Brain perfusion and markers of neurodegeneration in rapid eye movement sleep behavior disorder
Identifieur interne : 001831 ( Main/Merge ); précédent : 001830; suivant : 001832Brain perfusion and markers of neurodegeneration in rapid eye movement sleep behavior disorder
Auteurs : Mélanie Vendette [Canada] ; Jean-François Gagnon [Canada] ; Jean-Paul Soucy [Canada] ; Nadia Gosselin [Canada] ; Ronald B. Postuma [Canada] ; Maria Tuineag [Canada] ; Isabelle Godin [Canada] ; Jacques Montplaisir [Canada]Source :
- Movement Disorders [ 0885-3185 ] ; 2011-08-01.
English descriptors
- KwdEn :
- Aged, Brain (blood supply), Brain (physiopathology), Brain (radionuclide imaging), Brain Mapping, Cerebrovascular Circulation (physiology), Electroencephalography, Female, Humans, Lewy body dementia, Male, Middle Aged, Neurodegenerative Diseases (etiology), Neurodegenerative Diseases (pathology), Neurodegenerative Diseases (radionuclide imaging), Parkinson's disease, Perfusion (methods), Polysomnography, REM Sleep Behavior Disorder (complications), Severity of Illness Index, Statistics, Nonparametric, Tomography, Emission-Computed, Single-Photon, markers of neurodegeneration, rapid eye movement sleep behavior disorder, single‐photon emission computerized tomography (regional cerebral blood flow).
- MESH :
- blood supply : Brain.
- complications : REM Sleep Behavior Disorder.
- etiology : Neurodegenerative Diseases.
- methods : Perfusion.
- pathology : Neurodegenerative Diseases.
- physiology : Cerebrovascular Circulation.
- physiopathology : Brain.
- radionuclide imaging : Brain, Neurodegenerative Diseases.
- Aged, Brain Mapping, Electroencephalography, Female, Humans, Male, Middle Aged, Polysomnography, Severity of Illness Index, Statistics, Nonparametric, Tomography, Emission-Computed, Single-Photon.
Abstract
Potential early markers of neurodegeneration such as subtle motor signs, reduced color discrimination, olfactory impairment, and brain perfusion abnormalities have been reported in idiopathic rapid eye movement sleep behavior disorder, a risk factor for Parkinson's disease and Lewy body dementia. The aim of this study was to reproduce observations of regional cerebral blood flow abnormalities in a larger independent sample of patients and to explore correlations between regional cerebral blood flow and markers of neurodegeneration. Twenty patients with idiopathic rapid eye movement sleep behavior disorder and 20 healthy controls were studied by single‐photon emission computerized tomography. Motor examination, color discrimination, and olfactory identification were examined. Patients with rapid eye movement sleep behavior disorder showed decreased regional cerebral blood flow in the frontal cortex and in medial parietal areas and increased regional cerebral blood flow in subcortical regions including the bilateral pons, putamen, and hippocampus. In rapid eye movement sleep behavior disorder, brain perfusion in the frontal cortex and occipital areas was associated with poorer performance in the color discrimination test. Moreover, a relationship between loss of olfactory discrimination and regional cerebral blood flow reduction in the bilateral anterior parahippocampal gyrus, a region known to be involved in olfactory functions, was found. This study provides further evidence of regional cerebral blood flow abnormalities in rapid eye movement sleep behavior disorder that are similar to those seen in Parkinson's disease and Lewy body dementia. Moreover, regional cerebral blood flow anomalies were associated with markers of neurodegeneration. © 2011 Movement Disorder Society
Url:
DOI: 10.1002/mds.23721
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The aim of this study was to reproduce observations of regional cerebral blood flow abnormalities in a larger independent sample of patients and to explore correlations between regional cerebral blood flow and markers of neurodegeneration. Twenty patients with idiopathic rapid eye movement sleep behavior disorder and 20 healthy controls were studied by single‐photon emission computerized tomography. Motor examination, color discrimination, and olfactory identification were examined. Patients with rapid eye movement sleep behavior disorder showed decreased regional cerebral blood flow in the frontal cortex and in medial parietal areas and increased regional cerebral blood flow in subcortical regions including the bilateral pons, putamen, and hippocampus. In rapid eye movement sleep behavior disorder, brain perfusion in the frontal cortex and occipital areas was associated with poorer performance in the color discrimination test. Moreover, a relationship between loss of olfactory discrimination and regional cerebral blood flow reduction in the bilateral anterior parahippocampal gyrus, a region known to be involved in olfactory functions, was found. This study provides further evidence of regional cerebral blood flow abnormalities in rapid eye movement sleep behavior disorder that are similar to those seen in Parkinson's disease and Lewy body dementia. 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Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2011-08-01">2011-08-01</date><biblScope unit="vol">26</biblScope><biblScope unit="issue">9</biblScope><biblScope unit="page" from="1717">1717</biblScope><biblScope unit="page" to="1724">1724</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">3236139A4D2A2CE02F01B7BBB994D6F1E84CAA12</idno><idno type="DOI">10.1002/mds.23721</idno><idno type="ArticleID">MDS23721</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Lewy body dementia</term><term>Parkinson's disease</term><term>markers of neurodegeneration</term><term>rapid eye movement sleep behavior disorder</term><term>single‐photon emission computerized tomography (regional cerebral blood flow)</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Potential early markers of neurodegeneration such as subtle motor signs, reduced color discrimination, olfactory impairment, and brain perfusion abnormalities have been reported in idiopathic rapid eye movement sleep behavior disorder, a risk factor for Parkinson's disease and Lewy body dementia. The aim of this study was to reproduce observations of regional cerebral blood flow abnormalities in a larger independent sample of patients and to explore correlations between regional cerebral blood flow and markers of neurodegeneration. Twenty patients with idiopathic rapid eye movement sleep behavior disorder and 20 healthy controls were studied by single‐photon emission computerized tomography. Motor examination, color discrimination, and olfactory identification were examined. Patients with rapid eye movement sleep behavior disorder showed decreased regional cerebral blood flow in the frontal cortex and in medial parietal areas and increased regional cerebral blood flow in subcortical regions including the bilateral pons, putamen, and hippocampus. In rapid eye movement sleep behavior disorder, brain perfusion in the frontal cortex and occipital areas was associated with poorer performance in the color discrimination test. Moreover, a relationship between loss of olfactory discrimination and regional cerebral blood flow reduction in the bilateral anterior parahippocampal gyrus, a region known to be involved in olfactory functions, was found. This study provides further evidence of regional cerebral blood flow abnormalities in rapid eye movement sleep behavior disorder that are similar to those seen in Parkinson's disease and Lewy body dementia. Moreover, regional cerebral blood flow anomalies were associated with markers of neurodegeneration. © 2011 Movement Disorder Society</div></front></TEI></ISTEX><PubMed><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Brain perfusion and markers of neurodegeneration in rapid eye movement sleep behavior disorder.</title><author><name sortKey="Vendette, Melanie" sort="Vendette, Melanie" uniqKey="Vendette M" first="Mélanie" last="Vendette">Mélanie Vendette</name><affiliation wicri:level="1"><nlm:affiliation>Centre d'Études Avancées en Médecine du Sommeil, Hôpital du Sacré-Cœur de Montréal, and Department of Psychology, University of Montreal, Montreal, Quebec, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Centre d'Études Avancées en Médecine du Sommeil, Hôpital du Sacré-Cœur de Montréal, and Department of Psychology, University of Montreal, Montreal, Quebec</wicri:regionArea><wicri:noRegion>Quebec</wicri:noRegion></affiliation></author><author><name sortKey="Gagnon, Jean Francois" sort="Gagnon, Jean Francois" uniqKey="Gagnon J" first="Jean-François" last="Gagnon">Jean-François Gagnon</name></author><author><name sortKey="Soucy, Jean Paul" sort="Soucy, Jean Paul" uniqKey="Soucy J" first="Jean-Paul" last="Soucy">Jean-Paul Soucy</name></author><author><name sortKey="Gosselin, Nadia" sort="Gosselin, Nadia" uniqKey="Gosselin N" first="Nadia" last="Gosselin">Nadia Gosselin</name></author><author><name sortKey="Postuma, Ronald B" sort="Postuma, Ronald B" uniqKey="Postuma R" first="Ronald B" last="Postuma">Ronald B. Postuma</name></author><author><name sortKey="Tuineag, Maria" sort="Tuineag, Maria" uniqKey="Tuineag M" first="Maria" last="Tuineag">Maria Tuineag</name></author><author><name sortKey="Godin, Isabelle" sort="Godin, Isabelle" uniqKey="Godin I" first="Isabelle" last="Godin">Isabelle Godin</name></author><author><name sortKey="Montplaisir, Jacques" sort="Montplaisir, Jacques" uniqKey="Montplaisir J" first="Jacques" last="Montplaisir">Jacques Montplaisir</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2011">2011</date><idno type="doi">10.1002/mds.23721</idno><idno type="RBID">pubmed:21542022</idno><idno type="pmid">21542022</idno><idno type="wicri:Area/PubMed/Corpus">001219</idno><idno type="wicri:Area/PubMed/Curation">001219</idno><idno type="wicri:Area/PubMed/Checkpoint">001443</idno><idno type="wicri:Area/Ncbi/Merge">003208</idno><idno type="wicri:Area/Ncbi/Curation">003208</idno><idno type="wicri:Area/Ncbi/Checkpoint">003208</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Brain perfusion and markers of neurodegeneration in rapid eye movement sleep behavior disorder.</title><author><name sortKey="Vendette, Melanie" sort="Vendette, Melanie" uniqKey="Vendette M" first="Mélanie" last="Vendette">Mélanie Vendette</name><affiliation wicri:level="1"><nlm:affiliation>Centre d'Études Avancées en Médecine du Sommeil, Hôpital du Sacré-Cœur de Montréal, and Department of Psychology, University of Montreal, Montreal, Quebec, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Centre d'Études Avancées en Médecine du Sommeil, Hôpital du Sacré-Cœur de Montréal, and Department of Psychology, University of Montreal, Montreal, Quebec</wicri:regionArea><wicri:noRegion>Quebec</wicri:noRegion></affiliation></author><author><name sortKey="Gagnon, Jean Francois" sort="Gagnon, Jean Francois" uniqKey="Gagnon J" first="Jean-François" last="Gagnon">Jean-François Gagnon</name></author><author><name sortKey="Soucy, Jean Paul" sort="Soucy, Jean Paul" uniqKey="Soucy J" first="Jean-Paul" last="Soucy">Jean-Paul Soucy</name></author><author><name sortKey="Gosselin, Nadia" sort="Gosselin, Nadia" uniqKey="Gosselin N" first="Nadia" last="Gosselin">Nadia Gosselin</name></author><author><name sortKey="Postuma, Ronald B" sort="Postuma, Ronald B" uniqKey="Postuma R" first="Ronald B" last="Postuma">Ronald B. Postuma</name></author><author><name sortKey="Tuineag, Maria" sort="Tuineag, Maria" uniqKey="Tuineag M" first="Maria" last="Tuineag">Maria Tuineag</name></author><author><name sortKey="Godin, Isabelle" sort="Godin, Isabelle" uniqKey="Godin I" first="Isabelle" last="Godin">Isabelle Godin</name></author><author><name sortKey="Montplaisir, Jacques" sort="Montplaisir, Jacques" uniqKey="Montplaisir J" first="Jacques" last="Montplaisir">Jacques Montplaisir</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="eISSN">1531-8257</idno><imprint><date when="2011" type="published">2011</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Brain (blood supply)</term><term>Brain (physiopathology)</term><term>Brain (radionuclide imaging)</term><term>Brain Mapping</term><term>Cerebrovascular Circulation (physiology)</term><term>Electroencephalography</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Neurodegenerative Diseases (etiology)</term><term>Neurodegenerative Diseases (pathology)</term><term>Neurodegenerative Diseases (radionuclide imaging)</term><term>Perfusion (methods)</term><term>Polysomnography</term><term>REM Sleep Behavior Disorder (complications)</term><term>Severity of Illness Index</term><term>Statistics, Nonparametric</term><term>Tomography, Emission-Computed, Single-Photon</term></keywords><keywords scheme="MESH" qualifier="blood supply" xml:lang="en"><term>Brain</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>REM Sleep Behavior Disorder</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Neurodegenerative Diseases</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Perfusion</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Neurodegenerative Diseases</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Cerebrovascular Circulation</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Brain</term></keywords><keywords scheme="MESH" qualifier="radionuclide imaging" xml:lang="en"><term>Brain</term><term>Neurodegenerative Diseases</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Brain Mapping</term><term>Electroencephalography</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Polysomnography</term><term>Severity of Illness Index</term><term>Statistics, Nonparametric</term><term>Tomography, Emission-Computed, Single-Photon</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Potential early markers of neurodegeneration such as subtle motor signs, reduced color discrimination, olfactory impairment, and brain perfusion abnormalities have been reported in idiopathic rapid eye movement sleep behavior disorder, a risk factor for Parkinson's disease and Lewy body dementia. The aim of this study was to reproduce observations of regional cerebral blood flow abnormalities in a larger independent sample of patients and to explore correlations between regional cerebral blood flow and markers of neurodegeneration. Twenty patients with idiopathic rapid eye movement sleep behavior disorder and 20 healthy controls were studied by single-photon emission computerized tomography. Motor examination, color discrimination, and olfactory identification were examined. Patients with rapid eye movement sleep behavior disorder showed decreased regional cerebral blood flow in the frontal cortex and in medial parietal areas and increased regional cerebral blood flow in subcortical regions including the bilateral pons, putamen, and hippocampus. In rapid eye movement sleep behavior disorder, brain perfusion in the frontal cortex and occipital areas was associated with poorer performance in the color discrimination test. Moreover, a relationship between loss of olfactory discrimination and regional cerebral blood flow reduction in the bilateral anterior parahippocampal gyrus, a region known to be involved in olfactory functions, was found. This study provides further evidence of regional cerebral blood flow abnormalities in rapid eye movement sleep behavior disorder that are similar to those seen in Parkinson's disease and Lewy body dementia. Moreover, regional cerebral blood flow anomalies were associated with markers of neurodegeneration.</div></front></TEI></PubMed></double></record>Pour manipuler ce document sous Unix (Dilib)
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