MovDisordV3, Main, Merge, bibRecord, 001A94

Mood and Cognition in Leucine-Rich Repeat Kinase 2 G2019S Parkinson's Disease

Identifieur interne : 001A94 ( Main/Merge ); précédent : 001A93; suivant : 001A95

Mood and Cognition in Leucine-Rich Repeat Kinase 2 G2019S Parkinson's Disease

Auteurs : Vicki Shanker [États-Unis] ; Mark Groves [États-Unis] ; Gary Heiman [États-Unis] ; Christina Palmese [États-Unis] ; Rachel Saunders-Pullman [États-Unis] ; Laurie Ozelius [États-Unis] ; Deborah Raymond [États-Unis] ; Susan Bressman [États-Unis]

Source :

Movement disorders [ 0885-3185 ] ; 2011.

RBID : Pascal:11-0402088

Descripteurs français

Pascal (Inist)
- Maladie de Parkinson, Etat dépressif, Pathologie du système nerveux, Humeur, Cognition, Leucine, Kinase.

English descriptors

KwdEn :
- Cognition, Depression, Kinase, Leucine, Mood, Nervous system diseases, Parkinson disease.

Abstract

The behavioral and cognitive features of the leucine-rich repeat kinase G2019S mutation in Parkinson's disease in the Ashkenazi Jewish population are not well described; therefore, we sought to more systematically characterize these features using a semi-structured psychiatric interview and neuropsychological testing. Twenty-one Ashkenazi Jewish patients having the leucine-rich repeat kinase G2019S mutation were compared with age- and sex-matched Ashkenazi Jewish patients with Parkinson's disease without mutations. Although overall rates of affective disorders were not greater in mutation carriers, the carriers exhibited a 6-fold increased risk of premorbid affective disorders (odds ratio, 6.0; P = .10), as determined by the Structured Clinical Interview for the Diagnostic and Statistical Manual of Mental Disorders-IV. Of interest, we identified 2 leucine-rich repeat kinase carriers with bipolar disorder ; no mutation-negative subjects had this diagnosis. Performance on the Hopkins Verbal Learning Test-Revised, Judgment of Line Orientation, and Frontal Assessment Battery was consistent with previous reports and did not differ between groups. Study findings suggest a possible association between premorbid mood disorders and leucine-rich repeat kinase Parkinson's disease, warranting further evaluation.

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Pascal:11-0402088

Le document en format XML

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<front><div type="abstract" xml:lang="en">The behavioral and cognitive features of the leucine-rich repeat kinase G2019S mutation in Parkinson's disease in the Ashkenazi Jewish population are not well described; therefore, we sought to more systematically characterize these features using a semi-structured psychiatric interview and neuropsychological testing. Twenty-one Ashkenazi Jewish patients having the leucine-rich repeat kinase G2019S mutation were compared with age- and sex-matched Ashkenazi Jewish patients with Parkinson's disease without mutations. Although overall rates of affective disorders were not greater in mutation carriers, the carriers exhibited a 6-fold increased risk of premorbid affective disorders (odds ratio, 6.0; P = .10), as determined by the Structured Clinical Interview for the Diagnostic and Statistical Manual of Mental Disorders-IV. Of interest, we identified 2 leucine-rich repeat kinase carriers with bipolar disorder ; no mutation-negative subjects had this diagnosis. Performance on the Hopkins Verbal Learning Test-Revised, Judgment of Line Orientation, and Frontal Assessment Battery was consistent with previous reports and did not differ between groups. Study findings suggest a possible association between premorbid mood disorders and leucine-rich repeat kinase Parkinson's disease, warranting further evaluation.</div>
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<name sortKey="Bressman, Susan" sort="Bressman, Susan" uniqKey="Bressman S" first="Susan" last="Bressman">Susan Bressman</name>
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	Movement Disorders (revue)
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Movement Disorders (revue)

Mood and Cognition in Leucine-Rich Repeat Kinase 2 G2019S Parkinson's Disease

Mood and Cognition in Leucine-Rich Repeat Kinase 2 G2019S Parkinson's Disease

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri