CSF Aβ LEVELS CORRELATE WITH STRUCTURAL BRAIN CHANGES IN PARKINSON’S DISEASE
Identifieur interne : 000A82 ( Main/Merge ); précédent : 000A81; suivant : 000A83CSF Aβ LEVELS CORRELATE WITH STRUCTURAL BRAIN CHANGES IN PARKINSON’S DISEASE
Auteurs : Mona K. Beyer [Norvège] ; Guido Alves [Norvège] ; Kristy S. Hwang [États-Unis] ; Sona Babakchanian [États-Unis] ; Kolbjorn S. Bronnick [Norvège] ; Yi-Yu Chou [États-Unis] ; Turi O. Dalaker [Norvège] ; Martin W. Kurz [Norvège] ; Jan P. Larsen [Norvège] ; Johanne H. Somme [Espagne] ; Paul M. Thompson [États-Unis] ; Ole Bjorn Tysnes [Norvège] ; Liana G. Apostolova [États-Unis]Source :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 2013.
English descriptors
- KwdEn :
- Aged, Amyloid beta-Peptides (cerebrospinal fluid), Apolipoproteins E (genetics), Female, Hippocampus (pathology), Humans, Imaging, Three-Dimensional, Lateral Ventricles (pathology), Magnetic Resonance Imaging, Male, Mental Status Schedule, Middle Aged, Parkinson Disease (cerebrospinal fluid), Parkinson Disease (pathology), Peptide Fragments (cerebrospinal fluid), Regression Analysis, Statistics as Topic, Statistics, Nonparametric, tau Proteins (cerebrospinal fluid).
- MESH :
- chemical , cerebrospinal fluid : Amyloid beta-Peptides, Peptide Fragments, tau Proteins.
- chemical , genetics : Apolipoproteins E.
- cerebrospinal fluid : Parkinson Disease.
- pathology : Hippocampus, Lateral Ventricles, Parkinson Disease.
- Aged, Female, Humans, Imaging, Three-Dimensional, Magnetic Resonance Imaging, Male, Mental Status Schedule, Middle Aged, Regression Analysis, Statistics as Topic, Statistics, Nonparametric.
Abstract
ParkWest is a large Norwegian multicenter study of newly diagnosed drug-naïve subjects with Parkinson’s disease (PD). Cognitively normal PD subjects (PDCN) and PD subjects with mild cognitive impairment (PDMCI) from this cohort have significant hippocampal atrophy and ventricular enlargement compared to normal controls. Here we aimed to investigate whether the same structural changes are associated with CSF levels of Aβ38, Aβ40, Aβ42, total tau and phosphorylated tau.
We performed 3D radial distance analyses of the hippocampi and lateral ventricles using the MRI data from ParkWest subjects who provided CSF at baseline. Our sample consisted of 73 PDCN and 18 PDMCI subjects.
We found significant associations between the levels of all three CSF Aβ analytes and t-tau and lateral ventricular enlargement in the pooled sample. In the PDCN sample all three amyloid analytesshowed significant associations with the radial distance of the occipital and frontal horns of the lateral ventricles. CSF Aβ38 and Aβ42 showed negative associations with enlargement in occipital and frontal horns of the lateral ventricles in the pooled sample, and a negative association with the occipital horns in PDMCI.
CSF Aβ levels in early PD correlate with ventricular enlargement, previously associated with PDD. CSF and MRI markers may therefore help identify PD patients at high risk for developing cognitive decline and dementia in the course of their illness. Contrary to Alzheimer’s disease, we found no associations between CSF t-tau and p-tau and hippocampal atrophy.
Url:
DOI: 10.1002/mds.25282
PubMed: 23408705
PubMed Central: 3608817
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PMC:3608817Le document en format XML
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<country xml:lang="fr" wicri:curation="lc">Norvège</country>
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<author><name sortKey="Alves, Guido" sort="Alves, Guido" uniqKey="Alves G" first="Guido" last="Alves">Guido Alves</name>
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<author><name sortKey="Hwang, Kristy S" sort="Hwang, Kristy S" uniqKey="Hwang K" first="Kristy S." last="Hwang">Kristy S. Hwang</name>
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<country xml:lang="fr">États-Unis</country>
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<affiliation wicri:level="2"><nlm:aff id="A5">Laboratory of Neuro Imaging, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
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<author><name sortKey="Babakchanian, Sona" sort="Babakchanian, Sona" uniqKey="Babakchanian S" first="Sona" last="Babakchanian">Sona Babakchanian</name>
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<author><name sortKey="Bronnick, Kolbjorn S" sort="Bronnick, Kolbjorn S" uniqKey="Bronnick K" first="Kolbjorn S." last="Bronnick">Kolbjorn S. Bronnick</name>
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<author><name sortKey="Chou, Yi Yu" sort="Chou, Yi Yu" uniqKey="Chou Y" first="Yi-Yu" last="Chou">Yi-Yu Chou</name>
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<country xml:lang="fr">États-Unis</country>
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<author><name sortKey="Tysnes, Ole Bjorn" sort="Tysnes, Ole Bjorn" uniqKey="Tysnes O" first="Ole Bjorn" last="Tysnes">Ole Bjorn Tysnes</name>
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<country xml:lang="fr">Norvège</country>
<wicri:regionArea>Department of Neurology, Haukeland University Hospital, Bergen</wicri:regionArea>
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<author><name sortKey="Apostolova, Liana G" sort="Apostolova, Liana G" uniqKey="Apostolova L" first="Liana G." last="Apostolova">Liana G. Apostolova</name>
<affiliation wicri:level="2"><nlm:aff id="A4">Department of Neurology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA</wicri:regionArea>
<placeName><region type="state">Californie</region>
</placeName>
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<affiliation wicri:level="2"><nlm:aff id="A5">Laboratory of Neuro Imaging, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Laboratory of Neuro Imaging, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA</wicri:regionArea>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title>
<idno type="ISSN">0885-3185</idno>
<idno type="eISSN">1531-8257</idno>
<imprint><date when="2013">2013</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term>
<term>Amyloid beta-Peptides (cerebrospinal fluid)</term>
<term>Apolipoproteins E (genetics)</term>
<term>Female</term>
<term>Hippocampus (pathology)</term>
<term>Humans</term>
<term>Imaging, Three-Dimensional</term>
<term>Lateral Ventricles (pathology)</term>
<term>Magnetic Resonance Imaging</term>
<term>Male</term>
<term>Mental Status Schedule</term>
<term>Middle Aged</term>
<term>Parkinson Disease (cerebrospinal fluid)</term>
<term>Parkinson Disease (pathology)</term>
<term>Peptide Fragments (cerebrospinal fluid)</term>
<term>Regression Analysis</term>
<term>Statistics as Topic</term>
<term>Statistics, Nonparametric</term>
<term>tau Proteins (cerebrospinal fluid)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="cerebrospinal fluid" xml:lang="en"><term>Amyloid beta-Peptides</term>
<term>Peptide Fragments</term>
<term>tau Proteins</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Apolipoproteins E</term>
</keywords>
<keywords scheme="MESH" qualifier="cerebrospinal fluid" xml:lang="en"><term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Hippocampus</term>
<term>Lateral Ventricles</term>
<term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Aged</term>
<term>Female</term>
<term>Humans</term>
<term>Imaging, Three-Dimensional</term>
<term>Magnetic Resonance Imaging</term>
<term>Male</term>
<term>Mental Status Schedule</term>
<term>Middle Aged</term>
<term>Regression Analysis</term>
<term>Statistics as Topic</term>
<term>Statistics, Nonparametric</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><sec id="S1"><title>Background</title>
<p id="P1">ParkWest is a large Norwegian multicenter study of newly diagnosed drug-naïve subjects with Parkinson’s disease (PD). Cognitively normal PD subjects (PDCN) and PD subjects with mild cognitive impairment (PDMCI) from this cohort have significant hippocampal atrophy and ventricular enlargement compared to normal controls. Here we aimed to investigate whether the same structural changes are associated with CSF levels of Aβ<sub>38</sub>
, Aβ<sub>40</sub>
, Aβ<sub>42</sub>
, total tau and phosphorylated tau.</p>
</sec>
<sec id="S2"><title>Methods</title>
<p id="P2">We performed 3D radial distance analyses of the hippocampi and lateral ventricles using the MRI data from ParkWest subjects who provided CSF at baseline. Our sample consisted of 73 PDCN and 18 PDMCI subjects.</p>
</sec>
<sec id="S3"><title>Results</title>
<p id="P3">We found significant associations between the levels of all three CSF Aβ analytes and t-tau and lateral ventricular enlargement in the pooled sample. In the PDCN sample all three amyloid analytesshowed significant associations with the radial distance of the occipital and frontal horns of the lateral ventricles. CSF Aβ<sub>38</sub>
and Aβ<sub>42</sub>
showed negative associations with enlargement in occipital and frontal horns of the lateral ventricles in the pooled sample, and a negative association with the occipital horns in PDMCI.</p>
</sec>
<sec id="S4"><title>Conclusion</title>
<p id="P4">CSF Aβ levels in early PD correlate with ventricular enlargement, previously associated with PDD. CSF and MRI markers may therefore help identify PD patients at high risk for developing cognitive decline and dementia in the course of their illness. Contrary to Alzheimer’s disease, we found no associations between CSF t-tau and p-tau and hippocampal atrophy.</p>
</sec>
</div>
</front>
</TEI>
</record>
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