Inhibitory control during smooth pursuit in Parkinson's disease and Huntington's disease
Identifieur interne : 001669 ( Main/Merge ); précédent : 001668; suivant : 001670Inhibitory control during smooth pursuit in Parkinson's disease and Huntington's disease
Auteurs : Tracy Henderson [Australie] ; Nellie Georgiou-Karistianis [Australie] ; Owen White [Australie] ; Lynette Millist [Australie] ; David R. Williams [Australie] ; Andrew Churchyard [Australie] ; Joanne Fielding [Australie]Source :
- Movement Disorders [ 0885-3185 ] ; 2011-08-15.
English descriptors
- KwdEn :
- Adult, Aged, Attention (physiology), Female, Humans, Huntington Disease (physiopathology), Huntington Disease (psychology), Huntington's disease, Inhibition (Psychology), Linear Models, Male, Middle Aged, Parkinson Disease (physiopathology), Parkinson Disease (psychology), Parkinson's disease, Photic Stimulation, Pursuit, Smooth, Reaction Time (physiology), attention, inhibition, smooth pursuit.
- MESH :
- physiology : Attention, Reaction Time.
- physiopathology : Huntington Disease, Parkinson Disease.
- psychology : Huntington Disease, Parkinson Disease.
- Adult, Aged, Female, Humans, Inhibition (Psychology), Linear Models, Male, Middle Aged, Photic Stimulation, Pursuit, Smooth.
Abstract
The basal ganglia are involved in the preferential selection and suppression of competing responses. Parkinson's disease and Huntington's disease are 2 prototypical basal ganglia disorders that feature impaired inhibitory control, a function of poor conflict resolution. Previous saccadic studies showed that individuals with Parkinson's disease experience difficulty suppressing unwanted ocular motor responses, whereas evidence for a similar difficulty in Huntington's disease is more equivocal. Relative to saccades, few research studies have examined inhibitory control processes in the context of an ongoing smooth pursuit task. In this study, we examined the ability of 16 patients with Parkinson's disease and 12 patients with Huntington's disease to suppress automatic responses to irrelevant distracters that transiently appeared during the tracking of a moving visual stimulus. Compared with an equivalent number of age‐matched controls, patients with Parkinson's disease generated proportionately more saccades to distracter stimuli. This was particularly evident for distracters appearing far away from the target. Conversely, whereas individuals with early‐stage Huntington's disease and healthy controls made a comparable number of errors toward distracter stimuli, those in a more advanced clinical stage demonstrated significantly poorer inhibitory control. The current findings in parkinsonian patients replicate those previously reported in the saccadic and manual response literature, demonstrating difficulty inhibiting a competing motor response. However, in Huntington's disease we demonstrate for the first time that inhibitory control declines in more advanced‐disease stages. This suggests that ocular motility may provide a sensitive marker of clinical disease progression in Huntington's disease. © 2011 Movement Disorder Society
Url:
DOI: 10.1002/mds.23757
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Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2011-08-15">2011-08-15</date><biblScope unit="vol">26</biblScope><biblScope unit="issue">10</biblScope><biblScope unit="page" from="1893">1893</biblScope><biblScope unit="page" to="1899">1899</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">84C135DB672DCDA3A99759BFE3EAD44B850958A5</idno><idno type="DOI">10.1002/mds.23757</idno><idno type="ArticleID">MDS23757</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Aged</term><term>Attention (physiology)</term><term>Female</term><term>Humans</term><term>Huntington Disease (physiopathology)</term><term>Huntington Disease (psychology)</term><term>Huntington's disease</term><term>Inhibition (Psychology)</term><term>Linear Models</term><term>Male</term><term>Middle Aged</term><term>Parkinson Disease (physiopathology)</term><term>Parkinson Disease (psychology)</term><term>Parkinson's disease</term><term>Photic Stimulation</term><term>Pursuit, Smooth</term><term>Reaction Time (physiology)</term><term>attention</term><term>inhibition</term><term>smooth pursuit</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Attention</term><term>Reaction Time</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Huntington Disease</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="psychology" xml:lang="en"><term>Huntington Disease</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Female</term><term>Humans</term><term>Inhibition (Psychology)</term><term>Linear Models</term><term>Male</term><term>Middle Aged</term><term>Photic Stimulation</term><term>Pursuit, Smooth</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The basal ganglia are involved in the preferential selection and suppression of competing responses. Parkinson's disease and Huntington's disease are 2 prototypical basal ganglia disorders that feature impaired inhibitory control, a function of poor conflict resolution. Previous saccadic studies showed that individuals with Parkinson's disease experience difficulty suppressing unwanted ocular motor responses, whereas evidence for a similar difficulty in Huntington's disease is more equivocal. Relative to saccades, few research studies have examined inhibitory control processes in the context of an ongoing smooth pursuit task. In this study, we examined the ability of 16 patients with Parkinson's disease and 12 patients with Huntington's disease to suppress automatic responses to irrelevant distracters that transiently appeared during the tracking of a moving visual stimulus. Compared with an equivalent number of age‐matched controls, patients with Parkinson's disease generated proportionately more saccades to distracter stimuli. This was particularly evident for distracters appearing far away from the target. Conversely, whereas individuals with early‐stage Huntington's disease and healthy controls made a comparable number of errors toward distracter stimuli, those in a more advanced clinical stage demonstrated significantly poorer inhibitory control. The current findings in parkinsonian patients replicate those previously reported in the saccadic and manual response literature, demonstrating difficulty inhibiting a competing motor response. However, in Huntington's disease we demonstrate for the first time that inhibitory control declines in more advanced‐disease stages. This suggests that ocular motility may provide a sensitive marker of clinical disease progression in Huntington's disease. © 2011 Movement Disorder Society</div></front></TEI><double doi="10.1002/mds.23757"><ISTEX><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Inhibitory control during smooth pursuit in Parkinson's disease and Huntington's disease</title><author><name sortKey="Henderson, Tracy" sort="Henderson, Tracy" uniqKey="Henderson T" first="Tracy" last="Henderson">Tracy Henderson</name></author><author><name sortKey="Georgiou Aristianis, Nellie" sort="Georgiou Aristianis, Nellie" uniqKey="Georgiou Aristianis N" first="Nellie" last="Georgiou-Karistianis">Nellie Georgiou-Karistianis</name></author><author><name sortKey="White, Owen" sort="White, Owen" uniqKey="White O" first="Owen" last="White">Owen White</name></author><author><name sortKey="Millist, Lynette" sort="Millist, Lynette" uniqKey="Millist L" first="Lynette" last="Millist">Lynette Millist</name></author><author><name sortKey="Williams, David R" sort="Williams, David R" uniqKey="Williams D" first="David R." last="Williams">David R. Williams</name></author><author><name sortKey="Churchyard, Andrew" sort="Churchyard, Andrew" uniqKey="Churchyard A" first="Andrew" last="Churchyard">Andrew Churchyard</name></author><author><name sortKey="Fielding, Joanne" sort="Fielding, Joanne" uniqKey="Fielding J" first="Joanne" last="Fielding">Joanne Fielding</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:84C135DB672DCDA3A99759BFE3EAD44B850958A5</idno><date when="2011" year="2011">2011</date><idno type="doi">10.1002/mds.23757</idno><idno type="url">https://api.istex.fr/document/84C135DB672DCDA3A99759BFE3EAD44B850958A5/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">000990</idno><idno type="wicri:Area/Istex/Curation">000990</idno><idno type="wicri:Area/Istex/Checkpoint">000348</idno><idno type="wicri:doubleKey">0885-3185:2011:Henderson T:inhibitory:control:during</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Inhibitory control during smooth pursuit in Parkinson's disease and Huntington's disease</title><author><name sortKey="Henderson, Tracy" sort="Henderson, Tracy" uniqKey="Henderson T" first="Tracy" last="Henderson">Tracy Henderson</name><affiliation wicri:level="1"><country xml:lang="fr">Australie</country><wicri:regionArea>School of Psychology and Psychiatry, Clayton Campus, Monash University, Victoria</wicri:regionArea><wicri:noRegion>Victoria</wicri:noRegion></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Neurology, Royal Melbourne Hospital, Victoria</wicri:regionArea><wicri:noRegion>Victoria</wicri:noRegion></affiliation></author><author><name sortKey="Georgiou Aristianis, Nellie" sort="Georgiou Aristianis, Nellie" uniqKey="Georgiou Aristianis N" first="Nellie" last="Georgiou-Karistianis">Nellie Georgiou-Karistianis</name><affiliation wicri:level="1"><country xml:lang="fr">Australie</country><wicri:regionArea>School of Psychology and Psychiatry, Clayton Campus, Monash University, Victoria</wicri:regionArea><wicri:noRegion>Victoria</wicri:noRegion></affiliation></author><author><name sortKey="White, Owen" sort="White, Owen" uniqKey="White O" first="Owen" last="White">Owen White</name><affiliation wicri:level="1"><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Neurology, Royal Melbourne Hospital, Victoria</wicri:regionArea><wicri:noRegion>Victoria</wicri:noRegion></affiliation></author><author><name sortKey="Millist, Lynette" sort="Millist, Lynette" uniqKey="Millist L" first="Lynette" last="Millist">Lynette Millist</name><affiliation wicri:level="1"><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Neurology, Royal Melbourne Hospital, Victoria</wicri:regionArea><wicri:noRegion>Victoria</wicri:noRegion></affiliation></author><author><name sortKey="Williams, David R" sort="Williams, David R" uniqKey="Williams D" first="David R." last="Williams">David R. Williams</name><affiliation wicri:level="1"><country xml:lang="fr">Australie</country><wicri:regionArea>Van Cleef Roet Centre for Nervous Diseases, Faculty of Medicine, Nursing and Health Sciences, Monash University, Victoria</wicri:regionArea><wicri:noRegion>Victoria</wicri:noRegion></affiliation></author><author><name sortKey="Churchyard, Andrew" sort="Churchyard, Andrew" uniqKey="Churchyard A" first="Andrew" last="Churchyard">Andrew Churchyard</name><affiliation wicri:level="1"><country xml:lang="fr">Australie</country><wicri:regionArea>Huntington's Disease Unit, Bethlehem Hospital, Victoria</wicri:regionArea><wicri:noRegion>Victoria</wicri:noRegion></affiliation></author><author><name sortKey="Fielding, Joanne" sort="Fielding, Joanne" uniqKey="Fielding J" first="Joanne" last="Fielding">Joanne Fielding</name><affiliation wicri:level="1"><country xml:lang="fr">Australie</country><wicri:regionArea>School of Psychology and Psychiatry, Clayton Campus, Monash University, Victoria</wicri:regionArea><wicri:noRegion>Victoria</wicri:noRegion></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Neurology, Royal Melbourne Hospital, Victoria</wicri:regionArea><wicri:noRegion>Victoria</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2011-08-15">2011-08-15</date><biblScope unit="vol">26</biblScope><biblScope unit="issue">10</biblScope><biblScope unit="page" from="1893">1893</biblScope><biblScope unit="page" to="1899">1899</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">84C135DB672DCDA3A99759BFE3EAD44B850958A5</idno><idno type="DOI">10.1002/mds.23757</idno><idno type="ArticleID">MDS23757</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Huntington's disease</term><term>Parkinson's disease</term><term>attention</term><term>inhibition</term><term>smooth pursuit</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The basal ganglia are involved in the preferential selection and suppression of competing responses. Parkinson's disease and Huntington's disease are 2 prototypical basal ganglia disorders that feature impaired inhibitory control, a function of poor conflict resolution. Previous saccadic studies showed that individuals with Parkinson's disease experience difficulty suppressing unwanted ocular motor responses, whereas evidence for a similar difficulty in Huntington's disease is more equivocal. Relative to saccades, few research studies have examined inhibitory control processes in the context of an ongoing smooth pursuit task. In this study, we examined the ability of 16 patients with Parkinson's disease and 12 patients with Huntington's disease to suppress automatic responses to irrelevant distracters that transiently appeared during the tracking of a moving visual stimulus. Compared with an equivalent number of age‐matched controls, patients with Parkinson's disease generated proportionately more saccades to distracter stimuli. This was particularly evident for distracters appearing far away from the target. Conversely, whereas individuals with early‐stage Huntington's disease and healthy controls made a comparable number of errors toward distracter stimuli, those in a more advanced clinical stage demonstrated significantly poorer inhibitory control. The current findings in parkinsonian patients replicate those previously reported in the saccadic and manual response literature, demonstrating difficulty inhibiting a competing motor response. However, in Huntington's disease we demonstrate for the first time that inhibitory control declines in more advanced‐disease stages. This suggests that ocular motility may provide a sensitive marker of clinical disease progression in Huntington's disease. © 2011 Movement Disorder Society</div></front></TEI></ISTEX><PubMed><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Inhibitory control during smooth pursuit in Parkinson's disease and Huntington's disease.</title><author><name sortKey="Henderson, Tracy" sort="Henderson, Tracy" uniqKey="Henderson T" first="Tracy" last="Henderson">Tracy Henderson</name><affiliation wicri:level="1"><nlm:affiliation>School of Psychology and Psychiatry, Clayton Campus, Monash University, Victoria, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>School of Psychology and Psychiatry, Clayton Campus, Monash University, Victoria</wicri:regionArea><wicri:noRegion>Victoria</wicri:noRegion></affiliation></author><author><name sortKey="Georgiou Karistianis, Nellie" sort="Georgiou Karistianis, Nellie" uniqKey="Georgiou Karistianis N" first="Nellie" last="Georgiou-Karistianis">Nellie Georgiou-Karistianis</name></author><author><name sortKey="White, Owen" sort="White, Owen" uniqKey="White O" first="Owen" last="White">Owen White</name></author><author><name sortKey="Millist, Lynette" sort="Millist, Lynette" uniqKey="Millist L" first="Lynette" last="Millist">Lynette Millist</name></author><author><name sortKey="Williams, David R" sort="Williams, David R" uniqKey="Williams D" first="David R" last="Williams">David R. Williams</name></author><author><name sortKey="Churchyard, Andrew" sort="Churchyard, Andrew" uniqKey="Churchyard A" first="Andrew" last="Churchyard">Andrew Churchyard</name></author><author><name sortKey="Fielding, Joanne" sort="Fielding, Joanne" uniqKey="Fielding J" first="Joanne" last="Fielding">Joanne Fielding</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2011">2011</date><idno type="doi">10.1002/mds.23757</idno><idno type="RBID">pubmed:21630355</idno><idno type="pmid">21630355</idno><idno type="wicri:Area/PubMed/Corpus">001153</idno><idno type="wicri:Area/PubMed/Curation">001153</idno><idno type="wicri:Area/PubMed/Checkpoint">001296</idno><idno type="wicri:Area/Ncbi/Merge">003275</idno><idno type="wicri:Area/Ncbi/Curation">003275</idno><idno type="wicri:Area/Ncbi/Checkpoint">003275</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Inhibitory control during smooth pursuit in Parkinson's disease and Huntington's disease.</title><author><name sortKey="Henderson, Tracy" sort="Henderson, Tracy" uniqKey="Henderson T" first="Tracy" last="Henderson">Tracy Henderson</name><affiliation wicri:level="1"><nlm:affiliation>School of Psychology and Psychiatry, Clayton Campus, Monash University, Victoria, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>School of Psychology and Psychiatry, Clayton Campus, Monash University, Victoria</wicri:regionArea><wicri:noRegion>Victoria</wicri:noRegion></affiliation></author><author><name sortKey="Georgiou Karistianis, Nellie" sort="Georgiou Karistianis, Nellie" uniqKey="Georgiou Karistianis N" first="Nellie" last="Georgiou-Karistianis">Nellie Georgiou-Karistianis</name></author><author><name sortKey="White, Owen" sort="White, Owen" uniqKey="White O" first="Owen" last="White">Owen White</name></author><author><name sortKey="Millist, Lynette" sort="Millist, Lynette" uniqKey="Millist L" first="Lynette" last="Millist">Lynette Millist</name></author><author><name sortKey="Williams, David R" sort="Williams, David R" uniqKey="Williams D" first="David R" last="Williams">David R. Williams</name></author><author><name sortKey="Churchyard, Andrew" sort="Churchyard, Andrew" uniqKey="Churchyard A" first="Andrew" last="Churchyard">Andrew Churchyard</name></author><author><name sortKey="Fielding, Joanne" sort="Fielding, Joanne" uniqKey="Fielding J" first="Joanne" last="Fielding">Joanne Fielding</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="eISSN">1531-8257</idno><imprint><date when="2011" type="published">2011</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Aged</term><term>Attention (physiology)</term><term>Female</term><term>Humans</term><term>Huntington Disease (physiopathology)</term><term>Huntington Disease (psychology)</term><term>Inhibition (Psychology)</term><term>Linear Models</term><term>Male</term><term>Middle Aged</term><term>Parkinson Disease (physiopathology)</term><term>Parkinson Disease (psychology)</term><term>Photic Stimulation</term><term>Pursuit, Smooth</term><term>Reaction Time (physiology)</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Attention</term><term>Reaction Time</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Huntington Disease</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="psychology" xml:lang="en"><term>Huntington Disease</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Female</term><term>Humans</term><term>Inhibition (Psychology)</term><term>Linear Models</term><term>Male</term><term>Middle Aged</term><term>Photic Stimulation</term><term>Pursuit, Smooth</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The basal ganglia are involved in the preferential selection and suppression of competing responses. Parkinson's disease and Huntington's disease are 2 prototypical basal ganglia disorders that feature impaired inhibitory control, a function of poor conflict resolution. Previous saccadic studies showed that individuals with Parkinson's disease experience difficulty suppressing unwanted ocular motor responses, whereas evidence for a similar difficulty in Huntington's disease is more equivocal. Relative to saccades, few research studies have examined inhibitory control processes in the context of an ongoing smooth pursuit task. In this study, we examined the ability of 16 patients with Parkinson's disease and 12 patients with Huntington's disease to suppress automatic responses to irrelevant distracters that transiently appeared during the tracking of a moving visual stimulus. Compared with an equivalent number of age-matched controls, patients with Parkinson's disease generated proportionately more saccades to distracter stimuli. This was particularly evident for distracters appearing far away from the target. Conversely, whereas individuals with early-stage Huntington's disease and healthy controls made a comparable number of errors toward distracter stimuli, those in a more advanced clinical stage demonstrated significantly poorer inhibitory control. The current findings in parkinsonian patients replicate those previously reported in the saccadic and manual response literature, demonstrating difficulty inhibiting a competing motor response. However, in Huntington's disease we demonstrate for the first time that inhibitory control declines in more advanced-disease stages. This suggests that ocular motility may provide a sensitive marker of clinical disease progression in Huntington's disease.</div></front></TEI></PubMed></double></record>Pour manipuler ce document sous Unix (Dilib)
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