Pathological Gambling in Patients with Parkinson's Disease is Associated with Fronto-Striatal Disconnection: A Path Modeling Analysis
Identifieur interne : 001A46 ( Main/Merge ); précédent : 001A45; suivant : 001A47Pathological Gambling in Patients with Parkinson's Disease is Associated with Fronto-Striatal Disconnection: A Path Modeling Analysis
Auteurs : Roberto Cilia [Canada, Italie] ; SANG SOO CHO [Canada] ; Thilo Van Eimeren [Canada] ; Giorgio Marotta [Italie] ; Chiara Siri [Italie] ; JI HYUN KO [Canada] ; Giovanna Pellecchia [Canada] ; Gianni Pezzoli [Italie] ; Angelo Antonini [Italie] ; Antonio P. Strafella [Canada]Source :
- Movement disorders [ 0885-3185 ] ; 2011.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Homme.
English descriptors
- KwdEn :
Abstract
Background: Pathological gambling may occur in Parkinson's disease (PD) as a complication of dopaminergic therapy. Neuroimaging studies have suggested an abnormal dopamine transmission within the reward system, but the changes in the neural network characterizing PD patients with pathological gambling have never been investigated. Methods: Thirty PD patients (15 with active gambling and 15 matched controls, on-medication) and 15 healthy subjects underwent brain perfusion single photon emission tomography at rest. The severity of gambling was assessed using the South Oaks Gambling Scale. Covariance analysis was applied to identify brain regions whose activity was associated with gambling severity. These regions were used as volume-of-interest to identify functionally interconnected areas using voxel-wise covariance analysis. A path model was defined by means of effective connectivity analysis within the Structural Equation Modeling framework. Results: Gambling severity in PD was associated with a dysfunction of the brain network implicated in decision making, risk processing, and response inhibition, including the ventrolateral prefrontal cortex, anterior (ACC) and posterior cingulate cortex, medial prefrontal cortex, insula and striatum. PD gamblers showed a disconnection between the ACC and the striatum, while this interaction was very robust in both control groups. Discussion: ACC-striatal disconnection may underlie a specific impairment of shifting behaviors after negative outcomes, possibly explaining why PD gamblers use to perseverate into risktaking behaviors despite self-destructive consequences.
Links toward previous steps (curation, corpus...)
- to stream PascalFrancis, to step Corpus: 000717
- to stream PascalFrancis, to step Curation: 002601
- to stream PascalFrancis, to step Checkpoint: 000456
Links to Exploration step
Pascal:11-0188448Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">Pathological Gambling in Patients with Parkinson's Disease is Associated with Fronto-Striatal Disconnection: A Path Modeling Analysis</title><author><name sortKey="Cilia, Roberto" sort="Cilia, Roberto" uniqKey="Cilia R" first="Roberto" last="Cilia">Roberto Cilia</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Division of Brain, Imaging and Behaviorur-Systems Neuroscience, Toronto Western Research Institute and Hospital, UHN, University of Toronto</s1><s2>Toronto, Ontario</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>Canada</country><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName><orgName type="university">Université de Toronto</orgName></affiliation><affiliation wicri:level="4"><inist:fA14 i1="02"><s1>PET Imaging Centre, Centre for Addiction and Mental Health, University of Toronto</s1><s2>Toronto, Ontario</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>Canada</country><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName><orgName type="university">Université de Toronto</orgName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Parkinson Institute, Department of Neurology, Istituti Clinici di Perfezionamento</s1><s2>Milan</s2><s3>ITA</s3><sZ>1 aut.</sZ><sZ>5 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>Italie</country><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Sang Soo Cho" sort="Sang Soo Cho" uniqKey="Sang Soo Cho" last="Sang Soo Cho">SANG SOO CHO</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Division of Brain, Imaging and Behaviorur-Systems Neuroscience, Toronto Western Research Institute and Hospital, UHN, University of Toronto</s1><s2>Toronto, Ontario</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>Canada</country><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName><orgName type="university">Université de Toronto</orgName></affiliation><affiliation wicri:level="4"><inist:fA14 i1="02"><s1>PET Imaging Centre, Centre for Addiction and Mental Health, University of Toronto</s1><s2>Toronto, Ontario</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>Canada</country><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName><orgName type="university">Université de Toronto</orgName></affiliation></author><author><name sortKey="Van Eimeren, Thilo" sort="Van Eimeren, Thilo" uniqKey="Van Eimeren T" first="Thilo" last="Van Eimeren">Thilo Van Eimeren</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Division of Brain, Imaging and Behaviorur-Systems Neuroscience, Toronto Western Research Institute and Hospital, UHN, University of Toronto</s1><s2>Toronto, Ontario</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>Canada</country><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName><orgName type="university">Université de Toronto</orgName></affiliation><affiliation wicri:level="4"><inist:fA14 i1="02"><s1>PET Imaging Centre, Centre for Addiction and Mental Health, University of Toronto</s1><s2>Toronto, Ontario</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>Canada</country><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName><orgName type="university">Université de Toronto</orgName></affiliation></author><author><name sortKey="Marotta, Giorgio" sort="Marotta, Giorgio" uniqKey="Marotta G" first="Giorgio" last="Marotta">Giorgio Marotta</name><affiliation wicri:level="3"><inist:fA14 i1="04"><s1>Nuclear Medicine Department, IRCCS-OSpedale Maggiore</s1><s2>Milan</s2><s3>ITA</s3><sZ>4 aut.</sZ></inist:fA14><country>Italie</country><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Siri, Chiara" sort="Siri, Chiara" uniqKey="Siri C" first="Chiara" last="Siri">Chiara Siri</name><affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Parkinson Institute, Department of Neurology, Istituti Clinici di Perfezionamento</s1><s2>Milan</s2><s3>ITA</s3><sZ>1 aut.</sZ><sZ>5 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>Italie</country><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Ji Hyun Ko" sort="Ji Hyun Ko" uniqKey="Ji Hyun Ko" last="Ji Hyun Ko">JI HYUN KO</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Division of Brain, Imaging and Behaviorur-Systems Neuroscience, Toronto Western Research Institute and Hospital, UHN, University of Toronto</s1><s2>Toronto, Ontario</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>Canada</country><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName><orgName type="university">Université de Toronto</orgName></affiliation><affiliation wicri:level="4"><inist:fA14 i1="02"><s1>PET Imaging Centre, Centre for Addiction and Mental Health, University of Toronto</s1><s2>Toronto, Ontario</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>Canada</country><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName><orgName type="university">Université de Toronto</orgName></affiliation></author><author><name sortKey="Pellecchia, Giovanna" sort="Pellecchia, Giovanna" uniqKey="Pellecchia G" first="Giovanna" last="Pellecchia">Giovanna Pellecchia</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Division of Brain, Imaging and Behaviorur-Systems Neuroscience, Toronto Western Research Institute and Hospital, UHN, University of Toronto</s1><s2>Toronto, Ontario</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>Canada</country><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName><orgName type="university">Université de Toronto</orgName></affiliation><affiliation wicri:level="4"><inist:fA14 i1="02"><s1>PET Imaging Centre, Centre for Addiction and Mental Health, University of Toronto</s1><s2>Toronto, Ontario</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>Canada</country><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName><orgName type="university">Université de Toronto</orgName></affiliation></author><author><name sortKey="Pezzoli, Gianni" sort="Pezzoli, Gianni" uniqKey="Pezzoli G" first="Gianni" last="Pezzoli">Gianni Pezzoli</name><affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Parkinson Institute, Department of Neurology, Istituti Clinici di Perfezionamento</s1><s2>Milan</s2><s3>ITA</s3><sZ>1 aut.</sZ><sZ>5 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>Italie</country><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Antonini, Angelo" sort="Antonini, Angelo" uniqKey="Antonini A" first="Angelo" last="Antonini">Angelo Antonini</name><affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Parkinson Institute, Department of Neurology, Istituti Clinici di Perfezionamento</s1><s2>Milan</s2><s3>ITA</s3><sZ>1 aut.</sZ><sZ>5 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>Italie</country><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation><affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Institute of Neurology, IRCCS San Camillo Venice, University of Padua</s1><s2>Padua</s2><s3>ITA</s3><sZ>9 aut.</sZ></inist:fA14><country>Italie</country><wicri:noRegion>Padua</wicri:noRegion></affiliation></author><author><name sortKey="Strafella, Antonio P" sort="Strafella, Antonio P" uniqKey="Strafella A" first="Antonio P." last="Strafella">Antonio P. Strafella</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Division of Brain, Imaging and Behaviorur-Systems Neuroscience, Toronto Western Research Institute and Hospital, UHN, University of Toronto</s1><s2>Toronto, Ontario</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>Canada</country><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName><orgName type="university">Université de Toronto</orgName></affiliation><affiliation wicri:level="4"><inist:fA14 i1="02"><s1>PET Imaging Centre, Centre for Addiction and Mental Health, University of Toronto</s1><s2>Toronto, Ontario</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>Canada</country><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName><orgName type="university">Université de Toronto</orgName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">11-0188448</idno><date when="2011">2011</date><idno type="stanalyst">PASCAL 11-0188448 INIST</idno><idno type="RBID">Pascal:11-0188448</idno><idno type="wicri:Area/PascalFrancis/Corpus">000717</idno><idno type="wicri:Area/PascalFrancis/Curation">002601</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">000456</idno><idno type="wicri:doubleKey">0885-3185:2011:Cilia R:pathological:gambling:in</idno><idno type="wicri:Area/Main/Merge">001A46</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Pathological Gambling in Patients with Parkinson's Disease is Associated with Fronto-Striatal Disconnection: A Path Modeling Analysis</title><author><name sortKey="Cilia, Roberto" sort="Cilia, Roberto" uniqKey="Cilia R" first="Roberto" last="Cilia">Roberto Cilia</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Division of Brain, Imaging and Behaviorur-Systems Neuroscience, Toronto Western Research Institute and Hospital, UHN, University of Toronto</s1><s2>Toronto, Ontario</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>Canada</country><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName><orgName type="university">Université de Toronto</orgName></affiliation><affiliation wicri:level="4"><inist:fA14 i1="02"><s1>PET Imaging Centre, Centre for Addiction and Mental Health, University of Toronto</s1><s2>Toronto, Ontario</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>Canada</country><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName><orgName type="university">Université de Toronto</orgName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Parkinson Institute, Department of Neurology, Istituti Clinici di Perfezionamento</s1><s2>Milan</s2><s3>ITA</s3><sZ>1 aut.</sZ><sZ>5 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>Italie</country><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Sang Soo Cho" sort="Sang Soo Cho" uniqKey="Sang Soo Cho" last="Sang Soo Cho">SANG SOO CHO</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Division of Brain, Imaging and Behaviorur-Systems Neuroscience, Toronto Western Research Institute and Hospital, UHN, University of Toronto</s1><s2>Toronto, Ontario</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>Canada</country><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName><orgName type="university">Université de Toronto</orgName></affiliation><affiliation wicri:level="4"><inist:fA14 i1="02"><s1>PET Imaging Centre, Centre for Addiction and Mental Health, University of Toronto</s1><s2>Toronto, Ontario</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>Canada</country><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName><orgName type="university">Université de Toronto</orgName></affiliation></author><author><name sortKey="Van Eimeren, Thilo" sort="Van Eimeren, Thilo" uniqKey="Van Eimeren T" first="Thilo" last="Van Eimeren">Thilo Van Eimeren</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Division of Brain, Imaging and Behaviorur-Systems Neuroscience, Toronto Western Research Institute and Hospital, UHN, University of Toronto</s1><s2>Toronto, Ontario</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>Canada</country><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName><orgName type="university">Université de Toronto</orgName></affiliation><affiliation wicri:level="4"><inist:fA14 i1="02"><s1>PET Imaging Centre, Centre for Addiction and Mental Health, University of Toronto</s1><s2>Toronto, Ontario</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>Canada</country><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName><orgName type="university">Université de Toronto</orgName></affiliation></author><author><name sortKey="Marotta, Giorgio" sort="Marotta, Giorgio" uniqKey="Marotta G" first="Giorgio" last="Marotta">Giorgio Marotta</name><affiliation wicri:level="3"><inist:fA14 i1="04"><s1>Nuclear Medicine Department, IRCCS-OSpedale Maggiore</s1><s2>Milan</s2><s3>ITA</s3><sZ>4 aut.</sZ></inist:fA14><country>Italie</country><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Siri, Chiara" sort="Siri, Chiara" uniqKey="Siri C" first="Chiara" last="Siri">Chiara Siri</name><affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Parkinson Institute, Department of Neurology, Istituti Clinici di Perfezionamento</s1><s2>Milan</s2><s3>ITA</s3><sZ>1 aut.</sZ><sZ>5 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>Italie</country><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Ji Hyun Ko" sort="Ji Hyun Ko" uniqKey="Ji Hyun Ko" last="Ji Hyun Ko">JI HYUN KO</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Division of Brain, Imaging and Behaviorur-Systems Neuroscience, Toronto Western Research Institute and Hospital, UHN, University of Toronto</s1><s2>Toronto, Ontario</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>Canada</country><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName><orgName type="university">Université de Toronto</orgName></affiliation><affiliation wicri:level="4"><inist:fA14 i1="02"><s1>PET Imaging Centre, Centre for Addiction and Mental Health, University of Toronto</s1><s2>Toronto, Ontario</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>Canada</country><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName><orgName type="university">Université de Toronto</orgName></affiliation></author><author><name sortKey="Pellecchia, Giovanna" sort="Pellecchia, Giovanna" uniqKey="Pellecchia G" first="Giovanna" last="Pellecchia">Giovanna Pellecchia</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Division of Brain, Imaging and Behaviorur-Systems Neuroscience, Toronto Western Research Institute and Hospital, UHN, University of Toronto</s1><s2>Toronto, Ontario</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>Canada</country><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName><orgName type="university">Université de Toronto</orgName></affiliation><affiliation wicri:level="4"><inist:fA14 i1="02"><s1>PET Imaging Centre, Centre for Addiction and Mental Health, University of Toronto</s1><s2>Toronto, Ontario</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>Canada</country><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName><orgName type="university">Université de Toronto</orgName></affiliation></author><author><name sortKey="Pezzoli, Gianni" sort="Pezzoli, Gianni" uniqKey="Pezzoli G" first="Gianni" last="Pezzoli">Gianni Pezzoli</name><affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Parkinson Institute, Department of Neurology, Istituti Clinici di Perfezionamento</s1><s2>Milan</s2><s3>ITA</s3><sZ>1 aut.</sZ><sZ>5 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>Italie</country><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Antonini, Angelo" sort="Antonini, Angelo" uniqKey="Antonini A" first="Angelo" last="Antonini">Angelo Antonini</name><affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Parkinson Institute, Department of Neurology, Istituti Clinici di Perfezionamento</s1><s2>Milan</s2><s3>ITA</s3><sZ>1 aut.</sZ><sZ>5 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>Italie</country><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation><affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Institute of Neurology, IRCCS San Camillo Venice, University of Padua</s1><s2>Padua</s2><s3>ITA</s3><sZ>9 aut.</sZ></inist:fA14><country>Italie</country><wicri:noRegion>Padua</wicri:noRegion></affiliation></author><author><name sortKey="Strafella, Antonio P" sort="Strafella, Antonio P" uniqKey="Strafella A" first="Antonio P." last="Strafella">Antonio P. Strafella</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Division of Brain, Imaging and Behaviorur-Systems Neuroscience, Toronto Western Research Institute and Hospital, UHN, University of Toronto</s1><s2>Toronto, Ontario</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>Canada</country><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName><orgName type="university">Université de Toronto</orgName></affiliation><affiliation wicri:level="4"><inist:fA14 i1="02"><s1>PET Imaging Centre, Centre for Addiction and Mental Health, University of Toronto</s1><s2>Toronto, Ontario</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>Canada</country><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName><orgName type="university">Université de Toronto</orgName></affiliation></author></analytic><series><title level="j" type="main">Movement disorders</title><title level="j" type="abbreviated">Mov. disord.</title><idno type="ISSN">0885-3185</idno><imprint><date when="2011">2011</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Movement disorders</title><title level="j" type="abbreviated">Mov. disord.</title><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Human</term><term>Modeling</term><term>Nervous system diseases</term><term>Parkinson disease</term><term>Pathological gambling</term><term>Photon</term><term>Single photon emission tomography</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Jeu pathologique</term><term>Maladie de Parkinson</term><term>Pathologie du système nerveux</term><term>Homme</term><term>Modélisation</term><term>Tomoscintigraphie émission monophotonique</term><term>Photon</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Homme</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Background: Pathological gambling may occur in Parkinson's disease (PD) as a complication of dopaminergic therapy. Neuroimaging studies have suggested an abnormal dopamine transmission within the reward system, but the changes in the neural network characterizing PD patients with pathological gambling have never been investigated. Methods: Thirty PD patients (15 with active gambling and 15 matched controls, on-medication) and 15 healthy subjects underwent brain perfusion single photon emission tomography at rest. The severity of gambling was assessed using the South Oaks Gambling Scale. Covariance analysis was applied to identify brain regions whose activity was associated with gambling severity. These regions were used as volume-of-interest to identify functionally interconnected areas using voxel-wise covariance analysis. A path model was defined by means of effective connectivity analysis within the Structural Equation Modeling framework. Results: Gambling severity in PD was associated with a dysfunction of the brain network implicated in decision making, risk processing, and response inhibition, including the ventrolateral prefrontal cortex, anterior (ACC) and posterior cingulate cortex, medial prefrontal cortex, insula and striatum. PD gamblers showed a disconnection between the ACC and the striatum, while this interaction was very robust in both control groups. Discussion: ACC-striatal disconnection may underlie a specific impairment of shifting behaviors after negative outcomes, possibly explaining why PD gamblers use to perseverate into risktaking behaviors despite self-destructive consequences.</div></front></TEI><affiliations><list><country><li>Canada</li><li>Italie</li></country><region><li>Lombardie</li><li>Ontario</li></region><settlement><li>Milan</li><li>Toronto</li></settlement><orgName><li>Université de Toronto</li></orgName></list><tree><country name="Canada"><region name="Ontario"><name sortKey="Cilia, Roberto" sort="Cilia, Roberto" uniqKey="Cilia R" first="Roberto" last="Cilia">Roberto Cilia</name></region><name sortKey="Cilia, Roberto" sort="Cilia, Roberto" uniqKey="Cilia R" first="Roberto" last="Cilia">Roberto Cilia</name><name sortKey="Ji Hyun Ko" sort="Ji Hyun Ko" uniqKey="Ji Hyun Ko" last="Ji Hyun Ko">JI HYUN KO</name><name sortKey="Ji Hyun Ko" sort="Ji Hyun Ko" uniqKey="Ji Hyun Ko" last="Ji Hyun Ko">JI HYUN KO</name><name sortKey="Pellecchia, Giovanna" sort="Pellecchia, Giovanna" uniqKey="Pellecchia G" first="Giovanna" last="Pellecchia">Giovanna Pellecchia</name><name sortKey="Pellecchia, Giovanna" sort="Pellecchia, Giovanna" uniqKey="Pellecchia G" first="Giovanna" last="Pellecchia">Giovanna Pellecchia</name><name sortKey="Sang Soo Cho" sort="Sang Soo Cho" uniqKey="Sang Soo Cho" last="Sang Soo Cho">SANG SOO CHO</name><name sortKey="Sang Soo Cho" sort="Sang Soo Cho" uniqKey="Sang Soo Cho" last="Sang Soo Cho">SANG SOO CHO</name><name sortKey="Strafella, Antonio P" sort="Strafella, Antonio P" uniqKey="Strafella A" first="Antonio P." last="Strafella">Antonio P. Strafella</name><name sortKey="Strafella, Antonio P" sort="Strafella, Antonio P" uniqKey="Strafella A" first="Antonio P." last="Strafella">Antonio P. Strafella</name><name sortKey="Van Eimeren, Thilo" sort="Van Eimeren, Thilo" uniqKey="Van Eimeren T" first="Thilo" last="Van Eimeren">Thilo Van Eimeren</name><name sortKey="Van Eimeren, Thilo" sort="Van Eimeren, Thilo" uniqKey="Van Eimeren T" first="Thilo" last="Van Eimeren">Thilo Van Eimeren</name></country><country name="Italie"><region name="Lombardie"><name sortKey="Cilia, Roberto" sort="Cilia, Roberto" uniqKey="Cilia R" first="Roberto" last="Cilia">Roberto Cilia</name></region><name sortKey="Antonini, Angelo" sort="Antonini, Angelo" uniqKey="Antonini A" first="Angelo" last="Antonini">Angelo Antonini</name><name sortKey="Antonini, Angelo" sort="Antonini, Angelo" uniqKey="Antonini A" first="Angelo" last="Antonini">Angelo Antonini</name><name sortKey="Marotta, Giorgio" sort="Marotta, Giorgio" uniqKey="Marotta G" first="Giorgio" last="Marotta">Giorgio Marotta</name><name sortKey="Pezzoli, Gianni" sort="Pezzoli, Gianni" uniqKey="Pezzoli G" first="Gianni" last="Pezzoli">Gianni Pezzoli</name><name sortKey="Siri, Chiara" sort="Siri, Chiara" uniqKey="Siri C" first="Chiara" last="Siri">Chiara Siri</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Santé/explor/MovDisordV3/Data/Main/Merge
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001A46 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Merge/biblio.hfd -nk 001A46 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Santé
|area= MovDisordV3
|flux= Main
|étape= Merge
|type= RBID
|clé= Pascal:11-0188448
|texte= Pathological Gambling in Patients with Parkinson's Disease is Associated with Fronto-Striatal Disconnection: A Path Modeling Analysis
}}
| This area was generated with Dilib version V0.6.23. |  |