The Patients' Perception of Prodromal Symptoms Before the Initial Diagnosis of Parkinson's Disease
Identifieur interne : 001946 ( Main/Merge ); précédent : 001945; suivant : 001947The Patients' Perception of Prodromal Symptoms Before the Initial Diagnosis of Parkinson's Disease
Auteurs : Alexandra Gaenslen [Allemagne] ; Irene Swid [Allemagne] ; Inga Liepelt-Scarfone [Allemagne] ; Jana Godau [Allemagne] ; Daniela Berg [Allemagne]Source :
- Movement disorders [ 0885-3185 ] ; 2011.
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- Pascal (Inist)
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Abstract
Background: Before the occurrence of motor symptoms permits the clinical diagnosis of Parkinson's disease (PD), about or even more than 50% of the dopaminergic neurons of the substantia nigra have degenerated. This time be called the prodromal phase of PD. Objective: To evaluate the time span from onset of first prodromal symptoms to the initial diagnosis of PD as well as the order of symptom occurrence. Methods: Retrospective study of 93 consecutively interviewed PD patients without dementia and 93 sex and age matched controls free of neurodegenerative disorders. A standardized in-house telephone work-sheet assessing 19 nonmotor and six early motor signs was used. Results: A total of 98.8% of all patients interviewed reported to have experienced prodromal symptoms prior to receiving the initial diagnosis of PD. Patients noticed an average of 7.6 different symptoms during this time interval. The mean time span between the recalled onset of any one symptom and PD diagnosis was 10.2 years. In both groups, the course of prodromal sign onset was associated with early neuropathological disease stages proposed by Braak. Outlook: These retrospectively gathered data confirm the existence of a long prodromal phase for PD that is consistent with neuropathological staging. A standardized questionnaire assessing such early symptoms may be helpful in identifying subjects at high risk for PD while they are still in the prodromal phase of the disorder.
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type="wicri:Area/Main/Merge">001946</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">The Patients' Perception of Prodromal Symptoms Before the Initial Diagnosis of Parkinson's Disease</title><author><name sortKey="Gaenslen, Alexandra" sort="Gaenslen, Alexandra" uniqKey="Gaenslen A" first="Alexandra" last="Gaenslen">Alexandra Gaenslen</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Neurodegeneration, Hertie Institute of Clinical Brain Research</s1><s2>Tübingen</s2><s3>DEU</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Tübingen</region><settlement type="city">Tübingen</settlement></placeName></affiliation><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>German Center for Neurodegenerative Diseases, University of Tübingen</s1><s3>DEU</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>University of Tübingen</wicri:noRegion><wicri:noRegion>German Center for Neurodegenerative Diseases, University of Tübingen</wicri:noRegion></affiliation></author><author><name sortKey="Swid, Irene" sort="Swid, Irene" uniqKey="Swid I" first="Irene" last="Swid">Irene Swid</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Neurodegeneration, Hertie Institute of Clinical Brain Research</s1><s2>Tübingen</s2><s3>DEU</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Tübingen</region><settlement type="city">Tübingen</settlement></placeName></affiliation><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>German Center for Neurodegenerative Diseases, University of Tübingen</s1><s3>DEU</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>University of Tübingen</wicri:noRegion><wicri:noRegion>German Center for Neurodegenerative Diseases, University of Tübingen</wicri:noRegion></affiliation></author><author><name sortKey="Liepelt Scarfone, Inga" sort="Liepelt Scarfone, Inga" uniqKey="Liepelt Scarfone I" first="Inga" last="Liepelt-Scarfone">Inga Liepelt-Scarfone</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Neurodegeneration, Hertie Institute of Clinical Brain Research</s1><s2>Tübingen</s2><s3>DEU</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Tübingen</region><settlement type="city">Tübingen</settlement></placeName></affiliation><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>German Center for Neurodegenerative Diseases, University of Tübingen</s1><s3>DEU</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>University of Tübingen</wicri:noRegion><wicri:noRegion>German Center for Neurodegenerative Diseases, University of Tübingen</wicri:noRegion></affiliation></author><author><name sortKey="Godau, Jana" sort="Godau, Jana" uniqKey="Godau J" first="Jana" last="Godau">Jana Godau</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Neurodegeneration, Hertie Institute of Clinical Brain Research</s1><s2>Tübingen</s2><s3>DEU</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Tübingen</region><settlement type="city">Tübingen</settlement></placeName></affiliation><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>German Center for Neurodegenerative Diseases, University of Tübingen</s1><s3>DEU</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>University of Tübingen</wicri:noRegion><wicri:noRegion>German Center for Neurodegenerative Diseases, University of Tübingen</wicri:noRegion></affiliation></author><author><name sortKey="Berg, Daniela" sort="Berg, Daniela" uniqKey="Berg D" first="Daniela" last="Berg">Daniela Berg</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Neurodegeneration, Hertie Institute of Clinical Brain Research</s1><s2>Tübingen</s2><s3>DEU</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Tübingen</region><settlement type="city">Tübingen</settlement></placeName></affiliation><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>German Center for Neurodegenerative Diseases, University of Tübingen</s1><s3>DEU</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>University of Tübingen</wicri:noRegion><wicri:noRegion>German Center for Neurodegenerative Diseases, University of Tübingen</wicri:noRegion></affiliation></author></analytic><series><title level="j" type="main">Movement disorders</title><title level="j" type="abbreviated">Mov. disord.</title><idno type="ISSN">0885-3185</idno><imprint><date when="2011">2011</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Movement disorders</title><title level="j" type="abbreviated">Mov. disord.</title><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Diagnosis</term><term>Human</term><term>Nervous system diseases</term><term>Parkinson disease</term><term>Parkinsonism</term><term>Perception</term><term>Prodrome</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Maladie de Parkinson</term><term>Parkinsonisme</term><term>Pathologie du système nerveux</term><term>Homme</term><term>Perception</term><term>Diagnostic</term><term>Prodrome</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Homme</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Background: Before the occurrence of motor symptoms permits the clinical diagnosis of Parkinson's disease (PD), about or even more than 50% of the dopaminergic neurons of the substantia nigra have degenerated. This time be called the prodromal phase of PD. Objective: To evaluate the time span from onset of first prodromal symptoms to the initial diagnosis of PD as well as the order of symptom occurrence. Methods: Retrospective study of 93 consecutively interviewed PD patients without dementia and 93 sex and age matched controls free of neurodegenerative disorders. A standardized in-house telephone work-sheet assessing 19 nonmotor and six early motor signs was used. Results: A total of 98.8% of all patients interviewed reported to have experienced prodromal symptoms prior to receiving the initial diagnosis of PD. Patients noticed an average of 7.6 different symptoms during this time interval. The mean time span between the recalled onset of any one symptom and PD diagnosis was 10.2 years. In both groups, the course of prodromal sign onset was associated with early neuropathological disease stages proposed by Braak. Outlook: These retrospectively gathered data confirm the existence of a long prodromal phase for PD that is consistent with neuropathological staging. A standardized questionnaire assessing such early symptoms may be helpful in identifying subjects at high risk for PD while they are still in the prodromal phase of the disorder.</div></front></TEI><affiliations><list><country><li>Allemagne</li></country><region><li>Bade-Wurtemberg</li><li>District de Tübingen</li></region><settlement><li>Tübingen</li></settlement></list><tree><country name="Allemagne"><region name="Bade-Wurtemberg"><name sortKey="Gaenslen, Alexandra" sort="Gaenslen, Alexandra" uniqKey="Gaenslen A" first="Alexandra" last="Gaenslen">Alexandra Gaenslen</name></region><name sortKey="Berg, Daniela" sort="Berg, Daniela" uniqKey="Berg D" first="Daniela" last="Berg">Daniela Berg</name><name sortKey="Berg, Daniela" sort="Berg, Daniela" uniqKey="Berg D" first="Daniela" last="Berg">Daniela Berg</name><name sortKey="Gaenslen, Alexandra" sort="Gaenslen, Alexandra" uniqKey="Gaenslen A" first="Alexandra" last="Gaenslen">Alexandra Gaenslen</name><name sortKey="Godau, Jana" sort="Godau, Jana" uniqKey="Godau J" first="Jana" last="Godau">Jana Godau</name><name sortKey="Godau, Jana" sort="Godau, Jana" uniqKey="Godau J" first="Jana" last="Godau">Jana Godau</name><name sortKey="Liepelt Scarfone, Inga" sort="Liepelt Scarfone, Inga" uniqKey="Liepelt Scarfone I" first="Inga" last="Liepelt-Scarfone">Inga Liepelt-Scarfone</name><name sortKey="Liepelt Scarfone, Inga" sort="Liepelt Scarfone, Inga" uniqKey="Liepelt Scarfone I" first="Inga" last="Liepelt-Scarfone">Inga Liepelt-Scarfone</name><name sortKey="Swid, Irene" sort="Swid, Irene" uniqKey="Swid I" first="Irene" last="Swid">Irene Swid</name><name sortKey="Swid, Irene" sort="Swid, Irene" uniqKey="Swid I" first="Irene" last="Swid">Irene Swid</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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