Milestones in movement disorders clinical trials: Advances and landmark studies
Identifieur interne : 001607 ( Main/Merge ); précédent : 001606; suivant : 001608Milestones in movement disorders clinical trials: Advances and landmark studies
Auteurs : C. Warren Olanow [États-Unis] ; Kathryn B. Wunderle [États-Unis] ; Karl Kieburtz [États-Unis]Source :
- Movement Disorders [ 0885-3185 ] ; 2011-05.
English descriptors
- KwdEn :
- MESH :
- genetics : Movement Disorders.
- history : Clinical Trials as Topic, Movement Disorders.
- methods : Clinical Trials as Topic.
- therapy : Movement Disorders.
- History, 20th Century, History, 21st Century, Humans, Outcome Assessment (Health Care), Research Design.
Abstract
Over the past 25 years clinical trials testing in movement disorders has evolved in order to more effectively and efficiently analyze the safety and efficacy of new interventions. Studies today regularly incorporate methods to decrease placebo and bias effects and to ensure more rigorous statistical analyses. Newer, standardized, and validated rating scales such as the Unified Parkinson's Disease Rating Scale and the Unified Huntington's Disease Rating Scale are routinely employed in an effort to produce results that are comparable across different sites and studies. Several landmark studies in movement disorder research highlight these and other prominent procedural advances. The Deprenyl and Tocopherol Antioxidative Therapy of Parkinsonism trial pioneered the use of functional clinical end points, utilized a 2 × 2 factorial design to more efficiently analyze multiple interventions, and employed a washout design to assist in sorting putative neuroprotective from symptomatic effects. PRECEPT included neuroimaging as an outcome measure and highlighted the importance of futility studies in more efficiently directing resources. TEMPO and ADAGIO introduced the use of delayed‐start (or 2‐period) trials to try to identify disease‐modifying interventions. NET‐PD used futility studies to streamline the evaluation of potentially valuable treatments, followed by a large, long‐term simple study design to assess the clinical significance of a new intervention. There have also been advances in clinical trials testing new surgical interventions, with the introduction of blinded outcome assessments and sham‐surgery control groups. Collectively, methodological advances in clinical trials have permitted the safety and efficacy of new interventions to be tested more efficiently and economically and with a higher level of certainty that the potential benefits and adverse effects of interventions recommended for general use are well understood. © 2011 Movement Disorder Society
Url:
DOI: 10.1002/mds.23727
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: 000109
- to stream Istex, to step Curation: 000109
- to stream Istex, to step Checkpoint: 000286
- to stream PubMed, to step Corpus: 001177
- to stream PubMed, to step Curation: 001177
- to stream PubMed, to step Checkpoint: 001237
- to stream Ncbi, to step Merge: 003251
- to stream Ncbi, to step Curation: 003251
- to stream Ncbi, to step Checkpoint: 003251
Links to Exploration step
ISTEX:6B04D16CB34EB4EAB14364093891296355C6F8ACLe document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Milestones in movement disorders clinical trials: Advances and landmark studies</title>
<author><name sortKey="Olanow, C Warren" sort="Olanow, C Warren" uniqKey="Olanow C" first="C. Warren" last="Olanow">C. Warren Olanow</name>
</author>
<author><name sortKey="Wunderle, Kathryn B" sort="Wunderle, Kathryn B" uniqKey="Wunderle K" first="Kathryn B." last="Wunderle">Kathryn B. Wunderle</name>
</author>
<author><name sortKey="Kieburtz, Karl" sort="Kieburtz, Karl" uniqKey="Kieburtz K" first="Karl" last="Kieburtz">Karl Kieburtz</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">ISTEX</idno>
<idno type="RBID">ISTEX:6B04D16CB34EB4EAB14364093891296355C6F8AC</idno>
<date when="2011" year="2011">2011</date>
<idno type="doi">10.1002/mds.23727</idno>
<idno type="url">https://api.istex.fr/document/6B04D16CB34EB4EAB14364093891296355C6F8AC/fulltext/pdf</idno>
<idno type="wicri:Area/Istex/Corpus">000109</idno>
<idno type="wicri:Area/Istex/Curation">000109</idno>
<idno type="wicri:Area/Istex/Checkpoint">000286</idno>
<idno type="wicri:doubleKey">0885-3185:2011:Olanow C:milestones:in:movement</idno>
<idno type="wicri:source">PubMed</idno>
<idno type="RBID">pubmed:21626545</idno>
<idno type="wicri:Area/PubMed/Corpus">001177</idno>
<idno type="wicri:Area/PubMed/Curation">001177</idno>
<idno type="wicri:Area/PubMed/Checkpoint">001237</idno>
<idno type="wicri:Area/Ncbi/Merge">003251</idno>
<idno type="wicri:Area/Ncbi/Curation">003251</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">003251</idno>
<idno type="wicri:Area/Main/Merge">001607</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Milestones in movement disorders clinical trials: Advances and landmark studies</title>
<author><name sortKey="Olanow, C Warren" sort="Olanow, C Warren" uniqKey="Olanow C" first="C. Warren" last="Olanow">C. Warren Olanow</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Departments of Neurology and Neuroscience, Mount Sinai School of Medicine, New York, New York</wicri:regionArea>
<placeName><region type="state">État de New York</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Wunderle, Kathryn B" sort="Wunderle, Kathryn B" uniqKey="Wunderle K" first="Kathryn B." last="Wunderle">Kathryn B. Wunderle</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Center for Human Experimental Therapeutics, University of Rochester Medical Center, Rochester, New York</wicri:regionArea>
<placeName><region type="state">État de New York</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Kieburtz, Karl" sort="Kieburtz, Karl" uniqKey="Kieburtz K" first="Karl" last="Kieburtz">Karl Kieburtz</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Center for Human Experimental Therapeutics, University of Rochester Medical Center, Rochester, New York</wicri:regionArea>
<placeName><region type="state">État de New York</region>
</placeName>
</affiliation>
</author>
</analytic>
<monogr></monogr>
<series><title level="j">Movement Disorders</title>
<title level="j" type="abbrev">Mov. Disord.</title>
<idno type="ISSN">0885-3185</idno>
<idno type="eISSN">1531-8257</idno>
<imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher>
<pubPlace>Hoboken</pubPlace>
<date type="published" when="2011-05">2011-05</date>
<biblScope unit="vol">26</biblScope>
<biblScope unit="issue">6</biblScope>
<biblScope unit="page" from="1003">1003</biblScope>
<biblScope unit="page" to="1014">1014</biblScope>
</imprint>
<idno type="ISSN">0885-3185</idno>
</series>
<idno type="istex">6B04D16CB34EB4EAB14364093891296355C6F8AC</idno>
<idno type="DOI">10.1002/mds.23727</idno>
<idno type="ArticleID">MDS23727</idno>
</biblStruct>
</sourceDesc>
<seriesStmt><idno type="ISSN">0885-3185</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Clinical Trials as Topic (history)</term>
<term>Clinical Trials as Topic (methods)</term>
<term>History, 20th Century</term>
<term>History, 21st Century</term>
<term>Humans</term>
<term>Movement Disorders (genetics)</term>
<term>Movement Disorders (history)</term>
<term>Movement Disorders (therapy)</term>
<term>Outcome Assessment (Health Care)</term>
<term>Research Design</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Movement Disorders</term>
</keywords>
<keywords scheme="MESH" qualifier="history" xml:lang="en"><term>Clinical Trials as Topic</term>
<term>Movement Disorders</term>
</keywords>
<keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Clinical Trials as Topic</term>
</keywords>
<keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Movement Disorders</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>History, 20th Century</term>
<term>History, 21st Century</term>
<term>Humans</term>
<term>Outcome Assessment (Health Care)</term>
<term>Research Design</term>
</keywords>
</textClass>
<langUsage><language ident="en">en</language>
</langUsage>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Over the past 25 years clinical trials testing in movement disorders has evolved in order to more effectively and efficiently analyze the safety and efficacy of new interventions. Studies today regularly incorporate methods to decrease placebo and bias effects and to ensure more rigorous statistical analyses. Newer, standardized, and validated rating scales such as the Unified Parkinson's Disease Rating Scale and the Unified Huntington's Disease Rating Scale are routinely employed in an effort to produce results that are comparable across different sites and studies. Several landmark studies in movement disorder research highlight these and other prominent procedural advances. The Deprenyl and Tocopherol Antioxidative Therapy of Parkinsonism trial pioneered the use of functional clinical end points, utilized a 2 × 2 factorial design to more efficiently analyze multiple interventions, and employed a washout design to assist in sorting putative neuroprotective from symptomatic effects. PRECEPT included neuroimaging as an outcome measure and highlighted the importance of futility studies in more efficiently directing resources. TEMPO and ADAGIO introduced the use of delayed‐start (or 2‐period) trials to try to identify disease‐modifying interventions. NET‐PD used futility studies to streamline the evaluation of potentially valuable treatments, followed by a large, long‐term simple study design to assess the clinical significance of a new intervention. There have also been advances in clinical trials testing new surgical interventions, with the introduction of blinded outcome assessments and sham‐surgery control groups. Collectively, methodological advances in clinical trials have permitted the safety and efficacy of new interventions to be tested more efficiently and economically and with a higher level of certainty that the potential benefits and adverse effects of interventions recommended for general use are well understood. © 2011 Movement Disorder Society</div>
</front>
</TEI>
<double doi="10.1002/mds.23727"><ISTEX><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Milestones in movement disorders clinical trials: Advances and landmark studies</title>
<author><name sortKey="Olanow, C Warren" sort="Olanow, C Warren" uniqKey="Olanow C" first="C. Warren" last="Olanow">C. Warren Olanow</name>
</author>
<author><name sortKey="Wunderle, Kathryn B" sort="Wunderle, Kathryn B" uniqKey="Wunderle K" first="Kathryn B." last="Wunderle">Kathryn B. Wunderle</name>
</author>
<author><name sortKey="Kieburtz, Karl" sort="Kieburtz, Karl" uniqKey="Kieburtz K" first="Karl" last="Kieburtz">Karl Kieburtz</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">ISTEX</idno>
<idno type="RBID">ISTEX:6B04D16CB34EB4EAB14364093891296355C6F8AC</idno>
<date when="2011" year="2011">2011</date>
<idno type="doi">10.1002/mds.23727</idno>
<idno type="url">https://api.istex.fr/document/6B04D16CB34EB4EAB14364093891296355C6F8AC/fulltext/pdf</idno>
<idno type="wicri:Area/Istex/Corpus">000109</idno>
<idno type="wicri:Area/Istex/Curation">000109</idno>
<idno type="wicri:Area/Istex/Checkpoint">000286</idno>
<idno type="wicri:doubleKey">0885-3185:2011:Olanow C:milestones:in:movement</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Milestones in movement disorders clinical trials: Advances and landmark studies</title>
<author><name sortKey="Olanow, C Warren" sort="Olanow, C Warren" uniqKey="Olanow C" first="C. Warren" last="Olanow">C. Warren Olanow</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Departments of Neurology and Neuroscience, Mount Sinai School of Medicine, New York, New York</wicri:regionArea>
<placeName><region type="state">État de New York</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Wunderle, Kathryn B" sort="Wunderle, Kathryn B" uniqKey="Wunderle K" first="Kathryn B." last="Wunderle">Kathryn B. Wunderle</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Center for Human Experimental Therapeutics, University of Rochester Medical Center, Rochester, New York</wicri:regionArea>
<placeName><region type="state">État de New York</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Kieburtz, Karl" sort="Kieburtz, Karl" uniqKey="Kieburtz K" first="Karl" last="Kieburtz">Karl Kieburtz</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Center for Human Experimental Therapeutics, University of Rochester Medical Center, Rochester, New York</wicri:regionArea>
<placeName><region type="state">État de New York</region>
</placeName>
</affiliation>
</author>
</analytic>
<monogr></monogr>
<series><title level="j">Movement Disorders</title>
<title level="j" type="abbrev">Mov. Disord.</title>
<idno type="ISSN">0885-3185</idno>
<idno type="eISSN">1531-8257</idno>
<imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher>
<pubPlace>Hoboken</pubPlace>
<date type="published" when="2011-05">2011-05</date>
<biblScope unit="vol">26</biblScope>
<biblScope unit="issue">6</biblScope>
<biblScope unit="page" from="1003">1003</biblScope>
<biblScope unit="page" to="1014">1014</biblScope>
</imprint>
<idno type="ISSN">0885-3185</idno>
</series>
<idno type="istex">6B04D16CB34EB4EAB14364093891296355C6F8AC</idno>
<idno type="DOI">10.1002/mds.23727</idno>
<idno type="ArticleID">MDS23727</idno>
</biblStruct>
</sourceDesc>
<seriesStmt><idno type="ISSN">0885-3185</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass></textClass>
<langUsage><language ident="en">en</language>
</langUsage>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Over the past 25 years clinical trials testing in movement disorders has evolved in order to more effectively and efficiently analyze the safety and efficacy of new interventions. Studies today regularly incorporate methods to decrease placebo and bias effects and to ensure more rigorous statistical analyses. Newer, standardized, and validated rating scales such as the Unified Parkinson's Disease Rating Scale and the Unified Huntington's Disease Rating Scale are routinely employed in an effort to produce results that are comparable across different sites and studies. Several landmark studies in movement disorder research highlight these and other prominent procedural advances. The Deprenyl and Tocopherol Antioxidative Therapy of Parkinsonism trial pioneered the use of functional clinical end points, utilized a 2 × 2 factorial design to more efficiently analyze multiple interventions, and employed a washout design to assist in sorting putative neuroprotective from symptomatic effects. PRECEPT included neuroimaging as an outcome measure and highlighted the importance of futility studies in more efficiently directing resources. TEMPO and ADAGIO introduced the use of delayed‐start (or 2‐period) trials to try to identify disease‐modifying interventions. NET‐PD used futility studies to streamline the evaluation of potentially valuable treatments, followed by a large, long‐term simple study design to assess the clinical significance of a new intervention. There have also been advances in clinical trials testing new surgical interventions, with the introduction of blinded outcome assessments and sham‐surgery control groups. Collectively, methodological advances in clinical trials have permitted the safety and efficacy of new interventions to be tested more efficiently and economically and with a higher level of certainty that the potential benefits and adverse effects of interventions recommended for general use are well understood. © 2011 Movement Disorder Society</div>
</front>
</TEI>
</ISTEX>
<PubMed><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Milestones in movement disorders clinical trials: advances and landmark studies.</title>
<author><name sortKey="Olanow, C Warren" sort="Olanow, C Warren" uniqKey="Olanow C" first="C Warren" last="Olanow">C Warren Olanow</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Neurology, Mount Sinai School of Medicine, New York, New York, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, Mount Sinai School of Medicine, New York, New York</wicri:regionArea>
<placeName><region type="state">État de New York</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Wunderle, Kathryn B" sort="Wunderle, Kathryn B" uniqKey="Wunderle K" first="Kathryn B" last="Wunderle">Kathryn B. Wunderle</name>
</author>
<author><name sortKey="Kieburtz, Karl" sort="Kieburtz, Karl" uniqKey="Kieburtz K" first="Karl" last="Kieburtz">Karl Kieburtz</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="2011">2011</date>
<idno type="doi">10.1002/mds.23727</idno>
<idno type="RBID">pubmed:21626545</idno>
<idno type="pmid">21626545</idno>
<idno type="wicri:Area/PubMed/Corpus">001177</idno>
<idno type="wicri:Area/PubMed/Curation">001177</idno>
<idno type="wicri:Area/PubMed/Checkpoint">001237</idno>
<idno type="wicri:Area/Ncbi/Merge">003251</idno>
<idno type="wicri:Area/Ncbi/Curation">003251</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">003251</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">Milestones in movement disorders clinical trials: advances and landmark studies.</title>
<author><name sortKey="Olanow, C Warren" sort="Olanow, C Warren" uniqKey="Olanow C" first="C Warren" last="Olanow">C Warren Olanow</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Neurology, Mount Sinai School of Medicine, New York, New York, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, Mount Sinai School of Medicine, New York, New York</wicri:regionArea>
<placeName><region type="state">État de New York</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Wunderle, Kathryn B" sort="Wunderle, Kathryn B" uniqKey="Wunderle K" first="Kathryn B" last="Wunderle">Kathryn B. Wunderle</name>
</author>
<author><name sortKey="Kieburtz, Karl" sort="Kieburtz, Karl" uniqKey="Kieburtz K" first="Karl" last="Kieburtz">Karl Kieburtz</name>
</author>
</analytic>
<series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title>
<idno type="eISSN">1531-8257</idno>
<imprint><date when="2011" type="published">2011</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Clinical Trials as Topic (history)</term>
<term>Clinical Trials as Topic (methods)</term>
<term>History, 20th Century</term>
<term>History, 21st Century</term>
<term>Humans</term>
<term>Movement Disorders (genetics)</term>
<term>Movement Disorders (history)</term>
<term>Movement Disorders (therapy)</term>
<term>Outcome Assessment (Health Care)</term>
<term>Research Design</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Movement Disorders</term>
</keywords>
<keywords scheme="MESH" qualifier="history" xml:lang="en"><term>Clinical Trials as Topic</term>
<term>Movement Disorders</term>
</keywords>
<keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Clinical Trials as Topic</term>
</keywords>
<keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Movement Disorders</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>History, 20th Century</term>
<term>History, 21st Century</term>
<term>Humans</term>
<term>Outcome Assessment (Health Care)</term>
<term>Research Design</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Over the past 25 years clinical trials testing in movement disorders has evolved in order to more effectively and efficiently analyze the safety and efficacy of new interventions. Studies today regularly incorporate methods to decrease placebo and bias effects and to ensure more rigorous statistical analyses. Newer, standardized, and validated rating scales such as the Unified Parkinson's Disease Rating Scale and the Unified Huntington's Disease Rating Scale are routinely employed in an effort to produce results that are comparable across different sites and studies. Several landmark studies in movement disorder research highlight these and other prominent procedural advances. The Deprenyl and Tocopherol Antioxidative Therapy of Parkinsonism trial pioneered the use of functional clinical end points, utilized a 2 × 2 factorial design to more efficiently analyze multiple interventions, and employed a washout design to assist in sorting putative neuroprotective from symptomatic effects. PRECEPT included neuroimaging as an outcome measure and highlighted the importance of futility studies in more efficiently directing resources. TEMPO and ADAGIO introduced the use of delayed-start (or 2-period) trials to try to identify disease-modifying interventions. NET-PD used futility studies to streamline the evaluation of potentially valuable treatments, followed by a large, long-term simple study design to assess the clinical significance of a new intervention. There have also been advances in clinical trials testing new surgical interventions, with the introduction of blinded outcome assessments and sham-surgery control groups. Collectively, methodological advances in clinical trials have permitted the safety and efficacy of new interventions to be tested more efficiently and economically and with a higher level of certainty that the potential benefits and adverse effects of interventions recommended for general use are well understood.</div>
</front>
</TEI>
</PubMed>
</double>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Santé/explor/MovDisordV3/Data/Main/Merge
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001607 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Merge/biblio.hfd -nk 001607 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Santé |area= MovDisordV3 |flux= Main |étape= Merge |type= RBID |clé= ISTEX:6B04D16CB34EB4EAB14364093891296355C6F8AC |texte= Milestones in movement disorders clinical trials: Advances and landmark studies }}
![]() | This area was generated with Dilib version V0.6.23. | ![]() |