Odor identification deficits identify Parkinson's disease patients with poor cognitive performance
Identifieur interne : 001561 ( Main/Merge ); précédent : 001560; suivant : 001562Odor identification deficits identify Parkinson's disease patients with poor cognitive performance
Auteurs : Malene Flensborg Damholdt [Danemark] ; Per Borghammer [Danemark] ; Lars Larsen [Danemark] ; Karen Stergaard [Danemark]Source :
- Movement Disorders [ 0885-3185 ] ; 2011-09.
English descriptors
- KwdEn :
- Aged, Analysis of Variance, Choice Behavior, Cognition Disorders (complications), Executive Function, Female, Humans, Male, Memory, Middle Aged, Mood Disorders (etiology), Neuropsychological Tests, Olfaction Disorders (diagnosis), Olfaction Disorders (etiology), Parkinson Disease (complications), Parkinson Disease (diagnosis), Parkinson's disease, Smell (physiology), Verbal Learning, cognition, odor identification, olfaction.
- MESH :
- complications : Cognition Disorders, Parkinson Disease.
- diagnosis : Olfaction Disorders, Parkinson Disease.
- etiology : Mood Disorders, Olfaction Disorders.
- physiology : Smell.
- Aged, Analysis of Variance, Choice Behavior, Executive Function, Female, Humans, Male, Memory, Middle Aged, Neuropsychological Tests, Verbal Learning.
Abstract
Olfactory dysfunction is a prodromal and prevalent nonmotor symptom of Parkinson's disease. Unlike olfactory dysfunction in Alzheimer's disease, it is believed to be unrelated to cognitive impairment. However, recent research has implicated cholinergic denervation in Parkinson's disease hyposmia and linked it to verbal memory. This research hypothesized that severe odor identification deficits may identify patients with Parkinson's disease at risk for cognitive impairment. The current study tested this hypothesis by comparing 24 functionally anosmic, nondemented patients with Parkinson's disease and 39 nonanosmic, nondemented patients with Parkinson's disease with 29 healthy control participants on composite scores of memory, processing speed, executive function, and language. The functionally anosmic group had significantly poorer visual and verbal memory than the nonanosmic group, which was indistinguishable from the control group. Furthermore, the functionally anosmic group had reduced processing speed compared with the nonanosmic patients with Parkinson's disease, who, in turn, were outperformed by the control group. On the composite language score, the score of the functionally anosmic group was significantly reduced compared with that of the control group, whereas the nonanosmic group scored in the medium range. The 2 patient groups did not differ on executive functioning. These findings demonstrate co‐occurrence between reduced cognitive function and olfactory deficits in functionally anosmic patients with Parkinson's disease and support the notion of more severe cognitive deficits in this group. © 2011 Movement Disorder Society
Url:
DOI: 10.1002/mds.23782
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<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Odor identification deficits identify Parkinson's disease patients with poor cognitive performance</title><author><name sortKey="Damholdt, Malene Flensborg" sort="Damholdt, Malene Flensborg" uniqKey="Damholdt M" first="Malene Flensborg" last="Damholdt">Malene Flensborg Damholdt</name></author><author><name sortKey="Borghammer, Per" sort="Borghammer, Per" uniqKey="Borghammer P" first="Per" last="Borghammer">Per Borghammer</name></author><author><name sortKey="Larsen, Lars" sort="Larsen, Lars" uniqKey="Larsen L" first="Lars" last="Larsen">Lars Larsen</name></author><author><name sortKey=" Stergaard, Karen" sort=" Stergaard, Karen" uniqKey=" Stergaard K" first="Karen" last=" Stergaard">Karen Stergaard</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:AFAC657F8CFEB08DC807877D649F79D1ECBA4AAF</idno><date when="2011" year="2011">2011</date><idno type="doi">10.1002/mds.23782</idno><idno type="url">https://api.istex.fr/document/AFAC657F8CFEB08DC807877D649F79D1ECBA4AAF/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">001203</idno><idno type="wicri:Area/Istex/Curation">001203</idno><idno type="wicri:Area/Istex/Checkpoint">000240</idno><idno type="wicri:doubleKey">0885-3185:2011:Damholdt M:odor:identification:deficits</idno><idno type="wicri:source">PubMed</idno><idno type="RBID">pubmed:21638326</idno><idno type="wicri:Area/PubMed/Corpus">001147</idno><idno type="wicri:Area/PubMed/Curation">001147</idno><idno type="wicri:Area/PubMed/Checkpoint">001198</idno><idno type="wicri:Area/Ncbi/Merge">003281</idno><idno type="wicri:Area/Ncbi/Curation">003281</idno><idno type="wicri:Area/Ncbi/Checkpoint">003281</idno><idno type="wicri:Area/Main/Merge">001561</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Odor identification deficits identify Parkinson's disease patients with poor cognitive performance</title><author><name sortKey="Damholdt, Malene Flensborg" sort="Damholdt, Malene Flensborg" uniqKey="Damholdt M" first="Malene Flensborg" last="Damholdt">Malene Flensborg Damholdt</name><affiliation wicri:level="1"><country xml:lang="fr">Danemark</country><wicri:regionArea>Department of Psychology, Aarhus University, Aarhus</wicri:regionArea><wicri:noRegion>Aarhus</wicri:noRegion></affiliation></author><author><name sortKey="Borghammer, Per" sort="Borghammer, Per" uniqKey="Borghammer P" first="Per" last="Borghammer">Per Borghammer</name><affiliation wicri:level="1"><country xml:lang="fr">Danemark</country><wicri:regionArea>Department of Nuclear Medicine, Aarhus University Hospitals, Aarhus</wicri:regionArea><wicri:noRegion>Aarhus</wicri:noRegion></affiliation></author><author><name sortKey="Larsen, Lars" sort="Larsen, Lars" uniqKey="Larsen L" first="Lars" last="Larsen">Lars Larsen</name><affiliation wicri:level="1"><country xml:lang="fr">Danemark</country><wicri:regionArea>Department of Psychology, Aarhus University, Aarhus</wicri:regionArea><wicri:noRegion>Aarhus</wicri:noRegion></affiliation></author><author><name sortKey=" Stergaard, Karen" sort=" Stergaard, Karen" uniqKey=" Stergaard K" first="Karen" last=" Stergaard">Karen Stergaard</name><affiliation wicri:level="1"><country xml:lang="fr">Danemark</country><wicri:regionArea>Department of Neurology, Aarhus University Hospitals, Aarhus</wicri:regionArea><wicri:noRegion>Aarhus</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2011-09">2011-09</date><biblScope unit="vol">26</biblScope><biblScope unit="issue">11</biblScope><biblScope unit="page" from="2045">2045</biblScope><biblScope unit="page" to="2050">2050</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">AFAC657F8CFEB08DC807877D649F79D1ECBA4AAF</idno><idno type="DOI">10.1002/mds.23782</idno><idno type="ArticleID">MDS23782</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Analysis of Variance</term><term>Choice Behavior</term><term>Cognition Disorders (complications)</term><term>Executive Function</term><term>Female</term><term>Humans</term><term>Male</term><term>Memory</term><term>Middle Aged</term><term>Mood Disorders (etiology)</term><term>Neuropsychological Tests</term><term>Olfaction Disorders (diagnosis)</term><term>Olfaction Disorders (etiology)</term><term>Parkinson Disease (complications)</term><term>Parkinson Disease (diagnosis)</term><term>Parkinson's disease</term><term>Smell (physiology)</term><term>Verbal Learning</term><term>cognition</term><term>odor identification</term><term>olfaction</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Cognition Disorders</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Olfaction Disorders</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Mood Disorders</term><term>Olfaction Disorders</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Smell</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Analysis of Variance</term><term>Choice Behavior</term><term>Executive Function</term><term>Female</term><term>Humans</term><term>Male</term><term>Memory</term><term>Middle Aged</term><term>Neuropsychological Tests</term><term>Verbal Learning</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Olfactory dysfunction is a prodromal and prevalent nonmotor symptom of Parkinson's disease. Unlike olfactory dysfunction in Alzheimer's disease, it is believed to be unrelated to cognitive impairment. However, recent research has implicated cholinergic denervation in Parkinson's disease hyposmia and linked it to verbal memory. This research hypothesized that severe odor identification deficits may identify patients with Parkinson's disease at risk for cognitive impairment. The current study tested this hypothesis by comparing 24 functionally anosmic, nondemented patients with Parkinson's disease and 39 nonanosmic, nondemented patients with Parkinson's disease with 29 healthy control participants on composite scores of memory, processing speed, executive function, and language. The functionally anosmic group had significantly poorer visual and verbal memory than the nonanosmic group, which was indistinguishable from the control group. Furthermore, the functionally anosmic group had reduced processing speed compared with the nonanosmic patients with Parkinson's disease, who, in turn, were outperformed by the control group. On the composite language score, the score of the functionally anosmic group was significantly reduced compared with that of the control group, whereas the nonanosmic group scored in the medium range. The 2 patient groups did not differ on executive functioning. These findings demonstrate co‐occurrence between reduced cognitive function and olfactory deficits in functionally anosmic patients with Parkinson's disease and support the notion of more severe cognitive deficits in this group. © 2011 Movement Disorder Society</div></front></TEI><double doi="10.1002/mds.23782"><ISTEX><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Odor identification deficits identify Parkinson's disease patients with poor cognitive performance</title><author><name sortKey="Damholdt, Malene Flensborg" sort="Damholdt, Malene Flensborg" uniqKey="Damholdt M" first="Malene Flensborg" last="Damholdt">Malene Flensborg Damholdt</name></author><author><name sortKey="Borghammer, Per" sort="Borghammer, Per" uniqKey="Borghammer P" first="Per" last="Borghammer">Per Borghammer</name></author><author><name sortKey="Larsen, Lars" sort="Larsen, Lars" uniqKey="Larsen L" first="Lars" last="Larsen">Lars Larsen</name></author><author><name sortKey=" Stergaard, Karen" sort=" Stergaard, Karen" uniqKey=" Stergaard K" first="Karen" last=" Stergaard">Karen Stergaard</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:AFAC657F8CFEB08DC807877D649F79D1ECBA4AAF</idno><date when="2011" year="2011">2011</date><idno type="doi">10.1002/mds.23782</idno><idno type="url">https://api.istex.fr/document/AFAC657F8CFEB08DC807877D649F79D1ECBA4AAF/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">001203</idno><idno type="wicri:Area/Istex/Curation">001203</idno><idno type="wicri:Area/Istex/Checkpoint">000240</idno><idno type="wicri:doubleKey">0885-3185:2011:Damholdt M:odor:identification:deficits</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Odor identification deficits identify Parkinson's disease patients with poor cognitive performance</title><author><name sortKey="Damholdt, Malene Flensborg" sort="Damholdt, Malene Flensborg" uniqKey="Damholdt M" first="Malene Flensborg" last="Damholdt">Malene Flensborg Damholdt</name><affiliation wicri:level="1"><country xml:lang="fr">Danemark</country><wicri:regionArea>Department of Psychology, Aarhus University, Aarhus</wicri:regionArea><wicri:noRegion>Aarhus</wicri:noRegion></affiliation></author><author><name sortKey="Borghammer, Per" sort="Borghammer, Per" uniqKey="Borghammer P" first="Per" last="Borghammer">Per Borghammer</name><affiliation wicri:level="1"><country xml:lang="fr">Danemark</country><wicri:regionArea>Department of Nuclear Medicine, Aarhus University Hospitals, Aarhus</wicri:regionArea><wicri:noRegion>Aarhus</wicri:noRegion></affiliation></author><author><name sortKey="Larsen, Lars" sort="Larsen, Lars" uniqKey="Larsen L" first="Lars" last="Larsen">Lars Larsen</name><affiliation wicri:level="1"><country xml:lang="fr">Danemark</country><wicri:regionArea>Department of Psychology, Aarhus University, Aarhus</wicri:regionArea><wicri:noRegion>Aarhus</wicri:noRegion></affiliation></author><author><name sortKey=" Stergaard, Karen" sort=" Stergaard, Karen" uniqKey=" Stergaard K" first="Karen" last=" Stergaard">Karen Stergaard</name><affiliation wicri:level="1"><country xml:lang="fr">Danemark</country><wicri:regionArea>Department of Neurology, Aarhus University Hospitals, Aarhus</wicri:regionArea><wicri:noRegion>Aarhus</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2011-09">2011-09</date><biblScope unit="vol">26</biblScope><biblScope unit="issue">11</biblScope><biblScope unit="page" from="2045">2045</biblScope><biblScope unit="page" to="2050">2050</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">AFAC657F8CFEB08DC807877D649F79D1ECBA4AAF</idno><idno type="DOI">10.1002/mds.23782</idno><idno type="ArticleID">MDS23782</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Parkinson's disease</term><term>cognition</term><term>odor identification</term><term>olfaction</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Olfactory dysfunction is a prodromal and prevalent nonmotor symptom of Parkinson's disease. Unlike olfactory dysfunction in Alzheimer's disease, it is believed to be unrelated to cognitive impairment. However, recent research has implicated cholinergic denervation in Parkinson's disease hyposmia and linked it to verbal memory. This research hypothesized that severe odor identification deficits may identify patients with Parkinson's disease at risk for cognitive impairment. The current study tested this hypothesis by comparing 24 functionally anosmic, nondemented patients with Parkinson's disease and 39 nonanosmic, nondemented patients with Parkinson's disease with 29 healthy control participants on composite scores of memory, processing speed, executive function, and language. The functionally anosmic group had significantly poorer visual and verbal memory than the nonanosmic group, which was indistinguishable from the control group. Furthermore, the functionally anosmic group had reduced processing speed compared with the nonanosmic patients with Parkinson's disease, who, in turn, were outperformed by the control group. On the composite language score, the score of the functionally anosmic group was significantly reduced compared with that of the control group, whereas the nonanosmic group scored in the medium range. The 2 patient groups did not differ on executive functioning. These findings demonstrate co‐occurrence between reduced cognitive function and olfactory deficits in functionally anosmic patients with Parkinson's disease and support the notion of more severe cognitive deficits in this group. © 2011 Movement Disorder Society</div></front></TEI></ISTEX><PubMed><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Odor identification deficits identify Parkinson's disease patients with poor cognitive performance.</title><author><name sortKey="Damholdt, Malene Flensborg" sort="Damholdt, Malene Flensborg" uniqKey="Damholdt M" first="Malene Flensborg" last="Damholdt">Malene Flensborg Damholdt</name><affiliation wicri:level="1"><nlm:affiliation>Department of Psychology, Aarhus University, Aarhus, Denmark. malenefd@psy.au.dk</nlm:affiliation><country xml:lang="fr">Danemark</country><wicri:regionArea>Department of Psychology, Aarhus University, Aarhus</wicri:regionArea><wicri:noRegion>Aarhus</wicri:noRegion></affiliation></author><author><name sortKey="Borghammer, Per" sort="Borghammer, Per" uniqKey="Borghammer P" first="Per" last="Borghammer">Per Borghammer</name></author><author><name sortKey="Larsen, Lars" sort="Larsen, Lars" uniqKey="Larsen L" first="Lars" last="Larsen">Lars Larsen</name></author><author><name sortKey="Ostergaard, Karen" sort="Ostergaard, Karen" uniqKey="Ostergaard K" first="Karen" last="Ostergaard">Karen Ostergaard</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2011">2011</date><idno type="doi">10.1002/mds.23782</idno><idno type="RBID">pubmed:21638326</idno><idno type="pmid">21638326</idno><idno type="wicri:Area/PubMed/Corpus">001147</idno><idno type="wicri:Area/PubMed/Curation">001147</idno><idno type="wicri:Area/PubMed/Checkpoint">001198</idno><idno type="wicri:Area/Ncbi/Merge">003281</idno><idno type="wicri:Area/Ncbi/Curation">003281</idno><idno type="wicri:Area/Ncbi/Checkpoint">003281</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Odor identification deficits identify Parkinson's disease patients with poor cognitive performance.</title><author><name sortKey="Damholdt, Malene Flensborg" sort="Damholdt, Malene Flensborg" uniqKey="Damholdt M" first="Malene Flensborg" last="Damholdt">Malene Flensborg Damholdt</name><affiliation wicri:level="1"><nlm:affiliation>Department of Psychology, Aarhus University, Aarhus, Denmark. malenefd@psy.au.dk</nlm:affiliation><country xml:lang="fr">Danemark</country><wicri:regionArea>Department of Psychology, Aarhus University, Aarhus</wicri:regionArea><wicri:noRegion>Aarhus</wicri:noRegion></affiliation></author><author><name sortKey="Borghammer, Per" sort="Borghammer, Per" uniqKey="Borghammer P" first="Per" last="Borghammer">Per Borghammer</name></author><author><name sortKey="Larsen, Lars" sort="Larsen, Lars" uniqKey="Larsen L" first="Lars" last="Larsen">Lars Larsen</name></author><author><name sortKey="Ostergaard, Karen" sort="Ostergaard, Karen" uniqKey="Ostergaard K" first="Karen" last="Ostergaard">Karen Ostergaard</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="eISSN">1531-8257</idno><imprint><date when="2011" type="published">2011</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Analysis of Variance</term><term>Choice Behavior</term><term>Cognition Disorders (complications)</term><term>Executive Function</term><term>Female</term><term>Humans</term><term>Male</term><term>Memory</term><term>Middle Aged</term><term>Mood Disorders (etiology)</term><term>Neuropsychological Tests</term><term>Olfaction Disorders (diagnosis)</term><term>Olfaction Disorders (etiology)</term><term>Parkinson Disease (complications)</term><term>Parkinson Disease (diagnosis)</term><term>Smell (physiology)</term><term>Verbal Learning</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Cognition Disorders</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Olfaction Disorders</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Mood Disorders</term><term>Olfaction Disorders</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Smell</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Analysis of Variance</term><term>Choice Behavior</term><term>Executive Function</term><term>Female</term><term>Humans</term><term>Male</term><term>Memory</term><term>Middle Aged</term><term>Neuropsychological Tests</term><term>Verbal Learning</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Olfactory dysfunction is a prodromal and prevalent nonmotor symptom of Parkinson's disease. Unlike olfactory dysfunction in Alzheimer's disease, it is believed to be unrelated to cognitive impairment. However, recent research has implicated cholinergic denervation in Parkinson's disease hyposmia and linked it to verbal memory. This research hypothesized that severe odor identification deficits may identify patients with Parkinson's disease at risk for cognitive impairment. The current study tested this hypothesis by comparing 24 functionally anosmic, nondemented patients with Parkinson's disease and 39 nonanosmic, nondemented patients with Parkinson's disease with 29 healthy control participants on composite scores of memory, processing speed, executive function, and language. The functionally anosmic group had significantly poorer visual and verbal memory than the nonanosmic group, which was indistinguishable from the control group. Furthermore, the functionally anosmic group had reduced processing speed compared with the nonanosmic patients with Parkinson's disease, who, in turn, were outperformed by the control group. On the composite language score, the score of the functionally anosmic group was significantly reduced compared with that of the control group, whereas the nonanosmic group scored in the medium range. The 2 patient groups did not differ on executive functioning. These findings demonstrate co-occurrence between reduced cognitive function and olfactory deficits in functionally anosmic patients with Parkinson's disease and support the notion of more severe cognitive deficits in this group.</div></front></TEI></PubMed></double></record>Pour manipuler ce document sous Unix (Dilib)
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