An item response analysis of the motor and behavioral subscales of the unified Huntington's disease rating scale in huntington disease gene expansion carriers
Identifieur interne : 001811 ( Main/Exploration ); précédent : 001810; suivant : 001812An item response analysis of the motor and behavioral subscales of the unified Huntington's disease rating scale in huntington disease gene expansion carriers
Auteurs : Anthony L. Vaccarino [Canada] ; Karen Anderson [États-Unis] ; Beth Borowsky [États-Unis] ; Kevin Duff [États-Unis] ; Joseph Giuliano [États-Unis] ; Mark Guttman [Canada] ; Aileen K. Ho [Royaume-Uni] ; Michael Orth [Allemagne] ; Jane S. Paulsen [États-Unis] ; Terrence Sills [Canada] ; Daniel P. Van Kammen [États-Unis] ; Kenneth R. Evans [Canada]Source :
- Movement Disorders [ 0885-3185 ] ; 2011-04.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
- Adolescent, Adult, Aged, Aged, 80 and over, Behavioral Symptoms (etiology), Carrier, Disability Evaluation, Evaluation scale, Female, Humans, Huntington Disease (complications), Huntington Disease (diagnosis), Huntington Disease (genetics), Huntington disease, Male, Middle Aged, Movement Disorders (etiology), Nervous system diseases, Severity of Illness Index, Theory, Trinucleotide Repeat Expansion (genetics), UHDRS, Young Adult, item response theory.
- MESH :
- complications : Huntington Disease.
- diagnosis : Huntington Disease.
- etiology : Behavioral Symptoms, Movement Disorders.
- genetics : Huntington Disease, Trinucleotide Repeat Expansion.
- Adolescent, Adult, Aged, Aged, 80 and over, Disability Evaluation, Female, Humans, Male, Middle Aged, Severity of Illness Index, Young Adult.
Abstract
Although the Unified Huntington's Disease Rating Scale (UHDRS) is widely used in the assessment of Huntington disease (HD), the ability of individual items to discriminate individual differences in motor or behavioral manifestations has not been extensively studied in HD gene expansion carriers without a motor‐defined clinical diagnosis (ie, prodromal‐HD or prHD). To elucidate the relationship between scores on individual motor and behavioral UHDRS items and total score for each subscale, a nonparametric item response analysis was performed on retrospective data from 2 multicenter longitudinal studies. Motor and behavioral assessments were supplied for 737 prHD individuals with data from 2114 visits (PREDICT‐HD) and 686 HD individuals with data from 1482 visits (REGISTRY). Option characteristic curves were generated for UHDRS subscale items in relation to their subscale score. In prHD, overall severity of motor signs was low, and participants had scores of 2 or above on very few items. In HD, motor items that assessed ocular pursuit, saccade initiation, finger tapping, tandem walking, and to a lesser extent, saccade velocity, dysarthria, tongue protrusion, pronation/supination, Luria, bradykinesia, choreas, gait, and balance on the retropulsion test were found to discriminate individual differences across a broad range of motor severity. In prHD, depressed mood, anxiety, and irritable behavior demonstrated good discriminative properties. In HD, depressed mood demonstrated a good relationship with the overall behavioral score. These data suggest that at least some UHDRS items appear to have utility across a broad range of severity, although many items demonstrate problematic features. © 2011 Movement Disorder Society
Url:
- https://api.istex.fr/document/76839A9B21EBD52B441E3C13C242E33C562BEC5A/fulltext/pdf
- http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3157755
DOI: 10.1002/mds.23574
Affiliations:
- Allemagne, Canada, Royaume-Uni, États-Unis
- Bade-Wurtemberg, District de Tübingen, Iowa, Maryland, New Jersey, Utah
- Iowa City, Ulm
- Université d'Ulm, Université de l'Iowa
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Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2011-04">2011-04</date><biblScope unit="vol">26</biblScope><biblScope unit="issue">5</biblScope><biblScope unit="page" from="877">877</biblScope><biblScope unit="page" to="884">884</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">76839A9B21EBD52B441E3C13C242E33C562BEC5A</idno><idno type="DOI">10.1002/mds.23574</idno><idno type="ArticleID">MDS23574</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Behavioral Symptoms (etiology)</term><term>Carrier</term><term>Disability Evaluation</term><term>Evaluation scale</term><term>Female</term><term>Humans</term><term>Huntington Disease (complications)</term><term>Huntington Disease (diagnosis)</term><term>Huntington Disease (genetics)</term><term>Huntington disease</term><term>Male</term><term>Middle Aged</term><term>Movement Disorders (etiology)</term><term>Nervous system diseases</term><term>Severity of Illness Index</term><term>Theory</term><term>Trinucleotide Repeat Expansion (genetics)</term><term>UHDRS</term><term>Young Adult</term><term>item response theory</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Huntington Disease</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Huntington Disease</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Behavioral Symptoms</term><term>Movement Disorders</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Huntington Disease</term><term>Trinucleotide Repeat Expansion</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Disability Evaluation</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Severity of Illness Index</term><term>Young Adult</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Chorée de Huntington</term><term>Echelle d'évaluation</term><term>Pathologie du système nerveux</term><term>Porteur</term><term>Théorie</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Although the Unified Huntington's Disease Rating Scale (UHDRS) is widely used in the assessment of Huntington disease (HD), the ability of individual items to discriminate individual differences in motor or behavioral manifestations has not been extensively studied in HD gene expansion carriers without a motor‐defined clinical diagnosis (ie, prodromal‐HD or prHD). To elucidate the relationship between scores on individual motor and behavioral UHDRS items and total score for each subscale, a nonparametric item response analysis was performed on retrospective data from 2 multicenter longitudinal studies. Motor and behavioral assessments were supplied for 737 prHD individuals with data from 2114 visits (PREDICT‐HD) and 686 HD individuals with data from 1482 visits (REGISTRY). Option characteristic curves were generated for UHDRS subscale items in relation to their subscale score. In prHD, overall severity of motor signs was low, and participants had scores of 2 or above on very few items. In HD, motor items that assessed ocular pursuit, saccade initiation, finger tapping, tandem walking, and to a lesser extent, saccade velocity, dysarthria, tongue protrusion, pronation/supination, Luria, bradykinesia, choreas, gait, and balance on the retropulsion test were found to discriminate individual differences across a broad range of motor severity. In prHD, depressed mood, anxiety, and irritable behavior demonstrated good discriminative properties. In HD, depressed mood demonstrated a good relationship with the overall behavioral score. These data suggest that at least some UHDRS items appear to have utility across a broad range of severity, although many items demonstrate problematic features. © 2011 Movement Disorder Society</div></front></TEI><affiliations><list><country><li>Allemagne</li><li>Canada</li><li>Royaume-Uni</li><li>États-Unis</li></country><region><li>Bade-Wurtemberg</li><li>District de Tübingen</li><li>Iowa</li><li>Maryland</li><li>New Jersey</li><li>Utah</li></region><settlement><li>Iowa City</li><li>Ulm</li></settlement><orgName><li>Université d'Ulm</li><li>Université de l'Iowa</li></orgName></list><tree><country name="Canada"><noRegion><name sortKey="Vaccarino, Anthony L" sort="Vaccarino, Anthony L" uniqKey="Vaccarino A" first="Anthony L." last="Vaccarino">Anthony L. Vaccarino</name></noRegion><name sortKey="Evans, Kenneth R" sort="Evans, Kenneth R" uniqKey="Evans K" first="Kenneth R." last="Evans">Kenneth R. Evans</name><name sortKey="Guttman, Mark" sort="Guttman, Mark" uniqKey="Guttman M" first="Mark" last="Guttman">Mark Guttman</name><name sortKey="Sills, Terrence" sort="Sills, Terrence" uniqKey="Sills T" first="Terrence" last="Sills">Terrence Sills</name></country><country name="États-Unis"><region name="Maryland"><name sortKey="Anderson, Karen" sort="Anderson, Karen" uniqKey="Anderson K" first="Karen" last="Anderson">Karen Anderson</name></region><name sortKey="Borowsky, Beth" sort="Borowsky, Beth" uniqKey="Borowsky B" first="Beth" last="Borowsky">Beth Borowsky</name><name sortKey="Duff, Kevin" sort="Duff, Kevin" uniqKey="Duff K" first="Kevin" last="Duff">Kevin Duff</name><name sortKey="Giuliano, Joseph" sort="Giuliano, Joseph" uniqKey="Giuliano J" first="Joseph" last="Giuliano">Joseph Giuliano</name><name sortKey="Paulsen, Jane S" sort="Paulsen, Jane S" uniqKey="Paulsen J" first="Jane S." last="Paulsen">Jane S. Paulsen</name><name sortKey="Van Kammen, Daniel P" sort="Van Kammen, Daniel P" uniqKey="Van Kammen D" first="Daniel P." last="Van Kammen">Daniel P. Van Kammen</name></country><country name="Royaume-Uni"><noRegion><name sortKey="Ho, Aileen K" sort="Ho, Aileen K" uniqKey="Ho A" first="Aileen K." last="Ho">Aileen K. Ho</name></noRegion></country><country name="Allemagne"><region name="Bade-Wurtemberg"><name sortKey="Orth, Michael" sort="Orth, Michael" uniqKey="Orth M" first="Michael" last="Orth">Michael Orth</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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