The onset of nonmotor symptoms in Parkinson's disease (the ONSET PD study).
Identifieur interne : 000036 ( Main/Merge ); précédent : 000035; suivant : 000037The onset of nonmotor symptoms in Parkinson's disease (the ONSET PD study).
Auteurs : Claustre Pont-Sunyer [Espagne] ; Anna Hotter ; Carles Gaig ; Klaus Seppi ; Yaroslau Compta ; Regina Katzenschlager ; Natalia Mas ; Dominik Hofeneder ; Thomas Brücke ; Angels Bayés ; Karoline Wenzel ; Jon Infante ; Heidemarie Zach ; Walter Pirker ; Ignacio J. Posada ; Ramiro Álvarez ; Lourdes Ispierto ; Oriol De Fàbregues ; Antoni Callén ; Antoni Palasí ; Miquel Aguilar ; Maria José Martí ; Francesc Valldeoriola ; Manel Salamero ; Werner Poewe [Autriche] ; Eduardo TolosaSource :
- Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2015.
English descriptors
- KwdEn :
- Adult, Age of Onset, Aged, Aged, 80 and over, Constipation (diagnosis), Constipation (etiology), Diagnosis, Differential, Fatigue (etiology), Female, Humans, Male, Mental Disorders (diagnosis), Mental Disorders (etiology), Mental Disorders (physiopathology), Middle Aged, Olfaction Disorders (diagnosis), Olfaction Disorders (etiology), Parkinson Disease (complications), Parkinson Disease (diagnosis), Questionnaires, Risk.
- MESH :
- complications : Parkinson Disease.
- diagnosis : Constipation, Mental Disorders, Olfaction Disorders, Parkinson Disease.
- etiology : Constipation, Fatigue, Mental Disorders, Olfaction Disorders.
- physiopathology : Mental Disorders.
- Adult, Age of Onset, Aged, Aged, 80 and over, Diagnosis, Differential, Female, Humans, Male, Middle Aged, Questionnaires, Risk.
Abstract
Nonmotor symptoms (NMS) in Parkinson's disease (PD) can precede onset of motor symptoms. Relationship between premotor symptoms onset and motor features is limited. Our aim is to describe the presence and perceived onset of NMS in PD as well as their possible association with motor phenotype. Presence and onset of NMS were assessed by a custom-made questionnaire in 109 newly diagnosed untreated PD patients and 107 controls from 11 Spanish and Austrian centers. Seventeen of thirty-one NMS were more common in patients than controls (P < 0.05). They were usually mild and frequently reported to occur at different time-spans before motor symptoms. Anhedonia, apathy, memory complaints, and inattention occurred more frequently during the 2-year premotor period. Those reported more frequently in the 2- to 10-year premotor period were smell loss, mood disturbances, taste loss, excessive sweating, fatigue, and pain. Constipation, dream-enacting behavior, excessive daytime sleepiness, and postprandial fullness were frequently perceived more than 10 years before motor symptoms. No correlation between NMS burden and motor severity, age, or gender was observed. NMS associated in four clusters: rapid eye movement sleep behavior disorder symptoms-constipation, cognition-related, mood-related, and sensory clusters. No cluster was associated with a specific motor phenotype or severity. NMS are common in early unmedicated PD and frequently reported to occur in the premotor period. They are generally mild, but a patient subgroup showed high NMS burden mainly resulting from cognition-related symptoms. Certain NMS when present at the time of assessment or in the premotor stage, either alone or in combination, allowed discriminating PD from controls.
DOI: 10.1002/mds.26077
PubMed: 25449044
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<author><name sortKey="Gaig, Carles" sort="Gaig, Carles" uniqKey="Gaig C" first="Carles" last="Gaig">Carles Gaig</name>
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<author><name sortKey="Seppi, Klaus" sort="Seppi, Klaus" uniqKey="Seppi K" first="Klaus" last="Seppi">Klaus Seppi</name>
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<author><name sortKey="Compta, Yaroslau" sort="Compta, Yaroslau" uniqKey="Compta Y" first="Yaroslau" last="Compta">Yaroslau Compta</name>
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<author><name sortKey="Hofeneder, Dominik" sort="Hofeneder, Dominik" uniqKey="Hofeneder D" first="Dominik" last="Hofeneder">Dominik Hofeneder</name>
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<author><name sortKey="Brucke, Thomas" sort="Brucke, Thomas" uniqKey="Brucke T" first="Thomas" last="Brücke">Thomas Brücke</name>
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<author><name sortKey="Bayes, Angels" sort="Bayes, Angels" uniqKey="Bayes A" first="Angels" last="Bayés">Angels Bayés</name>
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<author><name sortKey="Wenzel, Karoline" sort="Wenzel, Karoline" uniqKey="Wenzel K" first="Karoline" last="Wenzel">Karoline Wenzel</name>
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<author><name sortKey="Infante, Jon" sort="Infante, Jon" uniqKey="Infante J" first="Jon" last="Infante">Jon Infante</name>
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<author><name sortKey="Zach, Heidemarie" sort="Zach, Heidemarie" uniqKey="Zach H" first="Heidemarie" last="Zach">Heidemarie Zach</name>
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<author><name sortKey="Pirker, Walter" sort="Pirker, Walter" uniqKey="Pirker W" first="Walter" last="Pirker">Walter Pirker</name>
</author>
<author><name sortKey="Posada, Ignacio J" sort="Posada, Ignacio J" uniqKey="Posada I" first="Ignacio J" last="Posada">Ignacio J. Posada</name>
</author>
<author><name sortKey="Alvarez, Ramiro" sort="Alvarez, Ramiro" uniqKey="Alvarez R" first="Ramiro" last="Álvarez">Ramiro Álvarez</name>
</author>
<author><name sortKey="Ispierto, Lourdes" sort="Ispierto, Lourdes" uniqKey="Ispierto L" first="Lourdes" last="Ispierto">Lourdes Ispierto</name>
</author>
<author><name sortKey="De Fabregues, Oriol" sort="De Fabregues, Oriol" uniqKey="De Fabregues O" first="Oriol" last="De Fàbregues">Oriol De Fàbregues</name>
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<author><name sortKey="Callen, Antoni" sort="Callen, Antoni" uniqKey="Callen A" first="Antoni" last="Callén">Antoni Callén</name>
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<author><name sortKey="Palasi, Antoni" sort="Palasi, Antoni" uniqKey="Palasi A" first="Antoni" last="Palasí">Antoni Palasí</name>
</author>
<author><name sortKey="Aguilar, Miquel" sort="Aguilar, Miquel" uniqKey="Aguilar M" first="Miquel" last="Aguilar">Miquel Aguilar</name>
</author>
<author><name sortKey="Marti, Maria Jose" sort="Marti, Maria Jose" uniqKey="Marti M" first="Maria José" last="Martí">Maria José Martí</name>
</author>
<author><name sortKey="Valldeoriola, Francesc" sort="Valldeoriola, Francesc" uniqKey="Valldeoriola F" first="Francesc" last="Valldeoriola">Francesc Valldeoriola</name>
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<author><name sortKey="Salamero, Manel" sort="Salamero, Manel" uniqKey="Salamero M" first="Manel" last="Salamero">Manel Salamero</name>
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<author><name sortKey="Tolosa, Eduardo" sort="Tolosa, Eduardo" uniqKey="Tolosa E" first="Eduardo" last="Tolosa">Eduardo Tolosa</name>
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<term>Age of Onset</term>
<term>Aged</term>
<term>Aged, 80 and over</term>
<term>Constipation (diagnosis)</term>
<term>Constipation (etiology)</term>
<term>Diagnosis, Differential</term>
<term>Fatigue (etiology)</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
<term>Mental Disorders (diagnosis)</term>
<term>Mental Disorders (etiology)</term>
<term>Mental Disorders (physiopathology)</term>
<term>Middle Aged</term>
<term>Olfaction Disorders (diagnosis)</term>
<term>Olfaction Disorders (etiology)</term>
<term>Parkinson Disease (complications)</term>
<term>Parkinson Disease (diagnosis)</term>
<term>Questionnaires</term>
<term>Risk</term>
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<keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Constipation</term>
<term>Mental Disorders</term>
<term>Olfaction Disorders</term>
<term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Constipation</term>
<term>Fatigue</term>
<term>Mental Disorders</term>
<term>Olfaction Disorders</term>
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<keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Mental Disorders</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Adult</term>
<term>Age of Onset</term>
<term>Aged</term>
<term>Aged, 80 and over</term>
<term>Diagnosis, Differential</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Questionnaires</term>
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<front><div type="abstract" xml:lang="en">Nonmotor symptoms (NMS) in Parkinson's disease (PD) can precede onset of motor symptoms. Relationship between premotor symptoms onset and motor features is limited. Our aim is to describe the presence and perceived onset of NMS in PD as well as their possible association with motor phenotype. Presence and onset of NMS were assessed by a custom-made questionnaire in 109 newly diagnosed untreated PD patients and 107 controls from 11 Spanish and Austrian centers. Seventeen of thirty-one NMS were more common in patients than controls (P < 0.05). They were usually mild and frequently reported to occur at different time-spans before motor symptoms. Anhedonia, apathy, memory complaints, and inattention occurred more frequently during the 2-year premotor period. Those reported more frequently in the 2- to 10-year premotor period were smell loss, mood disturbances, taste loss, excessive sweating, fatigue, and pain. Constipation, dream-enacting behavior, excessive daytime sleepiness, and postprandial fullness were frequently perceived more than 10 years before motor symptoms. No correlation between NMS burden and motor severity, age, or gender was observed. NMS associated in four clusters: rapid eye movement sleep behavior disorder symptoms-constipation, cognition-related, mood-related, and sensory clusters. No cluster was associated with a specific motor phenotype or severity. NMS are common in early unmedicated PD and frequently reported to occur in the premotor period. They are generally mild, but a patient subgroup showed high NMS burden mainly resulting from cognition-related symptoms. Certain NMS when present at the time of assessment or in the premotor stage, either alone or in combination, allowed discriminating PD from controls.</div>
</front>
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