Increased cortical hyperexcitability and exaggerated myoclonus with aging in benign adult familial myoclonus epilepsy
Identifieur interne : 001673 ( Main/Merge ); précédent : 001672; suivant : 001674Increased cortical hyperexcitability and exaggerated myoclonus with aging in benign adult familial myoclonus epilepsy
Auteurs : Takefumi Hitomi [Japon] ; Akio Ikeda [Japon] ; Takayuki Kondo [Japon] ; Hisaji Imamura [Japon] ; Morito Inouchi [Japon] ; Riki Matsumoto [Japon] ; Kiyohito Terada [Japon] ; Masutaro Kanda [Japon] ; Masao Matsuhashi [Japon] ; Takashi Nagamine [Japon] ; Hiroshi Shibasaki [Japon] ; Ryosuke Takahashi [Japon]Source :
- Movement Disorders [ 0885-3185 ] ; 2011-07.
English descriptors
- KwdEn :
- Adult, Aged, Aging, Electroencephalography, Epilepsies, Myoclonic (pathology), Epilepsies, Myoclonic (physiopathology), Evoked Potentials, Somatosensory (physiology), Female, Humans, Male, Middle Aged, Myoclonus (physiopathology), Reaction Time, Severity of Illness Index, Somatosensory Cortex (physiopathology), aging, benign adult familial myoclonus epilepsy, cortical myoclonic tremor, giant somatosensory evoked potential.
- MESH :
- pathology : Epilepsies, Myoclonic.
- physiology : Evoked Potentials, Somatosensory.
- physiopathology : Epilepsies, Myoclonic, Myoclonus, Somatosensory Cortex.
- Adult, Aged, Aging, Electroencephalography, Female, Humans, Male, Middle Aged, Reaction Time, Severity of Illness Index.
Abstract
The clinical implications of enlarged early cortical components of somatosensory evoked potentials in benign adult familial myoclonus epilepsy remain unknown. Somatosensory evoked potentials following electrical stimulation of the median nerve at the wrist were studied in 16 patients with a clinical diagnosis of benign adult familial myoclonus epilepsy (7 men and 9 women; mean age, 51 ± 18 years) and 19 age‐matched apparently healthy control subjects (11 men and 8 women; mean age, 49 ± 18 years). Giant somatosensory evoked potentials were observed in 13 of the 16 patients. P25 and N35 amplitudes in the patient group were 11.4 ± 6.1 and 19.2 ± 11.5 μV, respectively, and both were significantly larger compared with those in control subjects (P = 0.008 for P25 and P < 0.0001 for N35). There was a significant positive relationship between age at somatosensory evoked potential examination and N20, P25, and N35 amplitudes, both in the patient and in the control groups (P < 0.05). The linear regression gradient of the N35 amplitude with respect to age was significantly larger in the patient group than in the control group (P = 0.04). Furthermore, regression analysis showed a significant positive relationship between the myoclonus rating scale and age at time of somatosensory evoked potential examination (R = 0.645, P = 0.007). Somatosensory evoked potential amplitude increased with age in patients with benign adult familial myoclonus epilepsy to a greater extent than in the control subjects, which suggests a progressive increase in cortical excitability based on progressive pathophysiology in benign adult familial myoclonus epilepsy. © 2011 Movement Disorder Society
Url:
DOI: 10.1002/mds.23653
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xml:lang="fr">Japon</country><wicri:regionArea>Department of Epilepsy, National Epilepsy Center, Shizuoka Institute of Epilepsy and Neurological Disorders, Shizuoka</wicri:regionArea><wicri:noRegion>Shizuoka</wicri:noRegion></affiliation></author><author><name sortKey="Kanda, Masutaro" sort="Kanda, Masutaro" uniqKey="Kanda M" first="Masutaro" last="Kanda">Masutaro Kanda</name><affiliation wicri:level="1"><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Neurology, Takeda General Hospital, Kyoto</wicri:regionArea><wicri:noRegion>Kyoto</wicri:noRegion></affiliation></author><author><name sortKey="Matsuhashi, Masao" sort="Matsuhashi, Masao" uniqKey="Matsuhashi M" first="Masao" last="Matsuhashi">Masao Matsuhashi</name><affiliation wicri:level="1"><country xml:lang="fr">Japon</country><wicri:regionArea>Human Brain Research Center, Kyoto University Graduate School of Medicine, 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Takahashi</name><affiliation wicri:level="1"><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Neurology, Kyoto University School of Medicine, Kyoto</wicri:regionArea><wicri:noRegion>Kyoto</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="abbrev">Mov. 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Somatosensory evoked potentials following electrical stimulation of the median nerve at the wrist were studied in 16 patients with a clinical diagnosis of benign adult familial myoclonus epilepsy (7 men and 9 women; mean age, 51 ± 18 years) and 19 age‐matched apparently healthy control subjects (11 men and 8 women; mean age, 49 ± 18 years). Giant somatosensory evoked potentials were observed in 13 of the 16 patients. P25 and N35 amplitudes in the patient group were 11.4 ± 6.1 and 19.2 ± 11.5 μV, respectively, and both were significantly larger compared with those in control subjects (P = 0.008 for P25 and P < 0.0001 for N35). There was a significant positive relationship between age at somatosensory evoked potential examination and N20, P25, and N35 amplitudes, both in the patient and in the control groups (P < 0.05). The linear regression gradient of the N35 amplitude with respect to age was significantly larger in the patient group than in the control group (P = 0.04). Furthermore, regression analysis showed a significant positive relationship between the myoclonus rating scale and age at time of somatosensory evoked potential examination (R = 0.645, P = 0.007). Somatosensory evoked potential amplitude increased with age in patients with benign adult familial myoclonus epilepsy to a greater extent than in the control subjects, which suggests a progressive increase in cortical excitability based on progressive pathophysiology in benign adult familial myoclonus epilepsy. © 2011 Movement Disorder Society</div></front></TEI><double doi="10.1002/mds.23653"><ISTEX><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Increased cortical hyperexcitability and exaggerated myoclonus with aging in benign adult familial myoclonus epilepsy</title><author><name sortKey="Hitomi, Takefumi" sort="Hitomi, Takefumi" uniqKey="Hitomi T" first="Takefumi" last="Hitomi">Takefumi Hitomi</name></author><author><name sortKey="Ikeda, Akio" sort="Ikeda, Akio" uniqKey="Ikeda A" first="Akio" last="Ikeda">Akio Ikeda</name></author><author><name sortKey="Kondo, Takayuki" sort="Kondo, Takayuki" uniqKey="Kondo T" first="Takayuki" last="Kondo">Takayuki Kondo</name></author><author><name sortKey="Imamura, Hisaji" sort="Imamura, Hisaji" uniqKey="Imamura H" first="Hisaji" last="Imamura">Hisaji Imamura</name></author><author><name sortKey="Inouchi, Morito" sort="Inouchi, Morito" uniqKey="Inouchi M" first="Morito" last="Inouchi">Morito Inouchi</name></author><author><name sortKey="Matsumoto, Riki" sort="Matsumoto, Riki" uniqKey="Matsumoto R" first="Riki" last="Matsumoto">Riki Matsumoto</name></author><author><name sortKey="Terada, Kiyohito" sort="Terada, Kiyohito" uniqKey="Terada K" first="Kiyohito" last="Terada">Kiyohito Terada</name></author><author><name sortKey="Kanda, Masutaro" sort="Kanda, Masutaro" uniqKey="Kanda M" first="Masutaro" last="Kanda">Masutaro Kanda</name></author><author><name sortKey="Matsuhashi, Masao" sort="Matsuhashi, Masao" uniqKey="Matsuhashi M" first="Masao" last="Matsuhashi">Masao Matsuhashi</name></author><author><name sortKey="Nagamine, Takashi" sort="Nagamine, Takashi" uniqKey="Nagamine T" first="Takashi" last="Nagamine">Takashi Nagamine</name></author><author><name sortKey="Shibasaki, Hiroshi" sort="Shibasaki, Hiroshi" uniqKey="Shibasaki H" first="Hiroshi" last="Shibasaki">Hiroshi Shibasaki</name></author><author><name sortKey="Takahashi, Ryosuke" sort="Takahashi, Ryosuke" uniqKey="Takahashi R" first="Ryosuke" last="Takahashi">Ryosuke Takahashi</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:B8CCBD6EF65E0204CE2B4CF4F4264AFF3CA27FF0</idno><date when="2011" year="2011">2011</date><idno type="doi">10.1002/mds.23653</idno><idno type="url">https://api.istex.fr/document/B8CCBD6EF65E0204CE2B4CF4F4264AFF3CA27FF0/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">000E42</idno><idno type="wicri:Area/Istex/Curation">000E42</idno><idno type="wicri:Area/Istex/Checkpoint">000352</idno><idno type="wicri:doubleKey">0885-3185:2011:Hitomi T:increased:cortical:hyperexcitability</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Increased cortical hyperexcitability and exaggerated myoclonus with aging in benign adult familial myoclonus epilepsy</title><author><name sortKey="Hitomi, Takefumi" sort="Hitomi, Takefumi" uniqKey="Hitomi T" first="Takefumi" last="Hitomi">Takefumi Hitomi</name><affiliation wicri:level="1"><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Neurology, Kyoto University School of Medicine, Kyoto</wicri:regionArea><wicri:noRegion>Kyoto</wicri:noRegion></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Japon</country><wicri:regionArea>Current Address: Current address for Takefumi Hitomi: Department of Respiratory Care and Sleep Control Medicine, Kyoto University School of Medicine, Kyoto</wicri:regionArea><wicri:noRegion>Kyoto</wicri:noRegion></affiliation></author><author><name sortKey="Ikeda, Akio" sort="Ikeda, Akio" uniqKey="Ikeda A" first="Akio" last="Ikeda">Akio Ikeda</name><affiliation wicri:level="1"><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Neurology, Kyoto University School of Medicine, Kyoto</wicri:regionArea><wicri:noRegion>Kyoto</wicri:noRegion></affiliation></author><author><name sortKey="Kondo, Takayuki" sort="Kondo, Takayuki" uniqKey="Kondo T" first="Takayuki" last="Kondo">Takayuki Kondo</name><affiliation wicri:level="1"><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Neurology, Kyoto University School of Medicine, Kyoto</wicri:regionArea><wicri:noRegion>Kyoto</wicri:noRegion></affiliation></author><author><name sortKey="Imamura, Hisaji" sort="Imamura, Hisaji" uniqKey="Imamura H" first="Hisaji" last="Imamura">Hisaji Imamura</name><affiliation wicri:level="1"><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Neurology, Kyoto University School of Medicine, Kyoto</wicri:regionArea><wicri:noRegion>Kyoto</wicri:noRegion></affiliation></author><author><name sortKey="Inouchi, Morito" sort="Inouchi, Morito" uniqKey="Inouchi M" first="Morito" last="Inouchi">Morito Inouchi</name><affiliation wicri:level="1"><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Neurology, Kyoto University School of Medicine, Kyoto</wicri:regionArea><wicri:noRegion>Kyoto</wicri:noRegion></affiliation></author><author><name sortKey="Matsumoto, Riki" sort="Matsumoto, Riki" uniqKey="Matsumoto R" first="Riki" last="Matsumoto">Riki Matsumoto</name><affiliation wicri:level="1"><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Neurology, Kyoto University School of Medicine, Kyoto</wicri:regionArea><wicri:noRegion>Kyoto</wicri:noRegion></affiliation></author><author><name sortKey="Terada, Kiyohito" sort="Terada, Kiyohito" uniqKey="Terada K" first="Kiyohito" last="Terada">Kiyohito Terada</name><affiliation wicri:level="1"><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Epilepsy, National Epilepsy Center, Shizuoka Institute of Epilepsy and Neurological Disorders, Shizuoka</wicri:regionArea><wicri:noRegion>Shizuoka</wicri:noRegion></affiliation></author><author><name sortKey="Kanda, Masutaro" sort="Kanda, Masutaro" uniqKey="Kanda M" first="Masutaro" last="Kanda">Masutaro Kanda</name><affiliation wicri:level="1"><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Neurology, Takeda General Hospital, Kyoto</wicri:regionArea><wicri:noRegion>Kyoto</wicri:noRegion></affiliation></author><author><name sortKey="Matsuhashi, Masao" sort="Matsuhashi, Masao" uniqKey="Matsuhashi M" first="Masao" last="Matsuhashi">Masao Matsuhashi</name><affiliation wicri:level="1"><country xml:lang="fr">Japon</country><wicri:regionArea>Human Brain Research Center, Kyoto University Graduate School of Medicine, Kyoto</wicri:regionArea><wicri:noRegion>Kyoto</wicri:noRegion></affiliation></author><author><name sortKey="Nagamine, Takashi" sort="Nagamine, Takashi" uniqKey="Nagamine T" first="Takashi" last="Nagamine">Takashi Nagamine</name><affiliation wicri:level="1"><country xml:lang="fr">Japon</country><wicri:regionArea>Human Brain Research Center, Kyoto University Graduate School of Medicine, Kyoto</wicri:regionArea><wicri:noRegion>Kyoto</wicri:noRegion></affiliation></author><author><name sortKey="Shibasaki, Hiroshi" sort="Shibasaki, Hiroshi" uniqKey="Shibasaki H" first="Hiroshi" last="Shibasaki">Hiroshi Shibasaki</name><affiliation wicri:level="1"><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Neurology, Takeda General Hospital, Kyoto</wicri:regionArea><wicri:noRegion>Kyoto</wicri:noRegion></affiliation></author><author><name sortKey="Takahashi, Ryosuke" sort="Takahashi, Ryosuke" uniqKey="Takahashi R" first="Ryosuke" last="Takahashi">Ryosuke Takahashi</name><affiliation wicri:level="1"><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Neurology, Kyoto University School of Medicine, Kyoto</wicri:regionArea><wicri:noRegion>Kyoto</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2011-07">2011-07</date><biblScope unit="vol">26</biblScope><biblScope unit="issue">8</biblScope><biblScope unit="page" from="1509">1509</biblScope><biblScope unit="page" to="1514">1514</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">B8CCBD6EF65E0204CE2B4CF4F4264AFF3CA27FF0</idno><idno type="DOI">10.1002/mds.23653</idno><idno type="ArticleID">MDS23653</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>aging</term><term>benign adult familial myoclonus epilepsy</term><term>cortical myoclonic tremor</term><term>giant somatosensory evoked potential</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The clinical implications of enlarged early cortical components of somatosensory evoked potentials in benign adult familial myoclonus epilepsy remain unknown. Somatosensory evoked potentials following electrical stimulation of the median nerve at the wrist were studied in 16 patients with a clinical diagnosis of benign adult familial myoclonus epilepsy (7 men and 9 women; mean age, 51 ± 18 years) and 19 age‐matched apparently healthy control subjects (11 men and 8 women; mean age, 49 ± 18 years). Giant somatosensory evoked potentials were observed in 13 of the 16 patients. P25 and N35 amplitudes in the patient group were 11.4 ± 6.1 and 19.2 ± 11.5 μV, respectively, and both were significantly larger compared with those in control subjects (P = 0.008 for P25 and P < 0.0001 for N35). There was a significant positive relationship between age at somatosensory evoked potential examination and N20, P25, and N35 amplitudes, both in the patient and in the control groups (P < 0.05). The linear regression gradient of the N35 amplitude with respect to age was significantly larger in the patient group than in the control group (P = 0.04). Furthermore, regression analysis showed a significant positive relationship between the myoclonus rating scale and age at time of somatosensory evoked potential examination (R = 0.645, P = 0.007). Somatosensory evoked potential amplitude increased with age in patients with benign adult familial myoclonus epilepsy to a greater extent than in the control subjects, which suggests a progressive increase in cortical excitability based on progressive pathophysiology in benign adult familial myoclonus epilepsy. © 2011 Movement Disorder Society</div></front></TEI></ISTEX><PubMed><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Increased cortical hyperexcitability and exaggerated myoclonus with aging in benign adult familial myoclonus epilepsy.</title><author><name sortKey="Hitomi, Takefumi" sort="Hitomi, Takefumi" uniqKey="Hitomi T" first="Takefumi" last="Hitomi">Takefumi Hitomi</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, Kyoto University School of Medicine, Kyoto, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Neurology, Kyoto University School of Medicine, Kyoto</wicri:regionArea><wicri:noRegion>Kyoto</wicri:noRegion></affiliation></author><author><name sortKey="Ikeda, Akio" sort="Ikeda, Akio" uniqKey="Ikeda A" first="Akio" last="Ikeda">Akio Ikeda</name></author><author><name sortKey="Kondo, Takayuki" sort="Kondo, Takayuki" uniqKey="Kondo T" first="Takayuki" last="Kondo">Takayuki Kondo</name></author><author><name sortKey="Imamura, Hisaji" sort="Imamura, Hisaji" uniqKey="Imamura H" first="Hisaji" last="Imamura">Hisaji Imamura</name></author><author><name sortKey="Inouchi, Morito" sort="Inouchi, Morito" uniqKey="Inouchi M" first="Morito" last="Inouchi">Morito Inouchi</name></author><author><name sortKey="Matsumoto, Riki" sort="Matsumoto, Riki" uniqKey="Matsumoto R" first="Riki" last="Matsumoto">Riki Matsumoto</name></author><author><name sortKey="Terada, Kiyohito" sort="Terada, Kiyohito" uniqKey="Terada K" first="Kiyohito" last="Terada">Kiyohito Terada</name></author><author><name sortKey="Kanda, Masutaro" sort="Kanda, Masutaro" uniqKey="Kanda M" first="Masutaro" last="Kanda">Masutaro Kanda</name></author><author><name sortKey="Matsuhashi, Masao" sort="Matsuhashi, Masao" uniqKey="Matsuhashi M" first="Masao" last="Matsuhashi">Masao Matsuhashi</name></author><author><name sortKey="Nagamine, Takashi" sort="Nagamine, Takashi" uniqKey="Nagamine T" first="Takashi" last="Nagamine">Takashi Nagamine</name></author><author><name sortKey="Shibasaki, Hiroshi" sort="Shibasaki, Hiroshi" uniqKey="Shibasaki H" first="Hiroshi" last="Shibasaki">Hiroshi Shibasaki</name></author><author><name sortKey="Takahashi, Ryosuke" sort="Takahashi, Ryosuke" uniqKey="Takahashi R" first="Ryosuke" last="Takahashi">Ryosuke Takahashi</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2011">2011</date><idno type="doi">10.1002/mds.23653</idno><idno type="RBID">pubmed:21506164</idno><idno type="pmid">21506164</idno><idno type="wicri:Area/PubMed/Corpus">001257</idno><idno type="wicri:Area/PubMed/Curation">001257</idno><idno type="wicri:Area/PubMed/Checkpoint">001300</idno><idno type="wicri:Area/Ncbi/Merge">003170</idno><idno type="wicri:Area/Ncbi/Curation">003170</idno><idno type="wicri:Area/Ncbi/Checkpoint">003170</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Increased cortical hyperexcitability and exaggerated myoclonus with aging in benign adult familial myoclonus epilepsy.</title><author><name sortKey="Hitomi, Takefumi" sort="Hitomi, Takefumi" uniqKey="Hitomi T" first="Takefumi" last="Hitomi">Takefumi Hitomi</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, Kyoto University School of Medicine, Kyoto, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Neurology, Kyoto University School of Medicine, Kyoto</wicri:regionArea><wicri:noRegion>Kyoto</wicri:noRegion></affiliation></author><author><name sortKey="Ikeda, Akio" sort="Ikeda, Akio" uniqKey="Ikeda A" first="Akio" last="Ikeda">Akio Ikeda</name></author><author><name sortKey="Kondo, Takayuki" sort="Kondo, Takayuki" uniqKey="Kondo T" first="Takayuki" last="Kondo">Takayuki Kondo</name></author><author><name sortKey="Imamura, Hisaji" sort="Imamura, Hisaji" uniqKey="Imamura H" first="Hisaji" last="Imamura">Hisaji Imamura</name></author><author><name sortKey="Inouchi, Morito" sort="Inouchi, Morito" uniqKey="Inouchi M" first="Morito" last="Inouchi">Morito Inouchi</name></author><author><name sortKey="Matsumoto, Riki" sort="Matsumoto, Riki" uniqKey="Matsumoto R" first="Riki" last="Matsumoto">Riki Matsumoto</name></author><author><name sortKey="Terada, Kiyohito" sort="Terada, Kiyohito" uniqKey="Terada K" first="Kiyohito" last="Terada">Kiyohito Terada</name></author><author><name sortKey="Kanda, Masutaro" sort="Kanda, Masutaro" uniqKey="Kanda M" first="Masutaro" last="Kanda">Masutaro Kanda</name></author><author><name sortKey="Matsuhashi, Masao" sort="Matsuhashi, Masao" uniqKey="Matsuhashi M" first="Masao" last="Matsuhashi">Masao Matsuhashi</name></author><author><name sortKey="Nagamine, Takashi" sort="Nagamine, Takashi" uniqKey="Nagamine T" first="Takashi" last="Nagamine">Takashi Nagamine</name></author><author><name sortKey="Shibasaki, Hiroshi" sort="Shibasaki, Hiroshi" uniqKey="Shibasaki H" first="Hiroshi" last="Shibasaki">Hiroshi Shibasaki</name></author><author><name sortKey="Takahashi, Ryosuke" sort="Takahashi, Ryosuke" uniqKey="Takahashi R" first="Ryosuke" last="Takahashi">Ryosuke Takahashi</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="eISSN">1531-8257</idno><imprint><date when="2011" type="published">2011</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Aged</term><term>Aging</term><term>Electroencephalography</term><term>Epilepsies, Myoclonic (pathology)</term><term>Epilepsies, Myoclonic (physiopathology)</term><term>Evoked Potentials, Somatosensory (physiology)</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Myoclonus (physiopathology)</term><term>Reaction Time</term><term>Severity of Illness Index</term><term>Somatosensory Cortex (physiopathology)</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Epilepsies, Myoclonic</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Evoked Potentials, Somatosensory</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Epilepsies, Myoclonic</term><term>Myoclonus</term><term>Somatosensory Cortex</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Aging</term><term>Electroencephalography</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Reaction Time</term><term>Severity of Illness Index</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The clinical implications of enlarged early cortical components of somatosensory evoked potentials in benign adult familial myoclonus epilepsy remain unknown. Somatosensory evoked potentials following electrical stimulation of the median nerve at the wrist were studied in 16 patients with a clinical diagnosis of benign adult familial myoclonus epilepsy (7 men and 9 women; mean age, 51 ± 18 years) and 19 age-matched apparently healthy control subjects (11 men and 8 women; mean age, 49 ± 18 years). Giant somatosensory evoked potentials were observed in 13 of the 16 patients. P25 and N35 amplitudes in the patient group were 11.4 ± 6.1 and 19.2 ± 11.5 μV, respectively, and both were significantly larger compared with those in control subjects (P = 0.008 for P25 and P < 0.0001 for N35). There was a significant positive relationship between age at somatosensory evoked potential examination and N20, P25, and N35 amplitudes, both in the patient and in the control groups (P < 0.05). The linear regression gradient of the N35 amplitude with respect to age was significantly larger in the patient group than in the control group (P = 0.04). Furthermore, regression analysis showed a significant positive relationship between the myoclonus rating scale and age at time of somatosensory evoked potential examination (R = 0.645, P = 0.007). Somatosensory evoked potential amplitude increased with age in patients with benign adult familial myoclonus epilepsy to a greater extent than in the control subjects, which suggests a progressive increase in cortical excitability based on progressive pathophysiology in benign adult familial myoclonus epilepsy.</div></front></TEI></PubMed></double></record>Pour manipuler ce document sous Unix (Dilib)
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