Movement Disorders (revue)

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PREPARED: Comparison of prolonged and immediate release ropinirole in advanced Parkinson's disease

Identifieur interne : 001551 ( Main/Merge ); précédent : 001550; suivant : 001552

PREPARED: Comparison of prolonged and immediate release ropinirole in advanced Parkinson's disease

Auteurs : Fabrizio Stocchi [Italie] ; Luigi Giorgi [Royaume-Uni] ; Brian Hunter [Royaume-Uni] ; Anthony Hv Schapira [Royaume-Uni]

Source :

RBID : ISTEX:49FDA753190EDFEEB695C4DF604D6BFAA634EB3E

English descriptors

Abstract

Background: PREPARED was a randomized, parallel‐group, double‐blind, multicenter study to evaluate the efficacy of adjunctive ropinirole prolonged release (PR) versus immediate release (IR) in patients with advanced Parkinson's disease (PD). Methods: Patients received once‐daily PR (2–24 mg/d; n = 177) or three‐times‐daily IR (0.75–24 mg/d; n = 173) for 24 weeks. The primary endpoint was the proportion of patients maintaining ≥20% reduction from baseline in “off” time over two consecutive visits at Week 24 last observation carried forward (LOCF). Results: At Week 24 LOCF, PR significantly increased the proportion of patients maintaining ≥20% reduction in “off” time versus IR (adjusted odds ratio: 1.82; 95% CI: 1.16, 2.86; P = 0.009). Mean (SD) doses at Week 24 LOCF were: PR, 18.6 (6.5) mg/d; IR, 10.4 (6.4) mg/d; mean (SD) reductions from baseline in levodopa (L‐dopa) dose were –162 (226) mg and –113 (138) mg, respectively. Adverse events (AEs) were reported by 72% of patients in the PR group and 61% in the IR group; 12% and 9% of patients, respectively, withdrew from the study due to an AE, and 6% and 5%, respectively, reported serious AEs. Conclusions: Adjunctive PR provided a significantly greater improvement in symptom control in terms of the odds of achieving ≥20% maintained reduction in time spent “off” compared with IR. Interpretation may be confounded by the higher doses of PR versus IR that were achieved, in combination with lower doses of L‐dopa by the study end. Despite dosing differences, the PR titration regimen was generally well tolerated, with an AE profile similar to that of IR. © 2011 Movement Disorder Society

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DOI: 10.1002/mds.23498

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ISTEX:49FDA753190EDFEEB695C4DF604D6BFAA634EB3E

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   |flux=    Main
   |étape=   Merge
   |type=    RBID
   |clé=     ISTEX:49FDA753190EDFEEB695C4DF604D6BFAA634EB3E
   |texte=   PREPARED: Comparison of prolonged and immediate release ropinirole in advanced Parkinson's disease
}}

Wicri

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