Botulinum toxin type A for drooling in Parkinson's disease: A double‐blind, randomized, placebo‐controlled study
Identifieur interne : 003555 ( Main/Exploration ); précédent : 003554; suivant : 003556Botulinum toxin type A for drooling in Parkinson's disease: A double‐blind, randomized, placebo‐controlled study
Auteurs : Giovanni Lagalla [Italie] ; Marzia Millevolte [Italie] ; Marianna Capecci [Italie] ; Leandro Provinciali [Italie] ; Maria Gabriella Ceravolo [Italie]Source :
- Movement Disorders [ 0885-3185 ] ; 2006-05.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
- Aged, Bontoxilysin, Botox, Botulinum Toxins, Type A (therapeutic use), Double blind study, Double-Blind Method, Female, Humans, Male, Middle Aged, Nervous system diseases, Neuromuscular Agents (therapeutic use), Parkinson Disease (complications), Parkinson Disease (drug therapy), Parkinson Disease (physiopathology), Parkinson disease, Parkinson's disease, Placebo, Sialorrhea, Sialorrhea (drug therapy), Sialorrhea (etiology), botulinum toxin type A, drooling.
- MESH :
- chemical , therapeutic use : Botulinum Toxins, Type A, Neuromuscular Agents.
- complications : Parkinson Disease.
- drug therapy : Parkinson Disease, Sialorrhea.
- etiology : Sialorrhea.
- physiopathology : Parkinson Disease.
- Aged, Double-Blind Method, Female, Humans, Male, Middle Aged.
Abstract
To investigate the safety and efficacy of botulinum toxin type A (BoNTX) treatment to reduce sialorrhea in Parkinson's disease (PD), a double‐blind, randomized, placebo‐controlled study enrolled 32 PD patients complaining of excessive drooling. Patients received either 50 U Botox in each parotid gland or placebo without using ultrasound guidance. Subjects treated with BoNTX experienced a reduction in both drooling frequency and familial and social disability (Time × Group effect: P < 0.01), as well as in saliva production (Time × Group effect: P < 0.0001). No adverse events were recorded. BoNTX injections are safe and effective treatment for the management of PD‐related drooling. © 2006 Movement Disorder Society
Url:
DOI: 10.1002/mds.20793
Affiliations:
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Le document en format XML
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<front><div type="abstract" xml:lang="en">To investigate the safety and efficacy of botulinum toxin type A (BoNTX) treatment to reduce sialorrhea in Parkinson's disease (PD), a double‐blind, randomized, placebo‐controlled study enrolled 32 PD patients complaining of excessive drooling. Patients received either 50 U Botox in each parotid gland or placebo without using ultrasound guidance. Subjects treated with BoNTX experienced a reduction in both drooling frequency and familial and social disability (Time × Group effect: P < 0.01), as well as in saliva production (Time × Group effect: P < 0.0001). No adverse events were recorded. BoNTX injections are safe and effective treatment for the management of PD‐related drooling. © 2006 Movement Disorder Society</div>
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<tree><country name="Italie"><noRegion><name sortKey="Lagalla, Giovanni" sort="Lagalla, Giovanni" uniqKey="Lagalla G" first="Giovanni" last="Lagalla">Giovanni Lagalla</name>
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<name sortKey="Capecci, Marianna" sort="Capecci, Marianna" uniqKey="Capecci M" first="Marianna" last="Capecci">Marianna Capecci</name>
<name sortKey="Ceravolo, Maria Gabriella" sort="Ceravolo, Maria Gabriella" uniqKey="Ceravolo M" first="Maria Gabriella" last="Ceravolo">Maria Gabriella Ceravolo</name>
<name sortKey="Millevolte, Marzia" sort="Millevolte, Marzia" uniqKey="Millevolte M" first="Marzia" last="Millevolte">Marzia Millevolte</name>
<name sortKey="Provinciali, Leandro" sort="Provinciali, Leandro" uniqKey="Provinciali L" first="Leandro" last="Provinciali">Leandro Provinciali</name>
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