In Vivo Evidence for GABAA Receptor Changes in the Sensorimotor System in Primary Dystonia
Identifieur interne : 001B59 ( Main/Merge ); précédent : 001B58; suivant : 001B60In Vivo Evidence for GABAA Receptor Changes in the Sensorimotor System in Primary Dystonia
Auteurs : Valentina Garibotto [Italie] ; Luigi M. Romito [Italie] ; Antonio E. Elia [Italie] ; Paola Soliveri [Italie] ; Andrea Panzacchi [Italie] ; Assunta Carpinelli [Italie] ; Michele Tinazzi [Italie] ; Alberto Albanese [Italie] ; Daniela Perani [Italie]Source :
- Movement disorders [ 0885-3185 ] ; 2011.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
Abstract
Background: Preclinical and clinical evidence suggests that impaired gamma-aminobutyric (GABA) control, leading to disinhibition within the sensorimotor system, might play a role in dystonia. Aim of this study is the in vivo assessment of the GABAergic system in dystonia using positron emission tomography (PET) and 11C-flumazenil, a selective GABAA receptor ligand. Methods: Fourteen subjects with primary dystonia (9 carriers of the DYT1 mutation and 5 sporadic cases) were compared to 11 controls, using a simplified reference tissue model to measure binding potential. Results: Voxel-based analyses showed a reduction in GABAA receptor expression/affinity both in DYT1 carriers and sporadic patients in primary motor and premotor cortex, primary and secondary somatosensory cortex, and in the motor component of the cingulate gyrus. Conclusions: Dysfunction of GABAA receptors in sensorimotor systems in primary (genetic and sporadic) dystonia supports the view that lack of GABAergic control may be associated with the generation of dystonic movements.
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Receptor Changes in the Sensorimotor System in Primary Dystonia</title>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">In Vivo Evidence for GABA<sub>A</sub>
Receptor Changes in the Sensorimotor System in Primary Dystonia</title>
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<s2>Milan</s2>
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<placeName><settlement type="city">Milan</settlement>
<region nuts="2">Lombardie</region>
</placeName>
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<s2>Milan</s2>
<s3>ITA</s3>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>8 aut.</sZ>
</inist:fA14>
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<region nuts="2">Lombardie</region>
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<author><name sortKey="Perani, Daniela" sort="Perani, Daniela" uniqKey="Perani D" first="Daniela" last="Perani">Daniela Perani</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Division of Neuroscience, Vita-Salute San Raffaele University</s1>
<s2>Milan</s2>
<s3>ITA</s3>
<sZ>1 aut.</sZ>
<sZ>9 aut.</sZ>
</inist:fA14>
<country>Italie</country>
<placeName><settlement type="city">Milan</settlement>
<region nuts="2">Lombardie</region>
</placeName>
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<affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Division of Neuroscience, San Raffaele Scientific Institute</s1>
<s2>Milan</s2>
<s3>ITA</s3>
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<sZ>5 aut.</sZ>
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<placeName><settlement type="city">Milan</settlement>
<region nuts="2">Lombardie</region>
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<affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Nuclear Medicine Unit, San Raffaele Scientific Institute</s1>
<s2>Milan</s2>
<s3>ITA</s3>
<sZ>1 aut.</sZ>
<sZ>5 aut.</sZ>
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<series><title level="j" type="main">Movement disorders</title>
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<title level="j" type="abbreviated">Mov. disord.</title>
<idno type="ISSN">0885-3185</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Dystonia</term>
<term>Emission tomography</term>
<term>GABA</term>
<term>Gabaergic receptor A</term>
<term>Nervous system diseases</term>
<term>Positron emission tomography</term>
<term>Sensorimotor cortex</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Dystonie</term>
<term>Pathologie du système nerveux</term>
<term>Récepteur gabaergique A</term>
<term>GABA</term>
<term>Cortex sensorimoteur</term>
<term>Tomoscintigraphie</term>
<term>Tomographie par émission de positons</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Background: Preclinical and clinical evidence suggests that impaired gamma-aminobutyric (GABA) control, leading to disinhibition within the sensorimotor system, might play a role in dystonia. Aim of this study is the in vivo assessment of the GABAergic system in dystonia using positron emission tomography (PET) and <sup>11</sup>
C-flumazenil, a selective GABA<sub>A</sub>
receptor ligand. Methods: Fourteen subjects with primary dystonia (9 carriers of the DYT1 mutation and 5 sporadic cases) were compared to 11 controls, using a simplified reference tissue model to measure binding potential. Results: Voxel-based analyses showed a reduction in GABA<sub>A</sub>
receptor expression/affinity both in DYT1 carriers and sporadic patients in primary motor and premotor cortex, primary and secondary somatosensory cortex, and in the motor component of the cingulate gyrus. Conclusions: Dysfunction of GABA<sub>A</sub>
receptors in sensorimotor systems in primary (genetic and sporadic) dystonia supports the view that lack of GABAergic control may be associated with the generation of dystonic movements.</div>
</front>
</TEI>
<affiliations><list><country><li>Italie</li>
</country>
<region><li>Lombardie</li>
</region>
<settlement><li>Milan</li>
</settlement>
</list>
<tree><country name="Italie"><region name="Lombardie"><name sortKey="Garibotto, Valentina" sort="Garibotto, Valentina" uniqKey="Garibotto V" first="Valentina" last="Garibotto">Valentina Garibotto</name>
</region>
<name sortKey="Albanese, Alberto" sort="Albanese, Alberto" uniqKey="Albanese A" first="Alberto" last="Albanese">Alberto Albanese</name>
<name sortKey="Albanese, Alberto" sort="Albanese, Alberto" uniqKey="Albanese A" first="Alberto" last="Albanese">Alberto Albanese</name>
<name sortKey="Carpinelli, Assunta" sort="Carpinelli, Assunta" uniqKey="Carpinelli A" first="Assunta" last="Carpinelli">Assunta Carpinelli</name>
<name sortKey="Elia, Antonio E" sort="Elia, Antonio E" uniqKey="Elia A" first="Antonio E." last="Elia">Antonio E. Elia</name>
<name sortKey="Elia, Antonio E" sort="Elia, Antonio E" uniqKey="Elia A" first="Antonio E." last="Elia">Antonio E. Elia</name>
<name sortKey="Garibotto, Valentina" sort="Garibotto, Valentina" uniqKey="Garibotto V" first="Valentina" last="Garibotto">Valentina Garibotto</name>
<name sortKey="Garibotto, Valentina" sort="Garibotto, Valentina" uniqKey="Garibotto V" first="Valentina" last="Garibotto">Valentina Garibotto</name>
<name sortKey="Panzacchi, Andrea" sort="Panzacchi, Andrea" uniqKey="Panzacchi A" first="Andrea" last="Panzacchi">Andrea Panzacchi</name>
<name sortKey="Panzacchi, Andrea" sort="Panzacchi, Andrea" uniqKey="Panzacchi A" first="Andrea" last="Panzacchi">Andrea Panzacchi</name>
<name sortKey="Perani, Daniela" sort="Perani, Daniela" uniqKey="Perani D" first="Daniela" last="Perani">Daniela Perani</name>
<name sortKey="Perani, Daniela" sort="Perani, Daniela" uniqKey="Perani D" first="Daniela" last="Perani">Daniela Perani</name>
<name sortKey="Perani, Daniela" sort="Perani, Daniela" uniqKey="Perani D" first="Daniela" last="Perani">Daniela Perani</name>
<name sortKey="Romito, Luigi M" sort="Romito, Luigi M" uniqKey="Romito L" first="Luigi M." last="Romito">Luigi M. Romito</name>
<name sortKey="Romito, Luigi M" sort="Romito, Luigi M" uniqKey="Romito L" first="Luigi M." last="Romito">Luigi M. Romito</name>
<name sortKey="Soliveri, Paola" sort="Soliveri, Paola" uniqKey="Soliveri P" first="Paola" last="Soliveri">Paola Soliveri</name>
<name sortKey="Tinazzi, Michele" sort="Tinazzi, Michele" uniqKey="Tinazzi M" first="Michele" last="Tinazzi">Michele Tinazzi</name>
<name sortKey="Tinazzi, Michele" sort="Tinazzi, Michele" uniqKey="Tinazzi M" first="Michele" last="Tinazzi">Michele Tinazzi</name>
</country>
</tree>
</affiliations>
</record>
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