Graft‐induced dyskinesias in Parkinson's disease: High striatal serotonin/dopamine transporter ratio
Identifieur interne : 001699 ( Main/Merge ); précédent : 001698; suivant : 001700Graft‐induced dyskinesias in Parkinson's disease: High striatal serotonin/dopamine transporter ratio
Auteurs : Marios Politis [Royaume-Uni] ; Wolfgang H. Oertel [Allemagne] ; Kit Wu [Royaume-Uni] ; Niall P. Quinn [Royaume-Uni] ; Oliver Pogarell [Allemagne] ; David J. Brooks [Royaume-Uni] ; Anders Bjorklund [Suède] ; Olle Lindvall [Suède] ; Paola Piccini [Royaume-Uni]Source :
- Movement Disorders [ 0885-3185 ] ; 2011-09.
English descriptors
- KwdEn :
- Brain Mapping, Brain Tissue Transplantation (adverse effects), Corpus Striatum (drug effects), Corpus Striatum (metabolism), Corpus Striatum (radionuclide imaging), Dihydroxyphenylalanine (analogs & derivatives), Dihydroxyphenylalanine (pharmacokinetics), Dopamine Plasma Membrane Transport Proteins (metabolism), Dyskinesias (etiology), Dyskinesias (pathology), Dyskinesias (radionuclide imaging), Functional Laterality, Humans, Longitudinal Studies, Male, Middle Aged, Parkinson, Parkinson Disease (pathology), Parkinson Disease (surgery), Positron-Emission Tomography, Serotonin Plasma Membrane Transport Proteins (metabolism), Time Factors, Tomography, Emission-Computed, Single-Photon, Tropanes (pharmacokinetics), dyskinesias, serotonin transporter; dopamine transporter, transplantation.
- MESH :
- chemical , analogs & derivatives : Dihydroxyphenylalanine.
- adverse effects : Brain Tissue Transplantation.
- drug effects : Corpus Striatum.
- etiology : Dyskinesias.
- metabolism : Corpus Striatum, Dopamine Plasma Membrane Transport Proteins, Serotonin Plasma Membrane Transport Proteins.
- pathology : Dyskinesias, Parkinson Disease.
- chemical , pharmacokinetics : Dihydroxyphenylalanine, Tropanes.
- radionuclide imaging : Corpus Striatum, Dyskinesias.
- surgery : Parkinson Disease.
- Brain Mapping, Functional Laterality, Humans, Longitudinal Studies, Male, Middle Aged, Positron-Emission Tomography, Time Factors, Tomography, Emission-Computed, Single-Photon.
Abstract
Graft‐induced dyskinesias are a serious complication after neural transplantation in Parkinson's disease. One patient with Parkinson's disease, treated with fetal grafts 14 years ago and deep brain stimulation 6 years ago, showed marked improvement of motor symptoms but continued to suffer from OFF‐medication graft‐induced dyskinesias. The patient received a series of clinical and imaging assessments. Positron emission tomography and single‐photon emission computed tomography 14 years posttransplantation revealed an elevated serotonin/dopamine transporter ratio in the grafted striatum compatible with serotonergic hyperinnervation. Inhibition of serotonin neuron activity by systemic administration of a 5‐HT1A agonist suppressed graft‐induced dyskinesias. Our data provide further evidence that serotonergic neurons mediate graft‐induced dyskinesias in Parkinson's disease. Achieving a normal striatal serotonin/dopamine transporter ratio following transplantation of fetal tissue or stem cells should be necessary to avoid the development of graft‐induced dyskinesias. © 2011 Movement Disorder Society
Url:
DOI: 10.1002/mds.23743
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<term>Dihydroxyphenylalanine (analogs & derivatives)</term>
<term>Dihydroxyphenylalanine (pharmacokinetics)</term>
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<term>Dyskinesias (pathology)</term>
<term>Dyskinesias (radionuclide imaging)</term>
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<front><div type="abstract" xml:lang="en">Graft‐induced dyskinesias are a serious complication after neural transplantation in Parkinson's disease. One patient with Parkinson's disease, treated with fetal grafts 14 years ago and deep brain stimulation 6 years ago, showed marked improvement of motor symptoms but continued to suffer from OFF‐medication graft‐induced dyskinesias. The patient received a series of clinical and imaging assessments. Positron emission tomography and single‐photon emission computed tomography 14 years posttransplantation revealed an elevated serotonin/dopamine transporter ratio in the grafted striatum compatible with serotonergic hyperinnervation. Inhibition of serotonin neuron activity by systemic administration of a 5‐HT1A agonist suppressed graft‐induced dyskinesias. Our data provide further evidence that serotonergic neurons mediate graft‐induced dyskinesias in Parkinson's disease. Achieving a normal striatal serotonin/dopamine transporter ratio following transplantation of fetal tissue or stem cells should be necessary to avoid the development of graft‐induced dyskinesias. © 2011 Movement Disorder Society</div>
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<front><div type="abstract" xml:lang="en">Graft‐induced dyskinesias are a serious complication after neural transplantation in Parkinson's disease. One patient with Parkinson's disease, treated with fetal grafts 14 years ago and deep brain stimulation 6 years ago, showed marked improvement of motor symptoms but continued to suffer from OFF‐medication graft‐induced dyskinesias. The patient received a series of clinical and imaging assessments. Positron emission tomography and single‐photon emission computed tomography 14 years posttransplantation revealed an elevated serotonin/dopamine transporter ratio in the grafted striatum compatible with serotonergic hyperinnervation. Inhibition of serotonin neuron activity by systemic administration of a 5‐HT1A agonist suppressed graft‐induced dyskinesias. Our data provide further evidence that serotonergic neurons mediate graft‐induced dyskinesias in Parkinson's disease. Achieving a normal striatal serotonin/dopamine transporter ratio following transplantation of fetal tissue or stem cells should be necessary to avoid the development of graft‐induced dyskinesias. © 2011 Movement Disorder Society</div>
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<term>Corpus Striatum (radionuclide imaging)</term>
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<front><div type="abstract" xml:lang="en">Graft-induced dyskinesias are a serious complication after neural transplantation in Parkinson's disease. One patient with Parkinson's disease, treated with fetal grafts 14 years ago and deep brain stimulation 6 years ago, showed marked improvement of motor symptoms but continued to suffer from OFF-medication graft-induced dyskinesias. The patient received a series of clinical and imaging assessments. Positron emission tomography and single-photon emission computed tomography 14 years posttransplantation revealed an elevated serotonin/dopamine transporter ratio in the grafted striatum compatible with serotonergic hyperinnervation. Inhibition of serotonin neuron activity by systemic administration of a 5-HT(1A) agonist suppressed graft-induced dyskinesias. Our data provide further evidence that serotonergic neurons mediate graft-induced dyskinesias in Parkinson's disease. Achieving a normal striatal serotonin/dopamine transporter ratio following transplantation of fetal tissue or stem cells should be necessary to avoid the development of graft-induced dyskinesias.</div>
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