Paroxysmal dyskinesias in mice
Identifieur interne : 002702 ( Main/Exploration ); précédent : 002701; suivant : 002703Paroxysmal dyskinesias in mice
Auteurs : Thomas L. Shirley [États-Unis] ; Lekha M. Rao [États-Unis] ; Ellen J. Hess [États-Unis] ; H. A. Jinnah [États-Unis]Source :
- Movement Disorders [ 0885-3185 ] ; 2008-01-30.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
- Age Factors, Animal, Animals, Behavior, Animal, Chorea (genetics), Chorea (physiopathology), Disease Models, Animal, Dyskinesia, Dystonia, Mice, Mice, Inbred C57BL, Mice, Neurologic Mutants, Mouse, Nervous system diseases, Severity of Illness Index, channelopathy, dystonia, lethargic, paroxysmal dyskinesia, rocker, tottering.
- MESH :
- genetics : Chorea.
- physiopathology : Chorea.
- Age Factors, Animals, Behavior, Animal, Disease Models, Animal, Mice, Mice, Inbred C57BL, Mice, Neurologic Mutants, Severity of Illness Index.
Abstract
Animal models of human disease are important tools for revealing the underlying mechanisms of pathophysiology and developing therapeutic strategies. Several unique mouse calcium channel mutants have been identified with nonepileptic, episodic dyskinetic movements that are phenotypically similar to human paroxysmal dyskinesias. In this report, video demonstrations of these motor attacks are provided for two previously described mouse mutants, tottering and lethargic, as well as a new one, rocker. Semiquantitative comparisons using two different rating scales reveal differences in attack morphology, severity, and duration among the strains. These mice provide three independent models of paroxysmal dyskinesia and support for prior proposals that channelopathies may underlie the human disorders. © 2007 Movement Disorder Society
Url:
- https://api.istex.fr/document/BC5FF097585FB0A2A2D5F037E0FDF67F796B3BB5/fulltext/pdf
- http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2887756
DOI: 10.1002/mds.21829
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: 002958
- to stream Istex, to step Curation: 002958
- to stream Istex, to step Checkpoint: 001258
- to stream Pmc, to step Corpus: 000020
- to stream Pmc, to step Curation: 000020
- to stream Pmc, to step Checkpoint: 000436
- to stream PubMed, to step Corpus: 002437
- to stream PubMed, to step Curation: 002437
- to stream PubMed, to step Checkpoint: 002153
- to stream Ncbi, to step Merge: 001F22
- to stream Ncbi, to step Curation: 001F22
- to stream Ncbi, to step Checkpoint: 001F22
- to stream Main, to step Merge: 003280
- to stream PascalFrancis, to step Corpus: 001382
- to stream PascalFrancis, to step Curation: 001937
- to stream PascalFrancis, to step Checkpoint: 001146
- to stream Main, to step Merge: 003754
- to stream Main, to step Curation: 002702
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Paroxysmal dyskinesias in mice</title>
<author><name sortKey="Shirley, Thomas L" sort="Shirley, Thomas L" uniqKey="Shirley T" first="Thomas L." last="Shirley">Thomas L. Shirley</name>
</author>
<author><name sortKey="Rao, Lekha M" sort="Rao, Lekha M" uniqKey="Rao L" first="Lekha M." last="Rao">Lekha M. Rao</name>
</author>
<author><name sortKey="Hess, Ellen J" sort="Hess, Ellen J" uniqKey="Hess E" first="Ellen J." last="Hess">Ellen J. Hess</name>
</author>
<author><name sortKey="Jinnah, H A" sort="Jinnah, H A" uniqKey="Jinnah H" first="H. A." last="Jinnah">H. A. Jinnah</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">ISTEX</idno>
<idno type="RBID">ISTEX:BC5FF097585FB0A2A2D5F037E0FDF67F796B3BB5</idno>
<date when="2008" year="2008">2008</date>
<idno type="doi">10.1002/mds.21829</idno>
<idno type="url">https://api.istex.fr/document/BC5FF097585FB0A2A2D5F037E0FDF67F796B3BB5/fulltext/pdf</idno>
<idno type="wicri:Area/Istex/Corpus">002958</idno>
<idno type="wicri:Area/Istex/Curation">002958</idno>
<idno type="wicri:Area/Istex/Checkpoint">001258</idno>
<idno type="wicri:doubleKey">0885-3185:2008:Shirley T:paroxysmal:dyskinesias:in</idno>
<idno type="wicri:source">PMC</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2887756</idno>
<idno type="RBID">PMC:2887756</idno>
<idno type="wicri:Area/Pmc/Corpus">000020</idno>
<idno type="wicri:Area/Pmc/Curation">000020</idno>
<idno type="wicri:Area/Pmc/Checkpoint">000436</idno>
<idno type="wicri:source">PubMed</idno>
<idno type="wicri:Area/PubMed/Corpus">002437</idno>
<idno type="wicri:Area/PubMed/Curation">002437</idno>
<idno type="wicri:Area/PubMed/Checkpoint">002153</idno>
<idno type="wicri:Area/Ncbi/Merge">001F22</idno>
<idno type="wicri:Area/Ncbi/Curation">001F22</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">001F22</idno>
<idno type="wicri:doubleKey">0885-3185:2008:Shirley T:paroxysmal:dyskinesias:in</idno>
<idno type="wicri:Area/Main/Merge">003280</idno>
<idno type="wicri:source">INIST</idno>
<idno type="RBID">Pascal:08-0133670</idno>
<idno type="wicri:Area/PascalFrancis/Corpus">001382</idno>
<idno type="wicri:Area/PascalFrancis/Curation">001937</idno>
<idno type="wicri:Area/PascalFrancis/Checkpoint">001146</idno>
<idno type="wicri:doubleKey">0885-3185:2008:Shirley T:paroxysmal:dyskinesias:in</idno>
<idno type="wicri:Area/Main/Merge">003754</idno>
<idno type="wicri:Area/Main/Curation">002702</idno>
<idno type="wicri:Area/Main/Exploration">002702</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Paroxysmal dyskinesias in mice</title>
<author><name sortKey="Shirley, Thomas L" sort="Shirley, Thomas L" uniqKey="Shirley T" first="Thomas L." last="Shirley">Thomas L. Shirley</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, Johns Hopkins University, Baltimore, Maryland</wicri:regionArea>
<placeName><region type="state">Maryland</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Rao, Lekha M" sort="Rao, Lekha M" uniqKey="Rao L" first="Lekha M." last="Rao">Lekha M. Rao</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, Johns Hopkins University, Baltimore, Maryland</wicri:regionArea>
<placeName><region type="state">Maryland</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Hess, Ellen J" sort="Hess, Ellen J" uniqKey="Hess E" first="Ellen J." last="Hess">Ellen J. Hess</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, Johns Hopkins University, Baltimore, Maryland</wicri:regionArea>
<placeName><region type="state">Maryland</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Jinnah, H A" sort="Jinnah, H A" uniqKey="Jinnah H" first="H. A." last="Jinnah">H. A. Jinnah</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, Johns Hopkins University, Baltimore, Maryland</wicri:regionArea>
<placeName><region type="state">Maryland</region>
</placeName>
</affiliation>
</author>
</analytic>
<monogr></monogr>
<series><title level="j">Movement Disorders</title>
<title level="j" type="abbrev">Mov. Disord.</title>
<idno type="ISSN">0885-3185</idno>
<idno type="eISSN">1531-8257</idno>
<imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher>
<pubPlace>Hoboken</pubPlace>
<date type="published" when="2008-01-30">2008-01-30</date>
<biblScope unit="vol">23</biblScope>
<biblScope unit="issue">2</biblScope>
<biblScope unit="page" from="259">259</biblScope>
<biblScope unit="page" to="264">264</biblScope>
</imprint>
<idno type="ISSN">0885-3185</idno>
</series>
<idno type="istex">BC5FF097585FB0A2A2D5F037E0FDF67F796B3BB5</idno>
<idno type="DOI">10.1002/mds.21829</idno>
<idno type="ArticleID">MDS21829</idno>
</biblStruct>
</sourceDesc>
<seriesStmt><idno type="ISSN">0885-3185</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Age Factors</term>
<term>Animal</term>
<term>Animals</term>
<term>Behavior, Animal</term>
<term>Chorea (genetics)</term>
<term>Chorea (physiopathology)</term>
<term>Disease Models, Animal</term>
<term>Dyskinesia</term>
<term>Dystonia</term>
<term>Mice</term>
<term>Mice, Inbred C57BL</term>
<term>Mice, Neurologic Mutants</term>
<term>Mouse</term>
<term>Nervous system diseases</term>
<term>Severity of Illness Index</term>
<term>channelopathy</term>
<term>dystonia</term>
<term>lethargic</term>
<term>paroxysmal dyskinesia</term>
<term>rocker</term>
<term>tottering</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Chorea</term>
</keywords>
<keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Chorea</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Age Factors</term>
<term>Animals</term>
<term>Behavior, Animal</term>
<term>Disease Models, Animal</term>
<term>Mice</term>
<term>Mice, Inbred C57BL</term>
<term>Mice, Neurologic Mutants</term>
<term>Severity of Illness Index</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Animal</term>
<term>Dyskinésie</term>
<term>Dystonie</term>
<term>Pathologie du système nerveux</term>
<term>Souris</term>
</keywords>
</textClass>
<langUsage><language ident="en">en</language>
</langUsage>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Animal models of human disease are important tools for revealing the underlying mechanisms of pathophysiology and developing therapeutic strategies. Several unique mouse calcium channel mutants have been identified with nonepileptic, episodic dyskinetic movements that are phenotypically similar to human paroxysmal dyskinesias. In this report, video demonstrations of these motor attacks are provided for two previously described mouse mutants, tottering and lethargic, as well as a new one, rocker. Semiquantitative comparisons using two different rating scales reveal differences in attack morphology, severity, and duration among the strains. These mice provide three independent models of paroxysmal dyskinesia and support for prior proposals that channelopathies may underlie the human disorders. © 2007 Movement Disorder Society</div>
</front>
</TEI>
<affiliations><list><country><li>États-Unis</li>
</country>
<region><li>Maryland</li>
</region>
</list>
<tree><country name="États-Unis"><region name="Maryland"><name sortKey="Shirley, Thomas L" sort="Shirley, Thomas L" uniqKey="Shirley T" first="Thomas L." last="Shirley">Thomas L. Shirley</name>
</region>
<name sortKey="Hess, Ellen J" sort="Hess, Ellen J" uniqKey="Hess E" first="Ellen J." last="Hess">Ellen J. Hess</name>
<name sortKey="Jinnah, H A" sort="Jinnah, H A" uniqKey="Jinnah H" first="H. A." last="Jinnah">H. A. Jinnah</name>
<name sortKey="Rao, Lekha M" sort="Rao, Lekha M" uniqKey="Rao L" first="Lekha M." last="Rao">Lekha M. Rao</name>
</country>
</tree>
</affiliations>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Santé/explor/MovDisordV3/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 002702 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 002702 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Santé |area= MovDisordV3 |flux= Main |étape= Exploration |type= RBID |clé= ISTEX:BC5FF097585FB0A2A2D5F037E0FDF67F796B3BB5 |texte= Paroxysmal dyskinesias in mice }}
![]() | This area was generated with Dilib version V0.6.23. | ![]() |