rCBF changes associated with PPN stimulation in a patient with Parkinson's disease: A PET study
Identifieur interne : 002535 ( Main/Exploration ); précédent : 002534; suivant : 002536rCBF changes associated with PPN stimulation in a patient with Parkinson's disease: A PET study
Auteurs : Antonio P. Strafella [Canada] ; Andres M. Lozano [Canada] ; Benedicte Ballanger [Canada] ; Yu-Yan Poon [Canada] ; Anthony E. Lang [Canada] ; Elena Moro [Canada]Source :
- Movement Disorders [ 0885-3185 ] ; 2008-05-15.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Homme.
English descriptors
- KwdEn :
- Brain (blood supply), Brain (pathology), Cerebrovascular Circulation (physiology), Deep Brain Stimulation (methods), Deep brain stimulation, Emission tomography, Functional imaging, Human, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Nervous system diseases, PET, PPN, Parkinson Disease (diagnosis), Parkinson Disease (therapy), Parkinson disease, Parkinson's disease, Pedunculopontine Tegmental Nucleus (blood supply), Positron emission tomography, Positron-Emission Tomography, deep brain stimulation, functional imaging.
- MESH :
- blood supply : Brain, Pedunculopontine Tegmental Nucleus.
- diagnosis : Parkinson Disease.
- methods : Deep Brain Stimulation.
- pathology : Brain.
- physiology : Cerebrovascular Circulation.
- therapy : Parkinson Disease.
- Humans, Magnetic Resonance Imaging, Male, Middle Aged, Positron-Emission Tomography.
Abstract
Gait disturbances and akinesia are disabling symptoms in advanced Parkinson's disease (PD). The pedunculopontine nucleus (PPN) is involved in locomotion, control of posture, and behavioral states [i.e. wakefulness, rapid eye movement (REM) sleep]. Some reports have suggested that modulation of the activity of the PPN with deep brain stimulation (DBS) may be beneficial in the treatment of gait dysfunction and akinesia. To gain some insights on effects of PPN‐DBS in the human brain, we used [15O] H2O positron emission tomography (PET) to measure changes in regional cerebral blood flow (rCBF) at rest during Off and On stimulation in an advanced PD patient with unilateral PPN‐DBS. PPN‐DBS increased rCBF in different subcortical areas most notably the thalamus, bilaterally. Double‐blinded clinical evaluation revealed an improvement in motor function by ∼20%. The PET changes provide for the first time evidence in the human brain that PPN‐DBS may be able to influence and modify rCBF of closely connected subcortical structures. Given the importance of the PPN in locomotion, control of posture, and behavioral states, DBS may have significant implication for more complicated forms of movement disorders where deterioration of gait, postural instability, and REM sleep behavior disorders are very disabling. © 2008 Movement Disorder Society
Url:
DOI: 10.1002/mds.22055
Affiliations:
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The pedunculopontine nucleus (PPN) is involved in locomotion, control of posture, and behavioral states [i.e. wakefulness, rapid eye movement (REM) sleep]. Some reports have suggested that modulation of the activity of the PPN with deep brain stimulation (DBS) may be beneficial in the treatment of gait dysfunction and akinesia. To gain some insights on effects of PPN‐DBS in the human brain, we used [15O] H2O positron emission tomography (PET) to measure changes in regional cerebral blood flow (rCBF) at rest during Off and On stimulation in an advanced PD patient with unilateral PPN‐DBS. PPN‐DBS increased rCBF in different subcortical areas most notably the thalamus, bilaterally. Double‐blinded clinical evaluation revealed an improvement in motor function by ∼20%. The PET changes provide for the first time evidence in the human brain that PPN‐DBS may be able to influence and modify rCBF of closely connected subcortical structures. Given the importance of the PPN in locomotion, control of posture, and behavioral states, DBS may have significant implication for more complicated forms of movement disorders where deterioration of gait, postural instability, and REM sleep behavior disorders are very disabling. © 2008 Movement Disorder Society</div></front></TEI><affiliations><list><country><li>Canada</li></country><region><li>Ontario</li></region><settlement><li>Toronto</li></settlement><orgName><li>Université de Toronto</li></orgName></list><tree><country name="Canada"><region name="Ontario"><name sortKey="Strafella, Antonio P" sort="Strafella, Antonio P" uniqKey="Strafella A" first="Antonio P." last="Strafella">Antonio P. Strafella</name></region><name sortKey="Ballanger, Benedicte" sort="Ballanger, Benedicte" uniqKey="Ballanger B" first="Benedicte" last="Ballanger">Benedicte Ballanger</name><name sortKey="Lang, Anthony E" sort="Lang, Anthony E" uniqKey="Lang A" first="Anthony E." last="Lang">Anthony E. Lang</name><name sortKey="Lozano, Andres M" sort="Lozano, Andres M" uniqKey="Lozano A" first="Andres M." last="Lozano">Andres M. Lozano</name><name sortKey="Moro, Elena" sort="Moro, Elena" uniqKey="Moro E" first="Elena" last="Moro">Elena Moro</name><name sortKey="Poon, Yu An" sort="Poon, Yu An" uniqKey="Poon Y" first="Yu-Yan" last="Poon">Yu-Yan Poon</name><name sortKey="Strafella, Antonio P" sort="Strafella, Antonio P" uniqKey="Strafella A" first="Antonio P." last="Strafella">Antonio P. Strafella</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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