Use of botulinum toxin type F injections to treat torticollis in patients with immunity to botulinum toxin type A
Identifieur interne : 005D04 ( Main/Exploration ); précédent : 005D03; suivant : 005D05Use of botulinum toxin type F injections to treat torticollis in patients with immunity to botulinum toxin type A
Auteurs : Greene [États-Unis] ; Stanley Fahn [États-Unis]Source :
- Movement Disorders [ 0885-3185 ] ; 1993.
English descriptors
- KwdEn :
- Adolescent, Adult, Antibody, Antibody Formation, Botulinum Toxins (classification), Botulinum Toxins (immunology), Botulinum Toxins (therapeutic use), Botulinum toxin type A, Botulinum toxin type F, Dystonia, Dystonia (drug therapy), Dystonia (immunology), Female, Humans, Immunity, Immunotoxins, Male, Torticollis, Torticollis (drug therapy), Torticollis (immunology).
- MESH :
- chemical , classification : Botulinum Toxins.
- chemical , immunology : Botulinum Toxins.
- chemical , therapeutic use : Botulinum Toxins.
- drug therapy : Dystonia, Torticollis.
- immunology : Dystonia, Torticollis.
- Adolescent, Adult, Antibody Formation, Female, Humans, Immunity, Immunotoxins, Male.
Abstract
Fifteen patients with torticollis who had been treated with repeated injections of botulinum toxin type A (botox A) developed antibodies to the toxin. This resulted in loss of benefit in the 13 patients who had improved with botox A injections and failure to develop muscle atrophy after injection in all 15 patients. Patients were then injected with botulinum toxin type F (botox F) in the same muscles that had been injected with botox A. Ten of the 15 improved after botox F injections, including 9 of the 12 patients who had improved with type A toxin. Six of 9 patients with pain had improvement in pain after botox F injections. Patients reported similar improvement with type F and type A toxins, but duration of benefit was ˜3 months with type A and ˜1 month with type F. Botox F is an effective treatment for torticollis in patients who are immune to botox A. The usefulness of type F toxin, however, is limited by short duration of benefit.
Url:
DOI: 10.1002/mds.870080411
Affiliations:
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Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="1993">1993</date><biblScope unit="vol">8</biblScope><biblScope unit="issue">4</biblScope><biblScope unit="page" from="479">479</biblScope><biblScope unit="page" to="483">483</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">C97A592A850155E85A7C99EEC4E790E93DE6B014</idno><idno type="DOI">10.1002/mds.870080411</idno><idno type="ArticleID">MDS870080411</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Antibody</term><term>Antibody Formation</term><term>Botulinum Toxins (classification)</term><term>Botulinum Toxins (immunology)</term><term>Botulinum Toxins (therapeutic use)</term><term>Botulinum toxin type A</term><term>Botulinum toxin type F</term><term>Dystonia</term><term>Dystonia (drug therapy)</term><term>Dystonia (immunology)</term><term>Female</term><term>Humans</term><term>Immunity</term><term>Immunotoxins</term><term>Male</term><term>Torticollis</term><term>Torticollis (drug therapy)</term><term>Torticollis (immunology)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="classification" xml:lang="en"><term>Botulinum Toxins</term></keywords><keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Botulinum Toxins</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Botulinum Toxins</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Dystonia</term><term>Torticollis</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Dystonia</term><term>Torticollis</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Antibody Formation</term><term>Female</term><term>Humans</term><term>Immunity</term><term>Immunotoxins</term><term>Male</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Fifteen patients with torticollis who had been treated with repeated injections of botulinum toxin type A (botox A) developed antibodies to the toxin. This resulted in loss of benefit in the 13 patients who had improved with botox A injections and failure to develop muscle atrophy after injection in all 15 patients. Patients were then injected with botulinum toxin type F (botox F) in the same muscles that had been injected with botox A. Ten of the 15 improved after botox F injections, including 9 of the 12 patients who had improved with type A toxin. Six of 9 patients with pain had improvement in pain after botox F injections. Patients reported similar improvement with type F and type A toxins, but duration of benefit was ˜3 months with type A and ˜1 month with type F. Botox F is an effective treatment for torticollis in patients who are immune to botox A. The usefulness of type F toxin, however, is limited by short duration of benefit.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>État de New York</li></region></list><tree><country name="États-Unis"><region name="État de New York"><name sortKey="Greene" sort="Greene" uniqKey="Greene" last="Greene">Greene</name></region><name sortKey="Fahn, Stanley" sort="Fahn, Stanley" uniqKey="Fahn S" first="Stanley" last="Fahn">Stanley Fahn</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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