Long‐term clinical outcome in meige syndrome treated with internal pallidum deep brain stimulation
Identifieur interne : 001636 ( Main/Merge ); précédent : 001635; suivant : 001637Long‐term clinical outcome in meige syndrome treated with internal pallidum deep brain stimulation
Auteurs : René Reese [Allemagne] ; Doreen Gruber [Allemagne] ; Thomas Schoenecker [Allemagne] ; Hansjörg B Zner [Allemagne] ; Christian Blahak [Allemagne] ; H. Holger Capelle [Allemagne] ; Daniela Falk [Allemagne] ; Jan Herzog [Allemagne] ; Marcus O. Pinsker [Allemagne] ; Gerd H. Schneider [Allemagne] ; Christoph Schrader [Allemagne] ; Günther Deuschl [Allemagne] ; Günther M. Mehdorn [Allemagne] ; Andreas Kupsch [Allemagne] ; Jens Volkmann [Allemagne] ; Joachim K. Krauss [Allemagne]Source :
- Movement Disorders [ 0885-3185 ] ; 2011-03.
English descriptors
- KwdEn :
- Aged, Analysis of Variance, Deep Brain Stimulation (methods), Electrodes, Female, Globus Pallidus (physiology), Humans, Longitudinal Studies, Male, Meige Syndrome (physiopathology), Meige Syndrome (therapy), Meige syndrome, Middle Aged, Motor Activity (physiology), Severity of Illness Index, Treatment Outcome, deep brain stimulation, dystonia, globus pallidus.
- MESH :
- methods : Deep Brain Stimulation.
- physiology : Globus Pallidus, Motor Activity.
- physiopathology : Meige Syndrome.
- therapy : Meige Syndrome.
- Aged, Analysis of Variance, Electrodes, Female, Humans, Longitudinal Studies, Male, Middle Aged, Severity of Illness Index, Treatment Outcome.
Abstract
Deep brain stimulation of the globus pallidus internus (GPi DBS) is effective in the treatment of primary segmental and generalized dystonia. Although limb, neck, or truncal dystonia are markedly improved, orofacial dystonia is ameliorated to a lesser extent. Nevertheless, several case reports and small cohort studies have described favorable short‐term results of GPi DBS in patients with severe Meige syndrome. Here, we extend this preliminary experience by reporting long‐term outcome in a multicenter case series, following 12 patients (6 women, 6 men) with Meige syndrome for up to 78 months after bilateral GPi DBS. We retrospectively assessed dystonia severity based on preoperative and postoperative video documentation. Mean age of patients at surgery was 64.5 ± 4.4 years, and mean disease duration 8.3 ± 4.4 years. Dystonia severity as assessed by the Burke–Fahn–Marsden Dystonia Rating Scale showed a mean improvement of 45% at short‐term follow‐up (4.4 ± 1.5 months; P < 0.001) and of 53% at long‐term follow‐up (38.8 ± 21.7 months; P < 0.001). Subscores for eyes were improved by 38% (P = 0.004) and 47% (P < 0.001), for mouth by 50% (P < 0.001) and 56% (P < 0.001), and for speech/swallowing by 44% (P = 0.058) and 64% (P = 0.004). Mean improvements were 25% (P = 0.006) and 38% (P < 0.001) on the Blepharospasm Movement Scale and 44% (P < 0.001) and 49% (P < 0.001) on the Abnormal Involuntary Movement Scale. This series, which is the first to demonstrate a long‐term follow‐up in a large number of patients, shows that GPi DBS is a safe and highly effective therapy for Meige syndrome. The benefit is preserved for up to 6 years. © 2011 Movement Disorder Society
Url:
DOI: 10.1002/mds.23549
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Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2011-03">2011-03</date><biblScope unit="vol">26</biblScope><biblScope unit="issue">4</biblScope><biblScope unit="page" from="691">691</biblScope><biblScope unit="page" to="698">698</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">498EB25D68DB3B02951D5E9ADAAFEBAB64C3E7E4</idno><idno type="DOI">10.1002/mds.23549</idno><idno type="ArticleID">MDS23549</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Analysis of Variance</term><term>Deep Brain Stimulation (methods)</term><term>Electrodes</term><term>Female</term><term>Globus Pallidus (physiology)</term><term>Humans</term><term>Longitudinal Studies</term><term>Male</term><term>Meige Syndrome (physiopathology)</term><term>Meige Syndrome (therapy)</term><term>Meige syndrome</term><term>Middle Aged</term><term>Motor Activity (physiology)</term><term>Severity of Illness Index</term><term>Treatment Outcome</term><term>deep brain stimulation</term><term>dystonia</term><term>globus pallidus</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Deep Brain Stimulation</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Globus Pallidus</term><term>Motor Activity</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Meige Syndrome</term></keywords><keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Meige Syndrome</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Analysis of Variance</term><term>Electrodes</term><term>Female</term><term>Humans</term><term>Longitudinal Studies</term><term>Male</term><term>Middle Aged</term><term>Severity of Illness Index</term><term>Treatment Outcome</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Deep brain stimulation of the globus pallidus internus (GPi DBS) is effective in the treatment of primary segmental and generalized dystonia. Although limb, neck, or truncal dystonia are markedly improved, orofacial dystonia is ameliorated to a lesser extent. Nevertheless, several case reports and small cohort studies have described favorable short‐term results of GPi DBS in patients with severe Meige syndrome. Here, we extend this preliminary experience by reporting long‐term outcome in a multicenter case series, following 12 patients (6 women, 6 men) with Meige syndrome for up to 78 months after bilateral GPi DBS. We retrospectively assessed dystonia severity based on preoperative and postoperative video documentation. Mean age of patients at surgery was 64.5 ± 4.4 years, and mean disease duration 8.3 ± 4.4 years. Dystonia severity as assessed by the Burke–Fahn–Marsden Dystonia Rating Scale showed a mean improvement of 45% at short‐term follow‐up (4.4 ± 1.5 months; P < 0.001) and of 53% at long‐term follow‐up (38.8 ± 21.7 months; P < 0.001). Subscores for eyes were improved by 38% (P = 0.004) and 47% (P < 0.001), for mouth by 50% (P < 0.001) and 56% (P < 0.001), and for speech/swallowing by 44% (P = 0.058) and 64% (P = 0.004). Mean improvements were 25% (P = 0.006) and 38% (P < 0.001) on the Blepharospasm Movement Scale and 44% (P < 0.001) and 49% (P < 0.001) on the Abnormal Involuntary Movement Scale. This series, which is the first to demonstrate a long‐term follow‐up in a large number of patients, shows that GPi DBS is a safe and highly effective therapy for Meige syndrome. The benefit is preserved for up to 6 years. © 2011 Movement Disorder Society</div></front></TEI><double doi="10.1002/mds.23549"><ISTEX><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Long‐term clinical outcome in meige syndrome treated with internal pallidum deep brain stimulation</title><author><name sortKey="Reese, Rene" sort="Reese, Rene" uniqKey="Reese R" first="René" last="Reese">René Reese</name></author><author><name sortKey="Gruber, Doreen" sort="Gruber, Doreen" uniqKey="Gruber D" first="Doreen" last="Gruber">Doreen Gruber</name></author><author><name sortKey="Schoenecker, Thomas" sort="Schoenecker, Thomas" uniqKey="Schoenecker T" first="Thomas" last="Schoenecker">Thomas Schoenecker</name></author><author><name sortKey="B Zner, Hansjorg" sort="B Zner, Hansjorg" uniqKey="B Zner H" first="Hansjörg" last="B Zner">Hansjörg B Zner</name></author><author><name sortKey="Blahak, Christian" sort="Blahak, Christian" uniqKey="Blahak C" first="Christian" last="Blahak">Christian Blahak</name></author><author><name sortKey="Capelle, H Holger" sort="Capelle, H Holger" uniqKey="Capelle H" first="H. Holger" last="Capelle">H. Holger Capelle</name></author><author><name sortKey="Falk, Daniela" sort="Falk, Daniela" uniqKey="Falk D" first="Daniela" last="Falk">Daniela Falk</name></author><author><name sortKey="Herzog, Jan" sort="Herzog, Jan" uniqKey="Herzog J" first="Jan" last="Herzog">Jan Herzog</name></author><author><name sortKey="Pinsker, Marcus O" sort="Pinsker, Marcus O" uniqKey="Pinsker M" first="Marcus O." last="Pinsker">Marcus O. Pinsker</name></author><author><name sortKey="Schneider, Gerd H" sort="Schneider, Gerd H" uniqKey="Schneider G" first="Gerd H." last="Schneider">Gerd H. Schneider</name></author><author><name sortKey="Schrader, Christoph" sort="Schrader, Christoph" uniqKey="Schrader C" first="Christoph" last="Schrader">Christoph Schrader</name></author><author><name sortKey="Deuschl, Gunther" sort="Deuschl, Gunther" uniqKey="Deuschl G" first="Günther" last="Deuschl">Günther Deuschl</name></author><author><name sortKey="Mehdorn, Gunther M" sort="Mehdorn, Gunther M" uniqKey="Mehdorn G" first="Günther M." last="Mehdorn">Günther M. Mehdorn</name></author><author><name sortKey="Kupsch, Andreas" sort="Kupsch, Andreas" uniqKey="Kupsch A" first="Andreas" last="Kupsch">Andreas Kupsch</name></author><author><name sortKey="Volkmann, Jens" sort="Volkmann, Jens" uniqKey="Volkmann J" first="Jens" last="Volkmann">Jens Volkmann</name></author><author><name sortKey="Krauss, Joachim K" sort="Krauss, Joachim K" uniqKey="Krauss J" first="Joachim K." last="Krauss">Joachim K. Krauss</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:498EB25D68DB3B02951D5E9ADAAFEBAB64C3E7E4</idno><date when="2011" year="2011">2011</date><idno type="doi">10.1002/mds.23549</idno><idno type="url">https://api.istex.fr/document/498EB25D68DB3B02951D5E9ADAAFEBAB64C3E7E4/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">000636</idno><idno type="wicri:Area/Istex/Curation">000636</idno><idno type="wicri:Area/Istex/Checkpoint">000315</idno><idno type="wicri:doubleKey">0885-3185:2011:Reese R:long:term:clinical</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Long‐term clinical outcome in meige syndrome treated with internal pallidum deep brain stimulation</title><author><name sortKey="Reese, Rene" sort="Reese, Rene" uniqKey="Reese R" first="René" last="Reese">René Reese</name><affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurosurgery, Medizinische Hochschule Hannover, Carl‐Neuberg‐Str. 1, 30625 Hannover</wicri:regionArea><placeName><region type="land" nuts="2">Basse-Saxe</region><settlement type="city">Hanovre</settlement></placeName></affiliation></author><author><name sortKey="Gruber, Doreen" sort="Gruber, Doreen" uniqKey="Gruber D" first="Doreen" last="Gruber">Doreen Gruber</name><affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, University Medicine Berlin, Campus Virchow, Berlin</wicri:regionArea><placeName><region type="land" nuts="3">Berlin</region><settlement type="city">Berlin</settlement></placeName></affiliation></author><author><name sortKey="Schoenecker, Thomas" sort="Schoenecker, Thomas" uniqKey="Schoenecker T" first="Thomas" last="Schoenecker">Thomas Schoenecker</name><affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neuroradiology, University Medicine Berlin, Campus Virchow, Berlin</wicri:regionArea><placeName><region type="land" nuts="3">Berlin</region><settlement type="city">Berlin</settlement></placeName></affiliation></author><author><name sortKey="B Zner, Hansjorg" sort="B Zner, Hansjorg" uniqKey="B Zner H" first="Hansjörg" last="B Zner">Hansjörg B Zner</name><affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, Medical Faculty Mannheim, University of Heidelberg, Mannheim</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Mannheim</settlement></placeName></affiliation></author><author><name sortKey="Blahak, Christian" sort="Blahak, Christian" uniqKey="Blahak C" first="Christian" last="Blahak">Christian Blahak</name><affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, Medical Faculty Mannheim, University of Heidelberg, Mannheim</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Mannheim</settlement></placeName></affiliation></author><author><name sortKey="Capelle, H Holger" sort="Capelle, H Holger" uniqKey="Capelle H" first="H. Holger" last="Capelle">H. Holger Capelle</name><affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurosurgery, Hannover Medical School, Hannover</wicri:regionArea><placeName><region type="land" nuts="2">Basse-Saxe</region><settlement type="city">Hanovre</settlement></placeName></affiliation></author><author><name sortKey="Falk, Daniela" sort="Falk, Daniela" uniqKey="Falk D" first="Daniela" last="Falk">Daniela Falk</name><affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurosurgery, University Hospital Schleswig‐Holstein, Kiel</wicri:regionArea><placeName><region type="land" nuts="2">Schleswig-Holstein</region><settlement type="city">Kiel</settlement></placeName></affiliation></author><author><name sortKey="Herzog, Jan" sort="Herzog, Jan" uniqKey="Herzog J" first="Jan" last="Herzog">Jan Herzog</name><affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurosurgery, Medizinische Hochschule Hannover, Carl‐Neuberg‐Str. 1, 30625 Hannover</wicri:regionArea><placeName><region type="land" nuts="2">Basse-Saxe</region><settlement type="city">Hanovre</settlement></placeName></affiliation></author><author><name sortKey="Pinsker, Marcus O" sort="Pinsker, Marcus O" uniqKey="Pinsker M" first="Marcus O." last="Pinsker">Marcus O. Pinsker</name><affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurosurgery, University Hospital Schleswig‐Holstein, Kiel</wicri:regionArea><placeName><region type="land" nuts="2">Schleswig-Holstein</region><settlement type="city">Kiel</settlement></placeName></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Stereotactic and Functional Neurosurgery, University Medical Center Freiburg</wicri:regionArea><wicri:noRegion>University Medical Center Freiburg</wicri:noRegion><wicri:noRegion>University Medical Center Freiburg</wicri:noRegion></affiliation></author><author><name sortKey="Schneider, Gerd H" sort="Schneider, Gerd H" uniqKey="Schneider G" first="Gerd H." last="Schneider">Gerd H. Schneider</name><affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurosurgery, University Medicine Berlin, Campus Virchow, Berlin</wicri:regionArea><placeName><region type="land" nuts="3">Berlin</region><settlement type="city">Berlin</settlement></placeName></affiliation></author><author><name sortKey="Schrader, Christoph" sort="Schrader, Christoph" uniqKey="Schrader C" first="Christoph" last="Schrader">Christoph Schrader</name><affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, Hannover Medical School, Hannover</wicri:regionArea><placeName><region type="land" nuts="2">Basse-Saxe</region><settlement type="city">Hanovre</settlement></placeName></affiliation></author><author><name sortKey="Deuschl, Gunther" sort="Deuschl, Gunther" uniqKey="Deuschl G" first="Günther" last="Deuschl">Günther Deuschl</name><affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurosurgery, Medizinische Hochschule Hannover, Carl‐Neuberg‐Str. 1, 30625 Hannover</wicri:regionArea><placeName><region type="land" nuts="2">Basse-Saxe</region><settlement type="city">Hanovre</settlement></placeName></affiliation></author><author><name sortKey="Mehdorn, Gunther M" sort="Mehdorn, Gunther M" uniqKey="Mehdorn G" first="Günther M." last="Mehdorn">Günther M. Mehdorn</name><affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurosurgery, University Hospital Schleswig‐Holstein, Kiel</wicri:regionArea><placeName><region type="land" nuts="2">Schleswig-Holstein</region><settlement type="city">Kiel</settlement></placeName></affiliation></author><author><name sortKey="Kupsch, Andreas" sort="Kupsch, Andreas" uniqKey="Kupsch A" first="Andreas" last="Kupsch">Andreas Kupsch</name><affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, University Medicine Berlin, Campus Virchow, Berlin</wicri:regionArea><placeName><region type="land" nuts="3">Berlin</region><settlement type="city">Berlin</settlement></placeName></affiliation></author><author><name sortKey="Volkmann, Jens" sort="Volkmann, Jens" uniqKey="Volkmann J" first="Jens" last="Volkmann">Jens Volkmann</name><affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurosurgery, Medizinische Hochschule Hannover, Carl‐Neuberg‐Str. 1, 30625 Hannover</wicri:regionArea><placeName><region type="land" nuts="2">Basse-Saxe</region><settlement type="city">Hanovre</settlement></placeName></affiliation></author><author><name sortKey="Krauss, Joachim K" sort="Krauss, Joachim K" uniqKey="Krauss J" first="Joachim K." last="Krauss">Joachim K. Krauss</name><affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurosurgery, Hannover Medical School, Hannover</wicri:regionArea><placeName><region type="land" nuts="2">Basse-Saxe</region><settlement type="city">Hanovre</settlement></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2011-03">2011-03</date><biblScope unit="vol">26</biblScope><biblScope unit="issue">4</biblScope><biblScope unit="page" from="691">691</biblScope><biblScope unit="page" to="698">698</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">498EB25D68DB3B02951D5E9ADAAFEBAB64C3E7E4</idno><idno type="DOI">10.1002/mds.23549</idno><idno type="ArticleID">MDS23549</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Meige syndrome</term><term>deep brain stimulation</term><term>dystonia</term><term>globus pallidus</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Deep brain stimulation of the globus pallidus internus (GPi DBS) is effective in the treatment of primary segmental and generalized dystonia. Although limb, neck, or truncal dystonia are markedly improved, orofacial dystonia is ameliorated to a lesser extent. Nevertheless, several case reports and small cohort studies have described favorable short‐term results of GPi DBS in patients with severe Meige syndrome. Here, we extend this preliminary experience by reporting long‐term outcome in a multicenter case series, following 12 patients (6 women, 6 men) with Meige syndrome for up to 78 months after bilateral GPi DBS. We retrospectively assessed dystonia severity based on preoperative and postoperative video documentation. Mean age of patients at surgery was 64.5 ± 4.4 years, and mean disease duration 8.3 ± 4.4 years. Dystonia severity as assessed by the Burke–Fahn–Marsden Dystonia Rating Scale showed a mean improvement of 45% at short‐term follow‐up (4.4 ± 1.5 months; P < 0.001) and of 53% at long‐term follow‐up (38.8 ± 21.7 months; P < 0.001). Subscores for eyes were improved by 38% (P = 0.004) and 47% (P < 0.001), for mouth by 50% (P < 0.001) and 56% (P < 0.001), and for speech/swallowing by 44% (P = 0.058) and 64% (P = 0.004). Mean improvements were 25% (P = 0.006) and 38% (P < 0.001) on the Blepharospasm Movement Scale and 44% (P < 0.001) and 49% (P < 0.001) on the Abnormal Involuntary Movement Scale. This series, which is the first to demonstrate a long‐term follow‐up in a large number of patients, shows that GPi DBS is a safe and highly effective therapy for Meige syndrome. The benefit is preserved for up to 6 years. © 2011 Movement Disorder Society</div></front></TEI></ISTEX><PubMed><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Long-term clinical outcome in meige syndrome treated with internal pallidum deep brain stimulation.</title><author><name sortKey="Reese, Rene" sort="Reese, Rene" uniqKey="Reese R" first="René" last="Reese">René Reese</name><affiliation wicri:level="3"><nlm:affiliation>Department of Neurosurgery, Medizinische Hochschule Hannover, Carl-Neuberg-Str. 1, 30625 Hannover, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurosurgery, Medizinische Hochschule Hannover, Carl-Neuberg-Str. 1, 30625 Hannover</wicri:regionArea><placeName><region type="land" nuts="2">Basse-Saxe</region><settlement type="city">Hanovre</settlement></placeName></affiliation></author><author><name sortKey="Gruber, Doreen" sort="Gruber, Doreen" uniqKey="Gruber D" first="Doreen" last="Gruber">Doreen Gruber</name></author><author><name sortKey="Schoenecker, Thomas" sort="Schoenecker, Thomas" uniqKey="Schoenecker T" first="Thomas" last="Schoenecker">Thomas Schoenecker</name></author><author><name sortKey="B Zner, Hansjorg" sort="B Zner, Hansjorg" uniqKey="B Zner H" first="Hansjörg" last="B Zner">Hansjörg B Zner</name></author><author><name sortKey="Blahak, Christian" sort="Blahak, Christian" uniqKey="Blahak C" first="Christian" last="Blahak">Christian Blahak</name></author><author><name sortKey="Capelle, H Holger" sort="Capelle, H Holger" uniqKey="Capelle H" first="H Holger" last="Capelle">H Holger Capelle</name></author><author><name sortKey="Falk, Daniela" sort="Falk, Daniela" uniqKey="Falk D" first="Daniela" last="Falk">Daniela Falk</name></author><author><name sortKey="Herzog, Jan" sort="Herzog, Jan" uniqKey="Herzog J" first="Jan" last="Herzog">Jan Herzog</name></author><author><name sortKey="Pinsker, Marcus O" sort="Pinsker, Marcus O" uniqKey="Pinsker M" first="Marcus O" last="Pinsker">Marcus O. Pinsker</name></author><author><name sortKey="Schneider, Gerd H" sort="Schneider, Gerd H" uniqKey="Schneider G" first="Gerd H" last="Schneider">Gerd H. Schneider</name></author><author><name sortKey="Schrader, Christoph" sort="Schrader, Christoph" uniqKey="Schrader C" first="Christoph" last="Schrader">Christoph Schrader</name></author><author><name sortKey="Deuschl, Gunther" sort="Deuschl, Gunther" uniqKey="Deuschl G" first="Günther" last="Deuschl">Günther Deuschl</name></author><author><name sortKey="Mehdorn, Hubertus M" sort="Mehdorn, Hubertus M" uniqKey="Mehdorn H" first="Hubertus M" last="Mehdorn">Hubertus M. Mehdorn</name></author><author><name sortKey="Kupsch, Andreas" sort="Kupsch, Andreas" uniqKey="Kupsch A" first="Andreas" last="Kupsch">Andreas Kupsch</name></author><author><name sortKey="Volkmann, Jens" sort="Volkmann, Jens" uniqKey="Volkmann J" first="Jens" last="Volkmann">Jens Volkmann</name></author><author><name sortKey="Krauss, Joachim K" sort="Krauss, Joachim K" uniqKey="Krauss J" first="Joachim K" last="Krauss">Joachim K. Krauss</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2011">2011</date><idno type="doi">10.1002/mds.23549</idno><idno type="RBID">pubmed:21312284</idno><idno type="pmid">21312284</idno><idno type="wicri:Area/PubMed/Corpus">001447</idno><idno type="wicri:Area/PubMed/Curation">001447</idno><idno type="wicri:Area/PubMed/Checkpoint">001265</idno><idno type="wicri:Area/Ncbi/Merge">002F73</idno><idno type="wicri:Area/Ncbi/Curation">002F73</idno><idno type="wicri:Area/Ncbi/Checkpoint">002F73</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Long-term clinical outcome in meige syndrome treated with internal pallidum deep brain stimulation.</title><author><name sortKey="Reese, Rene" sort="Reese, Rene" uniqKey="Reese R" first="René" last="Reese">René Reese</name><affiliation wicri:level="3"><nlm:affiliation>Department of Neurosurgery, Medizinische Hochschule Hannover, Carl-Neuberg-Str. 1, 30625 Hannover, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurosurgery, Medizinische Hochschule Hannover, Carl-Neuberg-Str. 1, 30625 Hannover</wicri:regionArea><placeName><region type="land" nuts="2">Basse-Saxe</region><settlement type="city">Hanovre</settlement></placeName></affiliation></author><author><name sortKey="Gruber, Doreen" sort="Gruber, Doreen" uniqKey="Gruber D" first="Doreen" last="Gruber">Doreen Gruber</name></author><author><name sortKey="Schoenecker, Thomas" sort="Schoenecker, Thomas" uniqKey="Schoenecker T" first="Thomas" last="Schoenecker">Thomas Schoenecker</name></author><author><name sortKey="B Zner, Hansjorg" sort="B Zner, Hansjorg" uniqKey="B Zner H" first="Hansjörg" last="B Zner">Hansjörg B Zner</name></author><author><name sortKey="Blahak, Christian" sort="Blahak, Christian" uniqKey="Blahak C" first="Christian" last="Blahak">Christian Blahak</name></author><author><name sortKey="Capelle, H Holger" sort="Capelle, H Holger" uniqKey="Capelle H" first="H Holger" last="Capelle">H Holger Capelle</name></author><author><name sortKey="Falk, Daniela" sort="Falk, Daniela" uniqKey="Falk D" first="Daniela" last="Falk">Daniela Falk</name></author><author><name sortKey="Herzog, Jan" sort="Herzog, Jan" uniqKey="Herzog J" first="Jan" last="Herzog">Jan Herzog</name></author><author><name sortKey="Pinsker, Marcus O" sort="Pinsker, Marcus O" uniqKey="Pinsker M" first="Marcus O" last="Pinsker">Marcus O. Pinsker</name></author><author><name sortKey="Schneider, Gerd H" sort="Schneider, Gerd H" uniqKey="Schneider G" first="Gerd H" last="Schneider">Gerd H. Schneider</name></author><author><name sortKey="Schrader, Christoph" sort="Schrader, Christoph" uniqKey="Schrader C" first="Christoph" last="Schrader">Christoph Schrader</name></author><author><name sortKey="Deuschl, Gunther" sort="Deuschl, Gunther" uniqKey="Deuschl G" first="Günther" last="Deuschl">Günther Deuschl</name></author><author><name sortKey="Mehdorn, Hubertus M" sort="Mehdorn, Hubertus M" uniqKey="Mehdorn H" first="Hubertus M" last="Mehdorn">Hubertus M. Mehdorn</name></author><author><name sortKey="Kupsch, Andreas" sort="Kupsch, Andreas" uniqKey="Kupsch A" first="Andreas" last="Kupsch">Andreas Kupsch</name></author><author><name sortKey="Volkmann, Jens" sort="Volkmann, Jens" uniqKey="Volkmann J" first="Jens" last="Volkmann">Jens Volkmann</name></author><author><name sortKey="Krauss, Joachim K" sort="Krauss, Joachim K" uniqKey="Krauss J" first="Joachim K" last="Krauss">Joachim K. Krauss</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="eISSN">1531-8257</idno><imprint><date when="2011" type="published">2011</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Analysis of Variance</term><term>Deep Brain Stimulation (methods)</term><term>Electrodes</term><term>Female</term><term>Globus Pallidus (physiology)</term><term>Humans</term><term>Longitudinal Studies</term><term>Male</term><term>Meige Syndrome (physiopathology)</term><term>Meige Syndrome (therapy)</term><term>Middle Aged</term><term>Motor Activity (physiology)</term><term>Severity of Illness Index</term><term>Treatment Outcome</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Deep Brain Stimulation</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Globus Pallidus</term><term>Motor Activity</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Meige Syndrome</term></keywords><keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Meige Syndrome</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Analysis of Variance</term><term>Electrodes</term><term>Female</term><term>Humans</term><term>Longitudinal Studies</term><term>Male</term><term>Middle Aged</term><term>Severity of Illness Index</term><term>Treatment Outcome</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Deep brain stimulation of the globus pallidus internus (GPi DBS) is effective in the treatment of primary segmental and generalized dystonia. Although limb, neck, or truncal dystonia are markedly improved, orofacial dystonia is ameliorated to a lesser extent. Nevertheless, several case reports and small cohort studies have described favorable short-term results of GPi DBS in patients with severe Meige syndrome. Here, we extend this preliminary experience by reporting long-term outcome in a multicenter case series, following 12 patients (6 women, 6 men) with Meige syndrome for up to 78 months after bilateral GPi DBS. We retrospectively assessed dystonia severity based on preoperative and postoperative video documentation. Mean age of patients at surgery was 64.5 ± 4.4 years, and mean disease duration 8.3 ± 4.4 years. Dystonia severity as assessed by the Burke-Fahn-Marsden Dystonia Rating Scale showed a mean improvement of 45% at short-term follow-up (4.4 ± 1.5 months; P < 0.001) and of 53% at long-term follow-up (38.8 ± 21.7 months; P < 0.001). Subscores for eyes were improved by 38% (P = 0.004) and 47% (P < 0.001), for mouth by 50% (P < 0.001) and 56% (P < 0.001), and for speech/swallowing by 44% (P = 0.058) and 64% (P = 0.004). Mean improvements were 25% (P = 0.006) and 38% (P < 0.001) on the Blepharospasm Movement Scale and 44% (P < 0.001) and 49% (P < 0.001) on the Abnormal Involuntary Movement Scale. This series, which is the first to demonstrate a long-term follow-up in a large number of patients, shows that GPi DBS is a safe and highly effective therapy for Meige syndrome. The benefit is preserved for up to 6 years.</div></front></TEI></PubMed></double></record>Pour manipuler ce document sous Unix (Dilib)
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