MovDisordV3, Main, Exploration, bibRecordById, pubmed:1620140

Effect of aging and dopaminomimetic therapy on mitochondrial respiratory function in Parkinson's disease

Identifieur interne : 006028 ( Main/Exploration ); précédent : 006027; suivant : 006029

Effect of aging and dopaminomimetic therapy on mitochondrial respiratory function in Parkinson's disease

Auteurs : Daniele Bravi [États-Unis] ; Jeffrey J. Anderson [États-Unis] ; Fiorenzo Dagani [Italie] ; Thomas L. Davis [États-Unis] ; Rosaria Ferrari [Italie] ; Marge Gillespie [États-Unis] ; Chase [États-Unis]

Source :

Movement Disorders [ 0885-3185 ] ; 1992.

RBID : ISTEX:CC5EF4266868D9B9A52A82A774207936C3DFFF8A

Descripteurs français

Pascal (Inist)
- Age, Chaîne respiratoire, Chimiothérapie, Consommation oxygène, Exploration, Homme, Mitochondrie, Parkinson maladie, Stimulant dopaminergique, Thrombocyte, Traitement.
Wicri :
- topic : Glucose, Homme.

English descriptors

KwdEn :
- Age, Age Factors, Blood Glucose (metabolism), Blood Platelets (drug effects), Blood Platelets (physiology), Carbidopa (administration & dosage), Chemotherapy, Dopamine agonist, Drug Therapy, Combination, Energy Metabolism (drug effects), Energy Metabolism (physiology), Exploration, Female, Glucose, Human, Humans, Lactate, Lactates (blood), Lactic Acid, Levodopa (administration & dosage), Lisuride (administration & dosage), Male, Middle Aged, Mitochondria, Mitochondria (drug effects), Mitochondria (physiology), Oxygen Consumption (drug effects), Oxygen Consumption (physiology), Oxygen consumption, Parkinson Disease (drug therapy), Parkinson Disease (physiopathology), Parkinson disease, Platelet, Platelets, Receptors, Dopamine (drug effects), Receptors, Dopamine (physiology), Respiration, Respiratory chain, Selegiline (administration & dosage), Treatment.
MESH :
- chemical , administration & dosage : Carbidopa, Levodopa, Lisuride, Selegiline.
- chemical , blood : Lactates.
- chemical , drug effects : Receptors, Dopamine.
- chemical , metabolism : Blood Glucose.
- drug effects : Blood Platelets, Energy Metabolism, Mitochondria, Oxygen Consumption.
- drug therapy : Parkinson Disease.
- physiology : Blood Platelets, Energy Metabolism, Mitochondria, Oxygen Consumption, Receptors, Dopamine.
- physiopathology : Parkinson Disease.
- Age Factors, Drug Therapy, Combination, Female, Humans, Lactic Acid, Male, Middle Aged.

Abstract

Oxygen consumption and enzyme activity were evaluted in platelet mitochondria from 17 patients with Parkinson's disease. In comparison with age‐matched controls, no consistent abnormality could be discerned in complex I, complex II‐III, or complex IV oxygen consumption, or in the enzyme activity of these respiratory chain complexes. Neither chronic therapy with levodopa/carbidopa alone nor in combination with deprenyl significantly affected any measure of mitochondrial respiratory function. There was no discernible relationship between patient age or disease severity and any parameter of mitochondrial respiration. Moreover, blood lactate levels following glucose loading were not different in patients and controls. These results fail to support the occurrence of a generalized defect in any mitochondrial respiratory function in Parkinson's disease.

Url:

https://api.istex.fr/document/CC5EF4266868D9B9A52A82A774207936C3DFFF8A/fulltext/pdf

DOI: 10.1002/mds.870070307

Affiliations:

Le document en format XML

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<author><name sortKey="Anderson, Jeffrey J" sort="Anderson, Jeffrey J" uniqKey="Anderson J" first="Jeffrey J." last="Anderson">Jeffrey J. Anderson</name>
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<author><name sortKey="Dagani, Fiorenzo" sort="Dagani, Fiorenzo" uniqKey="Dagani F" first="Fiorenzo" last="Dagani">Fiorenzo Dagani</name>
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<author><name sortKey="Davis, Thomas L" sort="Davis, Thomas L" uniqKey="Davis T" first="Thomas L." last="Davis">Thomas L. Davis</name>
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<author><name sortKey="Ferrari, Rosaria" sort="Ferrari, Rosaria" uniqKey="Ferrari R" first="Rosaria" last="Ferrari">Rosaria Ferrari</name>
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<title level="j" type="sub">Official Journal of the Movement Disorder Society</title>
<title level="j" type="abbrev">Mov. Disord.</title>
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<term>Age Factors</term>
<term>Blood Glucose (metabolism)</term>
<term>Blood Platelets (drug effects)</term>
<term>Blood Platelets (physiology)</term>
<term>Carbidopa (administration & dosage)</term>
<term>Chemotherapy</term>
<term>Dopamine agonist</term>
<term>Drug Therapy, Combination</term>
<term>Energy Metabolism (drug effects)</term>
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<term>Exploration</term>
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<term>Lactic Acid</term>
<term>Levodopa (administration & dosage)</term>
<term>Lisuride (administration & dosage)</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Mitochondria</term>
<term>Mitochondria (drug effects)</term>
<term>Mitochondria (physiology)</term>
<term>Oxygen Consumption (drug effects)</term>
<term>Oxygen Consumption (physiology)</term>
<term>Oxygen consumption</term>
<term>Parkinson Disease (drug therapy)</term>
<term>Parkinson Disease (physiopathology)</term>
<term>Parkinson disease</term>
<term>Platelet</term>
<term>Platelets</term>
<term>Receptors, Dopamine (drug effects)</term>
<term>Receptors, Dopamine (physiology)</term>
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<term>Respiratory chain</term>
<term>Selegiline (administration & dosage)</term>
<term>Treatment</term>
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<term>Levodopa</term>
<term>Lisuride</term>
<term>Selegiline</term>
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</keywords>
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<term>Chaîne respiratoire</term>
<term>Chimiothérapie</term>
<term>Consommation oxygène</term>
<term>Exploration</term>
<term>Homme</term>
<term>Mitochondrie</term>
<term>Parkinson maladie</term>
<term>Stimulant dopaminergique</term>
<term>Thrombocyte</term>
<term>Traitement</term>
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<term>Homme</term>
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<keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Blood Platelets</term>
<term>Energy Metabolism</term>
<term>Mitochondria</term>
<term>Oxygen Consumption</term>
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<term>Receptors, Dopamine</term>
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<front><div type="abstract" xml:lang="en">Oxygen consumption and enzyme activity were evaluted in platelet mitochondria from 17 patients with Parkinson's disease. In comparison with age‐matched controls, no consistent abnormality could be discerned in complex I, complex II‐III, or complex IV oxygen consumption, or in the enzyme activity of these respiratory chain complexes. Neither chronic therapy with levodopa/carbidopa alone nor in combination with deprenyl significantly affected any measure of mitochondrial respiratory function. There was no discernible relationship between patient age or disease severity and any parameter of mitochondrial respiration. Moreover, blood lactate levels following glucose loading were not different in patients and controls. These results fail to support the occurrence of a generalized defect in any mitochondrial respiratory function in Parkinson's disease.</div>
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Movement Disorders (revue)

Effect of aging and dopaminomimetic therapy on mitochondrial respiratory function in Parkinson's disease

Effect of aging and dopaminomimetic therapy on mitochondrial respiratory function in Parkinson's disease

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

	Movement Disorders (revue)
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