MovDisordV3, Main, Merge, bibRecord, 001A70

Odor Identification Deficits Identify Parkinson's Disease Patients with Poor Cognitive Performance

Identifieur interne : 001A70 ( Main/Merge ); précédent : 001A69; suivant : 001A71

Odor Identification Deficits Identify Parkinson's Disease Patients with Poor Cognitive Performance

Auteurs : Malene Flensborg Damholdt [Danemark] ; Per Borghammer [Danemark] ; Lars Larsen [Danemark] ; Karen Stergaard [Danemark]

Source :

Movement disorders [ 0885-3185 ] ; 2011.

RBID : Pascal:11-0444610

Descripteurs français

Pascal (Inist)
- Maladie de Parkinson, Pathologie du système nerveux, Odeur, Homme, Performance, Cognition, Olfaction.
Wicri :
- topic : Homme.

English descriptors

KwdEn :
- Cognition, Human, Nervous system diseases, Odor, Olfaction, Parkinson disease, Performance.

Abstract

Olfactory dysfunction is a prodromal and prevalent nonmotor symptom of Parkinson's disease. Unlike olfactory dysfunction in Alzheimer's disease, it is believed to be unrelated to cognitive impairment. However, recent research has implicated cholinergic denervation in Parkinson's disease hyposmia and linked it to verbal memory. This research hypothesized that severe odor identification deficits may identify patients with Parkinson's disease at risk for cognitive impairment. The current study tested this hypothesis by comparing 24 functionally anosmic, nondemented patients with Parkinson's disease and 39 nonanosmic, nondemented patients with Parkinson's disease with 29 healthy control participants on composite scores of memory, processing speed, executive function, and language. The functionally anosmic group had significantly poorer visual and verbal memory than the nonanosmic group, which was indistinguishable from the control group. Furthermore, the functionally anosmic group had reduced processing speed compared with the nonanosmic patients with Parkinson's disease, who, in turn, were outperformed by the control group. On the composite language score, the score of the functionally anosmic group was significantly reduced compared with that of the control group, whereas the nonanosmic group scored in the medium range. The 2 patient groups did not differ on executive functioning. These findings demonstrate co-occurrence between reduced cognitive function and olfactory deficits in functionally anosmic patients with Parkinson's disease and support the notion of more severe cognitive deficits in this group.

Links toward previous steps (curation, corpus...)

to stream PascalFrancis, to step Corpus: 000416
to stream PascalFrancis, to step Curation: 002902
to stream PascalFrancis, to step Checkpoint: 000480

Links to Exploration step

Pascal:11-0444610

Le document en format XML

<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">Odor Identification Deficits Identify Parkinson's Disease Patients with Poor Cognitive Performance</title>
<author><name sortKey="Flensborg Damholdt, Malene" sort="Flensborg Damholdt, Malene" uniqKey="Flensborg Damholdt M" first="Malene" last="Flensborg Damholdt">Malene Flensborg Damholdt</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Psychology, Aarhus University</s1>
<s2>Aarhus</s2>
<s3>DNK</s3>
<sZ>1 aut.</sZ>
<sZ>3 aut.</sZ>
</inist:fA14>
<country>Danemark</country>
<wicri:noRegion>Aarhus</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Borghammer, Per" sort="Borghammer, Per" uniqKey="Borghammer P" first="Per" last="Borghammer">Per Borghammer</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Nuclear Medicine, Aarhus University Hospitals</s1>
<s2>Aarhus</s2>
<s3>DNK</s3>
<sZ>2 aut.</sZ>
</inist:fA14>
<country>Danemark</country>
<wicri:noRegion>Aarhus</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Larsen, Lars" sort="Larsen, Lars" uniqKey="Larsen L" first="Lars" last="Larsen">Lars Larsen</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Psychology, Aarhus University</s1>
<s2>Aarhus</s2>
<s3>DNK</s3>
<sZ>1 aut.</sZ>
<sZ>3 aut.</sZ>
</inist:fA14>
<country>Danemark</country>
<wicri:noRegion>Aarhus</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey=" Stergaard, Karen" sort=" Stergaard, Karen" uniqKey=" Stergaard K" first="Karen" last=" Stergaard">Karen  Stergaard</name>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Department of Neurology, Aarhus University Hospitals</s1>
<s2>Aarhus</s2>
<s3>DNK</s3>
<sZ>4 aut.</sZ>
</inist:fA14>
<country>Danemark</country>
<wicri:noRegion>Aarhus</wicri:noRegion>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">INIST</idno>
<idno type="inist">11-0444610</idno>
<date when="2011">2011</date>
<idno type="stanalyst">PASCAL 11-0444610 INIST</idno>
<idno type="RBID">Pascal:11-0444610</idno>
<idno type="wicri:Area/PascalFrancis/Corpus">000416</idno>
<idno type="wicri:Area/PascalFrancis/Curation">002902</idno>
<idno type="wicri:Area/PascalFrancis/Checkpoint">000480</idno>
<idno type="wicri:doubleKey">0885-3185:2011:Flensborg Damholdt M:odor:identification:deficits</idno>
<idno type="wicri:Area/Main/Merge">001A70</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Odor Identification Deficits Identify Parkinson's Disease Patients with Poor Cognitive Performance</title>
<author><name sortKey="Flensborg Damholdt, Malene" sort="Flensborg Damholdt, Malene" uniqKey="Flensborg Damholdt M" first="Malene" last="Flensborg Damholdt">Malene Flensborg Damholdt</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Psychology, Aarhus University</s1>
<s2>Aarhus</s2>
<s3>DNK</s3>
<sZ>1 aut.</sZ>
<sZ>3 aut.</sZ>
</inist:fA14>
<country>Danemark</country>
<wicri:noRegion>Aarhus</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Borghammer, Per" sort="Borghammer, Per" uniqKey="Borghammer P" first="Per" last="Borghammer">Per Borghammer</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Nuclear Medicine, Aarhus University Hospitals</s1>
<s2>Aarhus</s2>
<s3>DNK</s3>
<sZ>2 aut.</sZ>
</inist:fA14>
<country>Danemark</country>
<wicri:noRegion>Aarhus</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Larsen, Lars" sort="Larsen, Lars" uniqKey="Larsen L" first="Lars" last="Larsen">Lars Larsen</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Psychology, Aarhus University</s1>
<s2>Aarhus</s2>
<s3>DNK</s3>
<sZ>1 aut.</sZ>
<sZ>3 aut.</sZ>
</inist:fA14>
<country>Danemark</country>
<wicri:noRegion>Aarhus</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey=" Stergaard, Karen" sort=" Stergaard, Karen" uniqKey=" Stergaard K" first="Karen" last=" Stergaard">Karen  Stergaard</name>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Department of Neurology, Aarhus University Hospitals</s1>
<s2>Aarhus</s2>
<s3>DNK</s3>
<sZ>4 aut.</sZ>
</inist:fA14>
<country>Danemark</country>
<wicri:noRegion>Aarhus</wicri:noRegion>
</affiliation>
</author>
</analytic>
<series><title level="j" type="main">Movement disorders</title>
<title level="j" type="abbreviated">Mov. disord.</title>
<idno type="ISSN">0885-3185</idno>
<imprint><date when="2011">2011</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><title level="j" type="main">Movement disorders</title>
<title level="j" type="abbreviated">Mov. disord.</title>
<idno type="ISSN">0885-3185</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Cognition</term>
<term>Human</term>
<term>Nervous system diseases</term>
<term>Odor</term>
<term>Olfaction</term>
<term>Parkinson disease</term>
<term>Performance</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Maladie de Parkinson</term>
<term>Pathologie du   système nerveux</term>
<term>Odeur</term>
<term>Homme</term>
<term>Performance</term>
<term>Cognition</term>
<term>Olfaction</term>
</keywords>
<keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Homme</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Olfactory dysfunction is a prodromal and prevalent nonmotor symptom of Parkinson's disease. Unlike olfactory dysfunction in Alzheimer's disease, it is believed to be unrelated to cognitive impairment. However, recent research has implicated cholinergic denervation in Parkinson's disease hyposmia and linked it to verbal memory. This research hypothesized that severe odor identification deficits may identify patients with Parkinson's disease at risk for cognitive impairment. The current study tested this hypothesis by comparing 24 functionally anosmic, nondemented patients with Parkinson's disease and 39 nonanosmic, nondemented patients with Parkinson's disease with 29 healthy control participants on composite scores of memory, processing speed, executive function, and language. The functionally anosmic group had significantly poorer visual and verbal memory than the nonanosmic group, which was indistinguishable from the control group. Furthermore, the functionally anosmic group had reduced processing speed compared with the nonanosmic patients with Parkinson's disease, who, in turn, were outperformed by the control group. On the composite language score, the score of the functionally anosmic group was significantly reduced compared with that of the control group, whereas the nonanosmic group scored in the medium range. The 2 patient groups did not differ on executive functioning. These findings demonstrate co-occurrence between reduced cognitive function and olfactory deficits in functionally anosmic patients with Parkinson's disease and support the notion of more severe cognitive deficits in this group.</div>
</front>
</TEI>
<affiliations><list><country><li>Danemark</li>
</country>
</list>
<tree><country name="Danemark"><noRegion><name sortKey="Flensborg Damholdt, Malene" sort="Flensborg Damholdt, Malene" uniqKey="Flensborg Damholdt M" first="Malene" last="Flensborg Damholdt">Malene Flensborg Damholdt</name>
</noRegion>
<name sortKey=" Stergaard, Karen" sort=" Stergaard, Karen" uniqKey=" Stergaard K" first="Karen" last=" Stergaard">Karen  Stergaard</name>
<name sortKey="Borghammer, Per" sort="Borghammer, Per" uniqKey="Borghammer P" first="Per" last="Borghammer">Per Borghammer</name>
<name sortKey="Larsen, Lars" sort="Larsen, Lars" uniqKey="Larsen L" first="Lars" last="Larsen">Lars Larsen</name>
</country>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Wicri/Santé/explor/MovDisordV3/Data/Main/Merge

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001A70 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/Main/Merge/biblio.hfd -nk 001A70 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Wicri/Santé
   |area=    MovDisordV3
   |flux=    Main
   |étape=   Merge
   |type=    RBID
   |clé=     Pascal:11-0444610
   |texte=   Odor Identification Deficits Identify Parkinson's Disease Patients with Poor Cognitive Performance
}}

This area was generated with Dilib version V0.6.23.
Data generation: Sun Jul 3 12:29:32 2016. Site generation: Wed Feb 14 10:52:30 2024

	Movement Disorders (revue)
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.

Movement Disorders (revue)

Odor Identification Deficits Identify Parkinson's Disease Patients with Poor Cognitive Performance

Odor Identification Deficits Identify Parkinson's Disease Patients with Poor Cognitive Performance

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri