtke, Robert R" sort="Luedtke, Robert R" uniqKey="Luedtke R" first="Robert R." last="Luedtke">Robert R. Luedtke</name>
<name sortKey="Mach, Robert H" sort="Mach, Robert H" uniqKey="Mach R" first="Robert H." last="Mach">Robert H. Mach</name>
<name sortKey="Mach, Robert H" sort="Mach, Robert H" uniqKey="Mach R" first="Robert H." last="Mach">Robert H. Mach</name>
<name sortKey="Mach, Robert H" sort="Mach, Robert H" uniqKey="Mach R" first="Robert H." last="Mach">Robert H. Mach</name>
<name sortKey="Moerlein, Stephen M" sort="Moerlein, Stephen M" uniqKey="Moerlein S" first="Stephen M." last="Moerlein">Stephen M. Moerlein</name>
<name sortKey="Moerlein, Stephen M" sort="Moerlein, Stephen M" uniqKey="Moerlein S" first="Stephen M." last="Moerlein">Stephen M. Moerlein</name>
<name sortKey="Perlmutter, Joel S" sort="Perlmutter, Joel S" uniqKey="Perlmutter J" first="Joel S." last="Perlmutter">Joel S. Perlmutter</name>
<name sortKey="Perlmutter, Joel S" sort="Perlmutter, Joel S" uniqKey="Perlmutter J" first="Joel S." last="Perlmutter">Joel S. Perlmutter</name>
<name sortKey="Perlmutter, Joel S" sort="Perlmutter, Joel S" uniqKey="Perlmutter J" first="Joel S." last="Perlmutter">Joel S. Perlmutter</name>
<name sortKey="Perlmutter, Joel S" sort="Perlmutter, Joel S" uniqKey="Perlmutter J" first="Joel S." last="Perlmutter">Joel S. Perlmutter</name>
<name sortKey="Perlmutter, Joel S" sort="Perlmutter, Joel S" uniqKey="Perlmutter J" first="Joel S." last="Perlmutter">Joel S. Perlmutter</name>
<name sortKey="Taylor, Michelle" sort="Taylor, Michelle" uniqKey="Taylor M" first="Michelle" last="Taylor">Michelle Taylor</name>
<name sortKey="Videen, Tom O" sort="Videen, Tom O" uniqKey="Videen T" first="Tom O." last="Videen">Tom O. Videen</name>
<name sortKey="Videen, Tom O" sort="Videen, Tom O" uniqKey="Videen T" first="Tom O." last="Videen">Tom O. Videen</name>
</country>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Wicri/Santé/explor/MovDisordV3/Data/Main/Merge

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001C34 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/Main/Merge/biblio.hfd -nk 001C34 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Wicri/Santé
   |area=    MovDisordV3
   |flux=    Main
   |étape=   Merge
   |type=    RBID
   |clé=     Pascal:11-0143221
   |texte=   Decreased Striatal Dopamine Receptor Binding in Primary Focal Dystonia: A D2 or D3 Defect?
}}

This area was generated with Dilib version V0.6.23.
Data generation: Sun Jul 3 12:29:32 2016. Site generation: Wed Feb 14 10:52:30 2024

	Movement Disorders (revue)
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.

Movement Disorders (revue)

Decreased Striatal Dopamine Receptor Binding in Primary Focal Dystonia: A D2 or D3 Defect?

Decreased Striatal Dopamine Receptor Binding in Primary Focal Dystonia: A D2 or D3 Defect?

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri